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| 1 | Overview of macroautophagy regulation in mammalian cells显示文摘Macroautophagy 是 multistep, vacuolar,在 lysosomal 分隔空间终止的降级小径,和它具有在织物动态平衡的基本重要性。在这评论,我们在我们 autophagosomes 的形成的理解根据最近的进展考虑 macroautophagy,它是扣押的 double-membrane-bound 液泡细胞质的货物并且把他们送到 lysosomes。在大多数情况中,这最后的步被成熟步在哪个 autophagosomes 与 endocytic 小径交往期间先于。AuTophaGy 相关的基因的发现极大地关于为 autophagosome 形成负责的机制增加了我们的知识,并且也在 autophagosome 成熟的分子的方面的理解有进步。最后,因为 Atg 建筑群的活动被蛋白质 kinases 指向的发现, autophagy 的规定现在更好被理解,并且由于经由在调整 autophagy 基因的表示的抄写因素的原子规定的重要性。 | Maryam Mehrpour | 2010 | Cell Research2010，20，7： | 66 |
| 2 | 酸性矿山废水污染的水稻田土壤中重金属的微生物学效应显示文摘采样调查了广东大宝山地区受酸性采矿废水长期污染的亚热带水稻田的土壤理化性质 ,重金属 Cu、Pb、Zn、Cd的全量及其 DTPA浸提量 ,以及微生物生物量及其呼吸活性等指标。利用主成分和逐步回归分析了影响土壤重金属的有效性及其微生物学效应的因素。结果表明 :土壤高含硫 ,强酸性 ,有机碳、全氮较低 ,4种金属的全量普遍超标。DTPA可提取态金属含量较高 ,不仅与其全量呈显著正相关 ,而且与土壤酸度和粘粒含量正相关 ,和 Mn含量负相关。过量的金属显著降低了土壤微生物生物量 C、N、微生物商、生物量 N/全 N比 ,并抑制了微生物呼吸强度和对有机碳的矿化率 ,导致了土壤 C/N比的升高。同时 ,金属对微生物群落及生理代谢指标 ,如微生物生物量 C/N比和代谢商的影响不显著。 DTPA可提取态金属 ,特别是 DTPA- Cu是导致微生物生物量和活性指标变化的主要因素。以有机碳 (或全氮 )为基数的复合微生物指标降低了土壤性质差异造成的干扰 ,较单一指标更能准确指示微生物对金属胁迫的反应。土壤硫没有对金属有效性和微生物指标产生明显影响 。 | 李永涛 Thierry Becquer Cécile Quantin Marc Benedetti Patric kLavelle 戴军 | 2004 | 生态学报2004，24，11： | 31 |
| 3 | Obesity leads to higher risk of sperm DNA damage in infertile patients显示文摘在在富饶上的男营养的影响的过去几年有成长兴趣。不孕被连接了到男过重或肥胖,并且常规精液参数值似乎在高身体团索引(BMI ) 的情况下被改变。在精子 DNA 正直上估计 BMI 的影响的一些研究被出版了,但是他们没导致强壮的一致。我们的目的是进一步探索在精子 DNA 正直和 BMI 之间的关系,通过 3 年的 multicentre 研究。在 subfertile 夫妇的 330 个男搭挡被包括。用标记的终端 uridine 刻痕结束(TUNEL ) 试金,我们在肥胖的人观察了精子 DNA 损坏的增加的率(机会比率(95 %信心间隔) :2.5 (1.2-5.1 )) 。 | Charlotte Dupont Celine Fauret Nathalie Sermondade Marouane Boubaya Florence Eustache Patrice Clement Pascal Briot Isabelle Berthaut Vincent Levy Isabelle Cedrin-Durnerin Brigitte Benzacken Pascale Chavatte-Palmer Rachel Levy | 2013 | Asian Journal of Andrology2013，15，5： | 27 |
| 4 | Direct shear tests on cemented paste backfill-rock wall and cemented paste backfill-backfill interfaces显示文摘This paper presents the results of the shear strength(frictional strength) of cemented paste backfillcemented paste backfill(CPB-CPB) and cemented paste backfillerock wall(CPB-rock) interfaces. The frictional behaviors of these interfaces were assessed for the short-term curing times(3 d and 7 d) using a direct shear apparatus RDS-200 from GCTS(Geotechnical Consulting & Testing Systems). The shear(friction) tests were performed at three different constant normal stress levels on flat and smooth interfaces. These tests aimed at understanding the mobilized shear strength at the CPB-rock and CPB-CPB interfaces during and/or after open stope filling(no exposed face). The applied normal stress levels were varied in a range corresponding to the usually measured in-situ horizontal pressures(longitudinal or transverse) developed within paste-filled stopes(uniaxial compressive strength, s c 150 k Pa). Results show that the mobilized shear strength is higher at the CPB-CPB interface than that at the CPB-rock interface. Also, the perfect elastoplastic behaviors observed for the CPB-rock interfaces were not observed for the CPB-CPB interfaces with low cement content which exhibits a strain-hardening behavior. These results are useful to estimate or validate numerical model for pressures determination in cemented backfill stope at short term. The tests were performed on real backfill and granite. The results may help understanding the mechanical behavior of the cemented paste backfill in general and, in particular, analyzing the shear strength at backfillebackfill and backfill-rock interfaces. | Nabassé J.F.Koupouli Tikou Belem Patrice Rivard Hervé Effenguet | 2016 | Journal of Rock Mechanics and Geotechnical Engineering2016，8，4： | 19 |
| 5 | Current knowledge on diabetic retinopathy from human donor tissues显示文摘According to the American Diabetes Association,diabetes was the seventh leading cause of death,and diabetic retinopathy the leading cause of blindness in working age adults in the United States in 2010.Diabetes is characterized by hyperglycemia associated with either hypoinsulinemia or insulin resistance,and over time,this chronic metabolic condition may lead to various complications including kidney failure,heart attacks,and retinal degeneration.In order to better understand the molecular basis of this disease and its complications,animal models have been the primary approach used to investigate the effects of diabetes on various tissues or cell types of the body,including the retina.However,inherent to these animal models are critical limitations that make the insight gained from these models challenging to apply to the human pathology.These difficulties in translating the knowledge obtained from animal studies have led a growing number of research groups to explore the diabetes complications,especially diabetic retinopathy,on tissues from human donors.This review summarizes the data collected from diabetic patients at various stages of diabetic retinopathy and classifies the data based upon their relevance to the main aspects of diabetic retinopathy:retinal vasculature dysfunction,inflammation,and neurodegeneration.This review discusses the importance of those studies to discriminate and establish the relevance of the findings obtained from animal models but also the limitations of such approaches. | Jessica H Eisma Jennifer E Dulle Patrice E Fort | 2015 | World Journal of Diabetes2015，6，2： | 19 |
| 6 | Activation of lysosomal function in the course of autophagy via mTORC1 suppression and autophagosome-lysosome fusion显示文摘Lysosome 是在 autophagic 进程的执行的一个关键 subcellular 细胞器,目前,很少被知道 lysosomal 功能是否在 autophagy 的进程被控制。在这研究,我们首先由饥饿或二 mTOR 发现 rapamycin (mTOR ) 的哺乳动物的目标的那抑制活动催化禁止者(PP242 和 Torin1 ) ,然而并非由一个 allosteric 禁止者(rapamycin ) ,导致 lysosomal 的激活功能。第二,我们提供了 lysosomal 功能的激活与 mTOR 建筑群 1 的抑制(mTORC1 ) 被联系的证据,然而并非 mTORC2,和到 lysosomes 的 mTORC1 本地化直接没在 lysosomal 功能被相关到它的规章的角色。第三,我们检验了抄写因素 EB (TFEB ) 的参与并且证明 TFEB 激活追随者 mTORC1 抑制为 lysosomal 激活必要然而并非足够。最后, Atg5 或 Atg7 删除或 autophagosome-lysosome 熔化过程的阻塞有效地减少了 lysosomal 激活,建议发生在 autophagy 期间的那 lysosomal 激活依赖于 autophagosome-lysosome 熔化。一起拿,这研究证明在 autophagy 期间, lysosomal 功能是经由包含 mTORC1 抑制和 autophagosome-lysosome 熔化的双机制的 upregulated。 | Jing Zhou Shi-Hao Tan Valerie Nicolas Chantal Bauvy Nai-Di Yang Jianbin Zhang Yuan Xue Patrice Codogno Han-Ming Shen | 2013 | Cell Research2013，23，4： | 16 |
| 7 | 硅烷化聚氨酯技术在汽车工业中的应用显示文摘选择合适的硅烷,与聚氨酯预聚体中的异氰酸酯反应可以形成硅烷封端的聚氨酯(SPUR)。它作为汽车密封剂,具有优良的耐化学介质和耐候性等诸多优点,在汽车及交通运输等行业具有广泛的应用前景。 | 黄未雨 Patrice Lehmann 杨宇润 | 2005 | 粘接2005，26，2： | 14 |
| 8 | 高效抗病毒治疗促使艾滋病患者免疫功能重建显示文摘The characteristics of AIDS is that HIV infection induces CD4+ T cell defects that includes a quantitave CD4+ T cells depletion and a loss of T helper cells function leading to a progressive immune deficiency. Early report indicated that this immune deficiency was irreversible, even with the antiretroviral therapies. More recently, however, clinical benifits of hightly active antiretroviral therapies (HAART) are increasingly evidenced by resolving opportunistic infections and malignancies, as well as declining hospitalization and mortality rates. This suggests that potent and sustained suppression of viral replication, at least to some extent, is associated with reconstitution of the immune system even in adult patients treated at advanced stages of the disease. Such immune reconstitution which was demonstrated firstly by a French reseach group includes (the group leader is Pr Brigitte Autran)(1) a rapid rise in CD4+ and CD8+ T cells followed by a slower CD4+ T cell increase; (2) a rapid rise in memory CD4+ T cells during the first three months of treatment by late increase in naive T cells coexpressing CD45RA and CD62L molecules after 3 months of efficient antiviral treatment;(3) a significant reduction of CD4 and CD8 activation markers in parallel to plasma virus load reduction;(4) a restoration in CD4+ T cell reactivity to recall antigens. These observations open new perspectives for the understanding of CD4+ T cells deficiency and therapeutic strategies of HIV infection. In the present review we will address some of the questions raised by immune restoration with HAART when administered at advanced stages of the disease. | 李太生 Guislaine Carcelaine Patrice Debre Brigitte Autran | 2001 | 基础医学与临床2001，21，1： | 14 |
| 9 | Phytochemical and anti-bacterial activity of epidermal glands extract of Christella parasitica (L.) H. Lev.显示文摘Objective:To study the morphology,biochemistry and bioactivity of the epidermal glands of the glandular morphotype of Christella parasitica(C.parasitica)(L.) H.Lev.Methods: Morphological studies on epidermal glands were earned out by using light microscope and scanning electron microscope.To prepare the extract,the shade-dried fronds of glandular morphotype were soaked in acetone.For antibacterial studies paper disc method was followed by using various pathogenic bacteria.Results:Detailed micromorphological,phytochemical and bioactivity studies on a medicinal fern C.parasitica(L.) H.Lev.showed its inlraspecific variation in antibacterial activity.The presence or absence of the epidermal glands was the key factor for antibacterial activity in the morphovariants of this species.The epidermal glands were orange-coloured,stalked and elongated ones of about 84.2μm×45μm,and distributed on the undersurface of cosla,coslules and veins in croziers,young and mature leaves.Frequency of glands varied from 15/cm on costa in mature leaves to 140/cm on costules in croziers.The acetone extract of the glands showed antibacterial activities and also toxic effect against mosquito larvae and tadpoles of frog.Preliminary phytochemical analysis and HPLC studies of the gland extract showed the presence of various kinds of terpenoids,alkaloids,tannins,saponins and flavonoids in it.Conclusions:The present study shows that epidermal glands of the glandular morphotype of C. parasitica(L.) H.Lev.have several bioactive compounds and such rare moiphovariant should be conserved in nature.The next step is to isolate the pure compounds and to screen the bioactivity of individual compounds of the epidermal glands. | Paul Raj K Irudayaraj V Johnson M Patric Raja D | 2011 | Asian Pacific Journal of Tropical Biomedicine2011，1，1： | 14 |
| 10 | Diabetes mellitus, insulin resistance and hepatitis C virus infection: A contemporary review显示文摘AIM To summarise the literature data on hepatitis C virus(HCV)-infected patients concerning the prevalence of glucose abnormalities and associated risk.METHODS We conducted a PubM ed search and selected all studies found with the key words 'HCV' or 'hepatitis C virus' and 'diabetes' or 'insulin resistance'. We included only comparative studies written in English or in French, published from January 2000 to April 2015. We collected the literature data on HCV-infected patients concerning the prevalence of glucose abnormalities [diabetes mellitus (DM) and insulin resistance (IR)] and associated risk [i.e., severe liver fibrosis, response to antivirals, and the occurrence of hepatocellular carcinoma(HCC)]. RESULTS HCV infection is significantly associated with DM/IR compared with healthy volunteers and patients with hepatitis B virus infection. Glucose abnormalities were associated with advanced liver fibrosis, lack of sustained virologic response to interferon alfa-based treatment and with a higher risk of HCC development. As new antiviral therapies may offer a cure for HCV infection, such data should be taken into account, from a therapeutic and preventive point of view, for liver and non-liver consequences of HCV disease. The efficacy of antidiabetic treatment in improving the response toantiviral treatment and in decreasing the risk of HCC has been reported by some studies but not by others. Thus, the effects of glucose abnormalities correction in reducing liver events need further studies.CONCLUSION Glucose abnormalities are strongly associated with HCV infection and show a negative impact on the main liver related outcomes. | Anne-Claire Desbois Patrice Cacoub | 2017 | World Journal of Gastroenterology2017，23，9： | 14 |
| 11 | 经皮加压钢板内固定治疗股骨转子间骨折初步报告显示文摘[目的]探讨应用微创手术治疗股骨转子间骨折的方法和疗效,及就手术的侵袭性、手术时间、受辐射的时间、失血量等指标进行评估和比较。[方法]自2003年以来,应用经皮加压钢板(percutaneous compressionplating,PCCP),在C型臂X线机监视下,经皮小切口置入加压钢板行内固定治疗股骨转子间骨折19例,选择稳定性骨折或者轻度移位而容易复位的骨折为适应证。其中女11例,男8例,年龄54—85岁,平均68岁。随访6—28个月,平均16.8个月。[结果]手术时间30-55min,平均45min;应用C型臂X线机时间45—85s,平均58s;术中失血40-120ml,平均80ml。所有病例X线片骨折愈合时间为3个月。[结论]应用PCCP钢板经皮内固定手术治疗股骨转子间骨折,比照传统的DHS、Gamma钉和PFN具有手术创伤小,操作简单,手术时间短,出血少,减少术中X线片的曝光时间等特点,疗效满意,并发症少。 | 凌尚准 Hockman Patric | 2007 | 中国矫形外科杂志2007，15，4： | 12 |
| 12 | Cross-Talk between ROS and Calcium in Regulation of Nuclear Activities显示文摘钙和反应的氧种类(ROS ) 作为涉及对各种各样的关於生命、不能生活的压力的反应的关键秒送信人被承认。然而,这二混合物怎么能在对病原体带工厂到象根开发或防卫那样的许多过程的不同发信号的小径起一个作用,仍然不是清楚的。最近,这被显示出钙和 ROS 签名的概念,开始在细胞质发现了,能也被扩大到工厂房间的原子核。另外, ROS 和钙信号亲密地被互连,这清楚地被证明了。这串音怎么能最后调制 translocation 或导致特定的基因表示的控制的原子蛋白质的活动,是这评论的主要焦点。我们将特别集中钙和 ROS 怎么在分子的水平交往修改他们的目标。 | Christian Mazars | 2010 | Molecular Plant2010，3，4： | 11 |
| 13 | Molecular cross-talk between Helicobacter pylori and human gastric mucosa显示文摘Helicobacter pylori (H.pylori) has co-evolved with humans to be transmitted from person to person and to colonize the stomach persistently.A well-choreographed equilibrium between the bacterial effectors and host responses permits microbial persistence and health of the host,but confers a risk for serious diseases including gastric cancer.During its long coexistence with humans,H.pylori has developed complex strategies to limit the degree and extent of gastric mucosal damage and in? ammation,as well as immune effector activity.The present editorial thus aims to introduce and comment on major advances in the rapidly developing area of H.pylori/human gastric mucosa interaction (and its pathological sequelae),which is the result of millennia of co-evolution of,and thus of reciprocal knowledge between,the pathogen and its human host. | Vittorio Ricci Marco Romano Patrice Boquet | 2011 | World Journal of Gastroenterology2011，17，11： | 11 |
| 14 | 足月儿缺氧缺血性脑病的常规MRI、DWI、DTI及MRS表现(英文)显示文摘近年,先进的磁共振(MR)技术和3特斯拉磁体(3T)已越来越多地被应用于新生儿,拓宽了围产期缺氧缺血性脑病(HIE)的知识。本文介绍了足月儿缺氧缺血性脑病在3T磁共振的表现,其中包括常规和先进的成像技术,如扩散加权成像(DWI),扩散张量成像(DTI)和磁共振波谱(MRS);重点强调了每种技术发现病灶的时间过程,以及与神经系统预后的关联。 | Yan Liu Patrice Jissendi-Tchofo Thierry Metens Julie Absil Ming Zhu Danielle Baleriaux | 2011 | 磁共振成像2011，2，1： | 11 |
| 15 | Metastasized pancreatic carcinoma with neoadjuvant FOLFIRINOX therapy and R0 resection显示文摘Patients with metastasized carcinoma of the pancreas have a very poor prognosis, and long-term survival cannot be expected. This case report describes two patients with an initial diagnosis of metastatic pancreatic cancer, both with hepatic metastases and one with an additional peritoneal carcinomatosis. Initially, both patients were treated intravenously with the FOLFIRINOX chemotherapy regimen, consisting of 5-FU, folinic acid, irinotecan and oxaliplatin. Surprisingly, the FOLFIRINOX treatment resulted in complete resolution of the hepatic metastases in both patients, with no lesions detectable by computed tomography scan. Furthermore, treatment response included decreased diameter of the primary tumor in the tail of the pancreas and disappearance of the additional peritoneal carcinomatosis. Both patients were discussed by our multidisciplinary tumor board, which recommended surgical resections of the carcinoma. The R0 resection of the primary tumor was successful in both cases and, interestingly, the resected tissues showed no evidence of the hepatic metastases intraoperatively. In the first case, the patient received a postoperative 6-mo course of adjuvant chemotherapy with gemcitabine. In the second case, the patient continued to receive the FOLFIRINOX regimen for an additional 6 mo postoperatively. At 12 mo after the operation, a nonresectable retroperitoneal lymph node metastasis was detected in the first patient, whereas the second patient remained in complete remission at the time of this report(5 mo after the adjuvant therapy was discontinued). This case report is the first of its kind to describe two cases of hepatic metastatic pancreatic carcinoma that were resectable following treatment with FOLFIRINOX. Further studies are required to examine the role of FOLFIRINOX as a neoadjuvant treatment option in subgroups of patients with initially metastasized pancreatic carcinoma. | Sophie Schneitler Patric Krpil Jasmin Riemer Gerald Antoch Wolfram Trudo Knoefel Dieter Hussinger Dirk Graf | 2015 | World Journal of Gastroenterology2015，21，20： | 9 |
| 16 | Prospective comparison of transient elastography, Fibrotest, APRI, and liver biopsy for the assessment of fibrosis in chronic hepatitis C显示文摘 | Laurent Castéra Julien Vergniol Juliette Foucher Brigitte Le Bail Elise Chanteloup Maud Haaser Monique Darriet Patrice Couzigou Victor de Lédinghen | 2005 | Gastroenterology2005，，2： | 8 |
| 17 | 白细胞介素-1基因多态性与类风湿关节炎病情活动及骨代谢的相关性显示文摘目的 探讨IL 1α和 β基因多态性与类风湿关节炎 (RA)疾病活动性和骨代谢的相关以及IL 1基因多态性与RA优势基因 (motifgene)之间的相关关系。 方法 检测了 6 5例RA患者和6 0例非风湿病患者的IL 1等位基因分布。IL 1基因多态性分析采用PCR RFLP方法 ,HLA DR分型采用PCR SSOP方法。Fisher′s检验及方差分析被用于基因频率和携带率及临床参数统计。结果 IL 1α的频率和携带率在RA病人和对照组之间差异无显著性。在女性RA病人中IL 1β纯合子等位基因 2的出现频率更高 ,在男性RA病人中等位基因 1的频率较高而等位基因 2的携带率较低。IL 1β等位基因 2携带率与C反应蛋白 (CRP)、红细胞沉降率 (ESR)、关节痛和骨质密度 (BMD)呈相关 ,与尿脱氧吡啶 /肌酐比值 (Udpd/Crea)水平及维生素D3 水平呈负相关。IL 1α等位基因 1与CRP呈负相关 ,与类风湿因子 (RF)和关节肿胀呈正相关。IL 1α等位基因 2的出现伴随较高的ESR、健康质量评估积分 (HAQ) ,维生素D3 水平和较低的RF滴度、肿胀关节数 (SJC)和BMD。HLA DRB1RA优势等位基因和IL 1β等位基因 2的同时出现对RA的一些临床参数并没有影响。 结论 RA与IL 1基因多态性显著相关 ,特别是IL 1β等位基因 2与病情活动及骨密度增高直接相关。HLA | 张晓 Lindon Llamado Iris Pillay Patrical Price Robert Will | 2001 | 中华风湿病学杂志2001，5，2： | 7 |
| 18 | Assessment of Sediment and Pollutants in Buyo Lake, Ivory Coast, Using SWAT (Soil and Water Assessment Tool) Model显示文摘 | Tanoh Jean-Jacques Koua Jean Patrice Jourda Kan Jean Kouame Kouao Armand Anoh | 2013 | Journal of Chemistry and Chemical Engineering2013，7，11： | 7 |
| 19 | Usefulness of staging systems and prognostic scores for hepatocellular carcinoma treatments显示文摘Therapeutic management of hepatocellular carcinoma(HCC) is quite complex owing to the underlying cirrhosis and portal vein hypertension. Different scores or classification systems based on liver function and tumoral stages have been published in the recent years. If none of them is currently 'universally' recognized, the Barcelona Clinic Liver Cancer(BCLC) staging system has become the reference classification system in Western countries. Based on a robust treatment algorithm associated with stage stratification, it relies on a high level of evidence. However, BCLC stage B and C HCC include a broad spectrum of tumors but are only matched with a single therapeutic option. Some experts have thus suggested to extend the indications for surgery or for transarterial chemoembolization. In clinical practice, many patients are already treated beyond the scope of recommendations. Additional alternative prognostic scores that could be applied to any therapeutic modality have been recently proposed. They could represent complementary tools to the BCLC staging system and improve the stratification of HCC patients enrolled in clinical trials, as illustrated by the NIACE score. Prospective studies are needed to compare these scores and refine their role in the decision making process. | Xavier Adhoute Guillaume Penaranda Jean Luc Raoul Patrice Le Treut Emilie Bollon Jean Hardwigsen Paul Castellani Hervé Perrier Marc Bourlière | 2016 | World Journal of Hepatology2016，8，17： | 7 |
| 20 | 中国高等学校教学评价证据来源情况的调查研究显示文摘文章旨在调查目前中国高校用以评价教学状况的证据来源情况。调查发现,学生评教仍是最主要的教学评价手段。被调查者认为学生可以基于经验回答学生评教指标中的大部分问题,但在是否完全信赖学生评教结果问题上态度不明确。基于此,调查者希望找到其它评价方式来补充、配合学生评教。然而有近一半的被调查院系只使用学生评教一种证据,总体平均使用两种教学评价证据。被调查院校最常使用的教学评价证据有学生评教、课堂观察、非正式评论和教学奖励等四种,但后两种并不直接支持课堂评估。为了对教学各方面指标进行全方位评估,文章建议使用教学评价证据档案袋,除学生评教外,还应包括同行观察、课程大纲、测试、教师课堂笔记以及课程教学材料等内容。 | 王广成 Brian Patric Green | 2014 | 高教发展与评估2014，30，1： | 6 |
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