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| 1 | Aging and menopause reprogram osteoclast precursors for aggressive bone resorption显示文摘Women gradually lose bone from the age of〜35 years,but around menopause,the rate of bone loss escalates due to increasing bone resorption and decreasing bone formation levels,rendering these individuals more prone to developing osteoporosis.The increased osteoclast activity has been linked to a reduced estrogen level and other hormonal changes.However,it is unclear whether intrinsic changes in osteoclast precursors around menopause can also explain the increased osteoclast activity.Therefore,we set up a protocol in which CD14f blood monocytes were isolated from 49 female donors(40-66 years old).Cells were differentiated into osteoclasts,and data on differentiation and resorption activity were collected.Using multiple linear regression analyses combining in vitro and in vivo data,we found the following:(1)age and menopausal status correlate with aggressive osteoclastic bone resorption in vitro;(2)the type I procollagen N-terminal propeptide level in vivo inversely correlates with osteoclast resorption activity in vitro;(3)the protein level of mature cathepsin K in osteoclasts in vitro increases with age and menopause;and(4)the promoter of the gene encoding the dendritic cell-specific transmembrane protein is less methylated with age.We conclude that monocytes are'reprogrammed'in vivo,allowing them to'remember'age,the menopausal status,and the bone formation status in vitro,resulting in more aggressive osteoclasts.Our discovery suggests that this may be mediated through DNA methylation.We suggest that this may have clinical implications and could contribute to understanding individual differences in age-and menopause-induced bone loss. | Anais Marie Julie Moller Jean-Marie Delaisse Jacob Bastholm Olesen Jonna Skov Madsen Luisa Matos Canto Troels Bechmann Silvia Regina Rogatto Kent Soe | 2020 | Bone Research2020，8，3： | 4 |
| 2 | Histologic and Imaging Features of Mural Nodules in Mucinous Pancreatic Cysts显示文摘 | Ning Zhong Lizhi Zhang Naoki Takahashi Vladislav Shalmiyev Marcia Irene Canto Jonathan E. Clain John C. Deutsch John DeWitt Mohamad A. Eloubeidi Ferga C. Gleeson Michael J. Levy Shawn Mallery Massimo Raimondo Elizabeth Rajan Tyler Stevens Mark Topazian | 2012 | Clinical Gastroenterology and Hepatology2012，，2： | 2 |
| 3 | Mutant TP53 in Duodenal Samples of Pancreatic Juice From Patients With Pancreatic Cancer or High-Grade Dysplasia显示文摘 | Mitsuro Kanda Yoshihiko Sadakari Michael Borges Mark Topazian James Farrell Sapna Syngal Jeffrey Lee Ihab Kamel Anne Marie Lennon Spencer Knight Sho Fujiwara Ralph H. Hruban Marcia Irene Canto Michael Goggins | 2013 | Clinical Gastroenterology and Hepatology2013，，6： | 2 |
| 4 | Eigenvalue approximation by mixed method显示文摘 | Canto C | 1978 | RAIRO Anal Numer1978，12，： | 2 |
| 5 | Effect of high hydrostatic pressure on the color and texture parameters of refrigerated Caiman ( Caiman crocodilus yacare ) tail meat显示文摘 | A.C.V.C.S. Canto B.R.C.C. Lima A.G. Cruz C.A. Lázaro D.G.C. Freitas Jose A.F. Faria R. Torrezan M.Q. Freitas T.P.J. Silva | 2012 | Meat Science2012，，3： | 2 |
| 6 | Frequent Detection of Pancreatic Lesions in Asymptomatic High-Risk Individuals显示文摘 | Marcia Irene Canto Ralph H. Hruban Elliot K. Fishman Ihab R. Kamel Richard Schulick Zhe Zhang Mark Topazian Naoki Takahashi Joel Fletcher Gloria Petersen Alison P. Klein Jennifer Axilbund Constance Griffin Sapna Syngal John R. Saltzman Koenraad J. Mortele | 2012 | Gastroenterology2012，，4： | 2 |
| 7 | Medicinal plants from open-air markets in the State of Rio de Janeiro, Brazil as a potential source of new antimycobacterial agents显示文摘 | Fernanda Leit?o Suzana G. Leit?o Mara Zélia de Almeida Jéssica Cantos Tatiane Coelho Pedro Eduardo A. da Silva | 2013 | Journal of Ethnopharmacology2013，，： | 2 |
| 8 | Pancreatic cancer显示文摘 | Theresa Pluth Yeo Ralph H Hruban Steven D Leach Robb E Wilentz Taylor A Sohn Scott E Kern Christine A Iacobuzio-Donahue Anirban Maitra Michael Goggins Marcia I Canto Ross A Abrams Daniel Laheru Elizabeth M Jaffee Manuel Hidalgo Charles J Yeo | 2002 | Current Problems in Cancer2002，，4： | 2 |
| 9 | EUS-guided biliary drainage for patients with malignant biliary obstruction with an indwelling duodenal stent (with videos)显示文摘 | Mouen A. Khashab Larissa L. Fujii Todd H. Baron Marcia Irene Canto Christopher J. Gostout Bret T. Petersen Patrick I. Okolo Mark D. Topazian Michael J. Levy | 2012 | Gastrointestinal Endoscopy2012，，1： | 2 |
| 10 | A Comparative Evaluation of EUS-Guided Biliary Drainage and Percutaneous Drainage in Patients with Distal Malignant Biliary Obstruction and Failed ERCP显示文摘 | Mouen A. Khashab Ali Kord Valeshabad Elham Afghani Vikesh K. Singh Vivek Kumbhari Ahmed Messallam Payal Saxena Mohamad El Zein Anne Marie Lennon Marcia Irene Canto Anthony N. Kalloo | 2015 | Digestive Diseases and Sciences2015，，2： | 2 |
| 11 | Evaluation of Salt Tolerance of in Vitro-grown Grapevine Rootstock Varieties显示文摘 | Matte C Cantos M | 1999 | Vitis1999，38，2： | 1 |
| 12 | On M-Muhisplittings of Singular M-Matrices with Application to Markov Chains 显示文摘 | Bru R Canto R Climent J J | 1998 | Numerical Linear Algebra with Applications1998，5，： | 1 |
| 13 | AMPK regulates energy expenditure by modulating NAD+metabolism and SIRT1 activity显示文摘 | Canto C Gerhart-Hines Z Feige JN | | 0，，7241： | 1 |
| 14 | Methylene blue-di- rected biopsies improve detection of intestinal metaplasia and dysplasia in Barrett's esophagus 显示文摘 | Canto MI Setrakian S Willis J | 2000 | Gastrointest En- dosc2000，51，5： | 1 |
| 15 | A resource - based analysis of the fac- tors determining a firm~ R&D activities 显示文摘 | CANTO J G D GONZALEZ I S | 1999 | Research Policy1999，28，： | 1 |
| 16 | Successful posterior interlaminar fusion at the thoracic spine by sole use of beta-tricalcium phosphate显示文摘 | Knop C Sitte 1 Canto F | 2006 | Arch Or- thop Trauma Surg2006，126，3： | 1 |
| 17 | Interdependence of AMPK and SIRT1 for metabolic adaptation to fasting and exercise in skeletal muscle显示文摘 | Canto C Jiang LQ Deshmukh AS | 2010 | Cell Metab2010，11，3： | 1 |
| 18 | Endoscopic ultrasonography versus cholanglography for the diagnosis of choledocholithiasis显示文摘 | Canto MI Chak A Stellato T | 1998 | Gastrointest Endosc1998，47，6： | 1 |
| 19 | AMPK regulates energy expenditure by modulating NAD^+ metabolism and SIRT1 activity显示文摘 | Canto C Gerhart-Hines Z Feige JN | 2009 | Nature2009，458，7241： | 1 |
| 20 | Re- al-time embedded systems powered by FPGA dynamic par- tial self-reconfignration: A case study oriented to biometric recognition applications 显示文摘 | Francisco Fons Mariano Fons Enrique Canto | 2013 | Real-Time Image Processing2013，8，3： | 1 |
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