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| 1 | Differential mercury volatilization by tobacco organs expressing a modi-fied bacterial merA gene显示文摘Mercury pollution is a major environmental problem accompanying industrial activities. Most of the mercury released ends up and retained in the soil as complexes of the toxic ionic mercury (Hg2+), which then can be converted by microbes into the even more toxic methylmercury which tends to bioaccumulate. Mercury detoxification of the soil can also occur by microbes converting the ionic mercury into the least toxic metallic mercury (Hg0) form, which then evaporates. The remediation potentia1 of transgenic plants carrying the MerA gene from E. coLi encoding mercuric ion reductase could be evaluated. A modified version of the gene, optimized for plant codon preferences (merApe9, Rugh et al. 1996), was introduced into tobacco by Agrobacterium-mediated leaf disk transformation. Transgenic seeds were resistant to HgCl2 at 50 μM and some of them (10-20% ) could germinate on media containing as much as 350 μM HgCl2, while the control plants were fully inhibited or died on 50 μM HgCl2. The rate of elemental mercury evolution from Hg2+ (added as HgCl2) was 5-8 times higher for transgenic plants than the control. Mercury volatilization by isolated organs standardized for fresh weight was higher (up to 5 times) in the roots than in shoots or the leaves. The data suggest that it is the root system of the transgenic plants that volatilizes most of the reduced mercury (Hg0). It also suggests that much of the mercury need not enter the vascular system to be transported to the leaves for volatilization. Thansgenic plants with the merApe9 gene may be used to mercury detoxification for environmental improvement in mercury-- contaminated regions more efficiently than it had been predicted based on data on volatilization of whole plants via the upper parts only (Rugh et al. 1996). | HE YU KE, JIAN GE SUN, XIAN ZHONG FENG, MIHALY CZAKU, LASZLO MARTON Depariment of Biological Sciences, University of South Carolina, 700 Sumter Street, Columbia, SC29208, USA National Laboratory of Plant Molecular Genetics, Shanghai Institute of Plant Phy | 2001 | Cell Research2001，11，3： | 14 |
| 2 | Cysteine proteases as therapeutic targets:does selectivity matter? A systematic review of calpain and cathepsin inhibitors显示文摘Cysteine proteases continue to provide validated targets for treatment of human diseases.In neurodegenerative disorders,multiple cysteine proteases provide targets for enzyme inhibitors,notably caspases,calpains,and cathepsins.The reactive,active-site cysteine provides specificity for many inhibitor designs over other families of proteases,such as aspartate and serine;however,a)inhibitor strategies often use covalent enzyme modification,and b)obtaining selectivity within families of cysteine proteases and their isozymes is problematic.This review provides a general update on strategies for cysteine protease inhibitor design and a focus on cathepsin B and calpain 1 as drug targets for neurodegenerative disorders;the latter focus providing an interesting query for the contemporary assumptions that irreversible,covalent protein modification and low selectivity are anathema to therapeutic safety and efficacy. | Marton Siklos Manel Ben Aissa Gregory R.J.Thatcher | 2015 | Acta Pharmaceutica Sinica B2015，5，6： | 11 |
| 3 | Radiofrequency ablation of locally advanced pancreatic adenocarcinoma:An overview显示文摘Radiofrequency ablation(RFA)of pancreatic neoplasms is restricted to locally advanced,non-resectable but nonmetastatic tumors.RFA of pancreatic tumors is nowadays an ultrasound-guided procedure performed during laparotomy in open surgery.Intraoperative ultrasound covers the mandatory role of staging,evaluation of feasibility,guidance and monitoring of the procedure.Different types of needle can be used.The first aim in the evaluation of RFA as a treatment for locally advanced pancreatic ductal adenocarcinoma,in order of evaluation but not of importance,is to determine the feasibility of the procedure.The second aim is to establish the effect of RFA on tumoral mass in terms of necrosis andcytoreduction.The most important aim,third in order of evaluation,is the potential improvement of quality of life and survival rate.Nowadays,only a few studies assess the feasibility of the procedure.The present paper is an overview of RFA for pancreatic adenocarcinoma. | Mirko D’Onofrio Emilio Barbi Roberto Girelli Enrico Martone Anna Gallotti Roberto Salvia Paolo Tinazzi Martini Claudio Bassi Paolo Pederzoli Roberto Pozzi Mucelli | 2010 | World Journal of Gastroenterology2010，16，28： | 6 |
| 4 | Insight into the antifungal mechanism of Neosartorya fischeri antifungal protein显示文摘细丝状的子囊菌纲分泌的小、充满半胱氨酸的、高度稳定的抗真菌的蛋白质为新奇抗真菌的策略的发展有大潜力。然而,他们的实际申请仍然由于他们行动的不充分澄清的模式被限制。这个工作的目的是提供深卓见进 Neosartorya fischeri 的抗真菌的机制抗真菌的蛋白质(NFAP ) ,这个蛋白质组的一个新奇代表。在 NFAP 敏感的曲霉属菌 nidulans 在 NFAP,减少的细胞的新陈代谢, apoptosis 正式就职,在肌动朊分发的变化和在菌丝的尖端的几丁质免职的一短暴露时间以内被观察。NFAP 确实由 endocytosis 显示出既不直接的膜破坏效果也不举起。A 的调查。nidulans 发信号异种表明 NFAP 经由表明导致极的生长的 apoptosis 和抑制的 G 蛋白质激活营地 / 蛋白质 kinase A 小径。相反, NFAP 没在房间墙正直小径,而是小径无关的 mitogen 激活的未知房间墙正直上有任何影响蛋白质 kinase 激活 A 的目标被假定涉及房间死亡正式就职。一起拿, NFAP 从曲霉属菌 giganteus 和毛丛 chrysogenum 与二大多数调查 NFAP 相关的蛋白质相比在它抗真菌的行动的模式显示出类似,而且差别,这被结束。 | Mate Viragh Annamaria Marton Csaba Vizier Liliana Toth Csaba Vagvolgyi Florentine Marx Laszlo Galgoczy | 2015 | Protein & Cell2015，6，7： | 4 |
| 5 | Effects of Salinity on Denitrification and Greenhouse Gas Production from Laboratory-incubated Tidal Forest Soils显示文摘 | John M. Marton Ellen R. Herbert Christopher B. Craft | 2012 | Wetlands2012，，2： | 3 |
| 6 | Cardiac damage in athlete's heart: When the “supernormal” heart fails!显示文摘Intense exercise may cause heart remodeling to compensate increases in blood pressure or volume by increasing muscle mass. Cardiac changes do not involve only the left ventricle, but all heart chambers. Physiological cardiac modeling in athletes is associated with normal or enhanced cardiac function, but recent studies have documented decrements in left ventricular function during intense exercise and the release of cardiac markers of necrosis in athlete's blood of uncertain significance. Furthermore, cardiac remodeling may predispose athletes to heart disease and result in electrical remodeling, responsible for arrhythmias. Athlete's heart is a physiological condition and does not require a specific treatment. In some conditions, it is important to differentiate the physiological adaptations from pathological conditions, such as hypertrophic cardiomyopathy, arrhythmogenic dysplasia of the right ventricle, and non-compaction myocardium, for the greater risk of sudden cardiac death of these conditions. Moreover, some drugs and performance-enhancing drugs can cause structural alterations and arrhythmias, therefore, their use should be excluded. | Andreina Carbone Antonello D’Andrea Lucia Riegler Raffaella Scarafile Enrica Pezzullo Francesca Martone Raffaella America Biagio Liccardo Maurizio Galderisi Eduardo Bossone Raffaele Calabrò | 2017 | World Journal of Cardiology2017，9，6： | 3 |
| 7 | 借助疫苗控制肉种鸡球虫病显示文摘球虫感染在鸡场非常普遍,目前60%~70%的种鸡群在孵化场就接种了疫苗。球虫病活疫苗可通过粗喷雾、固体凝胶圆盘或卵内疫苗接种等方式接种。 | 王晶晶(译) 唐彩琰(审) 何闪(制图) Jose J.Bruzual Zoltan Marton | 2021 | 国外畜牧学(猪与禽)2021，41，4： | 2 |
| 8 | Incremental value of thoracic ultrasound in intensive care units:Indications,uses,and applications显示文摘Emergency physicians are required to care for unstable patients with life-threatening conditions, and thus must make decisions that are both quick and precise about unclear clinical situations. There is increasing consensus in favor of using ultrasound as a real-time bedside clinical tool for clinicians in emergency settings alongside the irreplaceable use of historical and physical examinations. B-mode sonography is an old technology that was first proposed for medical applications more than 50 years ago. Its application in the diagnosis of thoracic diseases has always been considered limited, due to the presence of air in the lung and the presence of the bones of the thoracic cage, which prevent the progression of the ultrasound beam. However, the close relationship between air and water in the lungs causes a variety of artifacts on ultrasounds. At the bedside, thoracic ultrasound is based primarily on the analysis of these artifacts, with the aim of improving accuracy and safety in the diagnosis and therapy of the various varieties of pulmonary pathologic diseases which are predominantly 'water-rich' or 'air-rich'. The indications, contraindications, advantages, disadvantages, and techniques of thoracic ultrasound and its related procedures are analyzed in the present review. | Biagio Liccardo Francesca Martone Paolo Trambaiolo Sergio Severino Gian Alfonso Cibinel Antonello D'Andrea | 2016 | World Journal of Radiology2016，8，5： | 2 |
| 9 | Towards 3D Point cloud based object maps for household environments显示文摘 | Radu Bogdan Rusu Zoltan Csaba Marton Nico Blodow Mihai Dolha Michael Beetz | 2008 | Robotics and Autonomous Systems2008，，11： | 2 |
| 10 | Role and function of granin proteins in diabetes mellitus显示文摘The granin glycoprotein family consists of nine acidic proteins;chromogranin A(CgA),chromogranin B(CgB),and secretogranin II–VIII.They are produced by a wide range of neuronal,neuroendocrine,and endocrine cells throughout the human body.Their major intracellular function is to sort peptides and proteins into secretory granules,but their cleavage products also take part in the extracellular regulation of diverse biological processes.The contribution of granins to carbohydrate metabolism and diabetes mellitus is a recent research area.CgA is associated with glucose homeostasis and the progression of type 1 diabetes.WE-14,CgA10-19,and CgA43-52 are peptide derivates of CgA,and act as CD4+or CD8+autoantigens in type 1 diabetes,whereas pancreastatin(PST)and catestatin have regulatory effects in carbohydrate metabolism.Furthermore,PST is related to gestational and type 2 diabetes.CgB has a crucial role in physiological insulin secretion.Secretogranins II and III have angiogenic activity in diabetic retinopathy(DR),and are novel targets in recent DR studies.Ongoing studies are beginning to investigate the potential use of granin derivatives as drugs to treat diabetes based on the divergent relationships between granins and different types of diabetes. | Zoltan Herold Marton Doleschall Aniko Somogyi | 2021 | World Journal of Diabetes2021，12，7： | 2 |
| 11 | Radiofrequency Ablation Versus Surgical Resection for the Treatment of Hepatocellular Carcinoma in Cirrhosis显示文摘 | Alfredo Guglielmi Andrea Ruzzenente Alessandro Valdegamberi Silvia Pachera Tommaso Campagnaro Mirko D'Onofrio Enrico Martone Paola Nicoli Calogero Iacono | 2008 | Journal of Gastrointestinal Surgery2008，，1： | 2 |
| 12 | The Cost-Effectiveness of an Extended Course (12 + 12 Weeks) of Varenicline Compared with Other Available Smoking Cessation Strategies in the United States: An Extension and Update to the BENESCO Model显示文摘 | Chris Knight Paul Howard Christine L. Baker Jeno P. Marton | 2010 | Value in Health2010，，： | 2 |
| 13 | 体育运动与活性氧对大脑的复杂作用显示文摘活性氧(ROS)在有氧代谢中以中度水平持续产生,有利于产生氧化还原信号,但数量较大时却能引起氧化损伤和神经退行性病变。由于大脑对ROS敏感度提高,在不同类型神经细胞中保持正常氧化还原状态尤为重要。过去10年的研究充分说明:有规律的运动对大脑功能产生有益影响,并对中风、老年痴呆和帕金森症的预防和治疗起重要作用。然而,研究运动的具体影响似乎又非常复杂,包括通过神经营养因子的神经发生、毛细血管化增加、氧化损伤减少,以及通过蛋白酶和脑啡肽酶的蛋白降解增加。来自我们及其他实验室的数据表明,运动诱导的ROS水平调节对蛋白含量以及脑源性神经营养因子(BDNF)、酪氨酸激酶B(TrkB)、cAMP反应元件结合蛋白(CREB)的表达有重要作用,有利于完善脑功能、增加神经生成。因此,运动诱导的氧化还原状态调节是一种重要方式,运动能通过这一方式造福于大脑功能、增强对氧化应激的抵抗力,协助从氧化应激中恢复、减弱年龄相关的认知能力下降。 | Zsolt Radak Orsolya Marton Eniko Nagy Erika Koltai Sataro Goto | 2013 | Journal of Sport and Health Science2013，2，2： | 2 |
| 14 | Karst Types and Their Karstification显示文摘Eighty-one karst types and their main characteristics are described in this study,including the conditions of their development,the main characteristics of their karstification and their characteristic features.The classification includes the karst types of the Earth,a concise description of each karst type and the possibilities of belonging to several types of various karst areas.The classification of types is hierarchical in terms of groups,subgroups,types and subtypes.Karst can be classified according to their momentary state(the group of static karst types)and to their development(group of dynamic karst types).The group of static karst types has the azonal and zonal subgroups.Azonal karst types may be situated under any climate.These karst types are categorized according to their geological characteristics(age of karstification,constituting rock,extent of coveredness,structure),their elevation,expansion,the morphology of their surface,hydrology and to the effects occurring on the karst.Taking the above mentioned factors into consideration,the author distinguishes various types and describes their characteristics.Zonal karst types are also described(tundra karst,temperate karst,subtropical karst,tropical karst),karst types that can be distinguished based on their geomorphic evolution are identified and their characteristics are presented. | Marton Veress | 2020 | Journal of Earth Science2020，31，3： | 2 |
| 15 | Stabilization of erythrocyte membranes by polyamines显示文摘 | Mohandas N Marton L J | 1983 | Pro Nat Acad Sci1983，80，： | 1 |
| 16 | Cloning, expression, Charac- terization, and nucleophile identification of family 3, Aspergillus niger beta-glucosidase显示文摘 | Dan S Marton I Dekcl M | 2000 | The Journal of Biological Chemistry2000，275，： | 1 |
| 17 | Practical aspects of alkaline sizing on kinetics of alkyl ketene dimmer reactions:hydrolysis of alkyl ketene dimmer显示文摘 | Marton Joseph | 1990 | Tappi Journal1990，73，11： | 1 |
| 18 | Ceramic precursor in flame retardant systems显示文摘 | Marosi G Marton A | 2002 | Polym Degrad Stab2002，77，2： | 1 |
| 19 | CDC definitions of nosocomial surgical site infections,1992:A modification of CDC definitions of surgical wound infections显示文摘 | Horan TC Gaynes RP Martone WJ | 1992 | Infect Control Hosp Epidemiol1992，13，10： | 1 |
| 20 | Postmortem changes in cytoskeletal elements of fish muscle 显示文摘 | Busconi L Folco E J Martone C B | 1989 | Journal of Food Bio- chemistry1989，13，6： | 1 |
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