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| 1 | Epithelioid hemangioendothelioma of the liver as a rare indication for liver transplantation显示文摘AIM: To investigate the indications and outcomes of liver transplantation for hepatic epithelioid hemangioendothelioma(HEHE). METHODS: Between 1989 and August 2013, in the Department of General, Transplant, and Liver Surgery, Medical University of Warsaw, 1306 orthotopic liver transplantations(OLTx) were performed, including 72 retransplantations. Unresectable HEHE was an indication for OLTx in 10 patients(0.8% of primary OLTx), the mean age of the patients was 40.5 ± 13.3 years(range 23-65 years), and the male-to-female ratio was 2:8. Kaplan-Meier survival analysis in HEHE, hepatocellular carcinoma(HCC), and other OLTx recipients groups was performed. The differences in mortality were compared using the χ2 test. A P-value < 0.05 indicated statistical significance.RESULTS: No concomitant liver disease was found in any patient. There was no neoadjuvant chemotherapy or radiotherapy. Liver function test results were normal in most of the patients. The levels of alpha-fetoprotein, carcinoembryonic antigen, and carbohydrate antigen 19-9 were normal. In immunohistochemical staining, the neoplastic cells were positive for factor Ⅷ-related antigen, CD31, and CD34, which are endothelial cell markers, and negative for cytokeratin 19, cytokeratin 7, and HepPar-1. Nine patients were alive without tumor recurrence. One patient died 2 mo after OLTx due to septic complications. No morbidity was observed. Maximum follow-up was 11.4 years, with a minimum of 1 mo. The cumulative survival rate at the end of followup in HEHE patients was 87.5% compared with 54.3% in the HCC group and 76.3% in the other OLTx recipients group(χ2 test = 1.784, df = 2, P = 0.409).CONCLUSION: Unresectable HEHE, without extrahepatic metastases is an excellent indication for liver transplantation. Long-term survival is very good and much better than in HCC patients and the entire group of OLTx patients. | Piotr Remiszewski Ewa Szczerba Piotr Kalinowski Beata Gierej Krzysztof Dudek Mariusz Grodzicki Marcin Kotulski Rafa Paluszkiewicz Waldemar Patkowski Krzysztof Zieniewicz Marek Krawczyk | 2014 | World Journal of Gastroenterology2014，20，32： | 10 |
| 2 | Computed tomography scan imaging in diagnosing acute uncomplicated pancreatitis: Usefulness vs cost显示文摘BACKGROUND Literature has suggested that imaging is over-utilized in the diagnosis of pancreatitis. If the diagnosis of acute pancreatitis(AP) is established with abdominal pain and increased serum amylase or lipase activity without systemic signs of severe disease, computed tomography(CT) imaging may not be necessary. We hypothesize that among patients with uncomplicated acute pancreatitis(AUP), there is a significant number of unwarranted CT imaging studies. This imposes increased expenditure and cost in our healthcare system and does not improve hospital stay or management of AUP.AIM To assess the overutilization and associated cost of CT imaging among patients meeting diagnostic criteria for AUP.METHODS In this Institutional Review Board-approved retrospective, single-center study,we identified all adult patients admitted with AP from January 1, 2012 through October 1, 2017. Patients were identified via International Classification of Diseases(ICD-9) code for AP(577.0) and ICD-10 codes for different etiological AP(K85.9 unspecified, K85.0 idiopathic, K85.1 biliary, K85.2 alcohol-induced, K85.3 drug-induced, and K85.8 other). Diagnosis was confirmed by chart review using established non-imaging diagnostic criteria(presence of typical abdominal pain and elevated lipase or amylase greater than 3 times upper limit of normal).Ranson criteria and BISAP scores on presentation were calculated and patients that met scores less than or equal to 2 for both were included to suggest AUP.The utilization and cost of imaging in these patients were recorded.RESULTS Between January 2012 and October 2017, 1305 patients presented to the emergency department with AP, and 405 patients(31%) met our inclusion criteria for AUP(201 males, 204 females; mean age 49 years, range 18-98). Of those, 210 patients(51.85%) underwent CT imaging. One patient(0.47%) had evidence of pancreatic necrosis, one patient had cyst formation(0.47%), and the remaining208 patients(99.05%) had either normal CT scan imaging or findings consistent with mild AP without necrosis. The average cost of CT scan imaging was $4510 with a total cost of $947056. Median length of hospitalization stay was 3 d among both groups. Combining Ranson's Criteria and BISAP score identified AUP in our patient population with an accuracy of 99.5%.CONCLUSION CT imaging is unnecessary when AUP is diagnosed clinically and biochemically.Reducing overuse of diagnostic CT scans will decrease healthcare expenditure and radiation exposure to patients. | Shana Kothari Michael Kalinowski Matthew Kobeszko Tarek Almouradi | 2019 | World Journal of Gastroenterology2019，25，9： | 5 |
| 3 | Overview of the Shenzhen Emergency Medical Service Call Pattern显示文摘BACKGROUND:In Shenzhen,the Emergency Medical Service(EMS) system has been in service since 1997.This study aims to examine the operation of Shenzhen 120 EMS center and to identify the reasons of calling EMS.METHODS:In this retrospective quantitative descriptive study,the data from the Shenzhen 120 EMS registry in 2011 were analyzed.RESULTS:Shenzhen 120 EMS center is a communication command center.When the number of 120 are dialed,it is forwarded to the closest appropriate hospital for ambulance dispatch.In2011,the Shenzhen 120 EMS center received 153 160 ambulance calls,with an average of 420 calls per day.Calling emergency services was mainly due to traffic accidents.Trauma and other acute diseases constituted a majority of ambulance transports.The adult patients aged 15-60 years are the principal users of EMS.There are no recognized 'paramedic' doctors and nurses.The pre-hospital emergency service is under the operation of emergency departments of hospitals.Shenzhen at present does not have specialized pre-hospital training for doctors and nurses in posttrauma management.Moreover,specialized pre-hospital training,financial support,and public health education on proper use of EMS should be emphasized.CONCLUSION:The Shenzhen 120 EMS center has its own epidemiology characteristics.Traumatic injury and traffic accident are the main reasons for calling ambulance service.In-depth study emphasizing the distribution and characteristics of trauma patients is crucial to the future development of EMS. | Shuk Man Lo Yi Min Yu Lap Yip Larry Lee Mi Ling Eliza Wong Sek Ying Chair Edward J Kalinowski Tak Shing Jimmy Chan | 2012 | World Journal of Emergency Medicine2012，3，4： | 4 |
| 4 | Molecular functions of the iron-regulated metastasis suppressor, NDRG1, and its potential as a molecular target for cancer therapy显示文摘 | Bernard A. Fang ?aklina Kova?evi? Kyung Chan Park Danuta S. Kalinowski Patric J. Jansson Darius J.R. Lane Sumit Sahni Des R. Richardson | 2014 | BBA - Reviews on Cancer2014，，1： | 2 |
| 5 | Endothelium-Derived Neuregulin Protects the Heart Against Ischemic Injury显示文摘 | Nadia Hedhli Qunhua Huang April Kalinowski Monica Palmeri Xiaoyue Hu Raymond R. Russell Kerry S. Russell | 2011 | Circulation2011，，20： | 2 |
| 6 | Occupational noiseinduced hearing loss surveillance in Michigan显示文摘 | Reilly M J Rosenman K D Kalinowski D J | 1998 | J Occup Environ Med1998，40，8： | 1 |
| 7 | Revising how the computer program cervus accommodates genotyping error increases success in paternity assignment显示文摘 | Kalinowski T Taper M L Marshall T C | 2007 | Molecular Ecology2007，16，5： | 1 |
| 8 | Cardiovascular effects of neuregulin-1/ ErbB signaling: role in vaseular signaling and angiogenesis显示文摘 | Hedhli N Kalinowski A S Rusell K | 2014 | Curr Pharm Des2014，20，30： | 1 |
| 9 | Statin stimulated nitric oxide release from endothelium显示文摘 | Dobrueki LW Kalinowski L Dobrueki IT | 2001 | Med Sci Monit2001，7，4： | 1 |
| 10 | A remote optical system for port and harbor defense显示文摘 | BLACKMON F ANTONELLI L KALINOWSKI A | 2005 | Proc of SPIE2005，，5780： | 1 |
| 11 | Integration of the CAD/CAPP/PPC systems显示文摘 | Grabowik C Kalinowski K Monica Z | 2005 | Materials Processing Technology2005，16，4165： | 1 |
| 12 | Cancer cell i ron metabolism and the development of potent iron chelators as anti-tumour agents显示文摘 | Richardson DR Kalinowski DS Lau S | 2009 | Biochimic Biophysica Acta2009，1790，7： | 1 |
| 13 | Bank Nationalization,Restructuring and Reprivatization:The Case of Korea since the Asian Financial Crisis显示文摘 | Cho Hyekyung Thomas Kalinowski | | 0，，01： | 1 |
| 14 | Qualitative and quantitative proteomics by two-dimensional gel electrophoresis,peptide mass fingerprint and a chemicaily-coded affinity tag (CCAT)显示文摘 | Watt SA Patschkowski T Kalinowski J | | 0，，2： | 1 |
| 15 | Quickcheck:an easy-to-use computer program for checking genotypes for agreement with HardyWeinberg expectations显示文摘 | Kalinowski S T | 2006 | Molecular Ecology Notes2006，6，4： | 1 |
| 16 | Revising how the computer program CERVUS accommodates genotyping error increases success in paternity assignment显示文摘 | Kalinowski ST Taper ML Marshall TC | | 0，，5： | 1 |
| 17 | The complete Corynebacterium glutamicum ATCC 13032 genome sequence and its impact on the production of L-aspartate-derived amino acids and vitamins显示文摘 | KALINOWSKI J BATHE B BARTELS D | 2003 | Journal of Biotechnology2003，104，123： | 1 |
| 18 | Two-dimensional patterns of soluble proteins including three hydrolytic enzymes of mature pollen of tristylous Lythrum alicaria 显示文摘 | Kalinowski A Bocian A Kosmala A | 2007 | Sexual Plant Reproduction2007，20，： | 1 |
| 19 | Novel options for the pharmacological treatment of chronic anal fissure-role of botulin toxin显示文摘 | Madalinski M Kalinowski L | 2009 | Curr Clin Pharmacol2009，4，1： | 1 |
| 20 | Water enclosed within the droplets of bitumen emulsions and its relation to viscosity changes during storage显示文摘 | Furlong S James A Kalinowski E | 1999 | Colloids and Surfaces1999，15，2： | 1 |
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