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| 1 | Application of next-generation sequencing technology to precision medicine in cancer: joint consensus of the Tumor Biomarker Committee of the Chinese Society of Clinical Oncology显示文摘Next-generation sequencing(NGS) technology is capable of sequencing millions or billions of DNA molecules simultaneously.Therefore, it represents a promising tool for the analysis of molecular targets for the initial diagnosis of disease, monitoring of disease progression, and identifying the mechanism of drug resistance. On behalf of the Tumor Biomarker Committee of the Chinese Society of Clinical Oncology(CSCO) and the China Actionable Genome Consortium(CAGC), the present expert group hereby proposes advisory guidelines on clinical applications of NGS technology for the analysis of cancer driver genes for precision cancer therapy. This group comprises an assembly of laboratory cancer geneticists, clinical oncologists, bioinformaticians,pathologists, and other professionals. After multiple rounds of discussions and revisions, the expert group has reached a preliminary consensus on the need of NGS in clinical diagnosis, its regulation, and compliance standards in clinical sample collection. Moreover, it has prepared NGS criteria, the sequencing standard operation procedure(SOP), data analysis, report, and NGS platform certification and validation. | Xuchao Zhang Zhiyong Liang Shengyue Wang Shun Lu Yong Song Ying Cheng Jianming Ying Weiping Liu Yingyong Hou Yangqiu Li Yi Liu Jun Hou Xiufeng Liu Jianyong Shao Yanhong Tai Zheng Wang Li Fu Hui Li Xiaojun Zhou Hua Bai Mengzhao Wang You Lu Jinji Yang Wenzhao Zhong Qing Zhou Xuening Yang Jie Wang Cheng Huang Xiaoqing Liu Xiaoyan Zhou Shirong Zhang Hongxia Tian Yu Chen Ruibao Ren Ning Liao Chunyan Wu Zhongzheng Zhu Hongming Pan Yanhong Gu Liwei Wang Yunpeng Liu Suzhan Zhang Tianshu Liu Gong Chen Zhimin Shao Binghe Xu Qingyuan Zhang Ruihua Xu Lin Shen Yilong Wu | 2019 | Cancer Biology & Medicine2019，16，1： | 14 |
| 2 | Spatial analyzing system for urban land-use management based on GIS and multi-criteria assessment modeling显示文摘城市的陆地管理在城市的计划和开发上在生态的过程,环境进程和过程上要求大量数据的集成。这篇论文联合了与遥感(RS ) 当模特儿的陆地适用性,美化生态的分析和地理信息系统(GIS ) 为城市的扩大陆地管理开发一个空间分析系统。空间分析系统为城市的扩大土地的适用性评估在 GIS 合并多标准机制的使用。灰关系分析(GRA ) 与分析层次过程(AHP ) 被相结合在评估的过程期间探讨不确定性。这条途径被使用明确地在长沙城市里为未来陆地保存和开发识别限制和机会,中国。方法论的确认关于生态的适用性与以前的独立研究显示出巧合的高度。方法论能在环境保护,陆地管理并且地区性的计划是有用的。 | Fu Yang Guangming Zeng Chunyan Du Lin Tang Jianfei Zhou Zhongwu Li | 2008 | Progress in Natural Science:Materials International2008，18，10： | 12 |
| 3 | A Multicenter Study of Viral Aetiology of Community-Acquired Pneumonia in Hospitalized Children in Chinese Mainland显示文摘Community-acquired pneumonia(CAP) is one of the leading causes of morbidity and mortality in children worldwide.In this study,we aimed to describe the aetiology of viral infection of pediatric CAP in Chinese mainland.During November2014 to June 2016,the prospective study was conducted in 13 hospitals.The hospitalized children under 18 years old who met the criteria for CAP were enrolled.The throat swabs or nasopharyngeal aspirates(NPAs) were collected which were then screened 18 respiratory viruses using multiplex PCR assay.Viral pathogens were present in 56.6%(1539/2721) of the enrolled cases,with the detection rate of single virus in 39.8% of the cases and multiple viruses in 16.8% of the cases.The most frequently detected virus was respiratory syncytial virus(RSV)(15.2%,414/2721).The highest detection rate of virus was in <6-month-age group(70.7%,292/413).RSV,human metapneumovirus(HMPV),human parainfluenza viruses(HPIVs) and influenza B virus(Flu B) showed the similar prevalence patterns both in north and south China,but HPIVs,Flu A,human bocavirus(HBoV),human adenovirus(HAdV) and human coronaviruses(HCoVs) showed the distinct circulating patterns in north and south China.Human enterovirus/human rhinovirus(HEV/HRV)(27.6%,27/98),HBoV(18.4%,18/98),RSV(16.3%,16/98) and HMPV(14.3%,14/98) were the most commonly detected viruses in severe pneumonia cases with single virus infection.In conclusion,viral pathogens are frequently detected in pediatric CAP cases and may therefore play a vital role in the aetiology of CAP.RSV was the most important virus in hospitalized children with CAP in Chinese mainland. | Yun Zhu Baoping Xu Changchong Li Zhimin Chen Ling Cao Zhou Fu Yunxiao Shang Aihuan Chen Li Deng Yixiao Bao Yun Sun Limin Ning Shuilian Yu Fang Gu Chunyan Liu Ju Yin Adong Shen Zhengde Xie Kunling Shen | 2021 | Virologica Sinica2021，36，6： | 7 |
| 4 | Identification of differentially expressed genes in rat silicosis model by suppression subtractive hybridization analysis显示文摘在肺的纤维变性的发展的批评分子的机制仍然保持未知,让有差的预后的病人诊断。孤立在肺的纤维变性明确地起来调整的基因,我们建立了一个老鼠矽肺模型在有水晶的硅石暂停的治疗以后的 360 d。胸的拍证明一些散布高密度的阴影出现在肺地里。典型显微镜的小谎 rosing silicotic 小瘤在肺,牙槽的上皮的房间和支气管的上皮的房间形成了,特别地在部分 fibrosing silicotic 小瘤附近;他们中的一些显示出建议了在矽肺和肺癌症之间的关联的不正常的增生。抑制减少性的杂交分析被执行在肺织物把基因表示与矽肺和正常的肺织物作比较。反向的抄写聚合酶链反应证明七个新奇 cDNA 序列的表情由在有矽肺的肺织物的减少性的杂交不同于的抑制识别了正常的肺织物。生物信息学分析证明 47 积极克隆代表了包含二通常认为的蛋白质的 35 基因,四预言了类似的蛋白质。分析也证明一些在矽肺屏蔽了基因,例如 prolyl 4-hydroxylases,肌动朊相关的 protein-2/3 建筑群和酸的哺乳动物的 chitinase,以前没被报导。这些基因可以为在肺的纤维变性的发展调查分子的机制提供新线索。 | Zhongyuan Jin Baoan Liu Deyun Feng Chen Chen Xiang Li Yongbin Hu Jinwu Peng Yu Liu Jing Du Chunyan Fu Jifang Wen | 2008 | Acta Biochimica et Biophysica Sinica2008，40，8： | 6 |
| 5 | Blocking the JAK2/STAT3 and ERK pathways suppresses the proliferation of gastrointestinal cancers by inducing apoptosis显示文摘Dysregulated crosstalk between different signaling pathways contributes to tumor development,including resistance to cancer therapy.In the present study,we found that the mitogen-activated extracellular signal-regulated kinase(MEK)inhibitor trametinib failed to suppress the proliferation of PANC-1 and MGC803 cells by activating the Janus kinase 2(JAK2)/signal transducer and activator of transcription 3(STAT3)signaling pathway,while the JAK2 inhibitor fedratinib failed to inhibit the growth of the PANC-1 cells upon stimulation of extracellular signal-regulated kinase(ERK)signaling.In particular,the most prominent enhancement of the anti-proliferative effect resulted from the concurrent blockage of the JAK2/STAT3 and ERK signaling pathways.Furthermore,the combination of the two inhibitors resulted in a reduced tumor burden in mice.Our evidence suggests novel crosstalk between JAK2/STAT3 and ERK signaling in gastric cancer(GC)and pancreatic ductal adenocarcinoma(PDAC)cells and provides a therapeutic strategy to overcome potential resistance in gastrointestinal cancer. | Xi WANG Chunyan DAI Yifei YIN Lin WU Weiyang JIN Yufei FU Zhe CHEN Ke HAO Bin LU | 2021 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2021，22，6： | 4 |
| 6 | The impact of transportation control measures on emission reductions during the 2008 Olympic Games in Beijing, China显示文摘 | Yu Zhou Ye Wu Liu Yang Lixin Fu Kebin He Shuxiao Wang Jiming Hao Jinchuan Chen Chunyan Li | 2009 | Atmospheric Environment2009，，3： | 2 |
| 7 | microRNA-21 overexpression contributes to cell proliferation by targetingPTEN in endometrioid endometrial cancer显示文摘 | Xiaoyan Qin Lei Yan Xingbo Zhao Chunyan Li Yibing Fu | 2012 | Oncology Letters2012，，： | 2 |
| 8 | Crystal structure of histidine-containing phosphocarrier protein from Thermoanaerobacter tengcongensis MB4 and the implications for thermostability显示文摘Protein thermostability is an inherent characteristic of proteins from thermophilic microorganisms,and therefore enables these organisms to survive at extreme temperatures.Although it is well-known that thermostable proteins are critical for the growth of thermophilic organisms,the structural basis of protein thermostability is not yet fully understood.The histidine-containing phosphocarrier (HPr) protein,a phosphate shuttle protein in the phosphoenolpyruvate-dependent sugar transport system (PTS) of bacterial species,is an ideal model for investigating protein thermostability with respect to its small size and deficiency in disulphide bonds or cofactors.In this study,the HPr protein from Thermoanaerobacter tengcongensis (TtHPr) is cloned and purified.Crystal structure with good quality has been determined at 2.3 resolution,which provides a firm foundation for exploring the thermostable mechanism.However,it shows that the crystal structure is conserved and no clue can be obtained from this single structure.Furthermore,detailed comparison of sequence and structure with the homologs from mesoor thermophilic bacteria shows no obvious rule for thermostability,but the extra salt-bridge existing only in thermophilic bacteria might be a better explanation for thermostability of HPr.Thus,mutations are performed to interrupt the salt-bridge in HPrs in thermophilic bacteria.Using site-directed mutations and the circular dichroism method,thermostability is evaluated,and the mutational variations are shown to have a faster denaturing rate than for wild-type viruses,indicating that mutations cause instability in the HPrs.Understanding the higher-temperature resistance of thermophilic and hyperthermophilic proteins is essential to studies on protein folding and stability,and is critical in engineering efficient enzymes that can work at a high temperature. | FENG ChunYan GAO Feng LIU YiWei WANG GuiHua PENG Hao MA YanHe YAN JingHua GAO George Fu | 2011 | Science China(Life Sciences)2011，54，6： | 2 |
| 9 | High-temperature Tensile Behavior of Laser Welded Ti-22Al-25Nb Joints at Different Temperatures显示文摘The high-temperature tensile behavior of laser welded Ti-22Al-25Nb (at%) joints was investigated at 500,650,800,and 1 000 ℃.The temperatures for tensile tests were selected according to the phase transformation sequence of Ti2AlNb-based alloys.At temperatures lower than the B2+O phase field (500 ℃) and higher than the B2+O phase field (1 000 ℃),the joints fracture in the base metal in ductile fracture mode.By contrast,the joints exhibit obvious high-temperature brittleness in the B2+O phase field (650 °C and 800 ℃).Heat treatments were conducted with respect to the thermal history of tensile specimens.Intergranular microcracks along the grain boundary of B2 phase are found in the fusion zone after the heat treatments at 650 ℃ and 800 ℃.The high-temperature brittleness at 650 ℃ and 800 ℃ is attributed to the B2→O transformation along the grain boundary.The stress concentration caused by the volume change of B2→O transformation also contributes to the high-temperature brittleness of laser welded Ti-22Al-25Nb joints. | 张可召 雷正龙 CHEN Yanbin YAN Chunyan FU Qiang BAO Yefeng | 2020 | Journal of Wuhan University of Technology(Materials Science)2020，35，6： | 1 |
| 10 | Sensitive and specific HBV genomic DNA detection using RCA-based QCM biosensor显示文摘 | Chunyan Yao Yang Xiang Kun Deng Han Xia Weiling Fu | 2013 | Sensors & Actuators: B Chemical2013，，： | 1 |
| 11 | A cross-layer architecture for signaling in multi-hop cellular networks显示文摘 | Fu Chunyan Glitho R and Khendek F | 2008 | IEEE Communications Magazine2008，46，9： | 1 |
| 12 | Adenovirus-mediated transfer of siRNA against Runx2/Cbfa1 inhibits the formation of heterotopic ossification in animal model显示文摘 | Lin Lin Lianxu Chen Haijun Wang Xuelei Wei Xin Fu Jiying Zhang Kangtao Ma Chunyan Zhou Changlong Yu | 2006 | Biochemical and Biophysical Research Communications2006，，2： | 1 |
| 13 | Recent progress of aptamer-drug conjugates in cancer therapy显示文摘Aptamers are single-stranded DNA or RNA sequences that can specifically bind with the target protein or molecule via specific secondary structures.Compared to antibody-drug conjugates(ADC),aptamer-drug conjugate(ApDC)is also an efficient,targeted drug for cancer therapy with a smaller size,higher chemical stability,lower immunogenicity,faster tissue penetration,and facile engineering.Despite all these advantages,several key factors have delayed the clinical translation of ApDC,such as in vivo off-target effects and potential safety issues.In this review,we highlight the most recent progress in the development of ApDC and discuss solutions to the problems noted above. | Jiaxuan He Qiao Duan Chunyan Ran Ting Fu Yuan Liu Weihong Tan | 2023 | Acta Pharmaceutica Sinica B2023，13，4： | 1 |
| 14 | Preventive Cardioprotection of Erythropoietin Against Doxorubicin-induced Cardiomyopathy显示文摘 | Xing Chen Yongli Chen Yanyong Bi Naikuan Fu Chunyan Shan Sili Wang Shahid Aslam Peixian Wang Jing Xu | 2007 | Cardiovascular Drugs and Therapy2007，，5： | 1 |
| 15 | Pomegranate micro/nano hierarchical plasma structure for superior microwave absorption显示文摘Inspired by the pomegranate natural artful structure,pomegranate micro/nano hierarchical plasma configuration of Fe/Fe3C@graphitized carbon(FFC/pCL)was constructed based on the green sol-gel method and in-situ chemical vapor deposition(CVD)synthesis protocol.Pomegranate-like FFC/pCL successfully overcame the agglomeration phenomenon of magnetic nanoparticles with each seed of the pomegranate consisting of Fe/Fe_(3)C as cores and graphitized carbon layers as shells.The high-density arrangement of magnetic nanoparticles and the design of pomegranate-like heterostructures lead to enhanced plasmon resonance.Thus,the pomegranate-like FFC/pCL achieved a great electromagnetic wave(EMW)absorbing performance of 6.12 GHz wide band absorption at a low mass adding of only 16.7 wt.%.Such excellent EMW performance can be attributed to its unique pomegranate hierarchical plasma configuration with separated nanoscale iron cores,surface porous texture,and good carbon conductive network.This investigation provides a new paradigm for the development of magnetic/carbon based EMW absorbing materials by taking advantage of pomegranate hierarchical plasma configuration. | Chunyan Ding Tao Wu Xinsen Hu Chengshuai Shao Zhipeng Xu Hui Fu Songsong Wu Guangwu Wen Xiaoxiao Huang | 2022 | Nano Research2022，15，10： | 1 |
| 16 | RESTful web services for service provisioning in next generationnetworks: a survey显示文摘 | Belqasmi F Glitho R Chunyan Fu | 2011 | Communications Magazine2011，49，12： | 1 |
| 17 | microRNA-21 overexpression contributes to cell proliferation by targetingPTEN in endometrioid endometrial cancer显示文摘 | Xiaoyan Qin Lei Yan Xingbo Zhao Chunyan Li Yibing Fu | 2012 | Oncology Letters2012，，6： | 1 |
| 18 | The impact of transportation control measures on emission reductions during the 2008 Olympic Games in Beijing, China显示文摘 | Yu Zhou Ye Wu Liu Yang Lixin Fu Kebin He Shuxiao Wang Jiming Hao Jinchuan Chen Chunyan Li | 2009 | Atmospheric Environment2009，，3： | 1 |
| 19 | The Fibroblast Growth Factor Receptor-4 Arg388 Allele is Associated with Gastric Cancer Progression显示文摘 | Yanwei Ye Yingqiang Shi Ye Zhou Chunyan Du Chunmeng Wang Heqin Zhan Biqiang Zheng Xi Cao Meng-hong Sun Hong Fu | 2010 | Annals of Surgical Oncology2010，，12： | 1 |
| 20 | Opti mal filtering for networked systems with Mark ovian communication delays显示文摘 | Han Chunyan Zhang Huanshui Fu Minyue | 2013 | Automatica2013，49，10： | 1 |
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