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| 1 | Genetic and biological characteristics of the globally circulating H5N8 avian influenza viruses and the protective efficacy offered by the poultry vaccine currently used in China显示文摘The H5N8 avian influenza viruses have been widely circulating in wild birds and are responsible for the loss of over 33 million domestic poultry in Europe, Russia, Middle East, and Asia since January 2020. To monitor the invasion and spread of the H5N8 virus in China, we performed active surveillance by analyzing 317 wild bird samples and swab samples collected from 41,172 poultry all over the country. We isolated 22 H5N8 viruses from wild birds and 14 H5N8 viruses from waterfowls. Genetic analysis indicated that the 36 viruses formed two different genotypes: one genotype viruses were widely detected from different wild birds and domestic waterfowls;the other genotype was isolated from a whopper swan. We further revealed the origin and spatiotemporal spread of these two distinct H5N8 virus genotypes in 2020 and 2021. Animal studies indicated that the H5N8 isolates are highly pathogenic to chickens, mildly pathogenic in ducks, but have distinct pathotypes in mice. Moreover, we found that vaccinated poultry in China could be completely protected against H5N8 virus challenge. Given that the H5N8 viruses are likely to continue to spread in wild birds, vaccination of poultry is highly recommended in high-risk countries to prevent H5N8 avian influenza. | Pengfei Cui Xianying Zeng Xuyong Li Yanbing Li Jianzhong Shi Conghui Zhao Zhiyuan Qu Yanwen Wang Jing Guo Wenli Gu Qi Ma Yuancheng Zhang Weipeng Lin Minghui Li Jingman Tian Dongxue Wang Xin Xing Yanjing Liu Shuxin Pan Yaping Zhang Hongmei Bao Liling Liu Guobin Tian Chengjun Li Guohua Deng Hualan Chen | 2022 | Science China(Life Sciences)2022，65，4： | 12 |
| 2 | Characteristics of strike-slip inversion structures of the Karatau fault and their petroleum geological significances in the South Turgay Basin,Kazakhstan显示文摘The Karatau fault is one of the important strike-slip faults in central Asia,and the South Turgay Basin is located towards its northern end.Detailed seismic interpretation indicated that the strikeslip tectonism of the Karatau fault weakened gradually from west to east in the South Turgay Basin.Typical flower structures developed on the section,and strike-slip faults showed an echelon pattern on planar view.The Karatau strike-slip fault affected the South Turgay Basin in two periods:(1) The South Turgay strike-slip pull-apart rift basin formed as a result of regional extensive stress in the Early-Middle Jurassic,characterized by the juxtaposition of horsts and grabens.The formation of horsts provided favorable reservoir spaces for later hydrocarbon accumulation,and different filling stages of grabens controlled different reservoir-forming factors in grabens.(2) Two stages of tectonic inversion occurred in the Late Jurassic and Late Cretaceous and played a crucial role in the final shape of the structure in the South Turgay Basin.The oil and gas migrated to form reservoirs and mainly concentrated in the horsts,graben slopes and in both sides of the strike-slip fault zone.In the case of the degree of accumulation of petroleum,the factor explaining why horsts are better than grabens is the strike-slip pull-apart of the South Turgay Basin,and the structure inversion of the South Turgay Basin explains why the west graben is better than the east one.Overall,the Karatau strike-slip fault played a very important role in the formation of the South Turgay Basin and its hydrocarbon accumulations. | Yin Wei Fan Zifei Zheng Junzhang Yin Jiquan Zhang Mingjun Sheng Xiaofeng Guo Jianjun Li Qiyan Lin yaping | 2012 | Petroleum Science2012，9，4： | 11 |
| 3 | Global Dynamic Molecular Profiling of Stomatal Lineage Cell Development by Single-Cell RNA Sequencing显示文摘The regulation of stomatal lineage cell development has been extensively investigated.However,a comprehensive characterization of this biological process based on single-cell transcriptome analysis has not yet been reported.In this study,we performed RNA sequencing on 12844 individual cells from the cotyledons of 5-day-old Arabidopsis seedlings.We identified 11 cell clusters corresponding mostly to cells at specific stomatal developmental stages using a series of marker genes.Comparative analysis of genes with the highest variable expression among these cell clusters revealed transcriptional networks that regulate development from meristemoid mother cells to guard mother cells.Examination of the developmental dynamics of marker genes via pseudo-time analysis revealed potential interactions between these genes.Collectively,our study opens the door for understanding how the identified novel marker genes participate in the regulation of stomatal lineage cell development. | Zhixin Liu Yaping Zhou Jinggong Guo Jiaoai Li Zixia Tian Zhinan Zhu Jiajing Wang Rui Wu Bo Zhang Yongjian Hu Yijing Sun Yan Shangguan Weiqiang Li Tao Li Yunhe Hu Chenxi Guo Jean-David Rochaix Yuchen Miao Xuwu Sun | 2020 | Molecular Plant2020，13，8： | 11 |
| 4 | Thermodynamic modeling and phase diagram prediction of salt lake brine systems.Ⅰ. Aqueous Mg^2+–Ca^2+–Cl^- binary and ternary systems显示文摘Salt lake brine is a complex salt-water system under natural environment.Although many models can express the thermodynamic properties and phase equilibrium of electrolyte aqueous solution,the multi-temperature characteristics and predictability are still the goals of model development.In this study,a comprehensive thermodynamic model system is re-established based on the eNRTL model and some improvements:(1) new expression of long-range electrostatic term with symmetrical reference state is proposed to handle the electrolyte solution covering entire concentration range;(2) the temperature dependence of the binary interaction parameters is formulated with a Gibbs Helmholtz expression containing three temperature coefficients,the liquid parameters,which associated with Gibbs energy,enthalpy,and heat capacity contribution;and(3) liquid parameters and solid species data are regressed from properties and solubility data at full temperature range.Together the activity coefficient model,property models and parameters of liquid and solid offer a comprehensive thermodynamic model system for the typical bittern of MgCl2-CaCl2-H2 O binary and ternary systems,and it shows excellent agreement with the literature data for the ternary and binary systems.The successful prediction of complete phase diagram of ternary system shows that the model has the ability to deal with high concentration and high non-idealitv system,and the ability to extrapolate the temperature. | Huan Zhou Xiaolong Gu Yaping Dai Jingjing Tang Jian Guo Guangbi Li Xiaoqin Bai | 2020 | Chinese Journal of Chemical Engineering2020，28，9： | 9 |
| 5 | A Survey on Emerging Computing Paradigms for Big Data显示文摘The explosive growth of data volume and the ever-increasing demands of data value extraction have driven us into the era of big data. The '5V'(Variety,Velocity, Volume, Value, and Veracity) characteristics of big data pose great challenges to traditional computing paradigms and motivate the emergence of new solutions.Cloud computing is one of the representative technologies that can perform massive-scale and complex data computing by taking advantages of virtualized resources, parallel processing and data service integration with scalable data storage. However, as we are also experiencing the revolution of Internet-of-things(IoT), the limitations of cloud computing on supporting lightweight end devices significantly impede the flourish of cloud computing at the intersection of big data and IoT era. It also promotes the urgency of proposing new computing paradigms. We provide an overview on the topic of big data, and a comprehensive survey on how cloud computing as well as its related technologies can address the challenges arisen by big data.Then, we analyze the disadvantages of cloud computing when big data encounters IoT, and introduce two promising computing paradigms, including fog computing and transparent computing, to support the big data services of IoT. Finally, some open challenges and future directions are summarized to foster continued research efforts into this evolving field of study. | ZHANG Yaoxue REN Ju LIU Jiagang XU Chugui GUO Hui LIU Yaping | 2017 | Chinese Journal of Electronics2017，26，1： | 8 |
| 6 | Study the ethanol SI/HCCI combustion mode transition by using the fast thermal management system显示文摘In this paper the ethanol homogeneous charge compression ignition (HCCI) is achieved in a modified single cylinder engine by means of a self-developed fast thermal management system (FTMS), and the ethanol SI/HCCI operation regions are defined. It can be concluded that the thermal efficiency is higher and the NOx emission is lower in the HCCI operation region. In addition, the maximum NOx emission drops by 98%. The ethanol SI/HCCI combustion mode transition is conducted in different conditions near the SI/HCCI operation boundaries. It is likely to realize the transition by the utilization of FTMS. However, it is impossible to complete the transition within one operating cycle under current operation conditions. There are fluctuations in engine speed and brake mean effective pressure during the transition process. In order to reduce the fluctuations during the transition, the initial work concerning the effects of the spark ignition on the transition smoothness is carried out and the investigation indicates that the engine speed and brake mean effective pressure fluctuations cannot be eradicated only through spark ignition. Therefore, the control strategies combined with other factors should be further optimized. | PENG YaPing TAN ManZhi GUO Liang LIU FaFa LI Hua GUO YingNan | 2007 | Chinese Science Bulletin2007，52，19： | 8 |
| 7 | RNA interference targeting CD147 inhibits metastasis and invasion of human breast cancer MCF-7 cells by downregulating MIVIP-9/VEGF expression显示文摘 | Fang Li Junping Zhang Jiqiang Guo Yuan Jia Yaping Han Zhuanhua Wang | 2018 | Acta Biochimica et Biophysica Sinica2018，50，7： | 7 |
| 8 | Oleic Acid and Eicosapentaenoic Acid Reverse Palmitic Acid-induced Insulin Resistance in Human HepG2 Cells via the Reactive Oxygen Species/JUN Pathway显示文摘Oleic acid(OA),a monounsaturated fatty acid(MUFA),has previously been shown to reverse saturated fatty acid palmitic acid(PA)-induced hepatic insulin resistance(IR).However,its underlying molecular mechanism is unclear.In addition,previous studies have shown that eicosapentaenoic acid(EPA),aω-3 polyunsaturated fatty acid(PUFA),reverses PA-induced muscle IR,but whether EPA plays the same role in hepatic IR and its possible mechanism involved need to be further clarified.Here,we confirmed that EPA reversed PA-induced IR in HepG2 cells and compared the proteomic changes in HepG2 cells after treatment with different free fatty acids(FFAs).A total of 234 proteins were determined to be differentially expressed after PA+OA treatment.Their functions were mainly related to responses to stress and endogenous stimuli,lipid metabolic process,and protein binding.For PA+EPA treatment,the PA-induced expression changes of 1326 proteins could be reversed by EPA,415 of which were mitochondrial proteins,with most of the functional proteins involved in oxidative phosphorylation(OXPHOS)and tricarboxylic acid(TCA)cycle.Mechanistic studies revealed that the protein encoded by JUN and reactive oxygen species(ROS)play a role in OA-and EPA-reversed PA-induced IR,respectively.EPA and OA alleviated PA-induced abnormal adenosine triphosphate(ATP)production,ROS generation,and calcium(Ca^(2+))content.Importantly,H_(2)O_(2)-activated production of ROS increased the protein expression of JUN,further resulting in IR in HepG2 cells.Taken together,we demonstrate that ROS/JUN is a common response pathway employed by HepG2 cells toward FFA-regulated IR. | Yaping Sun Jifeng Wang Xiaojing Guo Nali Zhu Lili Niu Xiang Ding Zhensheng Xie Xiulan Chen Fuquan Yang | 2021 | Genomics, Proteomics & Bioinformatics2021，19，5： | 6 |
| 9 | Antigenic analysis of grass carp reovirus using single-chain variable fragment antibody against IgM from Ctenopharyngodon idella显示文摘Grass carp (Ctenopharyngodon idella) is an important species of freshwater aquaculture fish in China. However, grass carp reovirus (GCRV) can cause fatal hemorrhagic disease in yearling populations. Until now, a strategy to define the antigenic capacity of the virus's structural proteins for preparing an effective vaccine has not been available. In this study, some single-chain variable fragment antibodies (scFv), which could specifically recognize grass carp IgM, were selected from a constructed mouse na ve antibody phage display cDNA library. The identified scFv C1B3 clone was shown to possess relatively higher specific binding activity to grass carp IgM. Furthermore, ELISA analysis indicated that the IgM level in serum from virus-infected grass carp was more than two times higher than that of the control group at 5-7 days post infection. Moreover, Western blot analysis demonstrated that the outer capsid protein VP7 has a specific immuno-binding-reaction with the serum IgM from virus-infected grass carp. Our results suggest that VP7 can induce a stronger immune response in grass carp than the other GCRV structural proteins, which implies that VP7 protein could be used as a preferred immunogen for vaccine design. | CHEN CongLin SUN XiaoYun LIAO LanJie LUO ShaoXiang LI ZhouQuan ZHANG XiaoHua WANG YaPing GUO QionLin FANG Qin DAI HePing | 2013 | Science China(Life Sciences)2013，56，1： | 6 |
| 10 | Natural selection and adaptive evolution of leptin显示文摘Leptin is an adiposity-secreted hormone that is pivotal in regulating feeding behavior,energy metabolism and body mass.The study of leptin has been of crucial importance for public health and pharmaceutical intervention given its role in obesity.Generally,leptin is highly conserved due to its functional importance.However,episodes of rapid sequence evolution and positive selection have been observed in some mammalian species,indicating that the leptin functions in these animals may have undergone adaptive modification to their environments.In this article,we review the adaptive evolution of leptin and its potential functional consequences.This review is expected to guide future research of molecular evolution and functional assays of this gene,and also to provide a theoretical foundation for the use of leptin in therapeutic applications. | ZOU Guo ZHANG YaPing YU Li | 2013 | Chinese Science Bulletin2013，58，17： | 5 |
| 11 | A New Species of the Genus Thermophis(Serpentes: Colubridae) from Shangri-La, Northern Yunnan, China, with a Proposal for an Eclectic Rule for Species Delimitation显示文摘The hot-spring snakes, Thermophis, were previously known only from the Tibet Autonomous Region and Western Sichuan, China. During the past two years, three adult hot-spring snakes(2 females, 1 male) were sampled in Shangri-La, northern Yunnan, China, thus expanding their known distribution region towards the southeast. This site is the southeastern-most corner of the Tibetan Plateau and the southernmost tip of the Hengduan Mountains(Mts.). Phylogenetic analysis of mitochondrial(mt) and nuclear(n) DNA segments suggested that the three specimens belong to the genus of Thermophis. Morphologically, the new species is more similar to T. zhaoermii. However, it is distinguished from T. zhaoermii in the number of maxillary teeth(15), distance between the two eyes/head width, rostral width/height, mental width/height, in one character limited to female: head width/length, and in four characters restricted to male: occurrence of the reduction from 10 to 8(8 to 6, 6 to 4) scales in each dorsal row on the tail. There are differences in morphology, genetics(mt DNA, n DNA), and geography between the putative new species and T. zhaoermii, the new species meets our proposed eclectic and feasible 'four-differences' rule. | Lifang PENG Changhu LU Song HUANG Peng GUO Yaping ZHANG | 2014 | Asian Herpetological Research2014，5，4： | 4 |
| 12 | Structural basis for bivalent binding and inhibition of SARS-CoV-2 infection by human potent neutralizing antibodies显示文摘Neutralizing monoclonal antibodies(nAbs)to severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)represent promising candidates for clinical intervention against coronavirus disease 2019(COVID-19).We isolated a large number of nAbs from SARS-CoV-2-infected individuals capable of disrupting proper interaction between the receptor binding domain(RBD)of the viral spike(S)protein and the receptor angiotensin converting enzyme 2(ACE2).However,the structural basis for their potent neutralizing activity remains unclear.Here,we report cryo-EM structures of the ten most potent nAbs in their native full-length IgG-form or in both IgG-form and Fab-form bound to the trimeric S protein of SARS-CoV-2.The bivalent binding of the full-length IgG is found to associate with more RBDs in the“up”conformation than the monovalent binding of Fab,perhaps contributing to the enhanced neutralizing activity of IgG and triggering more shedding of the S1 subunit from the S protein.Comparison of a large number of nAbs identified common and unique structural features associated with their potent neutralizing activities.This work provides a structural basis for further understanding the mechanism of nAbs,especially through revealing the bivalent binding and its correlation with more potent neutralization and the shedding of S1 subunit. | Renhong Yan Ruoke Wang Bin Ju Jinfang Yu Yuanyuan Zhang Nan Liu Jia Wang Qi Zhang Peng Chen Bing Zhou Yaning Li Yaping Shen Shuyuan Zhang Long Tian Yingying Guo Lu Xia Xinyue Zhong Lin Cheng Xiangyang Ge Juanjuan Zhao Hong-Wei Wang Xinquan Wang Zheng Zhang Linqi Zhang Qiang Zhou | 2021 | Cell Research2021，31，5： | 4 |
| 13 | Joining of Zirconia and Ti-6Al-4V Using a Ti-based Amorphous Filler显示文摘Polycrystalline ZrO2-3 mol.%Y2O3 was brazed to Ti-6Al-4V by using a Ti47Zr28Cu14Ni11(at.%) amorphous ribbon at 1123-1273 K in a high vacuum. The influences of brazing temperature on the microstructure and shear strength of the joints were investigated. The interfacial microstructures can be described as ZrO2/TiO+TiO2+Cu2Ti4O+Ni2Ti4O/α-Ti+(Ti,Zr)2(Cu,Ni) eutectic/acicular Widmanst¨aten structure/Ti-6Al-4V alloy. With the increase in the brazing temperature, the thickness of the TiO+TiO2+Cu2Ti4O+Ni2Ti4O layer reduced, the content of the α-Ti+(Ti,Zr)2(Cu,Ni) eutectic phase decreased, while that of the coarse α-Ti phase gradually increased. The shear strength of the joints did not show a close relationship with the thickness of the TiO+TiO2+Cu2Ti4O+Ni2Ti4O layer. However, when the coarse (Ti,Zr)2(Cu,Ni) phase was non-uniformly distributed in the α-Ti phase, or when α-Ti solely situated at the center of the joint, forming a coarse block or even connecting into a continuous strip, the shear strength greatly decreased. | Yuhua Liu Jiandong Hu Yaping Zhang Zuoxing Guo Yue Yang | 2011 | Journal of Materials Science & Technology2011，27，7： | 3 |
| 14 | Molecular cloning of growth hormone receptor (GHR) from common carp(Cyprinus carpio L.)and identification of its two forms of mRNA transcripts显示文摘The cDNA of growth hormone receptor (GHR) was cloned from the liver of 2-year common carp (Cyprinus carpio L.) by reverse transcription-polymerase chain reaction (RT-PCR) and rapid amplification of cDNA end (RACE). Its open reading frame (ORF) of 1806 nucleotides is translated into a putative peptide of 602 amino acids, including an extracellular ligand-binding domain of 244 amino acids (aa), a single transmembrane domain of 24 aa and an intracellular signal-transduction domain of 334 aa. Sequence analysis indicated that common carp GHR is highly homologous to goldfish (Carassius auratus) GHR at both gene and protein levels. Using a pair of gene-specific primers, a GHR fragment was amplified from the cDNA of 2-year common carp, a 224 bp product was identified in liver and a 321 bp product in other tissues. The sequencing of the products and the partial genomic DNA indicated that the difference in product size was the result of a 97 bp intron that alternatively spliced. In addition, the 321 bp fragment could be amplified from all the tissues of 4-month common carp including liver, demonstrating the occurrence of the alternative splicing of this intron during the development of common carp. Moreover, a semi-quantitative RT-PCR was performed to analyze the expression level of GHR in tissues of 2-year common carp and 4-month common carp. The result revealed that in the tissues of gill, thymus and brain, the expression level of GHR in 2-year common carp was significantly lower than that of 4-month common carp. | SUN Xiaofeng GUO Qionglin HU Wei WANG Yaping ZHU Zuoyan | 2006 | Progress in Natural Science:Materials International2006，16，11： | 3 |
| 15 | Applied Strain Field on Microstructure Optimization of Ti-Al-Nb Alloy Computer Simulated by Phase Field Approach显示文摘The effects of applied tensile strain on the coherent α2→O-phase transformation in Ti-AI-Nb alloys are explored by computer simulation using a phase-field method. The focus is on the influence of the applied strain direction on the microstructure and volume fraction of the O-phase precipitates. It is found that altering applied strain direction can modify microstructure of Ti-25Al-10-12Nb (at. pct) alloy during α→O-phase transformation effectively and full laminate microstructure in the Ti-25Al-10Nb (at. pct) alloy can be realized by an applied strain only along the direction 30° away from the α2 phase <101^-0> in magnitude equivalent to the stress-free transformation strain. The simulation also shows that not only the magnitude of applied strain but also the applied strain direction influences the O-phase volume fraction and the effect of strain direction on the volume fraction is up to 25%. | Wei GUO Yaping ZONG Gang WANG Liang ZUO Department of Materials Science and Engineeing,Northeastern University,Shenyang 110004, China | 2004 | Journal of Materials Science & Technology2004，20，3： | 3 |
| 16 | Anomalous Pore-Density Dependence in Nanofluidic Osmotic Power Generation显示文摘 | Jianjian Su Danyan Ji Jialiang Tang Hao Li Yaping Feng Liuxuan Cao Lei Jiang Wei Guo | 2018 | Chinese Journal of Chemistry2018，36，5： | 3 |
| 17 | Phylogenetic relationship and morphological evolution in the subfamily Limenitidinae(Lepidoptera:Nymphalidae)显示文摘mitochondrial 细胞色素氧子单元我(COI ) 基因和原子延伸因子 1 α(EF-1 α) 基因从 Nymphalidae 的 29 种类被定序(Nymphalidae,鳞翅目) 。种系发生的树基于从 29 种类决定的序列和在 GenBank 扔用的另外的 36 种类的序列被构造加入邻居(NJ ) ,最大的可能性(ML ) 和有 Libythea celtis (Libytheinae ) 的贝叶斯的方法作为外集团。我们的种系发生的树显示了四主要 clades。Clade A 包括三个亚科:Apaturinae, Nymphalinae,和 Limenitidinae,排除部落 Limenitidini;Clade B 包括亚科 Heliconiinae 和部落 Limenitidini;Clade C 包括 Satyrinae, Calinaginae, Charaxinae 和 Morphinae;并且 Clade D 包括亚科 Danainae。我们的学习建议部落 Pseudergolini, Biblidini, Limenitidini 和 Cyrestidini 应该被看作亚科并且在亚科 Pseudergolinae 以内证实了种间的关系,也就是 Amnosia +(Pseudergolis +(Stibochiona + Dichorragia )) 。我们然后印射三个词法字符(从后部的翅膀的外部边缘的肛门角度,视觉器官,和过程的点) 到 ML 分析用联合顺序数据构造的种系发生的树上。把这些词法人物的进化模式基于这被识别,他们显示三个人物在家庭 Nymphalidae 反复演变。 | Min Zhang Yang Zhong Tianwen Cao Yupeng Geng Yuan Zhang Ke Jin Zhumei Ren Rui Zhang Yaping Guo Enbo Ma | 2008 | Progress in Natural Science:Materials International2008，18，11： | 2 |
| 18 | Temporal and Spatial Variation of Phytoplankton Community and Main Pollution Indicators in the Cyanophyte Enrichment Area of North Dianchi Lake显示文摘[Objective]The study aimed to discuss the temporal and spatial variation of phytoplankton community and main pollution indicators in cyanophyte enrichment area of northern Dianchi Lake. [Method]In the cyanophyte enrichment area of northern Dianchi Lake,phytoplankton community,chlorophyll a,total nitrogen (TN) and total phosphorus (TP) concentration had been monitored monthly from January 2007 to December 2011,and the temporal and spatial variation of phytoplankton community and main pollution indicators were analyzed. [Result]From January 2007 to December 2011,algal diversity in the area increased slightly,and algal diversity in the alongshore region was less than that in the offshore region; chlorophyll a,TN and TP concentration decreased in the alongshore region,but it was otherwise in the offshore region; chlorophyll a,TN and TP concentration in the alongshore region were higher than those in the offshore region. [Conclusion]The research could provide theoretical references for the control of cyanophyte bloom and achievement evaluation of each control measure in Dianchi Lake. | Yanying Guo Feng He Aijun Li Yaping Han | 2013 | Meteorological and Environmental Research2013，4，2： | 2 |
| 19 | Transgene for growth hormone in common carp(Cyprinus carpio L.)promotes thymus development显示文摘The transgenic carp were produced by micro-injection of CAgcGHc into the fertilized eggs. Observation of the thymus development between the transgenics and non- transgenic controls was carried out. The thymus of one-year- old transgenics F1 showed a great increase in both size and weight. The unilateral thymus of the transgenics weighed from 190 to 295 mg with average 218.6 mg, whereas the uni-lateral thymus of the controls weighed 20—81 mg with av-erage 42.5 mg; i.e. the thymus weight in the transgenics was 5.14 fold over that in the controls. The index of thymus/body weight in the transgenics was 2.97 fold over the controls. Light microscopy observation indicated that the thymus of the transgenics well developed with the thickened outer re-gion and compactly arranged thymocytes, while the thymus in the controls were degenerating with the thinned outer region, scattered thymocytes and groups of fatty cells. Fur-ther analysis with the electron microscopy revealed that pro-liferous cells in the transgenics were mainly small lympho-cytes and no pathological changes were found. The results confirmed that the 揂ll-fish?GH-transgene promotes thy-mus development and thymocyte proliferation, and retards thymus degeneration. The study has laid a foundation for further analysis of the immunobiological function in GH- transgenic carp. | GUO Qionglin WANG Yaping JIA Weizhang ZHU Zuoyan | 2003 | Chinese Science Bulletin2003，48，16： | 2 |
| 20 | Genomic and transcriptomic analysis unveils population evolution and development of pesticide resistance in fall armyworm Spodoptera frugiperda显示文摘The fall armyworm(FAW),Spodoptera frugiperda,is a destructive pest native to America and has recently become an invasive insect pest in China.Because of its rapid spread and great risks in China,understanding of FAW genetic background and pesticide resistance is urgent and essential to develop effective management strategies.Here,we assembled a chromosome-level genome of a male FAW(SFynMstLFR)and compared re-sequencing results of the populations from America,Africa,and China.Strain identification of 163 individuals collected from America,Africa and China showed that both C and R strains were found in the American pop-ulations,while only C strain was found in the Chinese and African populations.Moreover,population geno-mics analysis showed that populations from Africa and China have close relationship with significantly genetic differentiation from American populations.Taken toge-ther,FAWs invaded into China were most likely origi-nated from Africa.Comparative genomics analysis displayed that the cytochrome p450 gene family is extremely expanded to 425 members in FAW,of which 283 genes are specific to FAW.Treatments of Chinese populations with twenty-three pesticides showed the variant patterns of transcriptome profiles,and several detoxification genes such as AOX,UGT and GST spe-cially responded to the pesticides.These findings will be useful in developing effective strategies for manage-ment of FAW in China and other invaded areas. | Furong Gui Tianming Lan Yue Zhao Wei Guo Yang Dong Dongming Fang Huan Liu Haimeng Li Hongli Wang Ruoshi Hao Xiaofang Cheng Yahong Li Pengcheng Yang Sunil Kumar Sahu Yaping Chen Le Cheng Shuqi He Ping Liu Guangyi Fan Haorong Lu Guohai Hu Wei Dong Bin Chen Yuan Jiang Yongwei Zhang Hanhong Xu Fei Lin Bernard Slippers Alisa Postma Matthew Jackson Birhan Addisie Abate Kassahun Tesfaye Aschalew Lemma Demie Meseret Destaw Bayeleygne Dawit Tesfaye Degefu Feng Chen Paul K.Kuria Zachary M.Kinyua Tong-Xian Liu Huanming Yang Fangneng Huang Xin Liu Jun Sheng Le Kang | 2022 | Protein & Cell2022，13，7： | 2 |
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