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| 1 | Receptor activator of NF-κB Ligand (RANKL) expression is associated with epithelial to mesenchymal transition in human prostate cancer cells显示文摘 | Valerie A Odero-Marah Ruoxiang Wang Gina Chu Majd Zayzafoon Jianchun Xu Chunmeng Shi Fray F Marshall Haiyen E Zhau Leland WK Chung | 2008 | Cell Research2008，18，8： | 6 |
| 2 | Imatinib as preoperative therapy in Chinese patients with recurrent or metastatic GISTs显示文摘Objective: Imatinib has dramatically altered the options for management of patients with gastrointestinal stromal tumours. However, it has become clear that secondary resistance to the drug develops during long-term therapy. The purpose of our study was to retrospectively analyze safety and long-term outcomes in Chinese patients with recurrent or metastatic GISTs treated with imatinib preoperatively. Methods: Between June 2003 and June 2011, 22 patients underwent surgery for recurrent or metastatic GISTs after preoperative treatment with imatinib. Results: Complete resection was accomplished in 8 of the 10 responsive disease (RD) patients (80%), and in 3 of the 12 patients (25%) who had progression disease (PD). The amount of blood loss during the operation in PD patients was higher than in RD patients. There was 1 hospital death in PD group related to surgery, while the other patients recovered with conservative therapy because complications were mild. The difference in median PFS between patients with RD and those with PD was significant (24.8 vs. 2.81 months, P<0.001). The difference in 2-year OS rate between patients with RD and those with PD was not significant (100% vs. 87.5%, P>0.05). Conclusions: Our study indicates that surgical intervention can improve the PFS of Chinese patients with recurrent or metastatic GISTs responsive to imatinib, but does not prolong OS as well as in patients who develop imatinib resistance. Surgical resection following imatinib treatment is feasible and can be considered for patients with advanced GISTs responsive to imatinib. | Chunmeng Wang Biqiang Zheng Yong Chen Xi Cao Ruming Zhang Yingqiang Shi | 2013 | Chinese Journal of Cancer Research2013，25，1： | 6 |
| 3 | An analytical biomarker for treatment of patients with recurrent B-ALL after remission induced by infusion of anti-CD19 chimeric antigen receptor T(CAR-T) cells显示文摘Anti-CD19 chimeric antigen receptor-modified T(CAR-T-19) cells have emerged as a powerful targeted immunotherapy for B-cell lineage acute lymphoblastic leukemia with a remarkable clinical response in recent trials. Nonetheless, few data are available on the subsequent clinical monitoring and treatment of the patients, especially those with disease recurrence after CAR-T-19 cell infusion. Here, we analyzed three patients who survived after our phase I clinical trial and who were studied by means of biomarkers reflecting persistence of CAR-T-19 cells in vivo and predictive factors directing further treatment. One patient achieved 9-week sustained complete remission and subsequently received an allogeneic hematopoietic stem cell transplant. Another patient who showed relapse after 20 weeks without detectable leukemia in the cerebrospinal fluid after CAR-T-19 cell treatment was able to achieve a morphological remission under the influence of stand-alone low-dose chemotherapeutic agents. The third patient gradually developed extensive extramedullary involvement in tissues with scarce immune-cell infiltration during a long period of hematopoietic remission after CAR-T-19 cell therapy. Long-term and discontinuous increases in serum cytokines(mainly interleukin 6 and C-reactive protein) were identified in two patients(Nos. 1 and 6) even though only a low copy number of CAR molecules could be detected in their peripheral blood. This finding was suggestive of persistent functional activity of CAR-T-19 cells. Combined analyses of laboratory biomarkers with their clinical manifestations before and after salvage treatment showed that the persistent immunosurveillance mediated by CAR-T-19 cells would inevitably potentiate the leukemia-killing effectiveness of subsequent chemotherapy in patients who showed relapse after CAR-T-19-induced remission. | Yajing Zhang Wenying Zhang Hanren Dai Yao Wang Fengxia Shi Chunmeng Wang Yelei Guo Yang Liu Meixia Chen Kaichao Feng Yan Zhang Chuanjie Liu Qingming Yang Suxia Li Weidong Han | 2016 | Science China(Life Sciences)2016，59，4： | 6 |
| 4 | Effect of organic materials on the chemical properties of saline soil in the Yellow River Delta of China显示文摘一个180天的孵化实验被进行与高度在沿海的土壤的化学性质上调查不同器官的材料的效果咸度和相对低的 pH 四器官的材料(三种植物残余:稻草, composted 稻草,并且新鲜芦苇;并且一个种家禽粪肥:鸡粪肥)从结果显示出的中国的黄河三角洲在 15 g ·k g 1的比率被用于肋骨的盐的土壤的样品土壤 pH 和可交换的钠百分比( ESP )减少了,而可交换的能力( CEC )和 macronutrient 集中增加了的土壤阳离子,不管使用的器官的材料的类型,所有处理在在180天的孵化期间,在下降的 SOC 的山峰价值订的可溶的器官的碳( SOC )是的土壤显示出显著增加鸡粪肥,芦苇, composted 稻草,在孵化的结束的稻草,和控制土壤, SOC 的高水平发生在修改稻草的土壤,由 composted 稻草列在后面,芦苇,并且鸡 manureamended 土壤玷污呼吸率和可得到的氮被尽管修改芦苇的土壤有相对高的 SOC 和呼吸率,使用的材料的类型显著地影响, ESP 就鸡肉引起粪肥的重金属的可能的风险而言最不被减少,稻草和 composted 稻草是更有效的材料使用回收肋骨的盐的土壤并且改进 macronutrients 的可获得性,这被建议。 | Yan YU Jie LIU Chunmeng LIU Shuang ZONG Zhaohua LU | 2015 | Frontiers of Earth Science2015，9，2： | 6 |
| 5 | Luminescence tuning of Ce^3+,Pr^3+activated(Y,Gd)AGG system by band gap engineering and energy transfer显示文摘Tuning of phosphor luminescence properties,including the emission energy/intensity and thermal stability,is an important way to develop superior luminescent materials for diverse applications.In this work,we discuss the effect of band gap engineering and energy transfer on the luminescence properties of Ce^3+or Pr^3+doped(Y,Gd)AGG systems,and analyze the underlying reasons for their different phenomena.By using VUV-UV excitation spectra and constructing VRBE schemes,the changes of host band structure,5 d excited level energies and emission thermal stability of Ce^3+and Pr^3+with the incorporation of Gd^3+ions were studied.In addition,the energy transfer dynamics was also investigated in terms of the luminescence decay curves.This work demonstrates a way to tune phosphor luminescence properties by combining band gap engineering and energy transfer tailoring and provides an inspiring discussion on the different results of Ce^3+doping on the Ce^3+and Pr^3+emissions. | Yiyi Ou Weijie Zhou Fengkai Ma Chunmeng Liu Rongfu Zhou Fang Su Yan Huang Pieter Dorenbos Hongbin Liang | 2020 | Journal of Rare Earths2020，38，5： | 3 |
| 6 | Quantitative prediction of shale gas sweet spots based on seismic data in Lower Silurian Longmaxi Formation,Weiyuan area,Sichuan Basin,SW China显示文摘Sweet spots in the shale reservoirs of the Lower Silurian Longmaxi Formation in Weiyuan 201 Block of Sichuan Basin were predicted quantitatively using seismic data and fuzzy optimization method. First, based on seismic and rock physics analysis, the rock physics characteristics of the reservoirs were determined, and elastic parameters sensitive to shale reservoirs with high gas content were selected. Second, data volumes with high precision of the elastic parameters were obtained from pre-stack simultaneous inversion. The horizontal distribution of key parameters for shale gas evaluation were calculated based on the results of rock physics analysis. Then, the fuzzy evaluation equation was established by fuzzy optimization method with test and logging data of horizontal wells with similar operation conditions. key parameters affecting the productivity of horizontal wells were sorted out and the weights of them in the sweet spots quantitative prediction were worked out by fuzzy optimization to set up a sweet spots evaluation system. Three classes of shale gas reservoirs which including two kinds of sweet spots were predicted with the above procedure, and the sweet spots have been predicted quantitatively by combining the above prediction results with the testing production. The testing results of 7 verification wells proved the reliability of the prediction results. | ZENG Qingcai CHEN Sheng HE Pei YANG Qing GUO Xiaolong CHEN Peng DAI Chunmeng LI Xuan GAI Shaohua DENG Yu HOU Huaxing | 2018 | Petroleum Exploration and Development2018，45，3： | 2 |
| 7 | Design of Novel S-plane Controller of Autonomous Underwater Vehicle Established on Sliding Mode Control显示文摘Based on the deep analysis of the mathematical model of an autonomous underwater vehicle( AUV),comprehensive considerations are given to the coupling effect of AUV's longitudinal velocity on the other degrees of freedom. In the meantime,discussions are made on the influence of residual buoyancy and restoring moment.A novel S-plane controller established on sliding mode control( SMC) is hereby proposed in this study. The strengths of traditional S-plane controller including simple structure and easily adjustable parameters are maintained in the improved design while the weakness of unsatisfactory control effect at the time of high-speed operation is also overcome. Lyapunov function is introduced to make the stability analysis of the controller before it is successfully applied to the basic motion control of AUV-X. Then the comparative experiment test is carried out between the traditional S-plane controller and the novel S-plane controller. The effectiveness and feasibility of the novel S-plane controller established on sliding mode control in the AUV basic motion control is verified by the comparative analysis of experiment results. | Chunmeng Jiang Lei Wan Yushan Sun | 2017 | Journal of Harbin Institute of Technology(New Series)2017，24，2： | 2 |
| 8 | The model of cytokine release syndrome in CAR T-cell treatment for B-cell non-Hodgkin lymphoma显示文摘Chimeric antigen receptor T(CAR T)cell therapy has demonstrated efficacy in the treatment of haematologic malignancies.However,the accompanying adverse events,the most common of which is cytokine release syndrome(CRS),substantially limit its wide application.Due to its unique physiological characteristics,CRS in CAR T-cell treatment for B-cell non-Hodgkin lymphoma(BNHL)may exhibit some special features.Although existing guidelines had greatly promoted the recognition and management of CRS,many recommendations are not fully applicable to B-NHL.Therefore,it is imperative to identify responses that are specific to CRS observed following CAR T treatment for B-NHL.Based on underlying biological processes and known pathophysiological mechanisms,we tentatively propose a new model to illustrate the occurrence and evolution of CAR T-cell-therapy-related CRS in BNHL.In this model,tumour burden and bone marrow suppression are considered determinants of CRS.Novel phenomena after CAR T-cell infusion(such as local inflammatory response)are further identified.The proposed model will help us better understand the basic biology of CRS and recognize and manage it more rationally. | Jianshu Wei Yang Liu Chunmeng Wang Yajing Zhang Chuan Tong Guanghai Dai Wei Wang John E.J.Rasko J.Joseph Melenhorst Wenbin Qian Aibin Liang Weidong Han | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 2 |
| 9 | Insights into constructing a stable and efficient microbial consortium显示文摘Microbial consortia are ubiquitous in nature,in which multiple microbial species cooperate to complete some important tasks such as lignocellulose degradation.Because of the advantages such as reduced metabolic burden and robustness to environment disturbances,developing a microbial consortium is a promising approach for valuable product synthesis,lignocellulose utilization,human health care,bioremediation and sustainable energy,etc.Despite the benefits,however,most artificial microbial consortia confront the problems of instability and low efficiency due to growth competition and metabolite incompatibility.To overcome these challenges,multiple strategies to design efficient synthetic microbial consortia have been reported.In this review,the interactions that determine the stability and performance of microbial consortia were described.Progress of artificial microbial consortia research was summarized,and the key strategies i.e.,spatial or temporal segregation,separated utilization of nutrients,nutrient cross-feeding and division of labor,that will be of great importance for achieving a stable and efficient microbial consortium were highlighted.Two novel advanced tools,signaling molecule systems and computational models,were also introduced and discussed.We believed that combining the universal cell–cell signaling molecule systems with computational models will be promising for synthetic microbial consortia construction in the future. | Chunmeng Xu Huimin Yu | 2021 | Chinese Journal of Chemical Engineering2021，34，2： | 2 |
| 10 | Cellular senescence is a promising target for chronic wounds:a comprehensive review显示文摘Chronic wounds include,but are not limited to,radiation ulcers,pressure ulcers,vascular ulcers and diabetic foot ulcers.These chronic wounds can persist for years without healing and severe ulcers may lead to amputation.Unfortunately,the underlying pathologies of refractory chronic wounds are not fully characterized,and new treatments are urgently needed.Recently,increasing evidence has indicated that cell senescence plays an important role in the development of chronic wounds,and preventing cell senescence or removing senescent cells holds promise as a new therapeutic strategy.In this review,we aim to probe these latest findings to promote the understanding of cellular senescence in the pathological process and potential management of chronic wounds. | Ziwen Wang Chunmeng Shi | 2020 | Burns & Trauma2020，8，1： | 2 |
| 11 | PC4 serves as a negative regulator of skin wound healing in mice显示文摘Background:Human positive cofactor 4(PC4)was initially characterized as a multifunctional transcriptional cofactor,but its role in skin wound healing is still unclear.The purpose of this study was to explore the role of PC4 in skin wound healing through PC4 knock-in mouse model.Methods:A PC4 knock-in mouse model(PC4^(+/+))with a dorsal full-thickness wound was used to investigate the biological functions of PC4 in skin wound healing.Quantitative PCR,Western blot analysis and immunohistochemistry were performed to evaluate the expression of PC4;Sirius red staining and immunofluorescence were performed to explore the change of collagen deposition and angiogenesis.Proliferation and apoptosis were detected using Ki67 staining and TUNEL assay.Primary dermal fibroblasts were isolated from mouse skin to perform cell scratch experiments,cck-8 assay and colony formation assay.Results:The PC4^(+/+)mice were fertile and did not display overt abnormalities but showed an obvious delay in cutaneous healing of dorsal skin.Histological staining showed insufficient re-epithelialization,decreased angiogenesis and collagen deposition,increased apoptosis and decreased cell proliferation in PC4^(+/+)skin.Our data also showed decreased migration rate and proliferation ability in cultured primary fibroblasts from PC4^(+/+)mice in vitro.Conclusions:This study suggests that PC4 might serve as a negative regulator of skin wound healing in mice. | Fengying Liao Long Chen Peng Luo Zhongyong Jiang Zelin Chen Ziwen Wang Chi Zhang Yu Wang JintaoHe Qing Wang Yawei Wang Lang Liu Yu Huang Huilan Wang Qingzhi Jiang Min Luo YiboGan Yunsheng Liu Yang Wang Jie Wu Wentao Xie Zhuo Cheng Yali Dai Jialun Li Zujuan Liu Fan Yang Chunmeng Shi | 2020 | Burns & Trauma2020，8，1： | 1 |
| 12 | Skin: a promising reservoir for adult stem cell populations 显示文摘 | Chunmeng S Tianmin C | 2004 | Med Hypotheses2004，62，5： | 1 |
| 13 | Effects of dermal multipotent cell transplantation on skin wound healing显示文摘 | Chunmeng S Tianmin C Yongping S | 2004 | J Surg Res2004，121，： | 1 |
| 14 | PC4 ,a novel marker for stem cell transformation and cancer progression显示文摘 | Chunmeng S Ying Z Haiyen E | 2008 | Journal of Biotechnology2008，136，： | 1 |
| 15 | Formation of multiple conductive filaments in the Cu/ZrO2:Cu/Pt device显示文摘 | Liu Qi Dou Chunmeng Wang Yan | 2009 | Applied Physics Letters2009，95，23： | 1 |
| 16 | Skin: A promising reservoir for adult stem cell populations显示文摘 | Chunmeng S Tianmin C | 2004 | Med Hypotheses2004，62，5： | 1 |
| 17 | A host sensitized reddish-orange Gd2MoO6:Sm3+phosphor for light emitting diodes显示文摘 | CHEN Yan WANG Jing LIU Chunmeng | 2011 | Applied Physics Letters2011，98，81： | 1 |
| 18 | Effects of dermal multipotent cell transplantation on skin wound healing 显示文摘 | Chunmeng S Tianmin C Youngping S | 2004 | J SurgRes2004，121，1： | 1 |
| 19 | Effects of dermal muhipotent cell transplantation on skin wound healing显示文摘 | Chunmeng S Tianmin C Yongping S | 2004 | J Surg Res2004，121，1： | 1 |
| 20 | 显示文摘 | Chiou Nan-Rong Lu Chunmeng Guan Jingiiao | 2007 | Nature Nanotechnology2007，2，： | 1 |
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