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| 1 | Imatinib as preoperative therapy in Chinese patients with recurrent or metastatic GISTs显示文摘Objective: Imatinib has dramatically altered the options for management of patients with gastrointestinal stromal tumours. However, it has become clear that secondary resistance to the drug develops during long-term therapy. The purpose of our study was to retrospectively analyze safety and long-term outcomes in Chinese patients with recurrent or metastatic GISTs treated with imatinib preoperatively. Methods: Between June 2003 and June 2011, 22 patients underwent surgery for recurrent or metastatic GISTs after preoperative treatment with imatinib. Results: Complete resection was accomplished in 8 of the 10 responsive disease (RD) patients (80%), and in 3 of the 12 patients (25%) who had progression disease (PD). The amount of blood loss during the operation in PD patients was higher than in RD patients. There was 1 hospital death in PD group related to surgery, while the other patients recovered with conservative therapy because complications were mild. The difference in median PFS between patients with RD and those with PD was significant (24.8 vs. 2.81 months, P<0.001). The difference in 2-year OS rate between patients with RD and those with PD was not significant (100% vs. 87.5%, P>0.05). Conclusions: Our study indicates that surgical intervention can improve the PFS of Chinese patients with recurrent or metastatic GISTs responsive to imatinib, but does not prolong OS as well as in patients who develop imatinib resistance. Surgical resection following imatinib treatment is feasible and can be considered for patients with advanced GISTs responsive to imatinib. | Chunmeng Wang Biqiang Zheng Yong Chen Xi Cao Ruming Zhang Yingqiang Shi | 2013 | Chinese Journal of Cancer Research2013，25，1： | 6 |
| 2 | High-efficiency second-order nonlinear processes in an optical microfibre assisted by few-layer GaSe显示文摘The centrosymmetric nature of silica fibre precludes the realisation of second-order nonlinear processes in optical fibre systems.Recently,the integration of 2D materials with optical fibres has opened up a great opportunity to develop allfibre active devices.Here,we demonstrate high-efficiency second-order nonlinear frequency conversions in an optical microfibre assisted with few-layer gallium selenide(GaSe)nanoflakes.Attributed to the strong evanescent field of the microfibre and ultrahigh second-order nonlinearity of the GaSe nanoflakes,second harmonic generation(SHG)and sum-frequency generation(SFG)are effectively achieved with only sub-milliwatt continuous-wave(CW)lasers in the wavelength range of 1500–1620 nm,covering the C and L telecom bands.The SHG intensity from the microfibre is enhanced by more than four orders of magnitude with the assistance of the GaSe nanoflakes on fibre nonlinear processes.Moreover,in the SFG process,the intensity transfer between different frequencies can be effectively manipulated by changing the wavelengths and powers of two pump lasers.The realised strong second-order nonlinearity in the GaSe-integrated microfibre might expand the applications of all-fibre devices in all-optical signal processing and new light source generation at awkward wavelengths. | Biqiang Jiang Zhen Hao Yafei Ji Yueguo Hou Ruixuan Yi Dong Mao Xuetao Gan Jianlin Zhao | 2020 | Light(Science & Applications)2020，9，1： | 4 |
| 3 | Empirical modeling of ionospheric F2 layer critical frequency over Wakkanai under geomagnetic quiet and disturbed conditions显示文摘The hourly values of the ionospheric F2 layer critical frequency, foF2, recorded at Wakkanai ionosonde station (45.4°N, 141.7°E) have been collected to construct a middle-latitude single-station model for forecasting foF2 under geomagnetic quiet and disturbed conditions. The module for the geomagnetic quiet conditions incorporates local time, seasonal, and solar variability of climatological foF2 and its upper and lower quartiles. It is the first attempt to predict the upper and lower quartiles of foF2 to account for the notable day-to-day variability in ionospheric foF2. The validation statistically verifies that the model captures the climatological variations of foF2 with higher accuracy than IRI does. The storm-time module is built to capture the geomagnetic storm induced relative deviations of foF2 from the quiet time references. In the geomagnetically disturbed module, the storm-induced deviations are described by diurnal and semidiurnal waves, which are modulated by a modified magnetic activity index, the Kf index, reflecting the delayed responses of foF2 to geomagnetic activity forcing. The coefficients of the model in each month are determined by fitting the model formula to the observation in a least-squares way. We provide two options for the geomagnetic disturbed module, including or not including Kalman filter algorithm. The Kalman filter algorithm is introduced to optimize these coefficients in real time. Our results demonstrate that the introduction of the Kalman filter algorithm in the storm time module is promising for improving the accuracy of predication. In addition, comparisons indicate that the IRI model prediction of the F2 layer can be improved to provide better performances over this region. | LIU Jing LIU LiBo ZHAO BiQiang WAN WeiXing CHEN YiDing | 2012 | Science China(Technological Sciences)2012，55，5： | 4 |
| 4 | Preliminary experimental results by the prototype of Sanya Incoherent Scatter Radar显示文摘In the past decades,the Incoherent Scatter Radar(ISR)has been demonstrated to be one of the most powerful instruments for ionosphere monitoring.The Institute of Geology and Geophysics at the Chinese Academy of Sciences was founded to build a state-ofthe-art phased-array ISR at Sanya(18.3°N,109.6°E),a low-latitude station on Hainan Island,named the Sanya ISR(SYISR).As a first step,a prototype radar system consisting of eight subarrays(SYISR-8)was built to reduce the technical risk of producing the entire large array.In this work,we have summarized the preliminary experimental results based on the SYISR-8.The amplitude and phase among 256 channels were first calibrated through an embedded internal monitoring network.The mean oscillation of the amplitude and phase after calibration were about 1 dB and 5°,respectively,which met the basic requirements.The beam directivity was confirmed by crossing screen of the International Space Station.The SYISR-8 was further used to detect the tropospheric wind profile and meteors.The derived winds were evaluated by comparison with independent radiosonde and balloon-based GPS measurements.The SYISR-8 was able to observe several typical meteor echoes,such as the meteor head echo,range-spread trail echo,and specular trail echo.These results confirmed the validity and reliability of the SYISR-8 system,thereby reducing the technical risk of producing the entire large array of the SYISR to some extent. | XinAn Yue WeiXing Wan Han Xiao LingQi Zeng ChangHai Ke BaiQi Ning Feng Ding BiQiang Zhao Lin Jin Chen Li MingYuan Li JunYi Wang HongLian Hao Ning Zhang | 2020 | Earth and Planetary Physics2020，4，6： | 3 |
| 5 | First results of optical meteor and meteor trail irregularity from simultaneous Sanya radar and video observations显示文摘Meteoroids entering the Earth's atmosphere can create meteor trail irregularity seriously disturbing the background ionosphere. Although numerous observations of meteor trail irregularities were performed with VHF/UHF coherent scatter radars in the past, no simultaneous radar and optical instruments were employed to investigate the characteristics of meteor trail irregularity and its corresponding meteoroid. By installing multiple video cameras near the Sanya VHF radar site, an observational campaign was conducted during the period from November 2016 to February 2017. A total of 242 optical meteors with simultaneous non-specular echoes backscattered from the plasma irregularities generated in the corresponding meteor trails were identified. A good agreement between the angular positions of non-specular echoes derived from the Sanya radar interferometer and those of optical meteors was found,validating that the radar system phase offsets have been properly calibrated. The results also verify the interferometry capability of Sanya radar for meteor trail irregularity observation. The non-specular echoes with simultaneous optical meteors were detected at magnetic aspect angles greater than ~78°. Based on the meteor visual magnitude estimated from the optical data, it was found that the radar nonspecular echoes corresponding to brighter meteors survived for longer duration. This could provide observational evidence for the significance of meteoroid mass on the duration of meteor trail irregularity. On the other hand, the simultaneous radar and video common-volume observations showed that there were some cases with optical meteors but without radar non-specular echoes. One possibility could be that some of the optical meteors appeared at extremely low altitudes where meteor trail irregularities rarely occur. | GuoZhu Li BaiQi Ning Ao Li SiPeng Yang XiuKuan Zhao BiQiang Zhao WeiXing Wan | 2018 | Earth and Planetary Physics2018，2，1： | 3 |
| 6 | Soliton fiber laser mode locked with two types of film-based Bi2Te3 saturable absorbers显示文摘We propose a low-threshold soliton fiber laser passively mode locked with two different types of film-like saturable absorbers, one of which is fabricated by mixing Bi2Te3 with de-ionized water, as well as polyvinyl alcohol(PVA), and then evaporating them in a Petri dish, and the other of which is prepared by directly dropping Bi2Te3 solution on the PVA film. Both Bi2Te3–PVA films exhibit outstanding features of low loss, high flexibility, and easy synthesis. By incorporating Bi2Te3–PVA films into fiber lasers, stable single-soliton emissions are obtained at a low pump power of 13 mW. Our results suggest that the Bi2Te3 can work as a promising mode locker for ultrafast lasers,while PVA is an excellent host for fabricating high-performance film-based saturable absorbers. | Dong Mao Biqiang Jiang Xuetao Gan Chaojie Ma Yu Chen Chujun Zhao Han Zhang Jianbang Zheng Jianlin Zhao | 2015 | Photonics Research2015，3，2： | 3 |
| 7 | Monitoring traveling ionospheric disturbances using the GPS network around China during the geomagnetic storm on 28 May 2011显示文摘Larger-scale traveling ionospheric disturbances (LSTIDs) are studied using the total electron content (TEC) data observed from 246 GPS receivers in and around China during the medium storm on 28 May 2011. It is the first attempt to get the two-dimensional TEC perturbation maps in China. Two LSTID events are detected: one is in southwestern China before midnight propagating from low to middle latitude to the distance of about 1200 km with the phase front extending to about 500 km, and the other is in northeastern China after midnight propagating from middle to low latitudes to the distance of about 1200 km with the phase front extending to nearly 1400 km. By using the multichannel maximum-entropy method, we get the propagation parameters of these two LSTIDs. The LSTID that occurs before midnight has a higher horizontal phase velocity and a larger damping rate corresponding to the after midnight LSTID, and this may be caused by the relatively large vertical background TEC 0 and high atmospheric temperature in the southwest of China before midnight. According to the variations of magnetic H component observed in high latitudes, the source region for the after midnight LSTID is likely to be located 1400-2600 km east of 140°E and north of 42°N; the before midnight LSTID is propably excited by the atmospheric gravity waves (AGWs) generated by the Joule heating of the equatorial electrojet. | SONG Qian DING Feng WAN WeiXing NING BaiQi ZHAO BiQiang | 2013 | Science China Earth Sciences2013，56，5： | 2 |
| 8 | Efficient production of chemicals from microorganism by metabolic engineering and synthetic biology显示文摘The use of traditional chemical catalysis to produce chemicals has a series of drawbacks,such as high dependence on fossil resources,high energy consumption,and environmental pollution.With the development of synthetic biology and metabolic engineering,the use of renewable biomass raw materials for chemicals synthesis by constructing efficient microbial cell factories is a green way to replace traditional chemical catalysis and traditional microbial fermentation.This review mainly summarizes several types of bulk chemicals and high value-added chemicals using metabolic engineering and synthetic biology strategies to achieve efficient microbial production.In addition,this review also summarizes several strategies for effectively regulating microbial cell metabolism.These strategies can achieve the coupling balance of material and energy by regulating intracellular material metabolism or energy metabolism,and promote the efficient production of target chemicals by microorganisms. | Yang Zhang Jing Yu Yilu Wu Mingda Li Yuxuan Zhao Haowen Zhu Changjing Chen Meng Wang Biqiang Chen Tianwei Tan | 2021 | Chinese Journal of Chemical Engineering2021，34，2： | 2 |
| 9 | TIME-IGGCAS model validation:Comparisons with empirical models and observations显示文摘The TIME-IGGCAS (Theoretical Ionospheric Model of the Earth in Institute of Ge- ology and Geophysics, Chinese Academy of Sciences) has been developed re- cently on the basis of previous works. To test its validity, we have made compari- sons of model results with other typical empirical ionospheric models (IRI, NeQuick-ITUR, and TItheridge temperature models) and multi-observations (GPS, Ionosondes, Topex, DMSP, FORMOSAT, and CHAMP) in this paper. Several conclu- sions are obtained from our comparisons. The modeled electron density and elec- tron and ion temperatures are quantitatively in good agreement with those of em- pirical models and observations. TIME-IGGCAS can model the electron density variations versus several factors such as local time, latitude, and season very well and can reproduce most anomalistic features of ionosphere including equatorial anomaly, winter anomaly, and semiannual anomaly. These results imply a good base for the development of ionospheric data assimilation model in the future. TIME-IGGCAS underestimates electron temperature and overestimates ion tem- perature in comparison with either empirical models or observations. The model results have relatively large deviations near sunrise time and sunset time and at the low altitudes. These results give us a reference to improve the model and enhance its performance in the future. | YUE XinAn WAN WeiXing LIU LiBo NING BaiQi ZHAO BiQiang ZHANG ManLian | 2008 | Science China(Technological Sciences)2008，51，3： | 2 |
| 10 | GPS detection of the coseismic ionospheric disturbances following the 12 May 2008 M7.9 Wenchuan earthquake in China显示文摘Here we report two cases of coseismic ionospheric disturbances observed through a GPS network in China after the great Wenchuan earthquake at 06:28 UT on 12 May,2008.One is detected 7.9 min after the earthquake and had an intensive'N'shape oscillated waveform with a pronounced amplitude of about 1 TECU,which propagates approximately southward to the distance about 1000 km with the horizontal phase velocity of 600±84 m/s and the period of 9.5±1.3 min.The other is detected8.5 min after the earthquake and has an oscillated waveform more like a positive pulse with an amplitude of about 0.5 TECU,which propagates eastward to the distance about 800 km with the horizontal phase velocity of 720±59 m/s and the period of7.4±0.8 min.These two coseismic ionospheric disturbances are caused by the acoustic gravity waves excited by partial transformation of the acoustic waves originated from the energy release of the earthquake,somewhere near the epicenter.The directional preferences of these two coseismic ionospheric disturbances may be associated with the oblique geomagnetic field lines and the background winds filtering effect. | SONG Qian DING Feng YU Tao WAN WeiXing NING BaiQi LIU LiBo ZHAO BiQiang | 2015 | Science China Earth Sciences2015，58，1： | 2 |
| 11 | Second harmonic generation in a hollow-core fiber filled with GaSe nanosheets显示文摘Frequency conversions using various all-fiber nonlinear devices can benefit many applications,including communications,sensing,microscope,and imaging.In this study,we report in-fiber second harmonic generation(SHG)in an optical hollow-core fiber(HCF)that can be used for frequency conversion.The HCF filled with a dispersion of gallium selenide(GaSe)nanosheets in the ultraviolet-cured optical adhesive supports a well-propagating mode in the fiber core,which enables effective light interaction with dispersed GaSe nanosheets and a strong SHG process.Based on theoretical analysis,the optimal HCF length for maximizing SHG is approximately 0.41 mm.The broadband SHG of the GaSe-filled HCF device is demonstrated by tuning the pump wavelength from 1460 to 1600 nm.Moreover,a time-varied SHG in the device is revealed due to additional second-order susceptibility induced by the polarization of silica.The proposed device with a compact and robust structure has the potential to be connected to existing all-fiber telecom and sensing systems for numerous nonlinear engineering applications. | Zhen HAO Yuxin MA Biqiang JIANG Yueguo HOU Ailun LI Ruixuan YI Xuetao GAN Jianlin ZHAO | 2022 | Science China(Information Sciences)2022，65，6： | 2 |
| 12 | Characteristics of the ionospheric total electron content of the equatorial ionization anomaly in the Asian-Australian region during 1996–2004显示文摘 | Biqiang Zhao Weixing Wan Libo Liu Zhipeng Ren | 2009 | Annales Geophysicae2009，，229： | 1 |
| 13 | Lipase-catalyzed synthesis of aliphatie polyesters and properties characterization显示文摘 | LIU Wenhui CHEN Biqiang WANG Fang | 2011 | Process Biochem2011，46，10： | 1 |
| 14 | Three- dimensional elastic-plastic stress analysis of rolling contact显示文摘 | Jiang Yanyao Xu Biqiang Sehitoglu H | 2002 | ASME Journal of Tribology2002，124，4： | 1 |
| 15 | Enzymatic synthesizing o3 phytosterol oleic esters 显示文摘 | Pan Xinxin Chen Biqiang Wang Juan | 2012 | Applied Biochemistry and Biotecimology2012，168，： | 1 |
| 16 | A modified ge- netic algorithm (GA) for optimization of process process planning 显示文摘 | Wang Jinfeng Du Biqiang Ding Haimin | 2011 | Journal of Computers2011，6，3： | 1 |
| 17 | Investigating formate tolerance mechanisms in Saccharomyces cerevisiae and its application显示文摘Current global energy and environmental crisis have spurred efforts towards developing sustainable biotechnological solutions,such as utilizing CO_(2) and its derivatives as raw materials.Formate is an attractive onecarbon source due to its high solubility and low reduction potential.However,the regulatory mechanism of formate metabolism in yeast remains largely unexplored.This study employed adaptive laboratory evolution(ALE)to improve formate tolerance in Saccharomyces cerevisiae and characterized the underlying molecular mechanisms.The evolved strain was applied to produce free fatty acids(FFAs)under high concentration of formate with glucose addition.The results showed that the evolved strain achieved a FFAs titer of 250 mg/L.Overall,this study sheds light on the regulatory mechanism of formate tolerance and provides a platform for future studies under high concentrations of formate. | Kai Wang Yining Liu Zhuoheng Wu Yilu Wu Haoran Bi Yanhui Liu Meng Wang Biqiang Chen Jens Nielsen Zihe Liu Tianwei Tan | 2023 | Green Carbon2023，1，1： | 1 |
| 18 | Amino silicones finished fabrics for lipase immobilization: fabrics finishing and catalytic performance of immobilized lipase显示文摘 | Weina Li Huaqing Shen Yifeng Tao Biqiang Chen Tianwei Tan | 2014 | Process Biochemistry2014，，： | 1 |
| 19 | Enzy- matic synthesizing of phytosterol oleic esters 显示文摘 | PAN Xinxin CHEN Biqiang WANG Juan | 2012 | Appl Biochem Biotechnol2012，168，： | 1 |
| 20 | Recent Progresses on Ionospheric Climatology Investigations显示文摘The ionosphere varies over multiple time scales,which are classified into two categories: the climatology and weather variations.In this national report,we give a brief summary of recent progresses in ionospheric climatology with focus on(1) the seasonal variations,(2) solar cycle effects, and(3) empirical modeling of the ionosphere.The seasonal variations of the ionosphere have been explored in many works to give a more detailed picture with regional and global features at various altitudes by analyzing the observation data from various sources and models.Moreover,a series of studies reported the response of the ionosphere to solar cycle variations,which revealed some novel and detailed features of solar activity dependence of ionospheric parameters at different altitudes. These investigations have improved our understanding on the states of the ionosphere and underlying fundamental processes,provided clues to future studies on ionospheric weather,and guided ionospheric modeling,forecasting and related applications. | LIU Libo WAN Weixing CHEN Yiding LE Huijun ZHAO Biqiang | 2012 | 空间科学学报2012，32，5： | 1 |
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