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| 1 | Uptake and mitochondrial dysfunction of alpha-synuclein in human astrocytes, cortical neurons and fibroblasts显示文摘The accumulation and aggregation of alpha-synuclein(α-syn)in several tissue including the brain is a major pathological hallmark in Parkinson’s disease(PD).In this study,we show that α-syn can be taken up by primary human cortical neurons,astrocytes and skin-derived fibroblasts in vitro.Our findings that brain and peripheral cells exposed to α-syn can lead to impaired mitochondrial function,leading to cellular degeneration and cell death,provides additional evidence for the involvement of mitochondrial dysfunction as a mechanism of toxicity of α-syn in human cells. | Nady Braidy Wei-Ping Gai Ying Hua Xu Perminder Sachdev Gilles J Guillemin Xing-Mai Jiang J William O Ballard Martin P Horan Zhi Ming Fang Beng H Chong Daniel Kam Yin Chan | 2013 | Translational Neurodegeneration2013，2，1： | 4 |
| 2 | The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase显示文摘 | Thomas F Franke Sung-Il Yang Tung O Chan Ketaki Datta Andrius Kazlauskas Deborah K Morrison David R Kaplan Philip N Tsichlis | 1995 | Cell1995，，5： | 2 |
| 3 | Soluble E-cadherin is a valid prognostic marker in gastric carcinoma显示文摘 | Chan A O Lam S K Chu K M | 2001 | Gut2001，48，6： | 2 |
| 4 | Phase II Pilot Study of Vemurafenib in Patients With Metastatic BRAF -Mutated Colorectal Cancer显示文摘 | Kopetz Scott Desai Jayesh Chan Emily Hecht Joel Randolph O’Dwyer Peter J. Maru Dipen Morris Van Janku Filip Dasari Arvind Chung Woonbook Issa Jean-Pierre J. Gibbs Peter James Brian Powis Garth Nolop Keith B. Bhattacharya Suman Saltz Leonard | 2015 | Journal of Clinical Oncology2015，，34： | 2 |
| 5 | Uncondi-tionally stable staggered solution procedure for soil-pore fluid interaction problems显示文摘 | Zienkiewicz O C Paul D K Chan A H | 1988 | Int J for Numerical Methods in Engineering1988，26，： | 2 |
| 6 | Dexamethasone Added to Mepivacaine Prolongs the Duration of Analgesia After Supraclavicular Brachial Plexus Blockade显示文摘 | Simon J. Parrington Dermot O’Donnell Vincent W.S. Chan Danielle Brown-Shreves Rajeev Subramanyam Melody Qu Richard Brull | 2010 | Regional Anesthesia and Pain Medicine2010，，5： | 2 |
| 7 | Axial strain enhances osteotomy repair with a concomitant increase in connexin43 expression显示文摘The mechanical environment is known to influence fracture healing. We speculated that connexin43(Cx43) gap junctions, which impact skeletal homeostasis, fracture healing and the osteogenic response to mechanical load,may play a role in mediating the response of the healing bone to mechanical strain. Here, we used an established rat fracture model, which uses a 2 mm osteotomy gap stabilized by an external fixator, to examine the impact of various cyclical axial loading protocols(2%, 10%, and 30% strain) on osteotomy healing. We examined the presence of Cx43 in the osteotomy-healing environment and assessed how mechanical strain modulates Cx43 expression patterns in the callus. We demonstrated that increased cyclical axial strain results in increased radiographic and histologic bone formation. In addition, we show by immunohistochemistry that Cx43 is abundantly expressed in the healing callus, with the expression most robust in samples exposed to increased cyclical axial strain. These data are consistent with the concept that an increase in Cx43 expression by mechanical load may be part of the mechanisms by which mechanical forces enhances fracture healing. | Rishi R Gupta Hyunchul Kim Yu-Kwan Chan Carla Hebert Leah Gitajn David J Yoo Robert V O’Toole Adam H Hsieh Joseph P Stains | 2015 | Bone Research2015，3，2： | 2 |
| 8 | Rapid Diagnosis of a Coronavirus Associated with SARS显示文摘 | Wong O K Chan K H et a1 | 2003 | Clin Chem2003，26，： | 1 |
| 9 | Molecular regulation of the hypothalamo-pituitary-adrenal axis in streptozotocin-induced diabetes:effects of insulin treatment显示文摘 | Chan O Chan S lnouye K | 2001 | Endocrinology2001，142，11： | 1 |
| 10 | A multicenter trial of photorefractive keratectomy for residual myopia after previous ocular surgery显示文摘 | Maloney RK chan WK Steinert R Hersh P O' Connell M | 1995 | Ophthalmology1995，102，7： | 1 |
| 11 | 显示文摘 | Ng S C Ma Y F Chan H S O | 1999 | Synth Met1999，100，： | 1 |
| 12 | Effects of diabetes and recurrent hypoglycemia on the regulation of the sympathoadrenal system and hypothalamo-pituitary-adrenal axis显示文摘 | Inouye K E Chan O Yue J T | 2005 | Am J Physiol Endocrinol Metab2005，288，： | 1 |
| 13 | A human gene that shows identity with the gene encoding the angiotensin receptor is located on chromosome 11 显示文摘 | O'Dowd BF Heiber M Chan A | 1993 | Gene1993，136，12： | 1 |
| 14 | The Effects of Enhanced Milieu Teaching and a Voice Output Communication Aid on the Requesting of Three Children with Autism显示文摘 | Melissa L. Olive Berenice Cruz Tonya N. Davis Jeffrey M. Chan Russell B. Lang Mark F. O’Reilly Sarah M. Dickson | 2007 | Journal of Autism and Developmental Disorders2007，，8： | 1 |
| 15 | High electric cur- rent density induced interfacial reactions in the micro Ball Grid Array (~BGA) solder joint 显示文摘 | Alam M O Wu B Y Chan Y C | 2006 | Acta Materialia2006，54，3： | 1 |
| 16 | Synthesis,characterization,and electronic and optical properties of donor-acceptor conjugated polymers based on alternating bis(3-alkylthiophene) and pyridine moieties显示文摘 | Lu Hong-Fang Chan Hardy S O Ng Siu-Choon | 2003 | Macromolecules2003，36，： | 1 |
| 17 | Weighted essentially non-oscillatory schems显示文摘 | Liu X D Osher O Chan T | 1994 | Journal of Computational Physics1994，115，1： | 1 |
| 18 | Diabetes and thehyl Do- thalamo-pituitary-adrenal(HPA) axis 显示文摘 | Chan O Inouye K Riddeli MC | 2005 | Minerva Endocrinol2005，28，： | 1 |
| 19 | A human gene that shows identity with the gene enconding the angiotensin receptor is located on chromosome 11显示文摘 | O′Dowd BF Heiber M Chan A | 1993 | Gene1993，136，12： | 1 |
| 20 | Compari- son of intestinal perme2 abilities determined in multi- ple in vitro and in situ models:Relation 2 ship to ab- sorption in humans 显示文摘 | BARBRA H S CHAN O H LU R H | 1995 | Pharm Res1995，12，6： | 1 |
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