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| 1 | Direct reprogramming of Sertoli cells into multipotent neural stem cells by defined factors显示文摘Multipotent 神经干细胞为房间治疗保持大诺言。到导致的 pluripotent 干细胞以及成熟神经原的成纤维细胞的 reprogramming 建议可能性没有首先建立 pluripotency,把一个严重地区分的体的房间变换成一个 multipotent 状态。这里,我们证明房间从中层导出的那 Sertoli 能直接被变换成拥有神经干细胞性质的一个 multipotent 状态。导致的神经干细胞(iNSCs ) 表示多重 NSC 特定的标记,展出类似于正常 NSC 的全球基因表示侧面,并且能够自强并且区分功能的神经原进神经胶质并且 electrophysiologically。为酷氨酸 hydroxylase (TH ) 积极的导出 iNSC 的神经原污点, γ -aminobutyric 酸,和胆碱 acetyltransferase。另外, iNSCs 能熬过并且产生跟随移植进有牙齿的回转的触处。iNSCs 的产生可以为疾病建模和再生药有重要含意。 | Chao Sheng Qinyuan Zheng Jianyu Wu Zhen Xu Libin Wang Wei Li Haijiang Zhang Xiao-Yang Zhao Lei Liu Ziwei Wang Changlong Guo Hua-Jun Wu Zhonghua Liu Liu Wang Shigang He Xiu-Jie Wang Zhiguo Chen Qi Zhou | 2012 | Cell Research2012，22，1： | 31 |
| 2 | Direct-impact of sieving coal and gangue显示文摘Gangue from underground separation of coal can directly be used for filling mined out areas, saving transport capacity and reducing the amount of waste polluting the environment above the ground. We introduced a structure and operating principle of an underground direct-impact sieving device by which a separation experiment was carried out. By means of high speed conveyer belts, coal and gangue impacted the breaking board at high speeds ranging from 6 to 14 m/s. Given the differences of hardness between coal and gangue, after selective crushing, the gangue with the higher hardness was crushed less and coal with lower hardness crushed more, which could be separated by a 50 mm sieving plate. The material above the sieving plate was disposed of as gangue and the material below as coal. The results indicate that the crush ratio below the 50 mm sieving plate increases linearly with an increase in impact velocity and decays exponentially with an increase in hardness. Employing this equipment to separate coal and gangue, the hardness of coal f should be <2. This separation device provides relatively good effect in separating coal and gangue with a relatively wide difference of hardness. | LI Jianping DU Changlong BAO Jianwei | 2010 | Mining Science and Technology2010，20，4： | 19 |
| 3 | Development of cell-based pseudovirus entry assay to identify potential viral entry inhibitors and neutralizing antibodies against SARS-CoV-2显示文摘Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is the causative virus of the coronavirus disease 2019(COVID-19)pandemic.To establish a safe and convenient assay system for studying entry inhibitors and neutralizing antibodies against SARS-CoV-2,we constructed a codon-optimized,full-length C-terminal mutant spike(S)gene of SARS-CoV-2.We generated a luciferase(Luc)-expressing pseudovirus containing the wild-type or mutant S protein of SARS-CoV-2 in the envelope-defective HIV-1 backbone.The key parameters for this pseudovirus-based assay,including the S mutants and virus incubation time,were optimized.This pseudovirus contains a Luc reporter gene that enabled us to easily quantify virus entry into angiotensin-converting enzyme 2(ACE2)-expressing 293T cells.Cathepsin(Cat)B/L inhibitor E64d could significantly block SARS-CoV-2 pseudovirus infection in 293T-ACE2 cells.Furthermore,the SARS-CoV-2 spike pseudotyped virus could be neutralized by sera from convalescent COVID-19 patients or recombinant ACE2 with the fused Fc region of human IgG1.Thus,we developed a pseudovirus-based assay for SARS-CoV-2,which will be valuable for evaluating viral entry inhibitors and neutralizing antibodies against this highly pathogenic virus. | Jie Hu Qingzhu Gao Changlong He Ailong Huang Ni Tang Kai Wang | 2020 | Genes & Diseases2020，7，4： | 15 |
| 4 | DEVELOPMENT OF A SHAPE-SHIFTING MOBILE ROBOT FOR URBAN SEARCH AND RESCUE显示文摘A portable shape-shifting mobile robot system named as Amoeba II (A-II) is developed for the urban search and rescue application.It is designed with three degrees of freedom and two tracked drive systems.This robot consists of two modular mobile units and a joint unit.The mobile unit is a tracked mechanism to enforce the propulsion of robot.And the joint unit can transform the robot shape to get high environment adaptation.A-If robot can not only adapt to the environment but also change its body shape according to the locus space.It behaves two work states including the linear state (named as I state) and the parallel state (named as II state).With the linear state the robot can climb upstairs and go through narrow space such as the pipe,cave,etc.The parallel state enables the robot with high mobility on rough ground.Also,the joint unit can propel the robot to roll in sidewise direction.Two modular A-II robots can be connected through jointing common interfaces on the joint unit to compose a stronger shape-shifting robot,which Can transform the body into four wheels-driven vehicle.The experimental results validate the adaptation and mobility of A-II robot. | YE Changlong MA Shugen LI Bin | 2008 | Chinese Journal of Mechanical Engineering2008，21，2： | 12 |
| 5 | Generation of dopaminergic neurons directly from mouse fibroblasts and fibroblast-derived neural progenitors显示文摘 | Chao Sheng Qinyuan Zheng Jianyu Wu Zhen Xu Lisi Sang Libin Wang Changlong Guo Wanwan Zhu Man Tong Lei Liu Wei Li Zhong-Hua Liu Xiao-Yang Zhao Liu Wang Zhiguo Chen Qi Zhou | 2012 | Cell Research2012，22，4： | 12 |
| 6 | Analytically Derived Wind Wave Growth Relations显示文摘By the use of the 3/2 power law presented by Toba combined with the significant wave energy balance equation forwind wave, wind wave growth at a limited fetch is analytically investigated. The new wind wave growth relations(WWGRs) are analytically derived with sheltering coefficient and wind drag coefficient as parameters. The geometricalaverage of observational values of sheltering coefficient and the arithmetic average of observational values of wind drag co-efficient are applied to determine the new WWGRs. Comparisons with existing empirical WWGRs are made. | GUAN Changlong(管长龙) SUN Qun(孙群) | 2002 | China Ocean Engineering2002，17，3： | 10 |
| 7 | Parameters analysis of shearer drum loading performance显示文摘Three drums with different helical angles(15°,20°,and 25°) were developed to investigate improved loading performance of the shearer drum.Nine trials were performed at different drum rotation speeds(80,100,and 120 r/min) and different haulage speeds(1.5,2.0,and 2.5 m/min) in an orthogonal test design.Loaded coal quantity and cutting power of the drum were the responses measured under the different conditions.The effect of the parameters was determined by means of the extreme difference method.The significance of the effects was determined by analysis of variance.The results indicate that the effect from changes in the helical vane on loading performance of the drum is the largest in magnitude.The haulage speed has the least affect on loading performance.The helical angle has the least affect on cutting power of the drum.Haulage speed has the largest affect on the cutting power of the drum. | Liu Songyong Du Changlong Zhang Jiajia Jiang Hao | 2011 | Mining Science and Technology2011，21，5： | 8 |
| 8 | X-BAND CIRCULARLY POLARIZED RECTENNAS FOR MICROWAVE POWER TRANSMISSION APPLICATIONS显示文摘Circularly polarized rectennas operating at X-band are studied in this paper. The quasi-square patches fed by aperture coupling are used as the circularly polarized receiving antennas, which are easily matched and integrated with the circuits of rectennas. The double-layer structure not only minimizes the size of the rectennas but also decreases the effects of the circuits on the an- tenna. The receiving elements have broader bandwidth and higher gain than the single-layer patches. Two rectennas operating at 10GHz are designed, fabricated and measured. The voltage of 3.86V on a load of 200? is measured and a high RF-DC conversion efficiency of 75% is obtained at 9.98GHz. It is convenient for this kind of rectennas to form large arrays for high power applications. | Yang Xuexia Xu Junshu Xu Deming Xu Changlong | 2008 | Journal of Electronics(China)2008，25，3： | 7 |
| 9 | A Genomic Variation Map Provides Insights into the Genetic Basis of Spring Chinese Cabbage (Brassica rapa ssp.pekinensis)Selection显示文摘Chinese cabbage is the most consumed leafy crop in East Asian countries.However,premature bolting induced by continuous low temperatures severely decreases the yield and quality of the Chinese cabbage, and therefore restricts its planting season and geographic distribution.In the past 40years,spring Chinese cabbage with strong winterness has been selected to meet the market demand.Here,we report a genome variation map of Chinese cabbage generated from the resequencing data of 194 geographically diverse accessions of three ecotypes.In-depth analyses of the selection sweeps and genome-wide patterns revealed that spring Chinese cabbage was selected from a specific population of autumn Chinese cabbage around the area of Shandong peninsula in northern China.We identified 23 genomic loci that underwent intensive selection,and further demonstrated by gene expression and haplotype analyses that the incorporation of elite alleles of VERNALISATION INSENTIVE 3.1(BrVIN3.1)and FLOWER LOCUS C 1(BrFLC1)is a determinant genetic source of variation during selection.Moreover,we showed that the quantitative response of BrVIN3.1 to cold due to the sequence variations in the cis elements of the BrVlN3.1 promoter significantly contributes to bolting-time variation in Chinese cabbage.Collectively, our study provides valuable insights into the genetic basis of spring Chinese cabbage selection and will facilitate the breeding of bolting-resistant Varieties by molecular-marker-assisted selection,transgenic or gene editingapproaches. | Tongbing Su Weihong Wang Peirong Li Bin Zhang Pan Li Xiaoyun Xin Honghe Sun Yangjun Yu Deshuang Zhang Xiuyun Zhao Changlong Wen Gang Zhou Yuntong Wang Hongkun Zheng Shuancang Yu Fenglan Zhang | 2018 | Molecular Plant2018，11，11： | 6 |
| 10 | Analysis of the Global Swell Distributions Using ECMWF Re-Analyses Wind Wave Data显示文摘The existence of three well-defined tongue-shaped zones of swell dominance,termed as 'swell pools',in the Pacific,the Atlantic and the Indian Oceans,was reported by Chen et al.(2002)using satellite data.In this paper,the ECMWF Re-analyses wind wave data,including wind speed,significant wave height,averaged wave period and direction,are applied to verify the existence of these swell pools.The swell indices calculated from wave height,wave age and correlation coefficient are used to identify swell events.The wave age swell index can be more appropriately related to physical processes compared to the other two swell indices.Based on the ECMWF data the swell pools in the Pacific and the Atlantic Oceans are confirmed,but the expected swell pool in the Indian Ocean is not pronounced.The seasonal variations of global and hemispherical swell indices are investigated,and the argument that swells in the pools seemed to originate mostly from the winter hemisphere is supported by the seasonal variation of the averaged wave direction.The northward bending of the swell pools in the Pacific and the Atlantic Oceans in summer is not revealed by the ECMWF data.The swell pool in the Indian Ocean and the summer northward bending of the swell pools in the Pacific and the Atlan-tic Oceans need to be further verified by other datasets. | ZHANG Jie WANG Weili GUAN Changlong | 2011 | Journal of Ocean University of China2011，10，4： | 6 |
| 11 | Combined genomic, transcriptomic, and metabolomic an alyses provide in sights into chayote (Sechium edule) evolution and fruit development显示文摘Chayote(Sechium edule)is an agricultural crop in the Cucurbitaceae family that is rich in bioactive components.To enhance genetic research on chayote,we used Nanopore third-generation sequencing combined with Hi-C data to assemble a draft chayote genome.A chromosome-level assembly anchored on 14 chromosomes(N50 contig and scaffold sizes of 8.40 and 46.56 Mb,respectively)estimated the genome size as 606.42 Mb,which is large for the Cucurbitaceae,with 65.94%(401.08 Mb)ofthe genome comprising repetitive sequences;28,237 protein-coding genes were predicted.Comparative genome analysis indicated that chayote and snake gourd diverged from sponge gourd and that a whole-genome duplication(WGD)event occurred in chayote at 25±4 Mya.Transcriptional and metabolic analysis revealed genes involved in fruit texture,pigment,fl avor,fl avonoids,antioxidants,and plant hormones during chayote fruit development.The analysis of the genome,transcriptome,and metabolome provides insights into chayote evolution and lays the groundwork for future research on fruit and tuber development and genetic improvements in chayote. | Anzhen Fu Qing Wang Jianlou Mu Lili Ma Changlong Wen Xiaoyan Zhao Lipu Gao Jian Li Kai Shi Yunxiang Wang Xuechuan Zhang Xuewen Zhang Fengling Wang Donald Grierson Jinhua Zuo | 2021 | Horticulture Research2021，8，1： | 6 |
| 12 | Numerical study of coarse coal particle breakage in pneumatic conveying显示文摘 | Jiawei Zhou Yu Liu Changlong Du Songyong Liu Jianping Li | 2018 | Particuology2018，16，3： | 6 |
| 13 | NAD+metabolism:pathophysiologic mechanisms and therapeutic potential显示文摘Nicotinamide adenine dinucleotide(NAD^(+))and its metabolites function as critical regulators to maintain physiologic processes,enabling the plastic cells to adapt to environmental changes including nutrient perturbation,genotoxic factors,circadian disorder,infection,inflammation and xenobiotics.These effects are mainly achieved by the driving effect of NAD^(+)on metabolic pathways as enzyme cofactors transferring hydrogen in oxidation-reduction reactions.Besides,multiple NAD^(+)-dependent enzymes are involved in physiology either by post-synthesis chemical modification of DNA,RNA and proteins,or releasing second messenger cyclic ADPribose(cADPR)and NAADP^(+).Prolonged disequilibrium of NAD^(+)metabolism disturbs the physiological functions,resulting in diseases including metabolic diseases,cancer,aging and neurodegeneration disorder.In this review,we summarize recent advances in our understanding of the molecular mechanisms of NAD^(+)-regulated physiological responses to stresses,the contribution of NAD^(+)deficiency to various diseases via manipulating cellular communication networks and the potential new avenues for therapeutic intervention. | Na Xie Lu Zhang Wei Gao Canhua Huang Peter Ernst Huber Xiaobo Zhou Changlong Li Guobo Shen Bingwen Zou | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 5 |
| 14 | Pain threshold, anxiety and other factors affect intensity of postoperative pain in gastric cancer patients: A prospective cohort study显示文摘Objective: This prospective cohort study explored factors related to postoperative pain in gastric cancer patients.Methods: A total of 236 patients who underwent gastrectomy were enrolled. All patients enrolled in the study completed the Hospital Anxiety and Depression Scale(HADS) questionnaire and Life Orientation Test-Revised(LOT-R) questionnaire on the day before surgery. Heat pain threshold(HPT), cold pain threshold(CPT) and pressure pain threshold(PPT) were measured for all patients one day prior to surgery and demographic details were collected. All patients were connected to a patient-controlled intravenous analgesia(PCIA) pump at the end of the surgery. The occurrence of postoperative pain was used as a dependent variable, and multivariate logistic regression analyses were conducted to screen for factors affecting postoperative pain.Results: In total, 83 patients(35.2%) had postoperative pain. Body mass index(BMI) ≥28 kg/m^(2) [odds ratio(OR): 2.67;95% confidence interval(95% CI): 1.07-6.67], total gastrectomy(OR: 2.64;95% CI: 1.42-4.91),preoperative anxiety score ≥8(OR: 2.37;95% CI: 1.12-5.02), heat pain threshold ≤4.9 s(OR: 2.14;95% CI:1.06-4.32), pressure pain threshold ≤4 g(OR: 2.05;95% CI: 1.05-4.03), and female gender(OR: 1.99;95% CI:1.04-3.83) were risk factors for postoperative pain.Conclusions: Obesity, wide range of gastrectomy, high preoperative anxiety, low HPT and PPT, and female gender are associated with increased risk for postoperative pain. | Hongyu Tan Jin Wei Shuo Li Ling Yu Hongwei Sun Ke Ji Yinkui Wang Changlong Li | 2021 | Chinese Journal of Cancer Research2021，33，3： | 5 |
| 15 | Highly efficient catalytic scavenging of oxygen free radicals with graphene-encapsulated metal nanoshields显示文摘 | Junying Wang Xiaoju Cui Haobo Li Jianping Xiao Jiang Yang Xiaoyu Mu Haixia Liu Yuan-Ming Sun Xuhui Xue Changlong Liu Xiao-Dong Zhang Dehui Deng Xinhe Bao | 2018 | Nano Research2018，11，5： | 4 |
| 16 | Model test of helical angle effect on coal loading performance of shear drum显示文摘The work presented in this paper focuses on improving coal loading performance of shear drum.Employing the similarity theory,we carried out a dimensional analysis of the correlation parameters which influence coal loading performance of shear drum.On the basis of similarity criterion,proportional relationship between the model and the prototype was taken on the condition of taking 1/3 as the similarity coefficient.Besides taking 1600 mm drum as the prototype,four helical angle models of shearer drums(15°,18°,21°,24°) were developed.Simultaneously,based on an established cutting test-bed,coal loading performance tests for the four drums were carried out at the same drum rotational and haulage speeds.After analyzing the data of coal-loading performance and torque,we concluded that:both the coal loading performance and torque vary along the track of the parabola with the opening side facing downwards;the best coal loading performance arises when the helical angle is at 19.3°,while the biggest torque arises at 22.1°;and the coal loading performance had nonlinear relationship with the torque. | Kuidong Gao Changlong Du Songyong Liu Lin Fu | 2012 | International Journal of Mining Science and Technology2012，22，2： | 4 |
| 17 | A KH Domain-Containing Putative RNA-Binding Protein Is Critical for Heat Stress-Responsive Gene Regulation and Thermotolerance in Arabidopsis显示文摘热应力是显著地减少植物生长和延期开发的一个严重环境因素。热压力因素(HSF ) 是在温度响应举起很快被综合并且为许多热的抄写负责的抄写因素的一个班压力应答的基因包括那些编码热吃惊蛋白质(HSP ) 。在 Arabidopsis 有 21 HSF,并且最近的研究证实了 HSFA1 家庭成员是为留下的 HSF 的主人管理者。然而,很,很少对在上游的分子的因素被知道在热应力下面控制 HSFA1 基因和另外的 HSF 基因的表达式。通过向前基因的分析,我们识别了 RCF3, K 相同(KH ) 包含域的原子局部性的通常认为的 RNA 有约束力的蛋白质。RCF3 是大多数 HSF 的一个否定管理者,包括 HSFA1a, HSFA1b,和 HSFA1d。相反, RCF3 断然控制 HSFA1e, HSFA3, HSFA9, HSFB3,和 DREB2C 的表示。一致地与外套增加了热应答的基因的累积, rcf3 异种植物比更容忍对热应力野类型。一起,我们的结果建议 KH 包含域的通常认为的 RNA 有约束力的蛋白质 RCF3 是为热的一个重要在上游的管理者在 Arabidopsis 的压力应答的基因表示和 thermotolerance。 | Qingmei Guan Changlong Wen Haitao Zeng Jianhua Zhu | 2013 | Molecular Plant2013，6，2： | 4 |
| 18 | Effect of Bi on graphite morphology and mechanical properties of heavy section ductile cast iron显示文摘To improve the mechanical properties of heavy section ductile cast iron, bismuth(Bi) was introduced into the iron. Five castings with different Bi content from 0 to 0.014 wt.% were prepared; and four positions in the casting from the edge to the center, with different solidifi cation cooling rates, were chosen for microstructure observation and mechanical properties test. The effect of the Bi content on the graphite morphology and mechanical properties of heavy section ductile cast iron were investigated. Results show that the tensile strength, elongation and impact toughness at different positions in the fi ve castings decrease with a decrease in cooling rate. With an increase in Bi content, the graphite morphology and the mechanical properties at the same position are improved, and the improvement of mechanical properties is obvious when the Bi content is no higher than 0.011wt.%. But when the Bi content is further increased to 0.014wt.%, the improvement of mechanical properties is not obvious due to the increase of chunky graphite number and the aggregation of chunky graphite. With an increase in Bi content, the tensile fracture mechanism is changed from brittle to mixture ductile-brittle fracture. | Song Liang Guo Erjun Tan Changlong | 2014 | China Foundry2014，11，2： | 4 |
| 19 | A proposed directional function and wind-wave directional spectrum显示文摘Aproposeddirectionalfunctionandwind-wavedirectionalspectrum￥WenShengchang;WuKejian;GuanChanglong;SunShicaiandZhangDacuo(Recei... | Wen Shengchang Wu Kejian Guan Changlong Sun Shicai and Zhang Dacuo (Institute of Physical Oceanography, Ocean University of Oingdao, Oingdao 266003, China) | 1995 | Acta Oceanologica Sinica1995，14，2： | 4 |
| 20 | A Method for Sea Surface Wind Field Retrieval from SAR Image Mode Data显示文摘To retrieve wind field from SAR images, the development for surface wind field retrieval from SAR images based on the improvement of new inversion model is present. Geophysical Model Functions(GMFs) have been widely applied for wind field retrieval from SAR images. Among them CMOD4 has a good performance under low and moderate wind conditions. Although CMOD5 is developed recently with a more fundamental basis, it has ambiguity of wind speed and a shape gradient of normalized radar cross section under low wind speed condition. This study proposes a method of wind field retrieval from SAR image by combining CMOD5 and CMOD4 Five VV-polarisation RADARSAT2 SAR images are implemented for validation and the retrieval results by a combination method(CMOD5 and CMOD4) together with CMOD4 GMF are compared with QuikSCAT wind data. The root-mean-square error(RMSE) of wind speed is 0.75 m s-1 with correlation coefficient 0.84 using the combination method and the RMSE of wind speed is 1.01 m s-1 with correlation coefficient 0.72 using CMOD4 GMF alone for those cases. The proposed method can be applied to SAR image for avoiding the internal defect in CMOD5 under low wind speed condition. | SHAO Weizeng SUN Jian GUAN Changlong SUN Zhanfeng | 2014 | Journal of Ocean University of China2014，13，2： | 4 |
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