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| 1 | 5-Hydroxymethylcytosine signatures in circulating cell-free DNA as diagnostic biomarkers for human cancers显示文摘象 5-methylcytosine (5mC ) 和 5-hydroxymethylcytosine (5hmC ) 那样的 DNA 修正是知道在哺乳动物影响全球基因表示的 epigenetic 标记。在人的染色体,与基因表示的靠近的关联和高化学的稳定性给他们的流行,这些 DNA epigenetic 标记能为癌症用作理想的 biomarkers 诊断。利用一种高度敏感、选择的化学标记技术,我们这里报导在传播没有房间的 DNA ( cfDNA )并且在从最近与 colorectal 诊断的 260 个病人的一个队收集的配对的肿瘤和邻近的纸巾的 genomic DNA ( gDNA )的 5hmC 的染色体宽的介绍,胃,胰腺,从 90 个健康个人的肝或甲状腺癌症和正常纸巾。5hmC 主要在与开的染色质和容许的 histone 修正重合的 transcriptionally 活跃的区域被散布。柔韧的联系癌症的 5hmC 签名在 cfDNA 被识别为特定的癌症类型是特征的。传播 cfDNA 的 5hmC 底 biomarkers colorectal 和胃的癌症是高度预兆的并且比常规 biomarkers 优异并且比得上从织物活体检视的 5hmC biomarkers。因此,这新策略能从血样品的分析为癌症的诊断和预后导致有效、最低限度地侵略的方法的发展。 | Wenshuai Li Xu Zhang Xingyu Lu Lei You Yanqun Song Zhongguang Luo Jun Zhang Ji Nie Wanwei Zheng Diannan Xu Yaping Wang Yuanqiang Dong Shulin Yu Jun Hong Jianping Shi Hankun Hao Fen Luo Luchun Hua Peng Wang Xiaoping Qian Fang Yuan Lianhuan Wei Ming Cui Taiping Zhang Quan Liao Menghua Dai Ziwen Liu Ge Chen Katherine Meckel Sarbani Adhikari Guifang Jia Marc B Bissonnette Xinxiang Zhang Yupei Zhao Wei Zhang Chuan He Jie Liu | 2017 | Cell Research2017，27，10： | 30 |
| 2 | Genetic and biological characteristics of the globally circulating H5N8 avian influenza viruses and the protective efficacy offered by the poultry vaccine currently used in China显示文摘The H5N8 avian influenza viruses have been widely circulating in wild birds and are responsible for the loss of over 33 million domestic poultry in Europe, Russia, Middle East, and Asia since January 2020. To monitor the invasion and spread of the H5N8 virus in China, we performed active surveillance by analyzing 317 wild bird samples and swab samples collected from 41,172 poultry all over the country. We isolated 22 H5N8 viruses from wild birds and 14 H5N8 viruses from waterfowls. Genetic analysis indicated that the 36 viruses formed two different genotypes: one genotype viruses were widely detected from different wild birds and domestic waterfowls;the other genotype was isolated from a whopper swan. We further revealed the origin and spatiotemporal spread of these two distinct H5N8 virus genotypes in 2020 and 2021. Animal studies indicated that the H5N8 isolates are highly pathogenic to chickens, mildly pathogenic in ducks, but have distinct pathotypes in mice. Moreover, we found that vaccinated poultry in China could be completely protected against H5N8 virus challenge. Given that the H5N8 viruses are likely to continue to spread in wild birds, vaccination of poultry is highly recommended in high-risk countries to prevent H5N8 avian influenza. | Pengfei Cui Xianying Zeng Xuyong Li Yanbing Li Jianzhong Shi Conghui Zhao Zhiyuan Qu Yanwen Wang Jing Guo Wenli Gu Qi Ma Yuancheng Zhang Weipeng Lin Minghui Li Jingman Tian Dongxue Wang Xin Xing Yanjing Liu Shuxin Pan Yaping Zhang Hongmei Bao Liling Liu Guobin Tian Chengjun Li Guohua Deng Hualan Chen | 2022 | Science China(Life Sciences)2022，65，4： | 12 |
| 3 | Impact of Mid-and Upper-Level Dry Air on Tropical Cyclone Genesis and Intensification:A Modeling Study of Durian(2001)显示文摘The impact of mid-and upper-level dry air,represented by low relative humidity(RH)values,on the genesis of tropical cyclone(TC)Durian(2001)in the South China Sea was investigated by a series of numerical experiments using the Weather Research and Forecasting model.The mid-level RH was lowered in different regions relative to TC Durian(2001)’s genesis location.Results suggest that the location of dry air was important to Durian(2001)’s genesis and intensification.The rapid development of the TC was accompanied by sustained near-saturated mid-and upper-level air,whereas low humidity decelerated its development.Water vapor budget analysis showed that moisture at mid and upper levels was mainly supplied by the vertical convergence of moisture flux and the divergence terms,and consumed by the condensation process.The horizontal convergence of moisture flux term supplied moisture in the air moistening process but consumed moisture in the air drying process.With a dryer mid-and upper-level environment,convective and stratiform precipitation were both inhibited.The upward mass fluxes and the diabatic heating rates associated with these two precipitation types were also suppressed.Generally,convection played the dominant role,since the impact of the stratiform process on vertical mass transportation and diabatic heating was much weaker.The vorticity budget showed that the negative vorticity convergence term,which was closely related to the inhibited convection,caused the vorticity to decrease above the lower troposphere in a dryer environment.The negative vorticity tendency is suggested to slow down the vertical coherence and the development rate of TCs. | Yaping WANG Yongjie HUANG Xiaopeng CUI | 2018 | Advances in Atmospheric Sciences2018，35，12： | 5 |
| 4 | Palaeodietary study of Sanxingcun Site,Jintan,Jiangsu显示文摘C and N stable isotope ratios of 19 human bones in Sanxingcun Site, Jintan, Jiangsu Province, were measured to explore the lifestyle and social economic structure. Although the bone collagen degraded to different extents, the atomic ratio of C/N was located in the range of 2.9-3.6, indicating that they were preserved very well. Average δ13C value (20.05±0.21‰), average δ 15N value (9.69 ±0.33‰) and poor positive correlation between each other suggested that rice agriculture was dominant with hunt-ing-fishing supplemented in human lifestyle. Poor negative correlation between δ 15N values and C3 percentages of foods implied relative independence of rice agriculture and hunting-fishing. Compared to Hemudu Site and Qingpu Site, rice agriculture was developed further, but hunting-fishing decreased. The mode for people in Sanxingcun Site to get the meat was still in the initial exploitation. | HU YaoWu WANG GenFu CUI YaPing DONG Yu GUAN Li WANG ChangSui | 2007 | Chinese Science Bulletin2007，52，5： | 4 |
| 5 | Decentralized Attribute-Based Encryption and Data Sharing Scheme in Cloud Storage显示文摘In this paper, we consider the problems of data sharing between multiple distrusted authorities. Prior solutions rely on trusted third parties such as CAs, or are susceptible to collusion between malicious authorities, which can comprise the security of honest ones. In this paper, we propose a new multi-authority data sharing scheme – Decentralized Multi-Authority ABE(DMA), which is derived from CP-ABE that is resilient to these types of misbehavior. Our system distinguishes between a data owner(DO) principal and attribute authorities(AAs): the DO owns the data but allows AAs to arbitrate access by providing attribute labels to users. The data is protected by policy encryption over these attributes. Unlike prior systems, attributes generated by AAs are not user-specific, and neither is the system susceptible to collusion between users who try to escalate their access by sharing keys. We prove our scheme correct under the Decisional Bilinear Diffie-Hellman(DBDH) assumption; we also include a complete end-to-end implementation that demonstrates the practical efficacy of our technique. | Xiehua Li Yanlong Wang Ming Xu Yaping Cui | 2018 | China Communications2018，15，2： | 4 |
| 6 | Effects of extracts from Chuanwu(Aconitum Carmichaelii) and Banxia(Rhizoma Pinelliae) on excisional wound healing in a rat's model显示文摘OBJEVTIVE: To investigate the effects of extracts from Chuanwu(Aconitum Carmichaelii) and Banxia(Rhizoma Pinelliae) on the excisional wound healing in a rat's model.METHODS: Rats were performed a surgical lesion with a 2.0 cm resected tissue in the dorsal fascia.Following, animals were randomly divided into model group, YNB group and APE group those were respectively treated with saline, 1 mg/mL of Yunnan Baiyao and 1 mg/mL of Chuanwu(Aconitum Carmichaelii) and Banxia(Rhizoma Pinelliae) extracts. Wound contractions in days 0, 3, 7, 14 and 21 were calculated by an image analyzer. Histological analysis was analyzed using hematoxilin and eosin.Levels of tumor necrosis factor-2(IL-2), IL-4, IL-10, transformαin(TNF-g growα), interleukinth factor-1(TGF-nd basic fibroblast growth factor(bFββ1) a-GF) were determined by real-time quantitative PCR.RESULTS: Compared with that of YNB group and APE gtoup, the skin of rats showed poor re-modeling and re-epithelization characterized by a significant decrease of neovascularization, epithelialization and fibroblast in the model group. In the APE group, levels of TNF-α-and IL-2 were significantly down-regulated and IL4 and IL-10 significantly upregulated in contrasted with that of model group.In addition, levels of TGF-roup were significantly iβ1 and bFGF in the APE gnduced compared with that of model group.CONCLUSION: The results suggest that the extracts from Chuanwu(Aconitum Carmichaelii) and Banxia(Rhizoma Pinelliae) promote wound healing in the rats, which is associated with enhancing antiinflammatory ability and inducing fibroblast formation. | Xia Xichao Ma Yuhong Wang Fuan Zheng Xinhua Liu Yang Zhang Junfeng Cui Juan Shi Bingqin Li Hongwen Liu Rongzhi Zhang Yaping Cheng Zhaofei Han Xiaolong | 2019 | Journal of Traditional Chinese Medicine2019，39，1： | 4 |
| 7 | Differences between Convective and Stratiform Precipitation Budgets in a Torrential Rainfall Event显示文摘Differences in rainfall budgets between convective and stratiform regions of a torrential rainfall event were investigated using high-resolution simulation data produced by the Weather Research and Forecasting(WRF) model. The convective and stratiform regions were reasonably separated by the radar-based convective–stratiform partitioning method, and the threedimensional WRF-based precipitation equation combining water vapor and hydrometeor budgets was further used to analyze the rainfall budgets. The results showed that the magnitude of precipitation budget processes in the convective region was one order larger than that in the stratiform region. In convective/stratiform updraft regions, precipitation was mainly from the contribution of moisture-related processes, with a small negative contribution from cloud-related processes. In convective/stratiform downdraft regions, cloud-related processes played positive roles in precipitation, while moisture-related processes made a negative contribution. Moisture flux convergence played a dominant role in the moisture-related processes in convective or stratiform updraft regions, which was closely related to large-scale dynamics. Differences in cloud-related processes between convective and stratiform regions were more complex compared with those in moisture-related processes.Both liquid-and ice-phase microphysical processes were strong in convective/stratiform updraft regions, and ice-phase processes were dominant in convective/stratiform downdraft regions. There was strong net latent heating within almost the whole troposphere in updraft regions, especially in the convective updraft region, while the net latent heating(cooling) mainly existed above(below) the zero-layer in convective/stratiform downdraft regions. | Yongjie HUANG Yaping WANG Xiaopeng CUI | 2019 | Advances in Atmospheric Sciences2019，36，5： | 4 |
| 8 | Uniform ordered mesoporous ZnCo2O4 nanospheres for super-sensitive enzyme-free H2O2 biosensing and glucose biofuel cell applications显示文摘一致、订的 mesoporous ZnCo 2 O 4(meso-ZnCo 2 O 4) nanospheres 成功地用一个牺牲的模板方法被综合。meso-ZnCo 2 O 4 nanospheres 为 H 2 O 2 biosensing 并且在葡萄糖 biofuel,房间(GBFC ) 作为酶模仿。meso-ZnCo 2 O 4 nanospheres 不仅在 H 2 O 2 传感器,完成高敏感(658.92 A ??? ? ??? 洠捩潲猭灵牥慣慰楣潴獲?? | Shiqiang Cui Li Li Yaping Ding Jiangjiang Zhang QingshengWu Zongqian Hu | 2017 | Nano Research2017，10，7： | 3 |
| 9 | Salivary protease spectrum biomarkers of oral cancer显示文摘Proteases are important molecules that are involved in many physiological and pathological processes of the human body,such as growth,apoptosis and metastasis cancer cells.They are potential targets in cancer diagnosis and biotherapy.In this study,we analyzed the salivary protease spectrum of patients with oral squamous cell carcinoma (OSCC),oral benign masses and chronic periodontitis,as well as that of health,using human protease array kits,enzyme-linked immunosorbent assay,western blot and immunofluorescence.The salivary protease spectrum was found to be associated with oral diseases.For example,the saliva of patients with OSCC contained increased numbers of proteases than those of other oral diseases and health.The levels of matrix metalloproteinase (MMP)-1,MMP-2,MMP-10,MMP-12,A disintegrin and metalloprotease (ADAM)9,A disintegrin and metalloprotease with thrombospondin type 13 motifs (ADAMST13),cathepsin V and kallikrein 5 in the saliva of patients with OSCC were significantly increased compared with those of other groups.Taking MMP-1,cathepsin V,kallikrein 5 and ADAM9 as biomarkers of OSCC,cutoff values were199,11.34,9.29 and 202.55 pg·mL?1,respectively.From the area under the curve,sensitivity and specificity,the combination of cathepsin V/kallikrein5/ADAM9 was an optimal biomarker for diagnosing OSCC.Thus,analysis of the salivary protease spectrum may be an innovative and cost-efficient approach to evaluating the health status of the oral cavity.Specifically,increases in cathepsin V,kallikrein 5 and ADAM9 may be useful biomarkers in the screening and diagnosis of OSCC. | Yun Feng Qian Li Jiao Chen Ping Yi Xin Xu Yaping Fan Bomiao Cui Yu Yu Xiaoying Li Yue Du Qianming Chen Lingling Zhang Jingjing Jiang Xuedong Zhou Ping Zhang | 2019 | International Journal of Oral Science2019，11，2： | 2 |
| 10 | Effects of high magnetic field on the evolutions of constituent phases in 7085 aluminum alloy during homogenization显示文摘 | Lizi He Xiehua Li Pei Zhu Yiheng Cao Yaping Guo Jianzhong Cui | 2012 | Materials Characterization2012，，： | 2 |
| 11 | Preparation and characterization of ovalbumin and carboxymethyl cellulose conjugates via glycosylation显示文摘 | Xiaopeng Geng Bing Cui Yan Li Weiping Jin Yaping An Bin Zhou Ting Ye Lei He Hongshan Liang Ling Wang Yijie Chen Bin Li | 2014 | Food Hydrocolloids2014，，： | 1 |
| 12 | Effects of high magnetic field on the evolutions of constituent phases in 7085 aluminum alloy during homogenization显示文摘 | Lizi He Xiehua Li Pei Zhu Yiheng Cao Yaping Guo Jianzhong Cui | 2012 | Materials Characterization2012，，： | 1 |
| 13 | Agronomic cultivation measures on productivity of oilseed flax:A review显示文摘Oilseed flax is one of the most important oil crops in China.With the improvement of people's living standards and the deepening knowledge of the nutritional value of oilseed flax,the demand and economic value of oilseed flax are increasing,and the cultivated area in China is expanding.However,the grain yield of oilseed flax is lower than other oil crops.It varies significantly from year to year,combined with a lower degree of mechanization,which has greatly limited the healthy development of the flax industry.Some of the effects of agronomic measures on productivity and water use efficiency of oilseed flax are reviewed in this paper.The major agronomic strategies for the productivity of oilseed flax were presented based on fertilization,plant density,irrigation,cropping pattern and weed control.Future research should investigate the effect of silicon and potassium fertilizers on the mechanism of lodging resistance of oilseed flax,the effects of diversified cropping systems(strip intercropping and crop rotation)on high and stable productivity and efficient utilization of resources. | Zhengjun Cui Bin Yan Yuhong Gao Bing Wu Yifan Wang Haidi Wang Peng Xu Bangqing Zhao Zhi Cao Yong Zhang Yaping Xie Yapeng Hu Xingbang Ma Junyi Niu | 2022 | Oil Crop Science2022，7，1： | 1 |
| 14 | Measured and Predicted Solubility Phase Diagrams of Quaternary Systems LiBr-NaBr-MgBr2-H2O and LiBr-KBr-MgBr2-H2O at 298.15 K显示文摘The stable phase equilibria of quaternary systems LiBr-NaBr-MgBrz-H2O and LiBr-KBr-MeBr-HO at 298.15 K were studied by both experimental measurement(isothermal solution saturation method)and theoretica prediction(Pitzer model).The solubilities of the saturated solution have been determined experimentally and two sta ble phase diagrams and relevant water diagrams of the two quaternary systems were obtained.Results show that qua ternary system LiBr-NaBr-MgBrz-H2O is hydrateⅡtype as NaBr and NaBr-2H2O coexistence.Its phase diagran consists of only one invariant point,four univariant curves,and five crystallization fields.The quaternary system LiBr-KBr-MgBr2-H2O is a complex type as the double salt KBr MgBrz-6H2O formed.In addition to this double salt the three single salts LiBr-2H2O,KBr and MgBr2:6H2O also crystallize.In this paper,the solubilities of phase equilibria in above quaternary systems were also calculated by the Pitzer's electrolyte solution model.All the neededparameters can be obtained from the literature or be fitted by experimental data.On the Basis of the experimental and alculated results,the phase diagram of the quaternary system was plotted for comparison.It shows that the calculation results are consistent with the experimental ones. | CUI Ruizhi LI Wu DONG Yaping LI Jun | 2020 | Chemical Research in Chinese Universities2020，36，6： | 1 |
| 15 | Based on the cost line toll lanes open operating costs and the number of driver optimization显示文摘 | CUI Hongjun LI Yaping | 2013 | Highway2013，，4： | 1 |
| 16 | Relationship between micro-porosity and tensile properties of 6063 alloy显示文摘The micro-porosity is usually present in the as-cast microstructure,which decreases the tensile strength and ductility and therefore limit the application of cast aluminum parts.Although much work has been done to investigate the effects of various casting parameters on the formation of porosity in various aluminum alloys,up to now,little information has been available for the relationship between micro-porosity and tensile properties of 6063 alloy.In this study,the influences of size and area fraction of micro-porosity on the tensile properties and fracture behavior of 6063 aluminum alloy were investigated by means of tensile testing,optical microscopy(OM),and scanning electron microscopy(SEM).The tensile tests were conducted in air at 100 ℃,200 ℃ and 300 ℃,respectively.Results show that the large micro-porosity with sizes between 100 μm and 800 μm located at the center and top of the ingot,while the small micro-porosity with size between 2 μm and 60 μm distributed at the edge and bottom of the ingot.The area fraction of micro-porosity at the center of the ingot is much bigger than that at the edge of the ingot.When tested at 100 ℃,with the decrease in the area fraction of micro-porosity from the top of the ingot to the bottom of the ingot,the ultimate tensile strength,yield strength and the elongation are increased from 82 to 99 MPa,32 to 66 MPa and 7% to 11%,respectively.When the temperature is no more than 200 ℃,the strain hardening exponent decreases with an increase in the area fraction of micro-porosity;while the deviation disappears when the temperature reaches 300 ℃.The fracture mode of the alloy is greatly influenced by the size and area fraction of the micro-porosity. | Li Xiehua He Lizi Zhu Pei Cao Yiheng Guo Yaping Cui Jianzhong | 2013 | China Foundry2013，10，1： | 1 |
| 17 | Functional properties of ovalbumin glycosylated with carboxymethyl cellulose of different substitution degree显示文摘 | An Yaping Cui Bing Wang Yuntao | 2014 | Food Hydrocolloids2014，40，： | 1 |
| 18 | Electron-ion collider in China显示文摘Lepton scattering is an established ideal tool for studying inner structure of small particles such as nucleons as well as nuclei.As a future high energy nuclear physics project,an Electron-ion collider in China(EicC)has been proposed.It will be constructed based on an upgraded heavy-ion accelerator,High Intensity heavy-ion Accelerator Facility(HIAF)which is currently under construction,together with a new electron ring.The proposed collider will provide highly polarized electrons(with a po-larization of 80%)and protons(with a polarization of 70%)with variable center of mass energies from 15 to 20 GeV and the luminosity of(2–3)×1033 cm^(−2)·s^(−1).Polarized deuterons and Helium-3,as well as unpolarized ion beams from Carbon to Uranium,will be also available at the EicC.The main foci of the EicC will be precision measurements of the structure of the nucleon in the sea quark region,including 3D tomography of nucleon;the partonic structure of nuclei and the parton interaction with the nuclear environment;the exotic states,especially those with heavy flavor quark contents.In addition,issues fundamental to understanding the origin of mass could be addressed by measurements of heavy quarkonia near-threshold production at the EicC.In order to achieve the above-mentioned physics goals,a hermetical detector system will be constructed with cutting-edge technologies.This document is the result of collective contributions and valuable inputs from experts across the globe.The EicC physics program complements the ongoing scientific programs at the Jefferson Laboratory and the future EIC project in the United States.The success of this project will also advance both nuclear and particle physics as well as accelerator and detector technology in China. | Daniele PAnderle Valerio Bertone Xu Cao Lei Chang Ningbo Chang Gu Chen Xurong Chen Zhuojun Chen Zhufang Cui Lingyun Dai Weitian Deng Minghui Ding Xu Feng Chang Gong Longcheng Gui Feng-Kun Guo Chengdong Han Jun He Tie-Jiun Hou Hongxia Huang Yin Huang KrešImir KumeričKi LPKaptari Demin Li Hengne Li Minxiang Li Xueqian Li Yutie Liang Zuotang Liang Chen Liu Chuan Liu Guoming Liu Jie Liu Liuming Liu Xiang Liu Tianbo Liu Xiaofeng Luo Zhun Lyu Boqiang Ma Fu Ma Jianping Ma Yugang Ma Lijun Mao Cédric Mezrag HervéMoutarde Jialun Ping Sixue Qin Hang Ren Craig DRoberts Juan Rojo Guodong Shen Chao Shi Qintao Song Hao Sun PawełSznajder Enke Wang Fan Wang Qian Wang Rong Wang Ruiru Wang Taofeng Wang Wei Wang Xiaoyu Wang Xiaoyun Wang Jiajun Wu Xinggang Wu Lei Xia Bowen Xiao Guoqing Xiao Ju-Jun Xie Yaping Xie Hongxi Xing Hushan Xu Nu Xu Shusheng Xu Mengshi Yan Wenbiao Yan Wencheng Yan Xinhu Yan Jiancheng Yang Yi-Bo Yang Zhi Yang Deliang Yao Zhihong Ye Peilin Yin C-PYuan Wenlong Zhan Jianhui Zhang Jinlong Zhang Pengming Zhang Yifei Zhang Chao-Hsi Chang Zhenyu Zhang Hongwei Zhao Kuang-Ta Chao Qiang Zhao Yuxiang Zhao Zhengguo Zhao Liang Zheng Jian Zhou Xiang Zhou Xiaorong Zhou Bingsong Zou Liping Zou | 2021 | Frontiers of physics2021，16，6： | 1 |
| 19 | Functional properties of ovalbumin glycosylated with carboxyrnethyl cellulose of different substitution degree 显示文摘 | An Yaping Cui Bing Wang Yuntao | 2014 | Food Hydrocolloids2014，40，： | 1 |
| 20 | Cryo-EM structures of PAC1 receptor reveal ligand binding mechanism显示文摘The pituitary adenylate cyclase-activating polypeptide type I receptor(PAC1R)belongs to the secretin receptor family and is widely distributed in the central neural system and peripheral organs.Abnormal activation of the receptor mediates trigeminovascular activation and sensitization,which is highly related to migraine,making PAC1R a potential therapeutic target.Elucidation of PAC1R activation mechanism would benefit discovery of therapeutic drugs for neuronal disorders.PAC1R activity is governed by pituitary adenylate cyclase-activating polypeptide(PACAP),known as a major vasodilator neuropeptide,and maxadilan,a native peptide from the sand fly,which is also capable of activating the receptor with similar potency.These peptide ligands have divergent sequences yet initiate convergent PAC1R activity.It is of interest to understand the mechanism of PAC1R ligand recognition and receptor activity regulation through structural biology.Here we report two near-atomic resolution cryo-EM structures of PAC1R activated by PACAP38 or maxadilan,providing structural insights into two distinct ligand binding modes.The structures illustrate flexibility of the extracellular domain(ECD)for ligands with distinct conformations,where ECD accommodates ligands in different orientations while extracellular loop 1(ECU)protrudes to further anchor the ligand bound in the orthosteric site.By structureguided molecular modeling and mutagenesis,we tested residues in the ligand-binding pockets and identified clusters of residues that are critical for receptor activity.The structures reported here for the first time elucidate the mechanism of specificity and flexibility of ligand recognition and binding for PACT R,and provide insights toward the design of therapeutic molecules targeting PAC1R. | Jia Wang Xianqiang Song Dandan Zhang Xiaoqing Chen Xun Li Yaping Sun Cui Li Yunpeng Song Yao Ding Ruobing Ren Essa Hu Harrington Liaoyuan AHu Wenge Zhong Cen Xu Xin Huang Hong-Wei Wang Yingli Ma | 2020 | Cell Research2020，30，5： | 1 |
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