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| 1 | MAPK信号通路与骨质疏松关系的研究进展显示文摘该综述介绍了MAPK信号通路(ERK1/2、JNK、P38和ERK5)与骨质疏松相关因子的关系,明确了MAPK信号通路参与骨质疏松的发生与发展。通过药物干预RANKL、OPG、1,25(OH)2D3、PTH、BMP、TGF-β、IL-1、IL-6、TNF-α和雌激素等因子而作用于MAPK信号通路,可提高骨质疏松的治疗效果。但IL6和TNF-α调节MAPK信号通路参与骨质疏松发生发展的作用还不清楚。骨质疏松发病机制复杂,多种相关信号通路之间存在交互和交叉的作用,以及ERK5通路在骨质疏松中发挥的作用还有待进一步研究。 | 张波 耿彬 谭小义 姜金 陈聪 Chandan Kumar Jayswal 吴卓 夏亚一 | 2014 | 中国矫形外科杂志2014，22，23： | 31 |
| 2 | Diffusion weighted imaging: Technique and applications显示文摘Diffusion weighted imaging(DWI) is a method of signal contrast generation based on the differences in Brownian motion. DWI is a method to evaluate the molecular function and micro-architecture of the human body. DWI signal contrast can be quantified by apparent diffusion coefficient maps and it acts as a tool for treatment respon-se evaluation and assessment of disease progression. Ability to detect and quantify the anisotropy of diffusion leads to a new paradigm called diffusion tensor imaging(DTI). DTI is a tool for assessment of the organs with highly organised fibre structure. DWI forms an integral part of modern state-of-art magnetic resonance imaging and is indispensable in neuroimaging and oncology. DWI is a field that has been undergoing rapid technical evolution and its applications are increasing every day. This review article provides insights in to the evolution of DWI as a new imaging paradigm and provides a summary of current role of DWI in various disease processes. | Vinit Baliyan Chandan J Das Raju Sharma Arun Kumar Gupta | 2016 | World Journal of Radiology2016，8，9： | 18 |
| 3 | Perfusion computed tomography in renal cell carcinoma显示文摘Various imaging modalities are available for the diagnosis, staging and response evaluation of patients with renal cell carcinoma(RCC). While contrast enhanced computed tomography(CT) is used as the standard of imaging for size, morphological evaluation and response assessment in RCC, a new functional imaging technique like perfusion CT(p CT), goes down to the molecular level and provides new perspectives in imaging of RCC. p CT depicts regional tumor perfusion and vascular permeability which are indirect parameters of tumor angiogenesis and thereby provides vital information regarding tumor microenvironment. Also response evaluation using p CT may predate the size criteria used in Response Evaluation Criteria in Solid Tumors, as changes in the perfusion occurs earlier following tissue kinase inhibitors before any actual change in size. This may potentially help in predicting prognosis, better selection of therapy and more accurate and better response evaluation in patients with RCC. This article describes the techniques and role of p CT in staging and response assessment in patients with RCCs. | Chandan J Das Usha Thingujam Ananya Panda Sanjay Sharma Arun Kumar Gupta | 2015 | World Journal of Radiology2015，7，7： | 8 |
| 4 | 股骨髁间窝的形态学测量及临床意义研究进展显示文摘股骨髁间窝的形态及大小与前交叉韧带损伤等膝关节疾病密切相关。本文从髁间窝的测量方法、大小、形态分型、影响因素及临床意义等方面对股骨髁间窝形态学测量的国内外研究现状进行综述,发现并讨论了目前面临的问题,为今后进一步深入研究提供借鉴。 | 谭小义 耿彬 张波 陈聪 姜金 Chandan Kumar Jayswal Shahidur Khan 夏亚一 | 2015 | 中国矫形外科杂志2015，23，13： | 3 |
| 5 | A New Voltage Control Strategy to Improve Performance of DSTATCOM in Electric Grid显示文摘A new voltage control strategy of distribution static compensator(DSTATCOM)has been proposed in this paper for electric grid applications.The proposed control scheme combines two methods of DSTATCOM operation to improve its performance.Considering power factor and voltage magnitude as degree of freedom,the DSTATCOM provides features such as mitigation of voltage and current harmonics,balancing of source currents,improvement of power factor,voltage regulation during voltage sag and swell,reduction in inverter losses,and control of load power to achieve energy conservation.The performance of proposed DSTATCOM control is better as compared to its conventional operation at any time of operation.PSCAD simulation and experimental results validate the performances. | Chandan Kumar Mahesh KMishra Saad Mekhilef | 2020 | CES Transactions on Electrical Machines and Systems2020，4，4： | 2 |
| 6 | Serum ferritin predicts early mortality in patients with decompensated cirrhosis显示文摘 | Rakhi Maiwall Suman Kumar A.K. Chaudhary Jaswinder Maras Zeeshan Wani Chandan Kumar A. Rastogi C. Bihari Chitranshu Vashisht S.K. Sarin | 2014 | Journal of Hepatology2014，，： | 1 |
| 7 | A Framework to- wards employee engagement: The PSU experience显示文摘 | Chandan Kumar Sahoo Sukanta Mishra | 2012 | AS- CI Journal of Management2012，42，1： | 1 |
| 8 | Antitubercular therapy in patients with cirrhosis:Challenges and options显示文摘Tuberculosis(TB)has been a human disease for centuries.Its frequency is increased manyfold in patients with liver cirrhosis.The gold standard of TB management is a 6-mo course of isoniazid,rifampicin,pyrazinamide and ethambutol.Although good results are seen with this treatment in general,the management of patients with underlying cirrhosis is a challenge.The underlying depressed immune response results in alterations in many diagnostic tests.The tests used for latent TB have many flaws in this group of patients.Three of four first-line antitubercular drugs are hepatotoxic and baseline liver function is often disrupted in patients with underlying cirrhosis.Frequency of hepatotoxicity is increased in patients with liver cirrhosis,frequently leading to severe liver failure.There are no established guidelines for the treatment of TB in relation to the severity of liver disease.There is no consensus on the frequency of liver function tests required or the cutoff used to define hepatotoxicity.No specific treatment exists for prevention or treatment of hepatotoxicity,making monitoring even more important.A high risk of multidrug-resistant TB is another major worry due to prolonged and interrupted treatment. | Naveen Kumar Chandan Kumar Kedarishetty Sachin Kumar Vikas Khillan Shiv Kumar Sarin | 2014 | World Journal of Gastroenterology2014，20，19： | 1 |
| 9 | Sertoli–Leydig cell tumor: A rare ovarian neoplasm. Case report and review of literature显示文摘 | Poonam Sachdeva Raksha Arora Chandan Dubey Astha Sukhija Mridula Daga Deepak Kumar Singh | 2008 | Gynecological Endocrinology2008，，4： | 1 |
| 10 | The keystone-design perforator-based flap for leg defects: a synthesis of philosophies显示文摘Aim:The classical keystone-design flap,although elegantly employed for various trunk defects,has limited movement on the leg.This study aims to modify the keystone–design flaps for leg defects.Methods:A keystone-design flap,in which perforators are identified and dissected,is described specifically for elliptical defects overlying the tibia.Results:It retains the unique advantages of both the perforator island flap concept as well as the keystone-design philosophy.Conclusion:The technique as well as the possibilities of raising such flaps over various areas of the leg is outlined. | Jerry R.John Jyoshid R.Balan Satyaswarup Tripathy Ramesh Kumar Sharma Chandan Jadhav | 2014 | Plastic and Aesthetic Research2014，1，1： | 1 |
| 11 | Rheological analysis of drilling fluid using Marsh Funnel显示文摘 | Chandan Guria Rajesh Kumar Prakash Mishra | 2013 | Journal of Petroleum Science and Engineering2013，105，2013： | 1 |
| 12 | Phosphorylation of SATB1,a global gene regulator,acts as a molecular switch regulating its transcriptional activity in vivo显示文摘 | Pavan Kumar P Prabhat Kumar Purbey Chandan Kumar Sinha | 2006 | Molecular Cell2006，22，： | 1 |
| 13 | An investigation on spermatozoal defects in gayal semen显示文摘 | Bhattacharya H K Kumar Subodh Mondal SK Rajkhowa Chandan | 2004 | The Indian Journal of Animal Sciences2004，74，5： | 1 |
| 14 | Altered Frequencies of Dendritic Cells and IFN ‐γ‐secreting T Cells with Granulocyte Colony‐Stimulating Factor (G‐ CSF ) Therapy in Acute‐on‐Chronic Liver Failure显示文摘 | Arshi Khanam Nirupama Trehanpati Vishal Garg Chandan Kumar Hitendra Garg Barjesh C. Sharma Shiv K. Sarin | 2014 | Liver Int2014，，4： | 1 |
| 15 | Phosphorylation of SATB1, a Global Gene Regulator, Acts as a Molecular Switch Regulating Its Transcriptional Activity In Vivo显示文摘 | P. Pavan Kumar Prabhat Kumar Purbey Chandan Kumar Sinha Dimple Notani Amita Limaye Ranveer S. Jayani Sanjeev Galande | 2006 | Molecular Cell2006，，2： | 1 |
| 16 | Microwave Preparation of SiO2-B2O3-Na2O-K2O-CaO-Fe2O3-TiO2 Glass System显示文摘 | Ashis Kumar Manda Prasanta Kumar Sinha Santanu Sen Sitendu Mondal Chandan Guha Ranjan Sen | 2014 | Journal of Chemistry and Chemical Engineering2014，8，4： | 1 |
| 17 | Liver Stiffness Measurements in Patients with Different Stages of Nonalcoholic Fatty Liver Disease: Diagnostic Performance and Clinicopathological Correlation显示文摘 | Ramesh Kumar Archana Rastogi Manoj Kumar Sharma Vikram Bhatia Pankaj Tyagi Praveen Sharma Hitendra Garg K. N. Chandan Kumar Chhagan Bihari Shiv Kumar Sarin | 2013 | Digestive Diseases and Sciences2013，，1： | 1 |
| 18 | Optimization of Groundwater Level Monitoring Network Using GIS-based Geostatistical Method and Multi-parameter Analysis:A Case Study in Wainganga Sub-basin,India显示文摘Groundwater is one of the most important resources, its monitoring and optimized management has now become the priority to satisfy the demand of rapidly increasing population. In many developing countries, optimized groundwater level monitoring networks are rarely designed to build up a strong groundwater level data base, and to reduce operation time and cost. The paper presents application of geostatistical method to optimize existing network of observation wells for 18 sub-watersheds within the Wainganga Sub-basin located in the central part of India. The average groundwater level fluctuation(GWLF) from 37 observation wells is compared with parameters like lineament density, recharge, density of irrigation wells, land use and hydrogeology(LiRDLH) of Wainganga Sub-basin and analyzed stochastically in Geographic Information System(GIS) environment using simple, ordinary, disjunctive and universal kriging methods. Semivariogram analyses have been performed separately for all kriging methods to fit the best theoretical model with experimental model. Results from gaussian, spherical, exponential and circular theoretical models were compared with those of experimental models obtained from the groundwater level data. Spatial analyses conclude that the exponential semivariogram model obtained from ordinary kriging gives the best fit model. Study demonstrates that ordinary kriging gives the optimal solution and additional number of observation wells can be added utilizing the error variance for optimal design of groundwater level monitoring networks. This study describes the use of Geostatistics methods in GIS to predict the groundwater level and upgrade groundwater level monitoring networks from the randomly distributed observation wells considering multiple parameters such as GWLF and LiRDLH. The method proposed in the present study is observed to be an efficient method for selecting observation well locations in a complex geological set up. The study concludes that minimum 82 wells are required for proper monitoring of groundwater level in the study area. | Kumar Singh CHANDAN Bhaskar Katpatal YASHWANT | 2017 | Chinese Geographical Science2017，27，2： | 1 |
| 19 | Fuzzy approach to control moisture content on a paper machine显示文摘 | Sharma S C Sharma Chhaya Kumar Chandan | 2008 | Paper Technology2008，49，4： | 1 |
| 20 | Liver Stiffness Measurements in Patients with Different Stages of Nonalcoholic Fatty Liver Disease: Diagnostic Performance and Clinicopathological Correlation显示文摘 | Ramesh Kumar Archana Rastogi Manoj Kumar Sharma Vikram Bhatia Pankaj Tyagi Praveen Sharma Hitendra Garg K. N. Chandan Kumar Chhagan Bihari Shiv Kumar Sarin | 2013 | Digestive Diseases and Sciences2013，，1： | 1 |
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