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您的检索式：作者名="Darius Widera"
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| 1 | Toll-like receptor 4 and protease-activated receptor 2 in physiology and pathophysiology of the nervous system:more than just receptor cooperation?显示文摘Toll-like receptor 4(TLR4) and protease-activated receptor 2(PAR2) play pivotal roles in the mammalian innate immune response.Notably,in addition to their involvement in detection of invading pathogens,PAR2 and TLR4 modulate the levels of cell death-induced sterile inflammation by activating pro-or anti-inflammatory downstream signaling cascades.Within the central nervous system,there is emerging evidence that both receptors are involved in synaptic transmission and brain plasticity.Furthermore,due to their prominent role in mediating neuroinflammation,PAR2 and TLR4 are associated with development and progression of neurodegenerative disorders including but not limited to Alzheimer's disease,Parkinson's disease and multiple sclerosis.In this article,we summarise the current knowledge on the cooperation between PAR2 and TLR4,discuss the potential cross-talk levels and highlight the impact of the cross-coupling on neuroinflammation. | Darius Widera Rocío Martínez Aguilar Graeme S.Cottrell | 2019 | Neural Regeneration Research2019，14，7： | 3 |
| 2 | TLR2 and TLR4-mediated inflammation in Alzheimer's disease: self-defense or sabotage?显示文摘Alzheimer's disease(AD) is an irreversible disease that leads to neurodegeneration.The underpinning mechanisms of neuronal cell death are a matter of ongoing debate regarding the impact of accumulation of the amyloid beta(Aβ)peptide and post-translation modifications of the tau protein.However,a growing area of research and one that may provide a more rigorous account of the early changes seen in Alzheimer's brains is inflammation. | Mark L.Dallas Darius Widera | 2021 | Neural Regeneration Research2021，16，8： | 3 |
| 3 | 1,8-cineol inhibits nuclear translocation of NF-κB p65 and NF-κB-dependent transcriptional activity显示文摘 | Johannes F.-W. Greiner Janine Müller Marie-Theres Zeuner Stefan Hauser Thorsten Seidel Christin Klenke Lena-Marie Grunwald Timo Schomann Darius Widera Holger Sudhoff Barbara Kaltschmidt Christian Kaltschmidt | 2013 | BBA - Molecular Cell Research2013，，： | 1 |
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