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| 1 | Liver transplantation for alcoholic liver disease显示文摘Alcoholic liver disease(ALD) is the second commonest indication for liver transplantation after viral hepatitis in the United States and Europe.Controversies surround the indications and allocation of scarce and expensive resource for this so called self inflicted disease.Controversies stem from the apprehension that alcoholic recipients are likely to relapse and cause damage to the graft.There is a need to select those candidates with lower risk for relapse with the available predictive factors and scores.Substance abuse specialist and psychiatrists are mandatory in the pre-transplant evaluation and in the post-transplant follow-up.There is conflicting evidence to support a fixed period of pretransplant abstinence,although most units do follow this.Alcoholic hepatitis(AH) continues to be a contraindication for transplantation,however there is a need for further research in this f ield as a subset of patients with AH who do not respond to medical treatment,have high early mortality and could benefit from transplantation.One year,3-year,and 5-year survival post-transplant is similar for both ALD and non-ALD recipients.The incidence of post-transplant rejection and retransplantation is also similar to other recipients.ALD with viral hepatitis especially hepatitis C virus leads to a more aggressive liver disease with early presentation for transplantation.ALD patients are more prone to develop de-novo malignancy;this is attributed to the long term effect of alcohol,tobacco combined with immunosuppression.Post-transplant surveillance is important to detect early relapse to alcoholism,presence of de-novo malignancy and treat the same adequately. | Vibha Varma Kerry Webb Darius F Mirza | 2010 | World Journal of Gastroenterology2010，16，35： | 6 |
| 2 | Evolution of indications and results of liver transplantation in Europe. A report from the European Liver Transplant Registry (ELTR)显示文摘 | René Adam Vincent Karam Valérie Delvart John O’Grady Darius Mirza Jurgen Klempnauer Denis Castaing Peter Neuhaus Neville Jamieson Mauro Salizzoni Stephen Pollard Jan Lerut Andreas Paul Juan Carlos Garcia-Valdecasas Fernando San Juan Rodríguez Andrew Burro | 2012 | Journal of Hepatology2012，，3： | 6 |
| 3 | 从多利到波来:用体细胞核转移克隆显示文摘绵羊多利(Dolly)是第一只从成年动物成熟体细胞克隆出来的哺乳动物,这一研究一方面向基础生物发生学原则提出了挑战;另一方面为生殖生物学、医学以及制药学等的基础研究和应用开创了全新的前景。因此,用体细胞核转移克隆的技术具有巨大潜在意义。同时,它也提出了伦理问题,不仅在专业领域,而且在社会上引起广泛的讨论。 | Darius Moradpour Hubert E.Blum 郝连杰 | 1999 | 德国医学1999，16，6： | 5 |
| 4 | Mechanisms of autophagy activation in endothelial cell and their targeting during normothermic machine liver perfusion显示文摘Ischaemia-reperfusion injury(IRI) is the leading cause of injury seen in the liver following transplantation. IRI also causes injury following liver surgery and haemodynamic shock. The first cells within the liver to be injured by IRI are the liver sinusoidal endothelial cells(LSEC). Recent evidence suggests that LSEC coordinate and regulates the livers response to a variety of injuries. It is becoming increasingly apparent that the cyto-protective cellular process of autophagy is a key regulator of IRI. In particular LSEC autophagy may be an essential gatekeeper to the development of IRI. The recent availability of liver perfusion devices has allowed for the therapeutic targeting of autophagy to reduce IRI. In particular normothermic machine liver perfusion(NMP-L) allow the delivery of pharmacological agents to donor livers whilst maintaining physiological temperature and hepatic flow rates. In this review we summarise the current understanding of endothelial autophagy and how this may be manipulated during NMP-L to reduce liver IRI. | Yuri L Boteon Richard Laing Hynek Mergental Gary M Reynolds Darius F Mirza Simon C Afford Ricky H Bhogal | 2017 | World Journal of Gastroenterology2017，23，48： | 4 |
| 5 | Toll-like receptor 4 and protease-activated receptor 2 in physiology and pathophysiology of the nervous system:more than just receptor cooperation?显示文摘Toll-like receptor 4(TLR4) and protease-activated receptor 2(PAR2) play pivotal roles in the mammalian innate immune response.Notably,in addition to their involvement in detection of invading pathogens,PAR2 and TLR4 modulate the levels of cell death-induced sterile inflammation by activating pro-or anti-inflammatory downstream signaling cascades.Within the central nervous system,there is emerging evidence that both receptors are involved in synaptic transmission and brain plasticity.Furthermore,due to their prominent role in mediating neuroinflammation,PAR2 and TLR4 are associated with development and progression of neurodegenerative disorders including but not limited to Alzheimer's disease,Parkinson's disease and multiple sclerosis.In this article,we summarise the current knowledge on the cooperation between PAR2 and TLR4,discuss the potential cross-talk levels and highlight the impact of the cross-coupling on neuroinflammation. | Darius Widera Rocío Martínez Aguilar Graeme S.Cottrell | 2019 | Neural Regeneration Research2019，14，7： | 3 |
| 6 | Different modes of foveal regeneration after closure of full-thickness macular holes by(re)vitrectomy and autologous platelet concentrate显示文摘AIM: To describe using spectral-domain optical coherence tomography the regeneration of the foveal morphology after pars plana(re)vitrectomy surgery and gas tamponade combined with injection of autologous platelet concentrate to treat full-thickness macular holes, and to describe different anatomical outcome. METHODS: A retrospective case series of 8 eyes of 8 patients was described. RESULTS: In all cases investigated, the plateletassisted closure of macular holes was associated with a rapid resolution of cystic cavities in the foveal walls. In two patients, there was a regular regeneration of the foveal morphology after hole closure;the regenerated central fovea had a regular structure with a foveola and photoreceptors. In three other patients, there was an irregular regeneration of the fovea;a foveola was not formed, photoreceptor cells were absent from the foveal center, and the center was composed of Müller and retinal pigment epithelial(RPE) cells. The foveal regeneration after hole closure may proceed with or without a temporary detachment of the foveal center from the RPE, and with or without a direct contact between the central outer nuclear layer(ONL) and the RPE. Contacts between the ONL and RPE were observed only in patients with an irregular foveal regeneration after hole closure.CONCLUSION: The data show that there are different modes of foveal regeneration after closure of macular holes with(re)vitrectomy and platelet concentrate. It is suggested that the regular regeneration of the foveal morphology proceeds by Müller cell-mediated tissue movements without cell proliferation, whereas the irregular foveal regeneration proceeds in part by proliferation of Müller and RPE cells. | Andreas Bringmann Claudia Jochmann Jan Darius Unterlauft Renate Wiedemann Matus Rehak Peter Wiedemann | 2020 | International Journal of Ophthalmology(English edition)2020，13，1： | 3 |
| 7 | Deletion or underexpression of the Y-chromosome genes CDY2 and HSFY is associated with maturation arrest in American men with nonobstructive azoospermia显示文摘成熟拘捕(麻省) 指导致临床的 nonobstructive 精子缺乏的细菌房间开发的失败。尽管人的 Y 染色体的 azoospermic 因素(AZF ) 区域清楚地在一些情况中被含有,因此,远,很,很少对哪个个人, Y 染色体基因为完全的男细菌房间开发是重要的被知道。我们寻求了在可以在在美国人口与麻省联系的 nonobstructive 精子缺乏的致病被含有的 Y 染色体上识别单个基因。有 Y 染色体 microdeletions 的 132 个人的遗传型显型分析被执行。与麻省联系的编码蛋白质的基因被一张遗传型显型地图的视觉分析识别。与麻省联系的基因在 Y 染色体的一个片断以内作为那些基因被选择完全或部分删除了,总是与可恢复的阴囊的精子的麻省和缺席被联系。每个识别基因抄本的表示然后与自发的麻省和妨碍的精子缺乏从病人的分开的队在阴囊的织物与量的 RT-PCR 被测量。为有麻省的协会的十候选人基因在重叠的 Y 染色体的一个 8.4-Mb 片断以内被识别 AZFb 区域。CDY2 和 HSFY 是唯一的识别了在表示的差别在麻省和妨碍的精子缺乏队之间为被观察的基因。有妨碍的精子缺乏的人有 12 褶层 CDY2 抄本的更高相对的表示(1.33 ± 0.40 对 0.11 ± 0.04;P=0.0003 ) 并且 16 褶层 HSFY 抄本的更高的表示(0.78 ± 0.32 对 0.05 ± 0.02;P=0.0005 ) 与有麻省的人相比。CDY2 和 HSFY 也仅仅是在有 Sertoli 房间的病人的 underexpressed 症候群。这些数据显示 CDY2 和 HSFY 位于为精子成熟是重要的,并且是在与麻省从人导出的阴囊的织物的 underexpressed 的 Y 染色体的一个片断以内。这些观察建议在 CDY2 或 HSFY 表示的缺陷能在麻省的致病被含有。 | Peter J Stahl Anna N Mielnik Christopher E Barbieri Peter N Schlegel Darius A Paduch | 2012 | Asian Journal of Andrology2012，14，5： | 3 |
| 8 | TLR2 and TLR4-mediated inflammation in Alzheimer's disease: self-defense or sabotage?显示文摘Alzheimer's disease(AD) is an irreversible disease that leads to neurodegeneration.The underpinning mechanisms of neuronal cell death are a matter of ongoing debate regarding the impact of accumulation of the amyloid beta(Aβ)peptide and post-translation modifications of the tau protein.However,a growing area of research and one that may provide a more rigorous account of the early changes seen in Alzheimer's brains is inflammation. | Mark L.Dallas Darius Widera | 2021 | Neural Regeneration Research2021，16，8： | 3 |
| 9 | Single Cr atom catalytic growth of graphene显示文摘 | Huy Q. Ta Uang Zhao Wanjian Yin Darius Pohl Bemd Rellinghaus Thomas Gemming Barbara Trzebicka Justinas Palisaitis Gao Jing Per O. A. Persson Zhongfan Liu Alicja Bachmatiuk Mark H. Rummeli | 2018 | Nano Research2018，11，5： | 3 |
| 10 | Laser additive manufacturing of Si/ZrO_(2)tunable crystalline phase 3D nanostructures显示文摘The current study is directed to the rapidly developing field of inorganic material 3D object production at nano-/micro scale.The fabrication method includes laser lithography of hybrid organic-inorganic materials with subsequent heat treatment leading to a variety of crystalline phases in 3D structures.In this work,it was examined a series of organometallic polymer precursors with different silicon(Si)and zirconium(Zr)molar ratios,ranging from 9:1 to 5:5,prepared via sol-gel method.All mixtures were examined for perspective to be used in 3D laser manufacturing by fabricating nano-and micro-feature sized structures.Their spatial downscaling and surface morphology were evaluated depending on chemical composition and crystallographic phase.The appearance of a crystalline phase was proven using single-crystal X-ray diffraction analysis,which revealed a lower crystallization temperature for microstructures compared to bulk materials.Fabricated 3D objects retained a complex geometry without any distortion after heat treatment up to 1400℃.Under the proper conditions,a wide variety of crystalline phases as well as zircon(ZrSiO_(4)-a highly stable material)can be observed.In addition,the highest new record of achieved resolution below 60 nm has been reached.The proposed preparation protocol can be used to manufacture micro/nano-devices with high precision and resistance to high temperature and aggressive environment. | Greta Merkininkaitė Edvinas Aleksandravičius Mangirdas Malinauskas Darius Gailevičius SimasŠakirzanovas | 2022 | Opto-Electronic Advances2022，5，5： | 3 |
| 11 | The use of foreign currency derivatives, corporate governance, and firm value around the world显示文摘 | George Allayannis Ugur Lel Darius P. Miller | 2011 | Journal of International Economics2011，，1： | 2 |
| 12 | KIinefeIter综合征的诊断:新型甲基化特异性实时定量PCR显示文摘本文研究目的为设计一种基于额外X染色体(X-ch)检测的分子检测方法用于Klinefelter综合征的诊断。从26名47,XXY男性,2名46,XY/47,XXY男性,22名46,XY男性和15名46,XX的女性的外周血标本中提取DNA,并进行脱氨基处理。甲基化特异性的定量多聚酶链反应(MS-qpPCR)以非甲基化和甲基化的X染色体非活化特异性转录基因(XIST-U和XIST-M)拷贝为模板。X染色体二倍体通过XIST基因甲基化状态来判定。46,XY/47,XXY男性的嵌合程度通过核型分析和原位荧光杂交(FISH)的结果比较来判定。数据分析应用Roche LightCycler software v.3.5.3,包括通过拟合点分析和溶解曲线分析决定交叉点(CPs)。所有对照组女性和Ks患者均检测到X染色体二倍体,而对照组男性只表达XIST-M。XIST-U和IXIST-M的交叉点范围分别是(29.5-32.5,SD0.8)和(29-31,SD0.6)。嵌合度的检测极限为1%。根据2名47,XXY/46,XY患者的XIST-U/)(IST-M比值分析,计算出的嵌合率(1.8%和17.8%)与FISH结果(2.3%和15%)相当。从DNA脱氨基到最终数据分析的间隔小于9小时。本文得出结论:MS-qpPCR是一种敏感、特异及快速的X染色体二体检测方法,可以用于KS的筛查和诊断,甚至在低嵌合水平的47,XXY/46,XY患者也适用。 | Akanksha Mehta Anna Mielnik Peter N Schlegel Darius A Paduch | 2014 | Asian Journal of Andrology2014，16，5： | 2 |
| 13 | Thermoelectric properties of silicon and recycled silicon sawing waste显示文摘Large-scale-applicable thermoelectric materials should be both self-sustaining,in order to survive longterm duty cycles,and nonpolluting.Among all classes of known thermoelectric materials,these criteria reduce the available candidate pool,leaving silicon as one of the remaining options.Here we first review the thermoelectric properties of various silicon-related materials with respect to their morphologies and microstructures.We then report the thermoelectric properties of silicon sawing wastes recycled from silicon wafer manufacturing.We obtain a high power factor of~32 mWcm1 K2 at 1273 K with 6%phosphorus substitution in the Si crystal,a value comparable to that of phosphorus-doped silicongermanium alloys.Our work suggests the large-scale thermoelectric applicability of recycled silicon that would otherwise contribute to the millions of tons of industrial waste produced by the semiconductor industry. | Ran He Wieland Heyn Felix Thiel Nicolas Perez Christine Damm Darius Pohl Bernd Rellinghaus Christian Reimann Maximilian Beier Jochen Friedrich Hangtian Zhu Zhifeng Ren Kornelius Nielsch Gabi Schierning | 2019 | Journal of Materiomics2019，5，1： | 2 |
| 14 | Co-evaporated Cu 2 ZnSnSe 4 films and devices显示文摘 | Ingrid Repins Carolyn Beall Nirav Vora Clay DeHart Darius Kuciauskas Pat Dippo Bobby To Jonathan Mann Wan-Ching Hsu Alan Goodrich Rommel Noufi | 2012 | Solar Energy Materials and Solar Cells2012，，： | 2 |
| 15 | 分子聚集体的光谱模拟显示文摘采用Frenkel激子理论研究了一维线性和二维人字形分子聚集体的吸收和发射光谱.通过引入激子离域长度的概念,将聚集体与单分子的光谱线形函数联系起来.计算的光谱结果表明,聚集体的光谱与分子在聚集体中的排列紧密相关.分析了一维J聚集光谱发生红移以及二维人字形分子聚集体吸收光谱形成J和H激子谱带的内在原因.模拟得到的聚集体的吸收和发射光谱与实验结果一致. | 李凯 韩蛟 张厚玉 ABRAMAVICIUS Darius 张汉壮 | 2011 | 高等学校化学学报2011，32，12： | 2 |
| 16 | Para-aortic lymph node involvement should not be a contraindication to resection of pancreatic ductal adenocarcinoma显示文摘BACKGROUND Para-aortic lymph nodes(PALN)are found in the aortocaval groove and they are staged as metastatic disease if involved by pancreatic ductal adenocarcinoma(PDAC).The data in the literature is conflicting with some studies having associated PALN involvement with poor prognosis,while others not sharing the same results.PALN resection is not included in the standard lymphadenectomy during pancreatic resections as per the International Study Group for Pancreatic Surgery and there is no consensus on the management of these cases.AIM To investigate the prognostic significance of PALN metastases on the oncological outcomes after resection for PDAC.METHODS This is a retrospective cohort study of data retrieved from a prospectively maintained database on consecutive patients undergoing pancreatectomies for PDAC where PALN was sampled between 2011 and 2020.Statistical comparison of the data between PALN+and PALN-subgroups,survival analysis with the Kaplan-Meier method and risk analysis with univariable and multivariable time to event Cox regression analysis were performed,specifically assessing oncological outcomes such as median overall survival(OS)and disease-free survival(DFS).RESULTS 81 cases had PALN sampling and 17(21%)were positive.Pathological N stage was significantly different between PALN+and PALN-patients(P=0.005),while no difference was observed in any of the other characteristics.Preoperative imaging diagnosed PALN positivity in one case.OS and DFS were comparable between PALN+and PALN-patients with lymph node positive disease(OS:13.2 mo vs 18.8 mo,P=0.161;DFS:13 mo vs 16.4 mo,P=0.179).No difference in OS or DFS was identified between PALN positive and negative patients when they received chemotherapy either in the neoadjuvant or in the adjuvant setting(OS:23.4 mo vs 20.6 mo,P=0.192;DFS:23.9 mo vs 20.5 mo,P=0.718).On the contrary,when patients did not receive chemotherapy,PALN disease had substantially shorter OS(5.5 mo vs 14.2 mo;P=0.015)and DFS(4.4 mo vs 9.8 mo;P<0.001).PALN involvement was not identified as an independent predictor for OS after multivariable analysis,while it was for DFS doubling the risk of recurrence.CONCLUSION PALN involvement does not affect OS when patients complete the indicated treatment pathway for PDAC,surgery and chemotherapy,and should not be considered as a contraindication to resection. | Rupaly Pande Shafiq Chughtai Manish Ahuja Rachel Brown David C Bartlett Bobby V Dasari Ravi Marudanayagam Darius Mirza Keith Roberts John Isaac Robert P Sutcliffe Nikolaos A Chatzizacharias | 2022 | World Journal of Gastrointestinal Surgery2022，14，5： | 2 |
| 17 | Hepatic Hemangiosarcoma: An Absolute Contraindication to Liver Transplantation—The European Liver Transplant Registry Experience显示文摘 | Giuseppe Orlando Rene Adam Darius Mirza Goran Soderdahl Robert J. Porte Andreas Paul Andrew K. Burroughs Christian A. Seiler Michele Colledan Ivo Graziadei Juan-Carlos Garcia Valdecasas Fran?ois-René Pruvot Vincent Karam Jan Lerut | 2013 | Transplantation Journal2013，，6： | 2 |
| 18 | Bulbocavernosus muscle area measurement: a novel method to assess androgenic activity显示文摘浆液睾丸激素不与雄激素织物活动相关,并且优化工具在男性评估如此的活动是批评的。bulbocavernosus 肌肉(BCM ) 的超声测量被用来在雄激素受体(AR ) 和 BCM 尺寸估计在 CAG 重复(CAGn ) 的数字之间的关系;在 CAGn 超龄的数字的变化也被评估。BCM 的 Transperineal 超声测量也被执行。AR CAGn 被高效液体层析,和早上荷尔蒙决定层次用免疫分析被决定。48 个人让 CAG 重复分析。25 是 < 30 岁,平均数 23.7 年(s.d = 3.24 ) 并且 23 是 > 45 岁,平均数 53 年(s.d = 5.58 ) 。中部的 CAGn 是 21 (13-29 ) 。当 CAGn 的数字是 < 时, BCM 区域更大; 18 作为与 CAGn > 的数字相比; 24 (P = 0.04 ) 。在 CAGn 和 BCM 区域 R 2= 的数字之间有线性关联 16%(P = 0.01 ) 。在 45 到 65-years-old 组,强壮得多的否定关联(R 2=29% , P = 0.01 ) 被注意。在 19,到 29-years-old 组,,没有如此的关联被发现(R 2=4% , P = 0.36 ) 。在老人, CAGn 的数字与年龄增加了(R 2=32% , P = 0.01 ) 。在 AR 的 CAGn 的数字与 BCM 的区域相关。对 BCM 的超声评价是一个有效代理人评估雄激素的结束器官活动。CAGn 的数字可以与年龄增加。 | Ali A Dabaja Matthew S Wosnitzer Anna Mielnik Alexander Bolyakov Peter N Schlegel Darius A Paduch | 2014 | Asian Journal of Andrology2014，16，4： | 2 |
| 19 | Molecular functions of the iron-regulated metastasis suppressor, NDRG1, and its potential as a molecular target for cancer therapy显示文摘 | Bernard A. Fang ?aklina Kova?evi? Kyung Chan Park Danuta S. Kalinowski Patric J. Jansson Darius J.R. Lane Sumit Sahni Des R. Richardson | 2014 | BBA - Reviews on Cancer2014，，1： | 2 |
| 20 | Unsedated small-caliber esophagogastroduodenoscopy (EGD) versus conventional EGD: A comparative study显示文摘 | Darius Sorbi Christopher J. Gostout Jessica Henry Keith D. Lindor | 1999 | Gastroenterology1999，，6： | 2 |
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