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| 1 | Association of -238G/A polymorphism of tumor necrosis factor-alpha gene promoter region with outcomes of hepatitis B virus infection in Chinese Han population显示文摘AIM: To clarify whether -238G/A polymorphism of tumor necrosis factor-a (TNF-a) gene promoter region was associated with outcomes of hepatitis B virus (HBV) infection in Han population of northern China, and to analyze the geneenvironment interaction between -238G/A polymorphism and cigarette smoking or alcohol consumption. METHODS: A case-control study was conducted to analyze the association of TNF-a gene promoter polymorphism with HBV infection outcomes. A total of 207 patients with chronic hepatitis B (HB) and 148 cases of self-limited HBV infection from Ditan Hospital and Shunyi District Hospital in Beijing, respectively were recruited. History of smoking and alcohol drinking was inquired by a questionnaire. The -238G/A polymorphism of TNF-a gene promoter was genotyped by polymerase chain reaction-restricted fragment length polymorphism (PCR-RFLP). RESULTS: The frequencies of GG and GA genotypes were 98.07% and 1.93% in chronic HB patients and 93.24% and 6.76% in self-limited HBV infection individuals, respectively (X^2=5.30, P=-0.02). The frequency of G allele was significantly higher in patients with chronic HB that in individuals with self-limited HBV infection (99.03% vs 96.62%, X^2=5.20, P=0.02). Only modestly increased risk of onset of chronic HB was found in smokers (OR=1.40, 95% CI: 0.87-2.28, P=0.14) and drinkers (OR=-1.26, 95%CI: 0.78-2.05, P=-0.32). There was a positive interaction between genotype GG and cigarette smoking with an interaction index (Ⅱ) of 2.95, or alcohol consumption with an Ⅱ of 1.64. CONCLUSION: The -238G/A polymorphism of TNF-a gene promoter region is independently associated with different outcomes of HBV infection. | Liang-PingLu Xing-WangLi YingLiu Guo-ChangSun Xue-PingWang Xi-LinZhu Quan-YouHu HuiLi | 2004 | World Journal of Gastroenterology2004，10，12： | 19 |
| 2 | Blocking effects of genistein on cell proliferation and possible mechanism in human gastric carcinoma显示文摘AIM: To study the blocking effects of genistein on cell proliferation cycle in human gastric carcinoma cells (SGC-7901) and the possible mechanism.METHODS: MTT assay was applied in the detection of the inhibitory effects of genistein on cell proliferation. Flow cytometry was used to analyze the cell cycle distribution.Immunocytochemical technique and Western blotting were performed to detect the protein expression of cyclin D1,cyclin B1 and p21waf1/cip1.RESULTS: Genistein significantly inhibited the growth and proliferation of human gastric carcinoma cells (SGC-7901).Seven days after treatment with different concentrations of genistein (2.5, 5.0, 10.0, 20.0 μg/mL), the growth inhibitory rates were 11.2%, 28.8%, 55.3%, 84.7%respectively and cell cycles were arrested at the G(2)/Mphase. Genistein decreased cyclin D1 protein expression and enhanced cyclin B1 and p21waf/cip1 protein expression in a concentration-dependent manner.CONCLUSION: The growth and proliferation of SGC-7901 cells can be inhibited by genistein via blocking the cell cycle,with reduced expression of cyclin D1 and enhanced expression of cyclin B1 and p21waf/cip1 protein in the concentration range of 0-20 μg/mL. | Hong-BinCui Xiao-LinNa Dan-FengSong YingLiu | 2005 | World Journal of Gastroenterology2005，11，1： | 15 |
| 3 | Specific lectin biomarkers for isolation of human pluripotent stem cells identified through array-based glycomic analysis显示文摘干细胞(hPSC ) 人口着急地在基本研究并且在基于房间的治疗应用为质量控制被需要的为孤立人的 pluripotent 的快速、可靠的方法。用 lectin 数组,我们分析了从 26 件 hPSC 样品和 22 件区分的房间样品提取的 glycoproteins,并且与是足够的把 hPSCs 与许多 non-pluripotent 房间类型区分开来的特殊有约束力的签名识别了 lectins 的一个小组。这些特定的 biomarkers 被所有 12 人的胚胎的干细胞和检验的 14 件人的导致的 pluripotent 干细胞样品分享,不管起源,文化条件,体的房间类型 reprogrammed,或使用的 reprogramming 方法的实验室。我们演示了由检测有调停 lectin 的染色的一张区分的房间人口由荧光显微镜学和流动 cytometry,并且由充实并且清除跟随了的在内的 hPSCs 有约束力的特定的 lectin 的一个实际应用程序从用调停 lectin 的房间分离的混合房间人口的可行 hPSCs。全球基因表示分析显示出特定的 fucosyltransferases 和 sialyltransferases 的联系 pluripotency 的微分表示,它可以在蛋白质 glycosylation 和 lectin 绑定位于这些差别下面。一起拿,我们的结果证明蛋白质 glycosylation 在 pluripotent 和 non-pluripotent 房间之间更加不同,并且证明 lectins 可以被用作 biomarkers 从混合房间人口在干细胞人口并且为可行 hPSCs 的移动监视 pluripotency。 | Yu-ChiehWang MasatoNakagawa IbonGaritaonandia IleanaSlavin GulsahAltun Robert MLacharite Kristopher LNazor Ha TTran Candace LLynch Trevor RLeonardo YingLiu Suzanne EPeterson Louise CLaurent ShinyaYamanaka Jeanne FLoring | 2011 | Cell Research2011，21，11： | 5 |
| 4 | Polymorphisms of Renin-angiotensin System in Essential Hypertension in Chinese Tibetans显示文摘Objective To evaluate the potential implications of the genetic variability of angiotensin converting enzyme, angiotensinogen and angiotensinⅡtype 1 receptor gene for essential hypertension in Tibetan. Methods A case-control study was conducted in 173 hypertensive individuals and 193 individuals with normal blood pressure. Multiple logistic regression analyses were used to estimate the risks of developing hypertension for different genotypes, and haplotype analyses of the angiotensinogen gene were used to determine the association between two-locus angiotensinogen gene polymorphisms and hypertension. Results As to the risk to high blood pressure and high systolic pressure, women with MM genotype were 7.7 (95% CI: 1.3-20.5) and 8.7 (95% CI: 1.8-20.1) times higher than those with TT genotype after adjustment for age and body mass index. Haplotype frequencies for M235T and G-6A were significantly different between hypertensive individuals and controls, which indicated an association of angiotensinogen gene haplotypes with hypertension, and a significant association of 235T/-6A haplotype with hypotensive effect. Conclusion Our results suggest that angiotensinogen gene 235MM is a predictor for hypertension development in Tibetan women but not in men, and may exert its hypertensive effect on linkage disequilibrum with a possible function locus of G-6A. | BEISUN TSERINGDRONMA WEI-JUNQIN CHAO-YINGCUI DANTSE TASHIPINGTSO YINGLIU CHANG-CHUNQIU | 2004 | Biomedical and Environmental Sciences2004，17，2： | 4 |
| 5 | Study on the Relationship Between Helicobacter pylori in the Dental Plaque and the Occurrence of Dental Caries or Oral Hygiene Index显示文摘 | YingLiu HuanjianLin YangBai XiaoshuQin XinZheng YongSun YaliZhang | 2008 | Helicobacter2008，，4： | 2 |
| 6 | A Rapid Parallel Synthesis of 2-Dialkylamino-4(3H)-quinazolines显示文摘Dialkylamino-4(3H)-quinazolinones 4 were rapidly synthesized by a solution-phase parallel synthetic method, which includes aza-Wittig reaction of iminophosphorane 1 with aromatic isocynate to give carbodiimide 2 and subsequent reaction of 2 with various aliphatic secondary amine in a parallel fashion. | MingWuDING YingLIU GuiFengZHANG ShangJunYANG | 2004 | Chinese Chemical Letters2004，15，3： | 2 |
| 7 | The effect of different macroalgae on the growth of sea cucumbers (Apostichopus japonicus Selenka)显示文摘 | YingLiu ShuanglinDong XiangliTian FangWang QinfengGao | 2010 | Aquaculture Research2010，，11： | 1 |
| 8 | Anatomical traits associated with absorption and mycorrhizal colonization are linked to root branch order in twenty‐three Chinese temperate tree species显示文摘 | DaliGuo MengxueXia XingWei WenjingChang YingLiu ZhengquanWang | 2008 | New Phytologist2008，，3： | 1 |
| 9 | Fetal tissue Doppler imaging in pregnancies complicated with preeclampsia with or without intrauterine growth restriction显示文摘 | Qiongjie Zhou Yunyun Ren Yingliu Yan Chen Chu Yonghao Gui Xiaotian Li | 2012 | Prenat Diagn2012，，11： | 1 |
| 10 | Peroxisome Proliferator‐Activated Receptor δ‐Agonist, GW501516, Ameliorates Insulin Resistance, Improves Dyslipidaemia in Monosodium l‐Glutamate Metabolic Syndrome Mice显示文摘 | WeiChen Li‐LiWang Hong‐YingLiu LongLong SongLi | 2008 | Basic & Clinical Pharmacology & Toxicology2008，，3： | 1 |
| 11 | Transcript profiles of Panax quinquefolius from flower, leaf and root bring new insights into genes related to ginsenosides biosynthesis and transcriptional regulation显示文摘 | QiongWu JingyuanSong YongqiaoSun FengmeiSuo ChenjiLi HongmeiLuo YingLiu YingLi XiaoweiZhang HuiYao XiwenLi SongnianHu ChaoSun | 2010 | Physiologia Plantarum2010，，2： | 1 |
| 12 | APsychometricEvaluation of a Brief School Relationship Questionnaire显示文摘 | YangDong YingLiu CodyDing | | 0，，01： | 1 |
| 13 | Synergy of magnesium and calcium oxides in intumescent flame‐retarded polypropylene显示文摘 | Zhi‐LingMa Cong‐RanFan Guang‐YuLu Xiu‐YingLiu HongZhang | 2012 | J Appl Polym Sci2012，，5： | 1 |
| 14 | Symptom burden and performance status in a population‐based cohort of ambulatory cancer patients显示文摘 | LisaBarbera HsienSeow DorisHowell RinkuSutradhar CraigEarle YingLiu AudraStitt AmnaHusain JonathanSussman DeborahDudgeon | 2010 | Cancer2010，，24： | 1 |
| 15 | Involvement of Abdominal and Pelvic Lymph Nodes in Non-Hodgkin Lymphoma: the Nodal Distribution in Chinese Patients显示文摘OBJECTIVE To study the distribution of abdominal and pelvic lymphadenopathy in non-Hodgkin lymphoma (NHL) in Chinese patients.METHODS CT images of 241 NHL patients with abdominal and/or pelviclymphadenopathy were reviewed. Among them, clinical and image datafrom 96 patients fulfilled the requirements for the analysis: 1. Abdominal and/or pelvic lymphadenopathy detected by CT in untreated patients (n=74). 2.Recurrent patients: new lesions in abdominal or pelvic lymph nodes whonever had any nodular lesion by previous abdominal and/or pelvic CT (n =14). 3. Treated patients who did not have abdominal and/or pelvic CTpreviously, showed regression of initial disease for at least 6 months afterchemotherapy and subsequently showed abdominal and/or pelviclymphadenopathy (n =8). According to the Clinical Schema for LymphoidTissue, these patients were divided into 3 histologic subtypes: indolent (IL;n=31), aggressive (AL; n=61)and very aggressive (VAL; n=2)lymphoma.The remaining 2 cases were unclassified lymphoma (UCL). Both abdominaland pelvic CT scans were undertaken in 46 patients, abdominal CT only in 47patients and pelvic CT only in 3 patients. Enhanced CT was obtained in 80patients. The anatomic sites involved were designated as retroperitoneal (ie.paraaortic), mesenteric, abdominal (i.e. celiac, paracardiac, gastrohepaticand hepatic hilum, etc.), retrocrural, subdiaphragmatic, common iliac,internal iliac, external iliac and inguinal nodes respectively.RESULTS The lesions located in the retroperitoneum were most common forIL and AL, the incidences being 83.3% (18/25) and 83.1% (49/59)respectively, results being similar. Among those, lymphadenopathydistributed mainly in the retroperitoneum, superior and inferior renal hila,with an incidence of 72.0% (18/25) in IL and 67.3% (33/49) in AL. Pelviclymphadenopathy came next, with the overall incidence of 41.9% (126/301),57.5% (50/87) in IL and 35.5% (76/214) in AL respectively. Mesenteric lymphnodes stood third with the overall incidence of 37.1% (33/89), 43.3% (13/30)in IL and 33.9% (20/59) in AL. Statistical analysis showed that external iliaclymph node involvement to be more common in I L than in AL (P<0.05), whilecomparisons of other groups showed no statistical significance.CONCLUSION For Chinese NHL patients, retroperitoneal lymph nodes weremostly involved, followed by iliac and mesenteric lymphadenopathy, whichwas different from that of the Western countries, The involved retroperitoneallymph nodes in NHL of Chinese patients were predominantly located in thesuperior and inferior renal hilum. | NingWu YingLiu DongmeiLin YuChen MulanShi | 2004 | Chinese Journal of Clinical Oncology2004，1，4： | 0 |
| 16 | A Mesoscopic Self-assembled Ring of a Femtomole Fluorescein Sessile Droplet on Glass Slide Support显示文摘Since the solvent evaporation of a droplet on a hydrophobically pretreated glass slide, femtomole amount of fluorescent materials is carried by the evaporation and results in outward capillary flow to the perimeter of the droplet spot where the solute deposits, and forms a fluorescent ring like deposit (RLD) with submicrometer-scale structures. | ChengZhiHUANG YingLIU YuanFangLI | 2004 | Chinese Chemical Letters2004，15，5： | 0 |
| 17 | Dynamic Demonstration on Hydrophilicity Protein Molecular of Fibrosing Hepatic Tissue in Rats with Interven-tion of Fuzhenghuayu Decoction显示文摘 | YingLIU PingLIU Cheng-HaiLIU Lie-MingXU Yun-FeiCHEN Yi-YingHU ChenLIU Guang-LiDU BingWANG Yong-PingWU | 2004 | Acta Biochimica et Biophysica Sinica2004，36，1： | 0 |
| 18 | A Novel Method for N-terminal Acetylation Prediction显示文摘The NetAcet method has been developed to make predictions of N-terminal acetylation sites, but more information of the data set could be utilized to improve the performance of the model. By employing a new way to extract patterns from sequences and using a sample balancing mechanism, we obtained a correlation coefficient of 0.85, and a sensitivity of 93% on an independent mammalian data set. A web server utilizing this method has been constructed and is available at http://gffzz2b2853b00c584272h6ufpckqxxqqb6qfb.ffgz.tsg.suse.edu.cn/acetylation.html. | YingLiu YuanlieLin | 2004 | Genomics, Proteomics & Bioinformatics2004，2，4： | 0 |
| 19 | β_2-ADRENERGIC RECEPTOR GENE POLYMORPHISM IN CHINESE NORTHERN ASTHMATICS显示文摘To investigate whether the polymorphisms of β2-adrenergic receptor (β2-AR) at position 16, 27, 164 are asso-ciated with asthma in Northern Chinese subjects. Methods Genomic DNA was collected from unrelated Northern Chinese population of Han ethnicity, including 125 un-related asthmatic individuals and 96 healthy controls. β2-AR genes at position 16, 27, 164 were amplified by using restriction fragment length polymorphism (RFLP) and allelic specific polymerase chain reaction methods. All asthmatics had their serum IgE (total and specific) antibody or skin-prick test measured, bronchial reactivity to methacholine (Mch) and bronchial rever-sibility by β2-agonist evaluated. Results (1) The frequency of Gly 16 homozygous was significantly higher in the asthmatic group than that in healthy controls (22.4% vs. 8.3%, P < 0.05), OR was 2.9 with 95% CI 1.26-6.78. The proportion of Gly 16 allele was also higher in asthmatics than that in control (0.46 vs. 0.36, P < 0.05); Gly16 homozygous was not independently associated with asthma pathogenesis (P = 0.21, OR 0.42 with 95% CI 0.11-1.61). (2) Of 51 night attack patients, 18 carrying Gly16 homozygosity, if compared with 10 of 74 nonnocturnal asthmatics carrying this genotype, there was significant difference between these two groups (35.3% vs. 13.5%, P < 0.01). (3) The average dose of PD20-Mch was significantly lower in patients carrying Gln 27 homozygous than those carrying homozygous Glu 27 and Gln/Glu 27 heterozygous (0.2 ± 0.3, 1.6 ± 0.8, and 2.1 ± 3.0 μmol/L,P < 0.05). Conclusion β2-AR gene polymorphisms might confer susceptibility to asthma in Chinese Northern patients. β2-AR gene, coordinated with other candidate loci, plays a role in the development of asthma. | Jin-mingGao Yao-guangLin Chang-chunQiu Yi-wenLiu YiMa YingLiu | 2004 | Chinese Medical Sciences Journal2004，19，3： | 0 |
| 20 | Physical Parameters of a Flare Derived from Multi-line 2D Spectroscopy显示文摘Time series of 2D spectra of Hα and CaⅡ λ8542 for a flare of 1999 December 22 are obtained and analyzed with a new fitting technique. The method we proposed can simultaneously yield the four parameters: the line source function, the optical thickness at line center, the line-of sight velocity and the Doppler width. We present the spatial distributions of the physical parameters and their temporal evolutions determined from the 2D spectra. Our results are consistent with the general picture predicted by the flare dynamic models. | YingLiu Ming-De-Ding | 2001 | Chinese Journal of Astronomy and Astrophysics2001，1，5： | 0 |
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