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| 1 | Cetuximab plus FOLFOX6 or FOLFIRI in metastatic colorectal cancer: CECOG trial显示文摘AIM: To investigate efficacy and safety of cetuximab combined with two chemotherapy regimens in patients with unresectable metastatic colorectal cancer (mCRC). METHODS: Randomized patients received cetuximab with 5-fluorouracil (5-FU), folinic acid (FA) and oxaliplatin (FOLFOX) 6 (arm A, n = 74) or 5-FU, FA and irinotecan (FOLFIRI) (arm B, n = 77). KRAS mutation status was determined retrospectively in a subset of tumors (n = 117). RESULTS: No significant difference was found between treatment arms A and B in the progression-free survival (PFS) rate at 9 mo, 45% vs 34%; median PFS, 8.6 mo vs 8.3 mo [hazard ratio (HR) = 1.06]; overall response rate (ORR) 43% vs 45% [odds ratio (OR) = 0.93] and median overall survival (OS), 17.4 mo vs 18.9 mo (HR = 0.98). Patients with KRAS wild-type tumors demonstrated improved PFS (HR = 0.55, P = 0.0051), OS, (HR = 0.62, P = 0.0296) and ORR (53% vs 36%) and in arm A, improved PFS (HR = 0.49, P = 0.0196), OS (HR = 0.48, P = 0.0201) and ORR (56%vs 30%), compared with patients with KRAS mutated tumors. In arm B no significant differences were found in efficacy by KRAS mutation status. Treatment in arms A and B was generally well tolerated. CONCLUSION: This study confirms that combinations of cetuximab with FOLFOX6 or FOLFIRI are effective and significantly improve clinical outcome in KRAS wild-type compared with KRAS mutated mCRC. | Janja Ocvirk Thomas Brodowicz Fritz Wrba Tudor E Ciuleanu Galina Kurteva Semir Beslija Ivan Koza Zsuzsanna Pápai Diethelm Messinger Ugur Yilmaz Zsolt Faluhelyi Suayib Yalcin Demetris Papamichael Miklós Wenczl Zrinka Mrsic-Krmpotic Einat Shacham-Shmueli Damir Vrbanec Regina Esser Werner Scheithauer Christoph C Zie-linski | 2010 | World Journal of Gastroenterology2010，16，25： | 17 |
| 2 | Biliary wound healing, ductular reactions, and IL-6/gp130 signaling in the development of liver disease显示文摘在胆汁的树上的 Basic 和翻译创伤愈合研究在皮和胃肠道上在类似的研究后面显著地落后。这是至少对为学习的胆道的容易的存取的缺乏部分可归因。但是临床的关联,对胆汁的上皮的房间(BEC ) 的更多的兴趣 BEC 文化的病理生理学,和普遍可获得性是颠倒这个趋势的因素。在额外肝的胆汁的树上,徒劳的创伤愈合,结疤,苛评开发紧迫发出。在损害的最小的 intra 肝的胆汁管任何一个, BEC 增长或繁的回答能贡献肝疾病。在大、小的胆汁管的慢性炎和坚持的创伤愈合反应经常导致肝癌症。当他们适用于胆道,依赖于表明小径的 IL-6/gp130/STAT3 的细胞的过程的重要性,未答复的问题,和未来方向,愈合的创伤的一般概念被讨论。 | A J Demetris John G Lunz Ⅲ Susan Specht Isao Nozaki | 2006 | World Journal of Gastroenterology2006，12，22： | 15 |
| 3 | Three-dimensional tomography of red blood cells using deep learning显示文摘We accurately reconstruct three-dimensional(3-D)refractive index(RI)distributions from highly ill-posed two-dimensional(2-D)measurements using a deep neural network(DNN).Strong distortions are introduced on reconstructions obtained by the Wolf transform inversion method due to the ill-posed measurements acquired from the limited numerical apertures(NAs)of the optical system.Despite the recent success of DNNs in solving ill-posed inverse problems,the application to 3-D optical imaging is particularly challenging due to the lack of the ground truth.We overcome this limitation by generating digital phantoms that serve as samples for the discrete dipole approximation(DDA)to generate multiple 2-D projection maps for a limited range of illumination angles.The presented samples are red blood cells(RBCs),which are highly affected by the ill-posed problems due to their morphology.The trained network using synthetic measurements from the digital phantoms successfully eliminates the introduced distortions.Most importantly,we obtain high fidelity reconstructions from experimentally recorded projections of real RBC sample using the network that was trained on digitally generated RBC phantoms.Finally,we confirm the reconstruction accuracy using the DDA to calculate the 2-D projections of the 3-D reconstructions and compare them to the experimentally recorded projections. | Joowon Lim Ahmed B.Ayoub Demetri Psaltis | 2020 | Advanced Photonics2020，2，2： | 13 |
| 4 | Multimode optical fiber transmission with a deep learning network显示文摘Multimode fibers(MMFs)are an example of a highly scattering medium,which scramble the coherent light propagating within them to produce seemingly random patterns.Thus,for applications such as imaging and image projection through an MMF,careful measurements of the relationship between the inputs and outputs of the fiber are required.We show,as a proof of concept,that a deep neural network can learn the input-output relationship in a 0.75 m long MMF.Specifically,we demonstrate that a deep convolutional neural network(CNN)can learn the nonlinear relationships between the amplitude of the speckle pattern(phase information lost)obtained at the output of the fiber and the phase or the amplitude at the input of the fiber.Effectively,the network performs a nonlinear inversion task.We obtained image fidelities(correlations)as high as~98%for reconstruction and~94%for image projection in the MMF compared with the image recovered using the full knowledge of the system transmission characterized with the complex measured matrix.We further show that the network can be trained for transfer learning,i.e.,it can transmit images through the MMF,which belongs to another class not used for training/testing. | Babak Rahmani Damien Loterie Georgia Konstantinou Demetri Psaltis Christophe Moser | 2018 | Light(Science & Applications)2018，7，1： | 9 |
| 5 | Snakes: Active contour models显示文摘 | Michael Kass Andrew Witkin Demetri Terzopoulos | 1988 | International Journal of Computer Vision1988，，4： | 9 |
| 6 | 大气边界层湍流特性的风洞模拟实验研究显示文摘为提高大气边界层湍流特性实验模拟的准确性,在尖劈和粗糙元组合的基础上增加挡板。通过调整湍流装置的位置,布置了8种实验工况,对比分析尖劈、粗糙元和挡板对边界层的影响机理。比较实验模拟和相关规范的风剖面指数得到地貌类型;再考虑几何相似,并对比风工程国际规范ASCE7,双重验证了地形模拟的准确性。实验结果表明,挡板后置可显著增加湍流强度,并改善边界层下部的湍流积分尺度;尖劈、后置粗糙元和后置挡板的组合可较好地实现比例因子为1∶267的地貌B大气边界层模拟。 | 贺林 王军 Demetri Bouris | 2018 | 可再生能源2018，36，6： | 7 |
| 7 | High-fidelity optical diffraction tomography of multiple scattering samples显示文摘We propose an iterative reconstruction scheme for optical diffraction tomography that exploits the split-step nonparaxial(SSNP)method as the forward model in a learning tomography scheme.Compared with the beam propagation method(BPM)previously used in learning tomography(LT-BPM),the improved accuracy of SSNP maximizes the information retrieved from measurements,relying less on prior assumptions about the sample.A rigorous evaluation of learning tomography based on SSNP(LT-SSNP)using both synthetic and experimental measurements confirms its superior performance compared with that of the LT-BPM.Benefiting from the accuracy of SSNP,LT-SSNP can clearly resolve structures that are highly distorted in the LT-BPM.A serious limitation for quantifying the reconstruction accuracy for biological samples is that the ground truth is unknown.To overcome this limitation,we describe a novel method that allows us to compare the performances of different reconstruction schemes by using the discrete dipole approximation to generate synthetic measurements.Finally,we explore the capacity of learning approaches to enable data compression by reducing the number of scanning angles,which is of particular interest in minimizing the measurement time. | Joowon Lim Ahmed B.Ayoub Elizabeth E.Antoine Demetri Psaltis | 2019 | Light(Science & Applications)2019，8，1： | 6 |
| 8 | Effects of KRAS, BRAF, NRAS , and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: a retrospective consortium analysis显示文摘 | Wendy De Roock Bart Claes David Bernasconi Jef De Schutter Bart Biesmans George Fountzilas Konstantine T Kalogeras Vassiliki Kotoula Demetris Papamichael Pierre Laurent-Puig Frédérique Penault-Llorca Philippe Rougier Bruno Vincenzi Daniele Santini Giusepp | 2010 | Lancet Oncology2010，，8： | 6 |
| 9 | 肝细胞癌与肝内胆管癌间基因表型差异分析显示文摘目的:通过对肝细胞癌(HCC)和肝内胆管癌(ICC)之间抑癌基因(tumor suppressor gene,TSG)和微卫星(mi—crosatellite,MS)变异谱特点进行对比分析,了解这两种肝脏最常见恶性肿瘤在基因发生路径上的差异。方法:采用微组织切割法,从石蜡包埋的组织切片中提取基因组DNA进行直接测序,对33例信息性(杂合性)HCC和22例ICC进行了6种TSG杂合性缺失(loss of heterozygosity,LOH)的检测,并对其中10例HCC和全部22例ICC做7个MS的LOH分析。结果:6种TSG的变异情况在HCC依次为:p53(4/5,80.0%)、OGG1(2/4,50.0%)、APC(5/12,41.7%)、RB1(1/5,20.0%)、DCC(0/4,0%)、MCC(0/3,0%);在ICC为:APC(11/16,68.8%)、DCC(6/13,46.2%)、OGG1(5/12,41.7%)、p53(6/16,37.5%)、RB1(2/9,22.2%)、MCC(1/7,14.3%)。HCC和ICC中7个MS的LOH发生率分别为30.0%(3/10)和59.1%(13/22)。7个MS在HCC中仅有2个发生LOH,而在ICC中则全部出现LOH,其中与p16/MTS-1和MXI-1基因连锁的4个MS仅在ICC中出现LOH。结论:HCC和ICC之间TSG和MS存在着明显不同的LOH谱,推测两者在发生过程中可能沿循各自不同的分子路径。对LOH基因谱成员的分析,有助于进一步认识HCC和ICC发生的分子机制。 | 丛文铭 Demetris AJ Finkelstein SD 吴孟超 | 2003 | 第二军医大学学报2003，24，4： | 4 |
| 10 | Phase Ⅲ randomized,intergroup trial assessing imatinib mesylate at two dose levels in patients with unresectable or metastatic gastrointestinal stromal tumors expressing the kit receptor tyrosine kinase:S0033显示文摘 | Blanke CD Rankin C Demetri GD | | 0，，04： | 3 |
| 11 | Long-term results from a randomized phase Ⅱ trial of standard-versus higher-dose imatinib mesylate for patients with unresectable or metastatic gastrointestinal stromal tumors expressing KIT显示文摘 | Blanke CD Demetri GD yon Mehren M | | 0，，04： | 3 |
| 12 | Adjuvant imatinib mesylate after resection of localised, primary gastrointestinal stromal tumour: a randomised, double-blind, placebo-controlled trial显示文摘 | Ronald P DeMatteo Karla V Ballman Cristina R Antonescu Robert G Maki Peter WT Pisters George D Demetri Martin E Blackstein Charles D Blanke Margaret von Mehren Murray F Brennan Shreyaskumar Patel Martin D McCarter Jonathan A Polikoff Benjamin R Tan Kouros | 2009 | The Lancet2009，，9669： | 2 |
| 13 | Physics-informed neural networks for diffraction tomography显示文摘We propose a physics-informed neural network(PINN)as the forward model for tomographic reconstructions of biological samples.We demonstrate that by training this network with the Helmholtz equation as a physical loss,we can predict the scattered field accurately.It will be shown that a pretrained network can be fine-tuned for different samples and used for solving the scattering problem much faster than other numerical solutions.We evaluate our methodology with numerical and experimental results.Our PINNs can be generalized for any forward and inverse scattering problem. | Amirhossein Saba Carlo Gigli Ahmed B.Ayoub Demetri Psaltis | 2022 | Advanced Photonics2022，4，6： | 2 |
| 14 | Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors显示文摘 | Demetri GD von Mehren M Blanke CD | | 0，，： | 2 |
| 15 | Progressive Fibrosis in Nonalcoholic Steatohepatitis: Association With Altered Regeneration and a Ductular Reaction显示文摘 | Michelle M. Richardson Julie R. Jonsson Elizabeth E. Powell Elizabeth M. Brunt Brent A. Neuschwander–Tetri Prithi S. Bhathal John B. Dixon Martin D. Weltman Herbert Tilg Alexander R. Moschen David M. Purdie Anthony J. Demetris Andrew D. Clouston | 2007 | Gastroenterology2007，，1： | 2 |
| 16 | “Plasma Cell Hepatitis” in Liver Allografts: Identification and Characterization of an IgG4‐Rich Cohort显示文摘 | M. Castillo‐Rama M. Sebagh E. Sasatomi P. Randhawa K. Isse A. D. Salgarkar K. Ruppert A. Humar A. J. Demetris | 2013 | American Journal of Transplantation2013，，11： | 2 |
| 17 | WEANING OF IMMUNOSUPPRESSION IN LIVER TRANSPLANT RECIPIENTS显示文摘 | George V. Mazariegos Jorge Reyes Ignazio R. Marino Anthony J. Demetris Bridget Flynn William Irish John McMichael John J. Fung Thomas E. Starzl | 1997 | Transplantation1997，，2： | 2 |
| 18 | Snakes: Active contour models显示文摘 | Michael Kass Andrew Witkin Demetri Terzopoulos | 1988 | International Journal of Computer Vision1988，，4： | 2 |
| 19 | 3.5 m×2.5 m风洞大气边界层被动模拟实验研究显示文摘为实现风洞大气边界层的准确模拟,提出一种综合多个参数几何比例一致性分析的风洞大气边界层被动模拟实验。实验布置8种不同湍流发生装置布局的工况以模拟不同地形,通过对平均风速、湍流强度、湍流积分尺度以及功率谱随高度变化的测量,开展考虑模拟地面粗糙度与大气边界层高度比例因子一致性的大气边界层模拟研究,并对比分析尖劈和粗糙元对模拟流场的影响。实验研究表明:在3.5m×2.5m风洞中建立的模拟大气边界层流场,可实现符合ASCE7标准比例因子为1:200的A地形及符合RLB—AJJ标准比例因子为1:300的B地形模拟。 | 周兴 李建兰 Demetri Bouris | 2018 | 太阳能学报2018，39，2： | 2 |
| 20 | Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors显示文摘 | Demetri GD von Mehren M Blanke CD | | 0，，07： | 2 |
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