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| 1 | Dexamethasone Added to Mepivacaine Prolongs the Duration of Analgesia After Supraclavicular Brachial Plexus Blockade显示文摘 | Simon J. Parrington Dermot O’Donnell Vincent W.S. Chan Danielle Brown-Shreves Rajeev Subramanyam Melody Qu Richard Brull | 2010 | Regional Anesthesia and Pain Medicine2010，，5： | 2 |
| 2 | Inflammatory response to coronary artery bypass surgery: Does the heme-oxygenase-1 gene microsatellite polymorphism play a role?显示文摘Background Heme-oxygenase 1 (HO-1) is a rate-limiting enzyme in the degradation of heme to bilirubin, ferritin and carbon monoxide (CO) and may have significant anti-inflammatory function. The HO-1 gene promoter region shows microsatellite polymorphism with different (GT)n repeats, reported to differently induce gene expression, with the short allele associated with higher gene expression. We measured the acute inflammatory response using coronary artery bypass surgery (CABG) as a well-characterized and uniform stimulus and examined the correlation between levels of IL-6, C-reactive protein (CRP) and fibrinogen and their relationship to HO-1 genotype.Methods Two hundred and seventy-five consecutive patients undergoing CABG were genotyped for the HO-1 promoter polymorphism using PCR and automated DNA capillary sequencer. IL-6, CRP and fibrinogen were measured at baseline and 6, 24, 48, 72, 96 and 120 hours after CABG.Results Complete IL-6,CRP and fibrinogen measures were available in 220 patients. Before surgery IL-6 levels showed a strong correlation with CRP and fibrinogen ( r =0.48, P <0.0001; r =0.41, P <0.0001 respectively), with a significant correlation between CRP and fibrinogen ( r =0.61, P <0.0001). All three acute phase reactants showed a significant increase after CABG. After surgery, peak IL-6 was strongly correlated with peak CRP ( r =0.34, P =0.0009) but not with peak fibrinogen ( r =0.15, P =0.13), while peak CRP and peak fibrinogen were significantly correlated ( r =0.415, P <0.0001). HO-1 allelic repeats ranged from 22-42, with (GT) 25 and (GT) 32 being the two most common alleles, and subsequently divided into three groups according to previous published work: <30(GT)n were designated as S (short), 30-37(GT)n as M (middle) and long repeats with >37(GT)n as L (long); allele frequency 0.35, 0.58 and 0.07 respectively. Baseline CRP differed by genotype: those carrying at least one long allele having higher CRP than those with no long allele (3.76±0.79 vs. 2.07±0.17, P =0.013). Conversely, those carrying at least one short allele had higher fibrinogen levels than those with no short allele (3.83±0.79 vs. 3.51±0.88, P =0.006). Conclusions There is a strong correlation between the measured acute phase reactants both at baseline and after the inflammatory response to CABG in patients with coronary disease. There was an association between the HO-1 microsatellite polymorphism and CRP and fibrinogen levels at baseline but there was no similar association following CABG. This may indicate that HO-1 is associated with chronic atherosclerotic inflammatory processes rather than acute. | LI Ping Jules Sanders Emma Hawe David Brull Hugh Montgomery Steve Humphries | 2005 | Chinese Medical Journal2005，，15： | 2 |
| 3 | Preemptive analgesia II : recent advances and current trends显示文摘 | Kelly DJ Ahmad M Brull SJ | 2001 | Can J Anesth2001，48，11： | 1 |
| 4 | Human CRP gene polymorphism influences CRP levels:implications for the prediction and pathogenesis of coronary heart disease显示文摘 | Brull DJ Serrano N Zito F | 2003 | Arterioscler Thromb Vasc Biol2003，23，11： | 1 |
| 5 | Human CRP gene poly- morphism influences CRP levels:implications for the pre- diction and pathogenesis of coronary heart disease显示文摘 | Brull DJ Serrano N Zito F | 2003 | Ar- terioscler Thromb Vasc Biol2003，23，11： | 1 |
| 6 | Preemptive analgesia I: physiologi- cal pathways and pharmacological modalities 显示文摘 | Kelly DJ Ahmad M Brull SJ | 2001 | Can J Anesth2001，48，10： | 1 |
| 7 | Preemptive analgesia I: physiological pathways and pharmacological modalities 显示文摘 | Kelly DJ Ahmad M Brull SJ | 2001 | Can J Anaesth2001，48，10： | 1 |
| 8 | Catalytic combustion of methaneover copper-and manganese - substituted bariumhexaalu minates 显示文摘 | ArtizzuDuart P Brulle Y Gaillard F | 1999 | Catalysis Today1999，54，： | 1 |
| 9 | Preemptive analgesia I:physiological pathways and pharmacological modalities显示文摘 | Ahmad M Brull SJ | 2001 | Can J Anesth2001，48，： | 1 |
| 10 | Preemptive analgesia II:re- cent advances and current trends 显示文摘 | Kelly DJ Ahmad M Brull SJ | 2001 | Can J Anaesth2001，48，11： | 1 |
| 11 | Human CRP gene polymorphism influences CRP levels:implications for the prediction and pathogenesis of coronary heart disease显示文摘 | Brull DJ Serrano N Zito F | 2003 | Arterioscler Thromb Vase Biol2003，23，11： | 1 |
| 12 | physiological pathway and pharmacological modalities显示文摘 | Ahmad M Brull SJ | 2001 | Can J Anesth2001，48，7： | 1 |
| 13 | Preempitive analgesia I:physiological pathways and pharmacological modalities显示文摘 | Kelly DJ Ahmad M Brull SJ | 2001 | Can J Anesth2001，48，10： | 1 |
| 14 | Preemptive analgesia I : physiological pathways and pharmacological modalities 显示文摘 | KELLY DJ AHMAD M BRULL SJ | 2001 | Can J Anaes2001，48，10： | 1 |
| 15 | Interleukin-6 gene-174g > c and-572g >c promoter polymorphisms are strong predictors of plasma interleukin- 6 levels after coronary artery bypass surgery显示文摘 | BRULL D J MONTGOMERY H E SANDERS J | 2001 | Arterioscler Thromb Vase Biol2001，21，： | 1 |
| 16 | Neurological complications after regional anesthesia:contemporary estimates of risk显示文摘 | Brull R Mccartney CJ Chan VW | 2007 | Anesth Analg2007，104，4： | 1 |
| 17 | Human CRP gene polymorphism influences CRP Ievels: implications for the prediction and pathogenesis of coronary heart disease arterioscler 显示文摘 | BRULL DJ SERRANO N ZITO F | 2003 | Thromb Vasc Biol2003，23，： | 1 |
| 18 | Preemptive analgesia I: physio- logical pathways and pharmacological modalities 显示文摘 | Kelly DJ Ahmad M Brull SJ | 2001 | Can J Anaesth2001，48，10： | 1 |
| 19 | Preemptive analgesia I: physiological pathways and pharmacological modalities显示文摘 | Kelly DJ Ahmad M Brull SJ | 2001 | Can JAnaesth2001，48，10： | 1 |
| 20 | The effect of heart rate control on myocardial ischemia among high-risk patients after vascular surgery显示文摘 | Baby KE Brull SJ Timimi F | 1999 | Anesth Analg1999，88，23： | 1 |
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