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您的检索式：作者名="Alexandre Caron"
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| 1 | interrelationships between ghrelin, insulin and glucose homeostasis: physiological relevance显示文摘Ghrelin is a 28 amino acid peptide mainly derived from the oxyntic gland of the stomach. Both acylated(AG) and unacylated(UAG) forms of ghrelin are found in the circulation. Initially, AG was considered as the only bioactive form of ghrelin. However, recent advances indicate that both AG and UAG exert distinct and common effects in organisms. Soon after its discovery, ghrelin was shown to promote appetite and adiposity in animal and human models. In response to these anabolic effects, an impressive number of elements have suggested the influence of ghrelin on the regulation of metabolic functions and the development of obesityrelated disorders. However, due to the complexity ofits biochemical nature and the physiological processes it governs, some of the effects of ghrelin are still debated in the literature. Evidence suggests that ghrelin influences glucose homeostasis through the modulation of insulin secretion and insulin receptor signaling. On the other hand, insulin was also shown to influence circulating levels of ghrelin. Here, we review the relationship between ghrelin and insulin and we describe the impact of this interaction on the modulation of glucose homeostasis. | FranCois Chabot Alexandre Caron Mathieu Laplante David H St-Pierre | 2014 | World Journal of Diabetes2014，5，3： | 9 |
| 2 | A CK2-RNF4 interplay coordinates non-canonical SUMOylation and degradation of nuclear receptor FXR显示文摘Farnesoid X 受体(FXR ) 是在调整涉及胆汁酸动态平衡,和脂肪和葡萄糖新陈代谢的基因起一个中央作用的激活 ligand 的原子受体。这里,我们表明在在 hepatocytes 指导受体进一条激活降级小径的 FXR phosphorylation, SUMOylation,和 ubiquitination 之间的 translational 以后相互影响。我们识别一个不在经典中的 SUMOylation 主题在酷蛋白 kinase 的直接控制下面在 FXR 的 Lys-325 结合 SUMO2 的称为的 pSuM 2 (CK2 ) ,它提供要求的否定费用让 Ubc9 和 PIAS1 执行 SUMOylation,由 phosphorylating Ser-327。Lys-325 SUMOylation 对有效 ligand 激活的提升和 FXR 的 transcriptional coactivation 不可缺少。用 phospho 模仿 Ser-327 变异或催化的 CK2 表情的组成的 pSuM 激活强烈导致 SUMO2 变化形式,它指导 FXR ubiquitination 和 proteasome 依赖的降级。我们也决定 FXR 的如此的 SUMOylation 依赖的 ubiquitination 被 E3 ubiquitin ligase RNF4 调停,它被要求完成 FXR 的最大的正式就职并且在上面最佳 -- 或涉及胆汁酸动态平衡和肝新生的应答的基因的 downregulation。我们的调查结果识别服务协调 FXR transcriptional 胜任的一个高度调整的不正常的相扑变化形式主题,从而扩展到来的信号过去常管理新陈代谢的基因规定的 SUMOylation 过程的复杂动力学。 | Stephanie Bilodeau Veronique Caron Jonathan Gagnon Alexandre Kuftedjian Andre Tremblay | 2017 | Journal of Molecular Cell Biology2017，9，3： | 1 |
| 3 | Influence of Plasma Instabilities in Ceramic Suspension Plasma Spraying显示文摘 | R. Etchart-Salas V. Rat J. F. Coudert P. Fauchais N. Caron K. Wittman S. Alexandre | 2007 | Journal of Thermal Spray Technology (-)2007，，5： | 1 |
| 4 | Role of leptin resistance in the development of obesity in older patients 显示文摘 | Sophie Carter Alexandre Caron Denis Richard | 2013 | Clin Interv Aging2013，04，08： | 1 |
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