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| 1 | interrelationships between ghrelin, insulin and glucose homeostasis: physiological relevance显示文摘Ghrelin is a 28 amino acid peptide mainly derived from the oxyntic gland of the stomach. Both acylated(AG) and unacylated(UAG) forms of ghrelin are found in the circulation. Initially, AG was considered as the only bioactive form of ghrelin. However, recent advances indicate that both AG and UAG exert distinct and common effects in organisms. Soon after its discovery, ghrelin was shown to promote appetite and adiposity in animal and human models. In response to these anabolic effects, an impressive number of elements have suggested the influence of ghrelin on the regulation of metabolic functions and the development of obesityrelated disorders. However, due to the complexity ofits biochemical nature and the physiological processes it governs, some of the effects of ghrelin are still debated in the literature. Evidence suggests that ghrelin influences glucose homeostasis through the modulation of insulin secretion and insulin receptor signaling. On the other hand, insulin was also shown to influence circulating levels of ghrelin. Here, we review the relationship between ghrelin and insulin and we describe the impact of this interaction on the modulation of glucose homeostasis. | FranCois Chabot Alexandre Caron Mathieu Laplante David H St-Pierre | 2014 | World Journal of Diabetes2014，5，3： | 9 |
| 2 | Tight junction disruption: Helicobacter pylori and dysregulation of the gastric mucosal barrier显示文摘Long-term chronic infection with Helicobacter pylori(H. pylori) is a risk factor for gastric cancer development. In the multi-step process that leads to gastric cancer,tight junction dysfunction is thought to occur and serve as a risk factor by permitting the permeation of luminal contents across an otherwise tight mucosa. Mechanisms that regulate tight junction function and structure in the normal stomach,or dysfunction in the infected stomach,however,are largely unknown. Although conventional tight junction components are expressed in gastric epithelial cells,claudins regulate paracellular permeability and are likely the target of inflammation or H. pylori itself. There are 27 different claudin molecules,each with unique properties that render the mucosa an intact barrier that is permselective in a way that is consistent with cell physiology. Understanding the architecture of tight junctions in the normal stomach and then changes that occur during infection is important but challenging,because most of the reports that catalog claudin expression in gastric cancer pathogenesis are contradictory. Furthermore,the role of H. pylori virulence factors,such as cytotoxin-associated gene A and vacoulating cytotoxin,in regulating tight junction dysfunction during infection is inconsistent in different gastric cell lines and in vivo,likely because non-gastric epithelial cell cultures were initially used to unravel the details of their effects on the stomach. Hampering further study,as well,is the relative lack of cultured cell models that have tight junction claudins that are consistent with native tissues. This summary will review the current state of knowledge about gastric tight junctions,normally and in H. pylori infection,and make predictions about the consequences of claudin reorganization during H. pylori infection. | Tyler J Caron Kathleen E Scott James G Fox Susan J Hagen | 2015 | World Journal of Gastroenterology2015，21，40： | 7 |
| 3 | Use of a new retrograde filling material(Biodentine) for endodontic surgery: two case reports显示文摘Mineral trioxide aggregate(MTA) is considered at the present time as the gold standard for root-end filling in endodontic surgery.However, this biocompatible material presents several drawbacks such as a long setting time and handling difficulties. The aim of this article is to present a new commercialized calcium silicate-based material named Biodentine with physical improved properties compared to MTA in a clinical application. Two endodontic microsurgeries were performed by using specific armamentarium(microsurgical instrumentation, ultrasonic tips) under high-power magnification with an operatory microscope. Biodentine was used as a root-end filling in order to seal the root canal system. The two cases were considered completely healed at 1 year and were followed for one more year. The 2-year follow-up consolidated the previous observation with absence of clinical symptoms and radiographic evidence of regeneration of the periapical tissues. | Grégory Caron Jean Azérad Marie-Odile Faure Pierre Machtou Yves Boucher | 2014 | International Journal of Oral Science2014，6，4： | 5 |
| 4 | Adrenomedullin and endocrine control of immune cells during pregnancy显示文摘怀孕的免疫学复杂、不完全地听说。在蜕膜并且在胎盘的异常有免疫力的活动被相信在怀孕的疾病起一个作用,例如不孕,流产,胎儿的生长限制和 preeclampsia。这里,我们简短由肽荷尔蒙 adrenomedullin 考察子宫的自然漂亮房间人口和他们的功能的内分泌的控制。在基因动物模型的研究在母亲胎儿的接口揭示了 adrenomedullin 剂量的批评重要性,与从两个的细胞贡献位于适当子宫的感受性,培植并且螺线动脉的脉管的改变下面的必要方面的母亲、胎儿的分隔空间。这些基本卓见进串音在之间内分泌并且在母亲胎儿的接口以内的免疫系统可以最终在临床上复杂的怀孕翻译到功能的更好的理解和 dysregulated adrenomedullin 层次的后果。 | Brooke C Matson Kathleen M Caron | 2014 | Cellular & Molecular Immunology2014，11，5： | 4 |
| 5 | Rck of Salmonella enterica, subspecies enterica serovar Enteritidis, mediates Zipper-like internalization显示文摘沙门氏菌能通过它的类型 III 分泌物系统(T3SS-1 ) 入侵非吞噬细胞的房间,它导致一个扳机入口过程。这研究显示出那沙门氏菌 enterica,亚种 enterica serovar Enteritidis 能也经由 Rck 外部膜蛋白质入侵房间。Rck 必要、足够启用非侵略的 E。coli 和 Rck 涂的祷告遵守并且入侵不同房间。与不同 Rck 肽涂的乳胶祷告的成为主观分析证明包含氨基酸 140-150 的肽支持了粘附,而在 150 和 159 之间的氨基酸调制了侵略。主导否定的衍生物的表示和特定的禁止者的使用在激活 Arp2/3 建筑群触发充满肌动朊的累积的形成表明了小 GTPases Rac1 和 Cdc42 的关键角色,导致 Rck 依赖的成为主观。最后,扫描并且有 Rck 涂的祷告和 E 的传播电子显微镜学。表示 Rck 的 coli 揭示了形成了像拉链的结构的象 microvillus 一样延期,吞没支持者祷告和细菌。总的来说,我们的结果提供新卓见进沙门氏菌 T3SS 独立的侵略机制并且强烈建议 Rck 导致像拉链的入口机制。因而,沙门氏菌似乎是发现能导致拉链和扳机机制入侵宿主细胞的第一个细菌。 | Manon Rosselin Isabelle Virlogeux-Payant Christian Roy Elisabeth Bottreau Pierre-Yves Sizaret Lily Mijouin Pierre Germon Emmanuelle Caron Philippe Velge Agnes Wiedemann | 2010 | Cell Research2010，20，6： | 4 |
| 6 | Wnt signaling and hepatocarcinogenesis: molecular targets for the development of innovative anticancer drugs显示文摘 | Floriane Pez Ana?s Lopez Miran Kim Jack R. Wands Claude Caron de Fromentel Philippe Merle | 2013 | Journal of Hepatology2013，，： | 3 |
| 7 | Numerical sensitivity analysis of welding-induced residual stress depending on variations in continuous cooling transformation behavior显示文摘连续冷却的用法在数字焊接的转变(CCT ) 图模拟现状。不过,说明在分别地导致不同 CCT 行为和 CCT 图的材料的化学作文提供限制。因此,在发展中的剩余压力上在 CCT 图分析变化的影响是必要的。在现在的纸,在剩余压力的数字计算以后的四张 CCT 图和他们的效果为煤气的金属弧焊(GMAW ) 焊接的广泛地使用的结构的钢 S355J2 + N 被调查过程。而非执行 CCT 行为的任意的调整,四个有理由的数据集合被用作输入到数字计算:在 Sysweld 数据库,通过 Gleeble dilatometry 测试获得的试验性的数据,和 TTT/CCT 预言可得到的数据从 JMatPro 和爱迪生焊接研究所(EWI ) 计算了虚拟加入门软件。执行数字分析就不同 CCT 图而言在剩余压力导致了显著偏差。而且,改进失真和剩余的预言的可能性基于 CCT 强调行为被讨论。 | C. HEINZE C. SCHWENK M. RETHMEIER J. CARON | 2011 | Frontiers of Materials Science2011，5，2： | 3 |
| 8 | Dynamics of a multimodule variable geometry manipulator显示文摘 | CARON M MODI V J MISRA A K | 2002 | Acta Astronautica2002，50，10： | 2 |
| 9 | Operation for acute type A aortic dissection in octogenarians: Is it justified?显示文摘 | Eugenio Neri Thomas Toscano Massimo Massetti Gianni Capannini Enrico Carone Enrico Tucci Francesco Diciolla Sabino Scolletta Rémy Morello Carlo Sassi | 2001 | The Journal of Thoracic and Cardiovascular Surgery2001，，2： | 2 |
| 10 | An assessment of the efficacy and safety of eszopiclone in the treatment of transient insomnia in healthy adults显示文摘 | Russell Rosenberg Judy Caron Thomas Roth David Amato | 2004 | Sleep Medicine2004，，1： | 2 |
| 11 | Neuroblastoma: Biology, Prognosis, and Treatment显示文摘 | Julie R. Park Angelika Eggert Huib Caron | 2010 | Hematology/Oncology Clinics of North America2010，，1： | 2 |
| 12 | Factors Associated With Diagnosis of Obscure Gastrointestinal Bleeding by Video Capsule Enteroscopy显示文摘 | Lucie Lepileur Xavier Dray Michel Antonietti Isabelle Iwanicki–Caron Sébastien Grigioni Ulriikka Chaput Aude Di–Fiore Raied Alhameedi Philippe Marteau Philippe Ducrotté Stéphane Lecleire | 2012 | Clinical Gastroenterology and Hepatology2012，，12： | 2 |
| 13 | Evolution of Ni-based superalloys for single crystal gas turbine blade applications显示文摘 | Pierre Caron Tasadduq Khan | 1999 | Aerospace Science and Technology1999，，8： | 2 |
| 14 | Ultrasonographic diagnosis of hepatic fibrosis or cirrhosis显示文摘 | Christophe Aubé Frédéric Oberti Nouri Korali Marc-Antoine Namour Didier Loisel Jean-Yves Tanguy Emmanuelle Valsesia Christophe Pilette Marie Christine Rousselet Pierre Bedossa Hervé Rifflet Moussa Y Ma?ga Dominique Penneau-Fontbonne Christine Caron Paul C | 1999 | Journal of Hepatology1999，，3： | 2 |
| 15 | Combined models for glaze ice accretion and de-icing of current-carrying electrical eonduetors显示文摘 | Huneault M Langheit C Caron J | 2005 | IEEE Transactions on Power Delivery2005，20，2： | 1 |
| 16 | Non-redundant roles of the Gabl and Gab2 scaffolding adapters in VEGF-mediated signalling, migration, and survival of endothelial cells显示文摘 | Caron C Spring K Laramee M | 2009 | Cell Signal2009，21，6： | 1 |
| 17 | Response of bacterioplankton and phytoplankton to organic carbon and inorganic nutrient additions in contrasting oceanic ecosystems显示文摘 | Caron D A Lira E L Sanders R W | 2000 | Aquatic Microbial Ecology2000，22，： | 1 |
| 18 | A Political Theory of Lnternational Courts and Tribunals显示文摘 | | 2006 | Berkeley Journal of Internationl law2006，24，： | 1 |
| 19 | Restoration of transcriptional activity of p53 mutants in human tumour cells by intracellular expression of anti-p53 single chain Fv fragments 显示文摘 | Caron de FC Gruel N Venot C | 1999 | Oncogene1999，18，： | 1 |
| 20 | Histone deacetylases(HDACs):characterization of the classical HDAC family显示文摘 | de Ruijter AJ van Gennip All Caron HN | 2003 | Biochem J2003，370，： | 1 |
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