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| 1 | Ferroptosis as a novel form of regulated cell death:Implications in the pathogenesis,oncometabolism and treatment of human cancer显示文摘The treatment of cancer mainly involves surgical excision supplemented by radiotherapy and chemotherapy.Chemotherapy drugs act by interfering with tumor growth and inducing the death of cancer cells.Anti-tumor drugs were developed to induce apoptosis,but some patient’s show apoptosis escape and chemotherapy resistance.Therefore,other forms of cell death that can overcome the resistance of tumor cells are important in the context of cancer treatment.Ferroptosis is a newly discovered iron-dependent,non-apoptotic type of cell death that is highly negatively correlated with cancer development.Ferroptosis is mainly caused by the abnormal increase in iron-dependent lipid reactive oxygen species and the imbalance of redox homeostasis.This review summarizes the progression and regulatory mechanism of ferroptosis in cancer and discusses its possible clinical applications in cancer diagnosis and treatment. | Feifei Pu Fengxia Chen Zhicai Zhang Deyao Shi Binlong Zhong Xiao Lv Andrew Blake Tucker Jiaming Fan Alexander J.Li Kevin Qin Daniel Hu Connie Chen Hao Wang Fang He Na Ni Linjuan Huang Qing Liu William Wagstaff Hue H.Luu Rex C.Haydon Le Shen Tong-Chuan He Jianxiang Liu Zengwu Shao | 2022 | Genes & Diseases2022，9，2： | 6 |
| 2 | Solar photocatalytic processes for the purification of water:State of development and barriers to commercialization显示文摘 | Yves Parent Daniel Blake Kim Magrini-Bair | 1996 | Solar Energy1996，56，5： | 1 |
| 3 | Bactericial mode of titanium dioxide photocatalysis 显示文摘 | Zheng Huang Pin-Ching Maness Daniel M Blake | 2000 | Journal of Photochemistry and Photobiology A: Chemistry2000，130，： | 1 |
| 4 | Solar photo catalytic process for the purification of water:state of development and barriers to commercialization 显示文摘 | Yves Parent Daniel Blake Kim margrini - Batr | 1996 | Solar Energy1996，56，5： | 1 |
| 5 | 显示文摘 | Zheng Huang Pin-Ching Maness Daniel Blake M | 2000 | Journal of Photochemistry and Photobiology A: Chemistry2000，130，： | 1 |
| 6 | Bactericidal mode of titanium dioxide photocatalysis显示文摘 | Zheng Huang Pin-Ching Maness Daniel M. Blake Edward J. Wolfrum Sharon L. Smolinski William A. Jacoby | 2000 | Journal of Photochemistry & Photobiology A: Chemistry2000，，2： | 1 |
| 7 | Bactericial mode of titanium dioxide photocatalysis显示文摘 | Zheng Huang Pin-Ching Maness Daniel M Blake Edward J Wolfrum Sharon L Smolinski William A Jaeoby | 2000 | Journal of Photochemistry and Photobiology A : Chemistry2000，130，： | 1 |
| 8 | 采用分析方法、毒理学和风险评估研究评估多环芳烃:以石油泄漏后海产品安全为案例显示文摘[背景]多环芳香烃(PAHs)是一种大量蔓延的环境化学物质。它们可通过自然和人为过程产生,通常存在于有机介质(包括石油)中。有几种PAHs是有毒的,其中一些还表现出致癌活性。PAHs以含有两个及以上苯环的一系列化学结构为特征,根据它们的来源,可以通过氧化、氮化和烷基化表现出多种侧链修饰。[目的]讨论当代分析方法日益增加的能力,其不仅可以分辨PAHs中不同的化学结构,而且可以识别它们在环境介质中的浓度。本文以深水地平线事故后海产品污染为例,确定由于个别PAHs的分析灵敏度增加而在PAHs风险评估过程中出现的一些问题,并描述其中许多化合物的毒理学文献缺乏的现状。[讨论]PAHs,包括种类繁多的经化学修饰或取代的PAHs,是自然产生的,如果人群暴露于有害水平就可能会遭受健康风险。然而,目前的毒性评估并没有跟上现代分析方法及其对于被替代的PAHs不断增加的检测能力。因此,尽管我们可以在海产品和其他媒介中检测这些化合物,但并没有足够的关于这些化合物的潜在毒性信息,无法将它们用于人类健康风险评估和特征描述。[结论]今后的研究工作应该尝试从战略上填补这一毒理学知识欠缺,从而更好地进行环境介质或食物中关于PAHs的人体健康风险评估。这对于石油泄漏之后的影响尤为重要。 | Jeffrey Wickliffe Edward Overton Scott Frickel Jessi Howard Mark Wilson Bridget Simon Stephen Echsner Daniel Nguyen David Gauthe Diane Blake Charles Miller Cornelis Elferink Shakeel Ansari Harshica Ferno Edward Trapido Andrew Kane 张晶 汪源 金泰廙 | 2014 | 环境与职业医学2014，31，6： | 1 |
| 9 | Bactericidal mode of titanium dioxide photocatalysis显示文摘 | Zheng Huang Pin-ching Maness Daniel M Blake | 2000 | Journal of Photochemistry and Photobiology A:Chemistry2000，13，： | 1 |
| 10 | The Suppression of Exciting Thoughts 显示文摘 | Daniel Wegner Joann Shoat Anne Blake Michelle Page | 1990 | Jour- nal of Personality and Social Psychology1990，58，3： | 1 |
| 11 | Advanced thermal storage fluids 显示文摘 | Moens Luc Blake Daniel M | 2003 | Journal of Solar Energy Engineering2003，125，： | 1 |
| 12 | Extranodal natural killer/T‐Cell lymphoma: A population‐based comparison of sinonasal and extranasal disease显示文摘 | Alejandro Vazquez Mohemmed N. Khan Danielle M. Blake Saurin Sanghvi Soly Baredes Jean Anderson Eloy | 2014 | The Laryngoscope2014，，4： | 1 |
| 13 | Bactericial mode of titanium dioxide photocatalysis显示文摘 | Zheng Huang Pin-Ching Maness Daniel M Blake etc | 2000 | Journal of Photochemistry and Photobiology A: Chemistry2000，130，： | 1 |
| 14 | Bactericidal mode of titanium dioxide photocatalysis 显示文摘 | Zheng Huang Pin Citing Maness Daniel M Blake | 2000 | Journal of Photochemistry and Photobiology A: Chemistry2000，130，： | 1 |
| 15 | Endovascular Treatment of Hepatic Artery Stenosis after Liver Transplantation显示文摘 | Blake A. Hamby Daniel E. Ramirez George E. Loss Hernan A. Bazan Taylor A. Smith Edward Bluth W. Charles Sternbergh | 2012 | Journal of Vascular Surgery2012，，： | 1 |
| 16 | Recent advances in operational tropical cyclone genesis forecast显示文摘Tropical cyclone(TC)genesis prediction is a major scientific challenge to the TC operation and research community.This report surveys the current status of TC genesis forecasts by a number of major operational centers covering the key ocean basins across both hemispheres.Since IWTC-9,we see an emergence of probabilistic TC genesis forecast products by operational centers,typically supported by the statistical processing of a combination of ensemble prediction and satellite analysis,covering time periods of couple of days to weeks ahead.The prevalence of multi-center grand ensemble approach highlights the uncertainties involved and the forecast challenges in quantitative genesis prediction.While operational practice might differ across agencies,verification efforts generally report a steady or slightly improving skill level in terms of reliability,which likely results from the continual improvement in global numerical weather prediction capability. | K.K.Hon Robert Ballard Eric Blake Steph Bond Robb Gile Daniel Halperin Charles Helms Hoang Lam Xinyan Lyu Mrutyunjay Mohapatra Monica Sharma Akira Shimokobe Ralf Toumi Seonghee Won | 2023 | Tropical Cyclone Research and Review2023，12，4： | 0 |
| 17 | 10,000 years of climate control over carbon accumulation in an Iberian bog(southwestern Europe)显示文摘The northwest region of the Iberian Peninsula is home to a unique ecosystem of bogs,which are particularly sensitive to projected climate cha nge.In this context,the rate of carbon(C)accumulation in Chao de Veiga Mol.an intact raised bog,was analysed.Changes in the accumulation rate over the past10 millennia were determined in a peat core of 847 cm in depth,with a high mean rate of peat growth(11 yr cm^-1,0.09 cm yr^-1).An age-depth model was generated from 22 14C dates and fallout radionuclides.Chronological,stratigraphical and physico-chemical data confirmed the existence of a single cycle of peat formation throughout the Holocene and the formation of ombrotrophic peat 9500 years ago.The total mean C content was 50.2%,and over 10 millennia 583 kg C m^-2 accumulated at a mean rate of 35.3 g C m^-2 yr^-1,with a long-term(apparent)rate of carbon accumulation in the catotelm of59.9 g C m^-2 yr^-1.These values are much higher than reported for other Iberian peatlands and are amongst the highest documented for peatlands in the northern hemisphere.The dynamics of C accumulation and other measured parameters reveals important variations throughout the Holocene.They could be associated with the main climatic events described in the northern hemisphere and are highly consistent with models established for northern latitudes.The Chao de Veiga Mol raised bog is unique and of great potential value for carrying out high resolution palaeoenvironmental studies,especially in relation to regional and Iocal modulations in southern Europe. | Xabier Pontevedra-Pombal Daniel Castro Martín Souto Isabel Fraga William H. Blake Maarten Blaauw José A. López-Sáez Sebastián Pérez-Díaz Marcos Valcárcel Eduardo García-Rodeja | 2019 | Geoscience Frontiers2019，10，4： | 0 |
| 18 | Lupus-associated thrombotic thrombocytopenic purpura-like microangiopathy显示文摘Recently reported cases of lupus complicated by a thrombotic thrombocytopenic purpura(TTP)-like syndrome suggest a survival benefit to early treatment with plasma exchange. The following is a report of the eighth such case in the last ten years. A 44-yearold lady known for lupus presented with the nephrotic syndrome and a renal biopsy was consistent with class 4G lupus nephritis. She was given high-dose steroids and cytotoxic therapy, but her induction therapy was complicated by the classic pentad of TTP. She was subsequently treated with another course of high-dose steroids, a different cytotoxic agent, and plasma exchange, with clinical resolution shortly thereafter. Similar to seven recently reported cases of microangiopathy in lupus, this lady's TTP-like syndrome improved dramatically after initiation of plasma exchange, despite not having a severely deficient ADAMTS13. This has implications on both current clinical practice and on the pathogenesis of TTP-like syndromes in lupus. | Daniel Blum Geoffrey Blake | 2015 | World Journal of Nephrology2015，4，5： | 0 |
| 19 | 阿梅格尔巴克/哥本山显示文摘垃圾焚烧发电厂阿梅格尔巴克/哥本山位于工业区,多年来,该工业区已成为冒险者们的极限运动目的地。原始的工业设施为各种极限运动活动提供了场所,如缆绳滑水、卡丁车和攀岩等。阿梅格尔巴克/哥本山是该地区最重要的地标,其建筑亟须更新。我们提出了一种新型的垃圾焚烧发电厂,这种工厂能产生经济、环保和社会效益。 | Nanna Gyldholm M■ller Alberto Cumerlato Aleksander Wadas Alexander Codda Alexander Ejsing Alexandra Gustafsson Alina Tamosiunaite Armor Gutierrez Anders Hjortn■s Andreas Klok Pedersen Annette Jensen Ariel Wallner Ask Andersen Balaj IIulian Blake Smith Borko Nikolic Brygida Zawadzka Buster Christensen Chris Falla Chris Zhongtian Yuan Daniel Selensky Dennis Rasmussen Espen Vik Finn N■rkj■r Franck Fdida Gonzalo Castro Gül Ertekin George Abraham Helen Chen Henrick Poulsen Henrik R■mer Kania Horia Spirescu Jakob Ohm Laursen Jelena Vucic Jeppe Ecklon Ji-young Yoon Jing Xu Joanna Jakubowska Johanna Nenander Kamilla Heskje Katarzyna Siedlecka Krzysztof Marciszewski Laura W■tte Liang Wang Lise Jessen Long Zuo Maciej Zawadzki Mads Enggaard Stidsen Marcelina Kolasinska Marcos Bano Maren Allen Mathias Bank Matti N■rgaard Michael Andersen Narisara Ladawal Schr■der Niklas A.Rasch Nynne Madsen ■ssur Nols■ Pero Vukovic Richard Howis Ryohei Koike Se Hyeon Kim Simon Masson Sunming Lee Toni Mateu Xing Xiong Zoltan David Kalaszi Rasmus Hjortshoj 陈子钰(译) | 2019 | 城市环境设计2019，0，2： | 0 |
| 20 | 曼哈顿Big U规划显示文摘'设计重建计划'是飓风桑迪重建工作组和美国住房与城市发展部的一项倡议,该计划旨在解决飓风肆虐之后造成的地区性结构破坏和环境缺陷问题,并衍生出一种经济上可行的解决方案以保护居民免受未来气候问题的影响。而Big U规划是一个围绕着曼哈顿的保护系统,从西54街向南至巴特里,并一直延伸至东40街:1条绵延10英里(约16.1千米)的低洼带,其中包含着分布密集、充满活力但又脆弱不已的都市空间。 | Kurt Nieminen Dammy Lee Yifu Sun Jack Lipson David Spittler Blake Smith David Dottelonde Ken Amoah Choonghyo Lee Wesley Chiang Daisy Zhong Hector Garcia Riccardo de Palma Yaziel Juarbe Taylor Hewett Jan Casimir Daniele Pronesti Tore Banke Yehezkiel Wiliardy 朱翰林(译) | 2019 | 城市环境设计2019，0，2： | 0 |
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