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| 1 | Anticancer immunotherapy by CTLA-4 blockade: obligatory contribution of IL-2 receptors and negative prognostic impact of soluble CD25显示文摘堵住抗体 ipilimumab 的细胞毒素的 T 淋巴细胞 antigen-4 (CTLA-4 ) 在很少的病人导致变形黑瘤的调停免疫者的长期的控制。尽管 ipilimumab 无疑经由 immunostimulation 施加它的治疗学的效果,这样远的临床上有用的、 immunologically 相关的 biomarkers 预言治疗效率是逃犯的。这里,我们显示出 IL-2 的那中立化或堵住 α并且 βIL-2 受体的子单元(CD25 和 CD122,分别地) 否则在现出症状之前的潜的老鼠模型由 CTLA-4 封锁导致了,废除了 antitumor 效果和 intratumoral T 受动器对规章的房间(Tregs ) 的比率的伴随的改进,它是。CTLA-4 封锁导致了在失去了 FoxP3 表示并且在 regressing 肿瘤积累了的 IL-2-producing 受动器房间与伴随物上升表示 Lag3, ICOS, IL-10 和 Egr2 的一个镇压 CD4 + T 房间子集的减小。当 recombinant IL-2 改进了 CTLA-4 封锁的治疗学的功效时,圈套 IL-2 受体 α(IL-2Rα, sCD25 ) 禁止了 CTLA-4 的 anticancer 效果封锁。在收到 ipilimumab 的 262 个变形黑瘤病人, sCD25 的基线浆液集中代表了全面幸存的独立指示物,与预言到治疗的抵抗的高水平。总的来说,这些结果解开为在 CTLA-4 的 anticancer 活动的 IL-2 和 IL-2 受体的一个角色封锁。重要地,我们的学习提供第一 immunologically 相关的 biomarker,也就是提高的浆液 sCD25,那与黑瘤在病人预言抵抗到 CTLA-4 封锁。 | Dalil Hannani Marie Vetizou David Enot Sylvie Rusakiewicz Nathalie Chaput David Klatzmann Melanie Desbois Nicolas Jacquelot Nadege Vimond Salem Chouaib Christine Mateus James P Allison Antoni Ribas Jedd D Wolchok Jianda Yuan Philip Wong Michael Postow Andrzej Mackiewicz Jacek Mackiewicz Dirk Schadendorff Dirk Jaeger Alan J Korman Keith Bahjat Michele Maio Luana Calabro Michele WL Teng Mark J Smyth Alexander Eggennont Caroline Robert Guido Kroemer Laurence Zitvogel | 2015 | Cell Research2015，25，2： | 14 |
| 2 | LMJ on its way to fusion显示文摘 | J Ebrardt J M Chaput | 2010 | Journal of Physics: Conference Series2010，，3： | 2 |
| 3 | Factors Associated With Diagnosis of Obscure Gastrointestinal Bleeding by Video Capsule Enteroscopy显示文摘 | Lucie Lepileur Xavier Dray Michel Antonietti Isabelle Iwanicki–Caron Sébastien Grigioni Ulriikka Chaput Aude Di–Fiore Raied Alhameedi Philippe Marteau Philippe Ducrotté Stéphane Lecleire | 2012 | Clinical Gastroenterology and Hepatology2012，，12： | 2 |
| 4 | The indications for interbody fusion cages in the treatment of spondylolisthesis:analysis of 120 cases显示文摘 | McAfee PC DeVine JG Chaput CD | 2005 | Spine2005，30，6： | 1 |
| 5 | Characterization of thermosensitive chitosan gels for the sustained delivery of drugs显示文摘 | Gariepy E R Chenite A Chaput C | 2000 | International Journal of Pharmaceutics2000，203，12： | 1 |
| 6 | The indications for interbody fusion cages in the treatment of spondylolisthesis:analysis of 120 cases显示文摘 | Mcafee PC Devine JG Chaput CD | | 0，，6： | 1 |
| 7 | Active Video Games and Health Indicators in Children and Youth: A Systematic Review 显示文摘 | LeBlanc A Chaput J Tremblay M | 2013 | Plos ONE2013，，6： | 1 |
| 8 | Mitral leaflet adaptation to ventricular remodeling: occurrence and adequacy in patients with functional mitral regurgitation 显示文摘 | Chaput M Handschumacher MD Tournoux F | 2008 | Circulation2008，118，8： | 1 |
| 9 | Nodl responds to peptidoglycan delivered by the Helicobacter pylori cag pathogenicity island 显示文摘 | Viala J Chaput C Boneca I G et ol | 2004 | Nat Immunol2004，5，： | 1 |
| 10 | Recent developments in calcium-related obesity research显示文摘 | Major GC Chaput JP Ledoux M | 2008 | Obes Rev2008，9，5： | 1 |
| 11 | Inadequate sleep as a contributor toobesity and type 2 diabetes显示文摘 | McNeil J Doucet E Chaput JP | 2013 | Can J Diabetes2013，37，2： | 1 |
| 12 | Nodl responds to peptidogly can delivered by the Helicobacter pylori cag pathogenicity island 显示文摘 | Viala J Chaput C Boneca IG | 2004 | Nat Immunol2004，5，11： | 1 |
| 13 | LMJ project status显示文摘 | Ebrardt J Chaput J M | 2008 | Journal of Physics: Conference Series2008，112，03： | 1 |
| 14 | Novel injectable neutral solu- tions of chitosan form biodegradable gels in situ 显示文摘 | Chenite A Chaput C Wang D | 2000 | Biomaterials2000，21，21： | 1 |
| 15 | Spatial analysis of human granulocytic ehrilichiosis near Lyme,Connecticut显示文摘 | Meek JI Heimer R | 2002 | Emerg Infect Dis2002，8，9： | 1 |
| 16 | Fenofibrate and rosiglitazone lower serum triglycerides with opposing effcts on body weight显示文摘 | Chaput E Saladin R Silvestre M | 2000 | Biochem Biophys Res Commun2000，271，2： | 1 |
| 17 | The indications for interbody fusion cages in the treatment of spondylolisthesis: analysis of 120 cases显示文摘 | McAfee PC DeVine JG Chaput CD | 2004 | Spine2004，4，6： | 1 |
| 18 | The potential of exosomes in immunotherapy of cancer 显示文摘 | Chaput N Taieb J Schartz N | 2005 | Blood Cells Mol Dis2005，35，2： | 1 |
| 19 | Alpha-2-macroglobulin and hepatic fibrosis显示文摘 | Dr. Sylvie Naveau MD Thierry Poynard Clarisse Benattar Pierre Bedossa Jean-Claude Chaput | 1994 | Digestive Diseases and Sciences1994，，11： | 1 |
| 20 | Acute Sleep Restric- tion Reduces Insulin Sensitivity in Adolescent Boys 显示文摘 | Klingenberg L Chaput JP Holmb ck U | 2013 | Sleep2013，36，7： | 1 |
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