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| 1 | 青藏高原东北部树木年轮记录揭示的最高最低温的非对称变化显示文摘江河源区自然环境严酷,生态系统脆弱.近年来由于该区域日趋严重的生态环境问题使之逐渐成为全社会所广泛关注的焦点地区.根据采自青藏高原东北部黄河源区西顷山和阿尼玛卿山的祁连园柏树轮样芯,重建了研究区过去近425a来冬半年的最低温和近700a来夏半年最高温.1578~1940年的近400a间研究区冬半年最低温度的波动较为平缓,但是自1941年来以来有急剧的升温趋势.夏半年最高温在20世纪末表现出明显的升温趋势.近425a来最高温和最低温的变化存在非对称现象.最高温和最低温在近425a来的变化非常相似,但最低温的变化比最高温的变化超前大约25a左右.如果在未来30a内最高温和最低温的变化保持过去近425a来的相关趋势,那么在未来30a内,最高温也将继续剧烈升温. | 勾晓华 陈发虎 杨梅学 Gordon Jacoby 方克艳 田沁花 张永 | 2007 | 中国科学(D辑)2007，37，11： | 19 |
| 2 | Asymmetric variability between maximum and minimum temperatures in Northeastern Tibetan Plateau:Evidence from tree rings显示文摘Ecological systems in the headwaters of the Yellow River, characterized by hash natural environmental conditions, are very vulnerable to climatic change. In the most recent decades, this area greatly attracted the public's attention for its more and more deteriorating environmental conditions. Based on tree-ring samples from the Xiqing Mountain and A'nyêmagên Mountains at the headwaters of the Yellow River in the Northeastern Tibetan Plateau, we reconstructed the minimum temperatures in the winter half year over the last 425 years and the maximum temperatures in the summer half year over the past 700 years in this region. The variation of minimum temperature in the winter half year during the time span of 1578―1940 was a relatively stable trend, which was followed by an abrupt warming trend since 1941. However, there is no significant warming trend for the maximum temperature in the summer half year over the 20th century. The asymmetric variation patterns between the minimum and maximum temperatures were observed in this study over the past 425 years. During the past 425 years, there are similar variation patterns between the minimum and maximum temperatures; however, the minimum temperatures vary about 25 years earlier compared to the maximum temperatures. If such a trend of variation patterns between the minimum and maximum temperatures over the past 425 years continues in the future 30 years, the maximum temperature in this region will increase significantly. | Jacoby GORDON | 2008 | Science China Earth Sciences2008，51，1： | 19 |
| 3 | 建成环境对步行和自行车出行的影响——以波哥大为例显示文摘哥伦比亚波哥大以可持续的城市交通系统闻名,包括其密集的自行车道网络以及Ciclovía系统——为骑车者和行人预留的道路空间,可在星期日和节假日休闲出行使用。探讨此类设施以及建成环境的其他属性——城市密度、混合用地、可达性以及与公共交通车站的距离——如何影响步行和自行车出行行为以及Ciclovía的使用。结果表明,道路设施设计要素例如道路密度、连通性、与Ciclovía车道的距离,与体力活动相关;而建成环境的其他属性如密度和用地混合程度,对体力活动影响甚微。这可能是由于波哥大建成区的大部分街区均在非机动交通出行占绝对优势的时期演变发展——紧凑、用地混合、交通可达性水平相似。由此可见,影响非机动交通出行的因素是设施设计而非一般的街区用地属性。 | Robert Cervero Olga L.Sarmiento Enrique Jacoby Luis Fernando Gomez Andrea Neiman 耿雪 | 2016 | 城市交通2016，14，5： | 13 |
| 4 | 糖尿病患者的急性心肌梗死显示文摘糖尿病患者中冠脉疾病发病率增加,急性心肌梗死则是糖尿病患者主要死亡原因。特尿病促进冠脉粥样硬化加速发展和血栓形成,从而促发急性心肌梗死。自主神经病则使梗死症状不典型,以致诊断困难和延误治疗时机。糖尿病伴心肌梗死的病程复杂,病死率高。 | Jacoby RM 胡琛 | 1993 | 国外医学(老年医学分册)1993，14，3： | 11 |
| 5 | Mitochondrial Composition,Function and Stress Response in Plants显示文摘The primary function of mitochondria is respiration,where catabolism of substrates is coupled to ATP synthesis via oxidative phosphorylation.In plants,mitochondrial composition is relatively complex and flexible and has specific pathways to support photosynthetic processes in illuminated leaves.This review begins with outlining current models of mitochondrial composition in plant cells,with an emphasis upon the assembly of the complexes of the classical electron transport chain (ETC).Next,we focus upon the comparative analysis of mitochondrial function from different tissue types.A prominent theme in the plant mitochondrial literature involves linking mitochondrial composition to environmental stressresponses,and this review then gives a detailed outline of how oxidative stress impacts upon the plant mitochondrial proteome with particular attention to the role of transition metals.This is followed by an analysis of the signaling capacity of mitochondrial reactive oxygen species,which studies the transcriptional changes of stress responsive genes as a framework to define specific signals emanating from the mitochondrion.Finally,specific mitochondrial roles during exposure to harsh environments are outlined,with attention paid to mitochondrial delivery of energy and intermediates,mitochondrial support for photosynthesis,and mitochondrial processes operating within root cells that mediate tolerance to anoxia and unfavorable soil chemistries. | Richard P. Jacoby Lei Li Shaobai Huang Chun Pong Lee A. Harvey Millar Nicolas L. Taylor | 2012 | Journal of Integrative Plant Biology2012，54，11： | 7 |
| 6 | Fractal and Multifractal Propertiesof the Spatial Distribution of Natural Fractures——Analyses and Applications显示文摘The Cantor’s dust theory is applied to investigate the scaling properties of the spatial distribution of natural fractures obtained from detailed scanline surveys of 27 field sites in the Appalachian Plateau of western New York, USA. The results obtained in this study indicate: 1) fracture spacing is characterized by fractal and multifractal properties. On small scales analyses yield an average fractal dimension of 0.15, which suggests a very high degree of clustering. In contrast, on large scales, fractures tend to be more regular and evenly distributed with an average fracture dimension of 0.52; 2) fractal dimension varies with different sets in different orientations, which can be attributed to interactions between pre-existing fractures and younger ones, as well as variations of the intensity of the stresses under which the fractures were formed; 3) a time sequence of fracture set formation can be proposed based on fractal and multifractal analyses, which consists of (from old to young): N-S, NW, | XU Jiandong QU Guosheng Robert D. JACOBI | 1999 | Acta Geologica Sinica(English Edition)1999，73，4： | 5 |
| 7 | Acute effects of rotavirus and malnutrition on intestinal barrier function in neonatal piglets显示文摘AIM: To investigate the effect of protein-energy malnutrition on intestinal barrier function during rotavirus enteritis in a piglet model.METHODS: Newborn piglets were allotted at day 4 of age to the following treatments:(1) full-strength formula(FSF)/noninfected;(2) FSF/rotavirus infected;(3) half-strength formula(HSF)/noninfected;or(4) HSF/rotavirus infected.After one day of adjustment to the feeding rates,pigs were infected with rotavirus and acute effects on growth and diarrhea were monitored for 3 d and jejunal samples were collected for Ussingchamber analyses.RESULTS: Piglets that were malnourished or infected had lower body weights on days 2 and 3 post-infection(P < 0.05).Three days post-infection,marked diarrhea and weight loss were accompanied by sharp reductions in villus height(59%) and lactase activity(91%) and increased crypt depth(21%) in infected compared with non-infected pigs(P < 0.05).Malnutrition also increased crypt depth(21%) compared to full-fed piglets.Villus:crypt ratio was reduced(67%) with viral infection.There was a trend for reduction in transepithelial electrical resistance with rotavirus infection and malnutrition(P = 0.1).3H-mannitol flux was significantly increased(50%;P < 0.001) in rotavirus-infected piglets compared to non-infected piglets,but there was no effect of nutritional status.Furthermore,rotavirus infection reduced localization of the tight junction protein,occludin,in the cell membrane and increased localization in the cytosol.CONCLUSION: Overall,malnutrition had no additive effects to rotavirus infection on intestinal barrier function at day 3 post-infection in a neonatal piglet model. | Sheila K Jacobi Adam J Moeser Anthony T Blikslager J Marc Rhoads Benjamin A Corl Robert J Harrell Jack Odle | 2013 | World Journal of Gastroenterology2013，19，31： | 4 |
| 8 | 细菌对抗菌药物新的耐药机理显示文摘细菌的失活酶或纯化酶对抗生素的失活作用、细胞外膜孔蛋白丢失或内膜激活抗生素流出系统的产生引起的抗生素摄取降低、PBP-2a新的青霉素结合蛋白的产生以及DNA旋转酶A或B亚基的变异引起的对抗生素的亲和性降低等均为目前细菌对抗菌药物新的耐药机理。本文就上述的耐药机理、多重耐药菌株的发展、耐药基因的起源和传播等问题作了详尽的阐说和综述,并对21世纪的细菌耐药性以及人们将作的努力作了展望。 | Jacoby GA and Archer GL 朱德妹 | 1991 | 国外医学(微生物学分册)1991，14，4： | 3 |
| 9 | Reproducibility of thrombus volume quantification in multicenter computed tomography pulmonary angiography studies显示文摘AIM To evaluate reproducibility of pulmonary embolism(PE) clot volume quantification using computed tomography pulmonary angiogram(CTPA) in a multicenter setting.METHODS This study was performed using anonymized data in conformance with HIPAA and IRB Regulations(March 2015-November 2016). Anonymized CTPA data was acquired from 23 scanners from 18 imaging centers using each site's standard PE protocol. Two independent analysts measured PE volumes using a semi-automated region-growing algorithm on an FDA-approved image analysis platform. Total thrombus volume(TTV) was calculated per patient as the primary endpoint. Secondary endpoints were individual thrombus volume(ITV), Qanadli score and modified Qanadli score per patient. Inter-and intra-observer reproducibility were assessed using intra-class correlation coefficient(ICC) and BlandAltman analysis. RESULTS Analyst 1 found 72 emboli in the 23 patients with a mean number of emboli of 3.13 per patient with a range of 0-11 emboli per patient. The clot volumes ranged from 0.0041-47.34 cm3(mean +/-SD, 5.93 +/-10.15 cm3). On the second read, analyst 1 found the same number and distribution of emboli with a range of volumes for read 2 from 0.0041 – 45.52 cm3(mean +/-SD, 5.42 +/-9.53 cm3). Analyst 2 found 73 emboli in the 23 patients with a mean number of emboli of 3.17 per patient with a range of 0-11 emboli per patient. The clot volumes ranged from 0.00459-46.29 cm3(mean +/-SD, 5.91 +/-10.06 cm3). Inter-and intraobserver variability measurements indicated excellent reproducibility of the semi-automated method for quantifying PE volume burden. ICC for all endpoints was greater than 0.95 for inter-and intra-observer analysis. Bland-Altman analysis indicated no significant biases.CONCLUSION Semi-automated region growing algorithm for quantifying PE is reproducible using data from multiple scanners and is a suitable method for image analysis in multicenter clinical trials. | Audrey E Kaufman Alison N Pruzan Ching Hsu Sarayu Ramachandran Adam Jacobi Indravadan Patel Lee Schwocho Michele F Mercuri Zahi A Fayad Venkatesh Mani | 2018 | World Journal of Radiology2018，10，10： | 3 |
| 10 | Relationship of anxiety disorders, sleep quality, and functional impairment in a community sample显示文摘 | Holly J. Ramsawh Murray B. Stein Shay-Lee Belik Frank Jacobi Jitender Sareen | 2009 | Journal of Psychiatric Research2009，，10： | 3 |
| 11 | Effect of varying computed tomography acquisition and reconstruction parameters on semi-automated clot volume quantification显示文摘AIM To examine effects of computed tomography(CT)image acquisition/reconstruction parameters on clot volume quantification in vitro for research method validation purposes.METHODS This study was performed in conformance with HIPAA and IRB Regulations(March 2015-November 2016).A ten blood clot phantom was designed and scanned on a dual-energy CT scanner(SOMATOM Force,Siemens Healthcare Gm BH,Erlangen,Germany)with varying pitch,iterative reconstruction,energy level and slicethickness.A range of clot and tube sizes were used in an attempt to replicate in vivo emboli found within central and segmental branches of the pulmonary arteries in patients with pulmonary emboli.Clot volume was the measured parameter and was analyzed by a single image analyst using a semi-automated region growing algorithm implemented in the FDA-approved Siemens syngo.via image analysis platform.Mixed model analysis was performed on the data.RESULTS On the acquisition side,the continuous factor of energy showed no statistically significant effect on absolute clot volume quantification(P=0.9898).On the other hand,when considering the fixed factor of pitch,there were statistically significant differences in clot volume quantification(P<0.0001).On the reconstruction side,with the continuous factor of reconstruction slice thickness no statistically significant effect on absolute clot volume quantification was demonstrated(P=0.4500).Also on the reconstruction side,with the fixed factor of using iterative reconstructions there was also no statistically significant effect on absolute clot volume quantification(P=0.3011).In addition,there was excellent R^2 correlation between the scale-measured mass of the clots both with respect to the CT measured volumes and with respect to volumes measure by the water displacement method.CONCLUSION Aside from varying pitch,changing CT acquisition parameters and using iterative reconstructions had no significant impact on clot volume quantification with a semi-automated region growing algorithm. | Audrey E Kaufman Alison N Pruzan Ching Hsu Sarayu Ramachandran Adam Jacobi Zahi A Fayad Venkatesh Mani | 2018 | World Journal of Radiology2018，10，3： | 3 |
| 12 | Regulation of axonal remodeling following spinal cord injury显示文摘Central nervous system injuries,such as spinal cord injury(SCI),are a leading cause of disability in young adults.SCIs generally have severe clinical consequences and often lead to loss of motor or sensory input below the segment of injury. | Anne Jacobi Florence M.Bareyre | 2015 | Neural Regeneration Research2015，10，10： | 2 |
| 13 | The Role of Synthetic Biology in Atmospheric Greenhouse Gas Reduction: Prospects and Challenges显示文摘The long atmospheric residence time of CO2 creates an urgent need to add atmospheric carbon drawdown to CO2 regulatory strategies.Synthetic and systems biology(SSB),which enables manipulation of cellular phenotypes,offers a powerful approach to amplifying and adding new possibilities to current land management practices aimed at reducing atmospheric carbon.The participants(in attendance:Christina Agapakis,George Annas,Adam Arkin,George Church,Robert Cook-Deegan,Charles DeLisi,Dan Drell,Sheldon Glashow,Steve Hamburg,Henry Jacoby,Henry Kelly,Mark Kon,Todd Kuiken,Mary Lidstrom,Mike MacCracken,June Medford,Jerry Melillo,Ron Milo,Pilar Ossorio,Ari Patrinos,Keith Paustian,Kristala Jones Prather,Kent Redford,David Resnik,John Reilly,Richard J.Roberts,Daniel Segre,Susan Solomon,Elizabeth Strychalski,Chris Voigt,Dominic Woolf,Stan Wullschleger,and Xiaohan Yang)identified a range of possibilities by which SSB might help reduce greenhouse gas concentrations and which might also contribute to environmental sustainability and adaptation.These include,among other possibilities,engineering plants to convert CO2 produced by respiration into a stable carbonate,designing plants with an increased root-to-shoot ratio,and creating plants with the ability to self-fertilize.A number of serious ecological and societal challenges must,however,be confronted and resolved before any such application can be fully assessed,realized,and deployed. | Charles DeLisi Aristides Patrinos Michael MacCracken Dan Drell George Annas Adam Arkin George Church Robert Cook-Deegan Henry Jacoby Mary Lidstrom Jerry Melillo Ron Milo Keith Paustian John Reilly Richard J.Roberts Daniel Segrè Susan Solomon Dominic Woolf Stan D.Wullschleger Xiaohan Yang | 2020 | BioDesign Research2020，，1： | 2 |
| 14 | The effects of epithelial cell supernatant on contractions of isolated canine tracheal smooth muscle显示文摘 | Barnett K Jacoby D B Nadel J A | 1988 | Am Rev Respir Dis1988，138，4： | 2 |
| 15 | An experimental study of flow and heat transfer in sinusoidal wavy passages显示文摘 | Rush T A Newell T A Jacobi A M | 1999 | Int J Heat Mass Transfer1999，42，9： | 2 |
| 16 | A functional classification scheme for beta-lactamases and its correlation with molecular structure 显示文摘 | Bush K Jacoby G A Medeiros A A | 1995 | Antimicrob Agents Chemother1995，39，： | 2 |
| 17 | A review on application of carbonaceous materials and carbon matrix composites for heat exchangers and heat sinks显示文摘 | Q. Wang X.H. Han A. Sommers Y. Park C. T’ Joen A. Jacobi | 2011 | International Journal of Refrigeration2011，，1： | 2 |
| 18 | Ru(0001)表面上O-Ru伸缩振动的覆盖度依赖特性显示文摘在Ru(0001)表面上,通过氧气以及二氧化氮气体的分解吸附,制备了具有不同氧覆盖度的氧覆盖层.高分辨电子能量损失谱的测量表明,ORu伸缩振动具有强烈的覆盖度依赖特性。 | 何丕模 Jacobi,K | 1999 | 物理学报1999，48，2： | 2 |
| 19 | Monopoly power and distribution in framented markets: The case of groundwater显示文摘 | Jacoby H Murgai R Rehman S | 2004 | Review of Economic Studies2004，71，： | 1 |
| 20 | Plamid determined AmpC type beta lactamases 显示文摘 | Philippon A Arlet G Jacoby GA | 2002 | Antimierob Agents Chemother2002，46，5： | 1 |
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