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| 1 | Propofol vs midazolam sedation for elective endoscopy in patients with cirrhosis:A systematic review and meta-analysis of randomized controlled trials显示文摘BACKGROUND Patients with cirrhosis frequently require sedation for elective endoscopic procedures.Several sedation protocols are available,but choosing an appropriate sedative in patients with cirrhosis is challenging.AIM To conduct a systematic review and meta-analysis to compare propofol and midazolam for sedation in patients with cirrhosis during elective endoscopic procedures in an attempt to understand the best approach.METHODS This systematic review and meta-analysis was conducted using the PRISMA guidelines.Electronic searches were performed using MEDLINE,EMBASE,Central Cochrane,LILACS databases.Only randomized control trials(RCTs)were included.The outcomes studied were procedure time,recovery time,discharge time,and adverse events(bradycardia,hypotension,and hypoxemia).The risk of bias assessment was performed using the Revised Cochrane Risk-of-Bias tool for randomized trials(RoB-2).Quality of evidence was evaluated by GRADEpro.The meta-analysis was performed using Review Manager.RESULTS The search yielded 3,576 records.Out of these,8 RCTs with a total of 596 patients(302 in the propofol group and 294 in the midazolam group)were included for the final analysis.Procedure time was similar between midazolam and propofol groups(MD:0.25,95%CI:-0.64 to 1.13,P=0.59).Recovery time(MD:-8.19,95%CI:-10.59 to-5.79,P<0.00001).and discharge time were significantly less in the propofol group(MD:-12.98,95%CI:-18.46 to-7.50,P<0.00001).Adverse events were similar in both groups(RD:0.02,95%CI:0-0.04,P=0.58).Moreover,no significant difference was found for bradycardia(RD:0.03,95%CI:-0.01 to 0.07,P=0.16),hypotension(RD:0.03,95%CI:-0.01 to 0.07,P=0.17),and hypoxemia(RD:0.00,95%CI:-0.04 to 0.04,P=0.93).Five studies had low risk of bias,two demonstrated some concerns,and one presented high risk.The quality of the evidence was very low for procedure time,recovery time,and adverse events;while low for discharge time.CONCLUSION This systematic review and meta-analysis based on RCTs show that propofol has shorter recovery and patient discharge time as compared to midazolam with a similar rate of adverse events.These results suggest that propofol should be the preferred agent for sedation in patients with cirrhosis. | John Alexander Lata Guacho Diogo Turiani Hourneaux de Moura Igor Braga Ribeiro Alberto Machado da Ponte Neto Shailendra Singh Marina Gammaro Baldavira Tucci Wanderley Marques Bernardo Eduardo Guimarães Hourneaux de Moura | 2020 | World Journal of Gastrointestinal Endoscopy2020，12，8： | 4 |
| 2 | A prospective phase II study of topotecan (Hycamtin?) and cisplatin as neoadjuvant chemotherapy in locally advanced cervical cancer显示文摘 | N. Manci C. Marchetti C. Di Tucci M. Giorgini F. Esposito I. Palaia A. Musella G. Perniola A. Carrone P. Benedetti Panici | 2011 | Gynecologic Oncology2011，，2： | 3 |
| 3 | Gut microbiota and immune system in liver cancer:Promising therapeutic implication from development to treatment显示文摘Liver cancer is a leading cause of death worldwide,and hepatocellular carcinoma(HCC)is the most frequent primary liver tumour,followed by cholangiocarcinoma.Notably,secondary tumours represent up to 90% of liver tumours.Chronic liver disease is a recognised risk factor for liver cancer development.Up to 90% of the patients with HCC and about 20% of those with cholangiocarcinoma have an underlying liver alteration.The gut microbiota-liver axis represents the bidirectional relationship between gut microbiota,its metabolites and the liver through the portal flow.The interplay between the immune system and gut microbiota is also well-known.Although primarily resulting from experiments in animal models and on HCC,growing evidence suggests a causal role for the gut microbiota in the development and progression of chronic liver pathologies and liver tumours.Despite the curative intent of“traditional”treatments,tumour recurrence remains high.Therefore,microbiota modulation is an appealing therapeutic target for liver cancer prevention and treatment.Furthermore,microbiota could represent a non-invasive biomarker for early liver cancer diagnosis.This review summarises the potential role of the microbiota and immune system in primary and secondary liver cancer development,focusing on the potential therapeutic implications. | Ilenia Bartolini Matteo Risaliti Rosaria Tucci Paolo Muiesan Maria Novella Ringressi Antonio Taddei Amedeo Amedei | 2021 | World Journal of Gastrointestinal Oncology2021，13，11： | 3 |
| 4 | Operation for acute type A aortic dissection in octogenarians: Is it justified?显示文摘 | Eugenio Neri Thomas Toscano Massimo Massetti Gianni Capannini Enrico Carone Enrico Tucci Francesco Diciolla Sabino Scolletta Rémy Morello Carlo Sassi | 2001 | The Journal of Thoracic and Cardiovascular Surgery2001，，2： | 2 |
| 5 | Transcriptome reprogramming,epigenetic modifications and alternative splicing orchestrate the tomato root response to the beneficial fungus Trichoderma harzianum显示文摘Beneficial interactions of rhizosphere microorganisms are widely exploited for plant biofertilization and mitigation of biotic and abiotic constraints.To provide new insights into the onset of the roots–beneficial microorganisms interplay,we characterised the transcriptomes expressed in tomato roots at 24,48 and 72 h post inoculation with the beneficial fungus Trichoderma harzianum T22 and analysed the epigenetic and post-trascriptional regulation mechanisms.We detected 1243 tomato transcripts that were differentially expressed between Trichoderma-interacting and control roots and 83 T.harzianum transcripts that were differentially expressed between the three experimental time points.Interaction with Trichoderma triggered a transcriptional response mainly ascribable to signal recognition and transduction,stress response,transcriptional regulation and transport.In tomato roots,salicylic acid,and not jasmonate,appears to have a prominent role in orchestrating the interplay with this beneficial strain.Differential regulation of many nutrient transporter genes indicated a strong effect on plant nutrition processes,which,together with the possible modifications in root architecture triggered by ethylene/indole-3-acetic acid signalling at 72 h post inoculation may concur to the well-described growth-promotion ability of this strain.Alongside,T.harzianum-induced defence priming and stress tolerance may be mediated by the induction of reactive oxygen species,detoxification and defence genes.A deeper insight into gene expression and regulation control provided first evidences for the involvement of cytosine methylation and alternative splicing mechanisms in the plant–Trichoderma interaction.A model is proposed that integrates the plant transcriptomic responses in the roots,where interaction between the plant and beneficial rhizosphere microorganisms occurs. | Monica De Palma Maria Salzano Clizia Villano Riccardo Aversano Matteo Lorito Michelina Ruocco Teresa Docimo Anna Lisa Piccinelli Nunzio D’Agostino Marina Tucci | 2019 | Horticulture Research2019，6，1： | 2 |
| 6 | PCR analysis of x- and y-type genes present at the complex Glu-A1 locus in durum and bread wheat显示文摘 | D. Lafiandra G. F. Tucci A. Pavoni T. Turchetta B. Margiotta | 1997 | TAG Theoretical and Applied Genetics1997，，2： | 2 |
| 7 | Results of novel strategies for treatment of Wilms' tumor 显示文摘 | TUCCI S J R COLOGNA A J SUAID H J | 2007 | Int Braz J Urol2007，33，2： | 1 |
| 8 | Clarifying business models:origins,present and future of the concept显示文摘 | Pigneur Y Tucci C | 2005 | Communications of AIS2005，，7： | 1 |
| 9 | Cannabinoids and ghrelin have both central and peripheral metabolic and cardiac effects via AMP-activated protein kinase显示文摘 | Kola B Hubina E Tucci S A | 2005 | J Biol Chem2005，280，25： | 1 |
| 10 | Systemic acute-phase response after laparoscopic and open cholecystectomy 显示文摘 | Grande M Tucci GF | 2002 | Surg Endosc2002，16，： | 1 |
| 11 | Interfirm modularity and its implications for product development显示文摘 | Staudenmayer N Tripsas M Tucci C L | 2005 | Journal of Product Innovation Management2005，22，4： | 1 |
| 12 | Unusual presentation of haemophilia in two paediatric patients显示文摘 | Maia De Luca Francesca I. Calò Carducci Valeria Pansini Valentina Coletti Filippo M. Tucci Marco Cirillo Maura Acquila Maria Patrizia Bicocchi Patrizia D’Argenio Matteo Luciani | 2013 | Blood Coagulation & Fibrinolysis2013，，6： | 1 |
| 13 | Clarifying Business Models : Origins, Present, and Future of the Con-cept 显示文摘 | Osterwalder A Yves Pigneur and Chirstopher L Tucci | 2005 | Communications of the Information Systems2005，15，5： | 1 |
| 14 | A longitudinal study of changes in body mass index and total body composition after radioiodine treatment for thyrotoxieosis显示文摘 | De La Rosa Rhennessey JV Tucci JR | 1997 | Thyroid1997，7，： | 1 |
| 15 | Unsteady water quality model for river network显示文摘 | Tucci C E M Chen Y H | 1981 | Proc ASCE1981，107，2： | 1 |
| 16 | The growing problem of intra- dialytic hypertension显示文摘 | Locatelli F Cavalli A Tucci B | 2010 | Nat Rev Nephrol2010，6，1： | 1 |
| 17 | Metabolic bone disease induced by prostate cancer: rationale for the use of bisphosphonates显示文摘 | Dogliotti L Tucci M | 2001 | J Urol2001，166，6： | 1 |
| 18 | In vitro expansion of CD+13, CD+33 dendritic cell precursors from multipotent progeni tors is regulated by a discrete fas-mediated apoptotic schedule显示文摘 | Borrero M Tucci J | 1997 | J Leukoc Biol1997，62，4： | 1 |
| 19 | Chitosan and gelatin as engineered dressing for wound repair显示文摘 | Ricotti G Mattioli-Belmonte M | 2001 | Journal of Bioactive and Compatible Polymers(English)2001，16，2： | 1 |
| 20 | levels of hydrogen peroxide in tissues adjacent to failing implantable devices may play an active role in cytokine production显示文摘 | Tucci M Baker R Benghuzzi H | 2000 | Biomed Sci Instrum2000，36，： | 1 |
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