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    题名 作者 年代 出处 被引量
1结直肠间质瘤诊治进展显示文摘胃肠间质瘤(gastrointestinal stromal tumor,GIST)是一组发生于胃肠道最常见的间叶源性肿瘤。它起源于胃肠道间质干细胞---Cajal细胞(intestinal cell of cajal,ICC)或向cajal细胞分化,由梭形细胞、上皮样细胞或多形性细胞呈束状或弥漫性排列组成。目前其新的诊断定义是:一组独立起源于胃肠道间质干细胞的肿瘤,实质上由未分化或多能的梭形或上皮样细胞组成,杨朝纲 综述 熊斌 审校 2015实用癌症杂志2015,30,10:5
2Primary gastrointestinal stromal tumor of the liver treated with sequential therapy显示文摘A 67-year-old female presented with a primary hepatic gastrointestinal stromal tumor that was detected by computed tomography and diagnosed based on histopathological and genetic analyses.The tumor was microscopically composed of spindle cells and epithelioid cells,and immunohistochemistry results showed positive staining for CD117 and CD34expression.A genetic analysis revealed a heterozygous point mutation and deletion in exon 11 of c-KIT.After an R0 resection,imatinib mesylate was administered for 1 year until its use was discontinued due to severe side effects.Two years after the original operation,the tumor recurred in the residual liver and was completely resected again.Imatinib mesylate was administered for 2 years until it was replaced by sunitinib malate because of disease progression.The patient has survived for 53 mo after undergoing a sequential therapy consisting of surgical excision,imatinib and sunitinib.Xian-Ke Lin Qing Zhang Wei-Li Yang Chun-Hui Shou Xiao-Sun Liu Jian-Yi Sun Ji-Ren Yu 2015World Journal of Gastroenterology2015,21,8:0
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