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| 1 | Current and future treatments for hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC) represents a unique challenge for physicians and patients.There is no definitively curative treatment.Rather,many treatment and management modalities exist with differing advantages and disadvantages.Both current guidelines and individual patient concerns must be taken into account in order to properly manage HCC.In addition,quality of life issues are particularly complex in patients with HCC and these concerns must also be factored into treatment strategies.Thus,considering all the options and their various pros and cons can quickly become complex for both clinicians and patients.In this review,we systematically discuss the current treatment modalities available for HCC,detailing relevant clinical data,risks and rewards and overall outcomes for each approach.Surgical options discussed include resection,transplantation and ablation.We also discuss the radiation modalities:conformal radiotherapy,yttrium 90 microspheres and proton and heavy ion radiotherapy.The biologic agent Sorafenib is discussed as a promising new approach,and recent clinical trials are reviewed.We then detail currently described molecular pathways implicated in the initiation and progression of HCC,and we explore the potential of each pathway as an avenue for drug exploitation.We hope this comprehensive and forward-looking review enables both clinicians and patients to understand various options and thereby make more informed decisions regarding this disease. | Alexander Schlachterman Willie W Craft Jr Eric Hilgenfeldt Avir Mitra Roniel Cabrera | 2015 | World Journal of Gastroenterology2015，21，28： | 76 |
| 2 | 美国国立老化研究所与阿尔茨海默病协会诊断指南写作组:阿尔茨海默病临床前阶段的定义显示文摘阿尔茨海默病(AD)的病理生理过程在痴呆诊断的多年前就开始了。这一长期的AD“临床前”阶段是治疗干预的关键机会,但需进一步阐明AD的病理级联过程和临床症状出现之间的联系。美国国立老化研究所和AD协会召集了一个国际工作组对AD生物标志物、流行病学和神经心理学的证据进行综述并提出建议,以确定能够预测由“正常”认知到轻度认知功能障碍(MCI)及AD痴呆的最佳预测指标。根据目前已有的主要科学证据,我们提出了一个概念性的框架和用于操作的研究标准,以通过纵向临床研究来验证和改进这些模型。这些建议仅用于研究目的,目前不涉及临床应用。我们希望这些建议能提供一个共识,以推进临床前AD的研究,最终推动更早期治疗干预的进展,使得一些疾病减缓药物的疗效发挥最大。 | Sperling RA Aisen PS Beckett LA Bennett DA Craft S Fagan AM Iwatsubo T Jack CR Jr Kaye J Montine TJ Park DC Reiman EM Rowe CC Siemers E Stern Y Yaffe K Carrillo MC Thies B Morrison-Bogorad M Wagster MV Phelps CH 贾建平(译) 郭起浩(译) 黄丽(译) 陆璐(译) 张逸驰(译) 邢怡(译) | 2012 | 中华神经科杂志2012，45，5： | 22 |
| 3 | 美国湿地保护制度变迁研究显示文摘本文提出了分析湿地保护制度变迁的理论框架,使不同国家的湿地保护制度研究能在统一语境下比较。首先基于科学计量学和系统研究方法筛选出公众、科学、政府和法律为影响湿地保护制度变迁的四个关键要素,并依赖博弈论工具建立了分析美国湿地保护制度的理论架构。基于这一架构,本文对包括关键利益相关者、政策执行路径、政策工具和管理挑战等内容的美国湿地政策史进行了讨论。对美国湿地保护制度的演化进行了四阶断之划分:'西进运动'与全民开垦(1900年之前)、'水鸟保护'与公众参与(1900-1970年)、核心法律与科学研究(1971-1980年)和完善制度与新的挑战(1980年至今)。分析得出如下结论:在湿地保护制度中,公众是源头、科学是前提、有效的政府管治和将湿地保护的规则和与政策制度化是关键。通过借鉴美国湿地保护制度变迁研究,本文构建了湿地保护制度变迁的'竹节模式'经验性模型,揭示了各动因之间的作用机理。虽然美国湿地保护制度也面临着公众教育、科学定义和政府管辖权等挑战,但中国的湿地管理者与政策制定者仍可从美国湿地政策执行的历史背景中吸取经验。同时本文的理论分析结构也可为自然资源及管理策略的研究提供参考。 | 陈溪 Magdeline Laba Robertson Morgan Barbara Cosens 王子彦 陈雪 James Anderson Marinus Otte Christopher Craft David Feldman 李杨帆 刘晶岚 Patrick Sullivan 吕宪国 | 2016 | 资源科学2016，38，4： | 13 |
| 4 | 认知策略教学对聋人学习者的影响显示文摘为了向聋人学习者教授更高水平的认知策略 ,对英国和中国的两所聋校部分教师进行了特别的培训。让两国教师在课堂教学中运用这些策略 ,为时 6个月 ,每周至少两次。对学生进行的测量包括 :瑞文非文字推理测验 (1 959)、认知行为系统观察检核表 (Martin&Craft,1 998)、及学生对批判性和创造性问题情境所做出的回答。把研究结果与美国以前一项类似研究(Martin&Jones,1 985)进行比较。在中、英、美这三个国家的比较中 ,得到的结果几乎一样 :三个国家的学生都在推理能力上得到提高 ;在包含批判性思维 (不包含创造性思维 )的真实情境下 ,解决问题的能力得到发展 ;在课堂上使用认知词汇的能力也提高了 ,并且表述他人观点的能力上有所提高。经过认知策略教学的实施 ,教师身上也发生了变化 :中国教师在认知策略教学中更多的运用恒常的次序 ;三个国家的教师在认知术语的运用 ,问题解决策略 。 | 张宁生 黄丽娇 David S.Martin Anna Craft 顾林 | 2004 | 心理科学2004，27，1： | 3 |
| 5 | Does low volume high-intensity interval training elicit superior benefits to continuous low to moderate-intensity training in cancer survivors?显示文摘AIM To determine the impact ofm low volume high-intensity interval training(LVHIIT) and continuous low to moderate-intensity exercise training(CLMIT) on cardiovascular disease(CVD) risk and health outcomes in cancer survivors.METHODS Sedentary cancer survivors(n=75,aged 51±12year)within 24 months of diagnosis,were randomised into three groups for 12 wk of LVHIIT(n=25),CLMIT(n=25)or control group(n=25).The exercise intervention involved 36 sessions(three sessions per week).The LVHIIT group performed 7 x 30 s intervals(≥85%predicted maximal heart rate)with a 60 s rest between intervals,and the CLMIT group performed continuous aerobic training for 20 min(≤55%predicted maximal heart rate)on a stationary bike.Outcome variables were measured at baseline and at12 weeks and analysed using a 3 x 2(group x time)repeated measures ANCOVA to evaluate main and interaction effects.RESULTS Significant improvements(time)were observed for seven of the 22 variables(ES 0.35-0.97,P≤0.05).There was an interaction effect(P<0.01)after 12 in the LVHIIT group for six-minute walk test(P<0.01;d=0.97;95%CI:0.36,1.56;large),sit to stand test(P<0.01;d=-0.83;95%CI:-1.40,-0.22;large)and waist circumference reduction(P=0.01;d=-0.48;95%CI:-1.10,0.10;medium).An interaction effect(P<0.01)was also observed for quality of life in both the LVHIIT(d=1.11;95CI:0.50,1.72;large)and CLMIT(d=0.57;95%CI:-0.00,1.20;moderate)compared with the control group(d=-0.15;95%CI:-0.95,0.65;trivial).CONCLUSION Low-volume high-intensity training shows promise as an effective exercise prescription within the cancer population,showing greater improvements in cardiorespiratory fitness,lower body strength and waist circumference compared with traditional CLMIT and control groups.Both LVHIIT and CLMIT improved quality of life.A proposed benefit of LVHIIT is the short duration(3 min)of exercise required,which may entice more cancer survivors to participate in exercise,improving health outcomes and lowing the risk of CVD. | Kellie Toohey Kate Pumpa Andrew McKune Julie Cooke Katrina D DuBose Desmond Yip Paul Craft Stuart Semple | 2018 | World Journal of Clinical Oncology2018，9，1： | 3 |
| 6 | Effects of Salinity on Denitrification and Greenhouse Gas Production from Laboratory-incubated Tidal Forest Soils显示文摘 | John M. Marton Ellen R. Herbert Christopher B. Craft | 2012 | Wetlands2012，，2： | 3 |
| 7 | Radiation exposure from CT scans in childhood and subsequent risk of leukaemia and brain tumours: a retrospective cohort study显示文摘 | Mark S Pearce Jane A Salotti Mark P Little Kieran McHugh Choonsik Lee Kwang Pyo Kim Nicola L Howe Cecile M Ronckers Preetha Rajaraman Alan W Craft Louise Parker Amy Berrington de González | 2012 | The Lancet . 2012 (9840)2012，，： | 3 |
| 8 | Comparison of modified Thrombelastograph and Plateletworks whole blood assays to optical p latelet aggregation for monitoring reversal of clop idogrel inhibition in elective surgery patients 显示文摘 | Craft RM Chavez JJ Snider CC | 2005 | J Lab Clin Med2005，145，6： | 1 |
| 9 | lead free ball-grid array balls: production method and properties 显示文摘 | Kempf B Craft M Hutin O | 2002 | Journal of Electronic Materials2002，31，11： | 1 |
| 10 | Evaluation of methods forthe simultaneous analysis of cations and anions using HPLCwith charged aerosol detection and a zwitterionic stationaryphase显示文摘 | Crafts C Bailey B Plante M | 2009 | J Chromatogr Sci2009，47，7： | 1 |
| 11 | Comparison of pregnancy outcome of pronuclear-and muhicelllular-stage frozen-thawed embryo transfers显示文摘 | Kattrea S Shrivastav P Craft I | 1999 | Assist Reprod Genet1999，16，7： | 1 |
| 12 | Sediment and nutrient accumulation in floodplain and depressional freshwater wetlands of Georgia, USA显示文摘 | Craft C B and Casey W P | 2000 | Wetlands2000，20，2： | 1 |
| 13 | A miniaturized and rapid bioassay for the selection of soil bacteria suppressive to Pythium blight of turigrass 显示文摘 | Nelson E B Craft C M | 1922 | Phytopathology1922，82，： | 1 |
| 14 | Insulin and neurodegenerative disorders 显示文摘 | Craft S Watson GS | 2004 | Lancet Neurol2004，3，： | 1 |
| 15 | Pyrosequencing of Mytilus galloprovincialis cDNAs= tissue-specific ex pression patterns显示文摘 | Craft J A Gilbert J A Temperton B | 2010 | PLoS ONE2010，5，1： | 1 |
| 16 | Cerebrospinal fluidand plasma insulin levels in Alzheimer's disease: relationshipto severity of dementia and apolipoprotein E genotype 显示文摘 | Craft S Peskind E Schwartz MW | 1998 | Neurology1998，50，1： | 1 |
| 17 | Role of IL-1 in poststroke depressive- like behavior in mice 显示文摘 | Craft T K S DeVries A C | 2006 | Biological psychiatry2006，60，8： | 1 |
| 18 | Effects of sewage effluent and ethynyl oestradiol upon molecular markers of oestrogenic exposure, maturation and repro ductive success in the sand goby显示文摘 | CRAIG D R BROWN E CRAFT J A | 2003 | Aquatic Toxicology2003，，62： | 1 |
| 19 | Torsade de pointes after astemizole overdose显示文摘 | CRAFT T M | 1986 | British Med J(Clin Res Ed)1986，292，： | 1 |
| 20 | Selection based on CD133 and high aldehyde dehydrogenase activity isolates long term reconsituting human hematopoiellc stem cells显示文摘 | Hess DA Wirthlin L Craft TP | 2006 | Blood2006，107，5： | 1 |
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