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| 1 | In Vivo Therapeutic Silencing of Hypoxia-Inducible Factor 1 Alpha(HIF-1)Using Single-Walled Carbon Nanotubes Noncovalently Coated with siRNA显示文摘A new approach is described for delivering small interfering RNA(siRNA)into cancer cells by noncovalently complexing unmodifi ed siRNA with pristine single-walled carbon nanotubes(SWCNTs).The complexes were prepared by simple sonication of pristine SWCNTs in a solution of siRNA,which then served both as the cargo and as the suspending agent for the SWCNTs.When complexes containing siRNA targeted to hypoxia-inducible factor 1 alpha(HIF-1)were added to cells growing in serum containing culture media,there was strong specific inhibition of cellular HIF-1 activity.The ability to obtain a biological response to SWCNT/siRNA complexes was seen in a wide variety of cancer cell types.Moreover,intratumoral administration of SWCNT-HIF-1 siRNA complexes in mice bearing MiaPaCa-2/HRE tumors signifi cantly inhibited the activity of tumor HIF-1.As elevated levels of HIF-1 are found in many human cancers and are associated with resistance to therapy and decreased patient survival,these results imply that SWCNT/siRNA complexes may have value as therapeutic agents. | Geoffrey Bartholomeusz Paul Cherukuri John Kingston Laurent Cognet Robert Lemos Jr Tonya KLeeuw Laura Gumbiner-Russo RBruce Weisman Garth Powis | 2009 | Nano Research2009，2，4： | 7 |
| 2 | Abnormal liver enzymes: A review for clinicians显示文摘Liver biochemical tests are some of the most commonly ordered routine tests in the inpatient and outpatient setting,especially with the automatization of testing in this technological era.These tests include aminotransferases,alkaline phosphatase,gamma-glutamyl transferase,bilirubin,albumin,prothrombin time and international normalized ratio(INR).Abnormal liver biochemical tests can be categorized based on the pattern and the magnitude of aminotransferases elevation.Generally,abnormalities in aminotransferases can be classified into a hepatocellular pattern or cholestatic pattern and can be further sub-classified based on the magnitude of aminotransferase elevation to mild[<5×upper limit of normal(ULN)],moderate(>5-<15×ULN)and severe(>15×ULN).Hepatocellular pattern causes include but are not limited to;non-alcoholic fatty liver disease/non-alcoholic steatohepatitis,alcohol use,chronic viral hepatitis,liver cirrhosis(variable),autoimmune hepatitis,hemochromatosis,Wilson’s disease,alpha-1 antitrypsin deficiency,celiac disease,medication-induced and ischemic hepatitis.Cholestatic pattern causes include but is not limited to;biliary pathology(obstruction,autoimmune),other conditions with hyperbilirubinemia(conjugated and unconjugated).It is crucial to interpret these commonly ordered tests accurately as appropriate further workup,treatment and referral can greatly benefit the patient due to prompt treatment which can improve the natural history of several of the diseases mentioned and possibly reduce the risk of progression to the liver cirrhosis. | M Ammar Kalas Luis Chavez Monica Leon Pahnwat Tonya Taweesedt Salim Surani | 2021 | World Journal of Hepatology2021，13，11： | 5 |
| 3 | Validation of a Simple Classification System for Endoscopic Diagnosis of Small Colorectal Polyps Using Narrow-Band Imaging显示文摘 | David G. Hewett Tonya Kaltenbach Yasushi Sano Shinji Tanaka Brian P. Saunders Thierry Ponchon Roy Soetikno Douglas K. Rex | 2012 | Gastroenterology2012，，3： | 4 |
| 4 | Size-Dependent Joule Heating of Gold Nanoparticles Using Capacitively Coupled Radiofrequency Fields显示文摘Capacitively coupled shortwave radiofrequency fields(13.56 MHz)resistively heat low concentrations(~1 ppm)of gold nanoparticles with a thermal power dissipation of~380 kW/g of gold.Smaller diameter gold nanoparticles(<50 nm)heat at nearly twice the rate of larger diameter gold nanoparticles(≥50 nm),which is attributed to the higher resistivity of smaller gold nanostructures.A Joule heating model has been developed to explain this phenomenon and provides critical insights into the rational design and engineering of nanoscale materials for noninvasive thermal therapy of cancer. | Christine H.Moran Sean M.Wainerdi Tonya K.Cherukuri Carter Kittrell Benjamin J.Wiley Nolan W.Nicholas Steven A.Curley John S.Kanzius Paul Cherukuri | 2009 | Nano Research2009，2，5： | 4 |
| 5 | 同步构绘学龄儿童脑模版和生长曲线显示文摘大脑的生长发育曲线和各年龄的标准脑模版是研究个体发育异常的必要工具.本研究构建了以一岁为间隔的儿科脑模版及相应的脑发育轨线,探究了年龄和民族在儿科脑影像研究中的影响.本研究使用了来自中美共四个站点且实验设计相同的两组纵向加速儿童脑影像队列数据,对正常发育的学龄儿童间隔五个季节进行了三次磁共振扫描.我们分别构建并比较了不同民族和年龄阶段的脑模版及发育轨线.对457名和133名正常发育的中美儿童青少年进行了总计674次和190次磁共振扫描.我们评估了使用不同民族和年龄阶段的脑模版进行配准产生的形变量,并建模大脑皮层400个不同区域体积的生长曲线.分析结果表明:构建各年龄阶段和民族特异性的脑模版对于脑生长发育曲线的绘制是必要的.脑体积在不同民族间的发育差异主要体现在结构和功能上个体差异较为明显的外侧额叶和顶叶区域,使用年龄和民族相对应的脑模版可以避免在构绘脑生长曲线时由此产生的系统偏差.本研究的所有结果及分析代码均已公开. | 董昊铭 F.Xavier Castellanos 杨宁 张喆 周荃 何叶 张蕾 徐婷 Avram J.Holmes B.T.Thomas Yeo 陈飞燕 王滨 Christian Beckmann Tonya White Olaf Sporns 邱江 冯廷勇 陈安涛 刘勋 陈旭 翁旭初 Michael P.Milham 左西年 | 2020 | Science Bulletin2020，65，22： | 4 |
| 6 | A tandem colonoscopy study of adenoma miss rates during endoscopic training: a venture into uncharted territory显示文摘 | Craig A. Munroe Philip Lee Andrew Copland Kuan K. Wu Tonya Kaltenbach Roy M. Soetikno Shai Friedland | 2012 | Gastrointestinal Endoscopy2012，，3： | 3 |
| 7 | International Consensus Statement on surveillance and management of dysplasia in inflammatory bowel disease显示文摘 | Loren Laine Tonya Kaltenbach Alan Barkun Kenneth R. McQuaid Venkataraman Subramanian Roy Soetikno James E. East Francis A. Farraye Brian Feagan John Ioannidis Ralf Kiesslich Michael Krier Takayuki Matsumoto Robert P. McCabe Klaus M?nkemüller Robert Odze M | 2014 | Gastrointestinal Endoscopy2014，，： | 3 |
| 8 | Narrow band imaging to differentiate neoplastic and non-neoplastic colorectal polyps in real time: a meta-analysis of diagnostic operating characteristics显示文摘 | Sarah K McGill Evangelos Evangelou John P A Ioannidis Roy M Soetikno Tonya Kaltenbach | 2013 | Gut2013，，12： | 2 |
| 9 | The Effects of Enhanced Milieu Teaching and a Voice Output Communication Aid on the Requesting of Three Children with Autism显示文摘 | Melissa L. Olive Berenice Cruz Tonya N. Davis Jeffrey M. Chan Russell B. Lang Mark F. O’Reilly Sarah M. Dickson | 2007 | Journal of Autism and Developmental Disorders2007，，8： | 1 |
| 10 | Is hafnium a valid surrogate for plutonium for biochemical and biokinetic seudies in vivo显示文摘 | GILLS TONYA M | 1998 | Chemical Speciation and Bioavailability1998，10，3： | 1 |
| 11 | Endoscopic appearance of proximal colorectal neoplasms and potential implications for colonoscopy in cancer prevention显示文摘 | Eveline J.A. Rondagh Mari?lle W.E. Bouwens Robert G. Riedl Bjorn Winkens Rogier de Ridder Tonya Kaltenbach Roy M. Soetikno Ad A.M. Masclee Silvia Sanduleanu | 2012 | Gastrointestinal Endoscopy2012，，6： | 1 |
| 12 | Development of expertise in endoscopic mucosal resection and endoscopic submucosal dissection显示文摘 | Tonya Kaltenbach Roy Soetikno Chika Kusano Takuji Gotoda | 2011 | Techniques in Gastrointestinal Endoscopy2011，，1： | 1 |
| 13 | Hepatopulmonary syndrome: An update显示文摘Hepatopulmonary syndrome(HPS)is characterized by defects in oxygenation caused by intra-pulmonary vasodilation occurring because of chronic liver disease,portal hypertension,or congenital portosystemic shunts.Clinical implications of portal hypertension are very well-known,however,awareness of its effect on multiple organs such as the lungs are less known.The presence of HPS in chronic liver disease is associated with increased mortality.Medical therapies available for HPS have not been proven effective and definitive treatment for HPS is mainly liver transplantation(LT).LT improves mortality for patients with HPS drastically.This article provides a review on the definition,clinical presentation,diagnosis,and management of HPS. | Kejal D Gandhi Pahnwat Tonya Taweesedt Munish Sharma Salim Surani | 2021 | World Journal of Hepatology2021，13，11： | 1 |
| 14 | A tandem colonoscopy study of adenoma miss rates during endoscopic training: a venture into uncharted territory显示文摘 | Craig A. Munroe Philip Lee Andrew Copland Kuan K. Wu Tonya Kaltenbach Roy M. Soetikno Shai Friedland | 2012 | Gastrointestinal Endoscopy2012，，3： | 1 |
| 15 | Zinc finger nuclease-mediated transgene deletion显示文摘 | Joseph F. Petolino Andrew Worden Krisi Curlee James Connell Tonya L. Strange Moynahan Cory Larsen Sean Russell | 2010 | Plant Molecular Biology2010，，6： | 1 |
| 16 | Catalytic deoxygenation of triglycerides to hydrocarbons over supported nickel catalysts显示文摘 | Tonya Morgan Eduardo Santillan-Jimenez Anne E. Harman-Ware Yaying Ji Daniel Grubb Mark Crocker | 2012 | Chemical Engineering Journal2012，，： | 1 |
| 17 | Bio-oil upgrading over platinum catalysts using in situ generated hydrogen显示文摘 | COURTNEY A F TONYA M YAYING Ji | 2009 | Applied Catalysis(A): General2009，358，： | 1 |
| 18 | The Detection of Nonpolypoid (Flat and Depressed) Colorectal Neoplasms in Patients With Inflammatory Bowel Disease显示文摘 | Roy Soetikno Venkataraman Subramanian Tonya Kaltenbach Robert V. Rouse Silvia Sanduleanu Noriko Suzuki Shinji Tanaka Kenneth McQuaid | 2013 | Gastroenterology2013，，7： | 1 |
| 19 | Catalytic deoxygenation of triglycerides and fatty acids to hydrocarbons over carbon-supported nickel显示文摘 | Eduardo Santillan-Jimenez Tonya Morgan Joseph Lacny | 2013 | Fuel2013，103，： | 1 |
| 20 | The effects of loading and unloading treadmill walking on balance, gait, fall risk, and daily function in Parkinsonism显示文摘 | Tonya Toole Charles G. Maitland Earl Warren Monica F. Hubmann Lynn Panton | 2005 | Neurorehabilitation2005，，4： | 1 |
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