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| 1 | Low-volume plus ascorbic acid vs high-volume plus simethicone bowel preparation before colonoscopy显示文摘AIM:To investigate the effectiveness of low-volumeplus ascorbic acid [polyethylene glycol plus ascorbicacid(PEG + Asc) ] and high-volume plus simethicone[polyethylene glycol plus simethicone(PEG + Sim) ]bowel preparations.METHODS:A total of one hundred and forty-fourout patients(76 males) ,aged from 20 to 84 years(me-dian age 59.5 years) ,who attended our Department,were divided into two groups,age and sex matched,and underwent colonoscopy. Two questionnaires,onefor patients reporting acceptability and the other forendoscopists evaluating bowel cleansing effectivenes saccording to validated scales,were completed. Indications,timing of examination and endoscopical findings were recorded. Biopsy forceps were used as a measuring tool in order to determine polyp endoscopic sizeestimation. Difficulty in completing the preparation wasrated in a 5-point Likert scale(1 = easy to 5 = un-able) . Adverse experiences(fullness,cramps,nausea,vomiting,ab dominal pain,headache and insomnia) ,number of evacuations and types of activities performed during preparation(walking or resting in bed) were also investigated.RESULTS:Seventy-two patients were selected for eachgroup. The two groups were age and sex matched aswell as being comparable in terms of medical historyand drug therapies taken. Fourteen patients droppedout from the trial because they did not complete the preparation procedure. Ratings of global bowel cleansing examinations were considered to be adequate in91% of PEG + Asc and 88% of PEG + Sim patients.Residual Stool Score indicated similar levels of amountand consistency of residual stool;there was a significant difference in the percentage of bowel wall visuali-zation in favour of PEG + Sim patients. In the PEG +Sim group,12 adenomas ≤ 10 mm diameter(5/left co-lon + 7/right colon) vs 9(8/left colon + 1/right colon) in the PEG + Asc group were diagnosed. Visualization of small lesions seems to be one of the primary advantages of the PEG + Sim preparation.CONCLUSION:PEG + Asc is a good alternative solution as a bowel preparation but more improvements arenecessary in order to achieve the target of a perfect preparation. | Stefano Pontone Rita Angelini Monica Standoli Gregorio Patrizi Franco Culasso Paolo Pontone Adriano Redler | 2011 | World Journal of Gastroenterology2011，17，42： | 22 |
| 2 | Proton pump inhibitors and dysbiosis: Current knowledge and aspects to be clarified显示文摘Proton pump inhibitors (PPIs) are common medications within the practice of gastroenterology. These drugs, which act through the irreversible inhibition of the hydrogen/potassium pump (H+/K+-ATPase pump) in the gastric parietal cells, are used in the treatment of several acid-related disorders. PPIs are generally well tolerated but, through the long-term reduction of gastric acid secretion, can increase the risk of an imbalance in gut microbiota composition (i.e., dysbiosis). The gut microbiota is a complex ecosystem in which microbes coexist and interact with the human host. Indeed, the resident gut bacteria are needed for multiple vital functions, such as nutrient and drug metabolism, the production of energy, defense against pathogens, the modulation of the immune system and support of the integrity of the gut mucosal barrier. The bacteria are collected in communities that vary in density and composition within each segment of the gastrointestinal (GI) tract. Therefore, every change in the gut ecosystem has been connected to an increased susceptibility or exacerbation of various GI disorders. The aim of this review is to summarize the recently available data on PPI-related microbiota alterations in each segment of the GI tract and to analyze the possible involvement of PPIs in the pathogenesis of several specific GI diseases. | Giovanni Bruno Piera Zaccari Giulia Rocco Giulia Scalese Cristina Panetta Barbara Porowska Stefano Pontone Carola Severi | 2019 | World Journal of Gastroenterology2019，25，22： | 4 |
| 3 | Dyspepsia and celiac disease: Prevalence, diagnostic tools and therapy显示文摘The prevalence of dyspepsia is up to 40% in population-based study. Functional dyspepsia is an exclusion diagnosis and it is classified as a chronic abdominal pain-related functional disorder, characterized by the presence of persistent or recurrent pain or discomfort centered in the upper abdomen, neither relief by defecation, nor association with the onset of a change in stool frequency or form. Celiac disease(CD) is a common autoimmune enteropathy, with a prevalence around 1% in the general population. Its diagnosis includes a serological screening and an upper gastrointestinal endoscopy with multiple biopsies. Gluten-free diet is the only effective treatment. CD diagnosis is often delayed in asymptomatic patients or in individuals with less clinical gastrointestinal symptoms. Several studies performed coeliac disease screening in patients with symptoms suggestive of dyspepsia, showing a biopsy-proved prevalence that ranged from 0.5% to 2%. The typical endoscopic markers of villous atrophy are not sufficiently sensitive, so some endoscopic techniques, such as 'water immersion' and confocal endomicroscopy were proposed to improve the diagnosticsensitivity and target biopsies. A recent meta-analysis estimated that the prevalence of CD was higher in patients with dyspepsia, but not in a statistically significant way. However this assumption should be confirmed further larger studies. | Laura Petrarca Raffaella Nenna Gerarda Mastrogiorgio Matteo Florio Manuela Brighi Stefano Pontone | 2014 | World Journal of Methodology2014，4，3： | 3 |
| 4 | SCCT guidelines for the interpretation and reporting of coronary CT angiography: A report of the Society of Cardiovascular Computed Tomography Guidelines Committee显示文摘 | Jonathon Leipsic Suhny Abbara Stephan Achenbach Ricardo Cury James P. Earls GB John Mancini Koen Nieman Gianluca Pontone Gilbert L. Raff | 2014 | Journal of Cardiovascular Computed Tomography2014，，5： | 2 |
| 5 | Colorectal cancer screening behavior and willingness显示文摘The outpatient-based study by Deng et al [World J Gastroenterol 2011 July 14; 17(26): 3133-3139] on the factors that may influence the colorectal cancer (CRC) screening feasibility, encouraged our curiosity. Establishing a simple method for quickly assessing the educational level of patients and modulating a questionnaire for each type of patient, may be an effective protocol to increase the people participation, mainly in countries where sufficient medical resources and financial support are lacking. In fact, the knowledge directly affects the feasibility when screening is offered. Patient educational level influences the understanding of the knowledge and the screening method. This factor may affect patient's priority level on the study participation, the understanding of questions, and the motivation to complete the questionnaire and, consequently, the screening success. Recent studies have found a relationship between high educational level and CRC screening participation, and emphasized the question-naire ineffectiveness in the illiterate people. Although the questionnaire is an excellent method for this kind of evaluation, physician's contribution could be the most important factor associated with the screening method. Thus, further studies should be conducted to explore the compliance of patients with low educational level and to look for the best solutions for their enrollment. | Stefano Pontone | 2012 | World Journal of Gastroenterology2012，18，22： | 2 |
| 6 | A randomized controlled trial evaluating a new 2-L PEG solution plus ascorbic acid vs 4-L PEG for bowel cleansing prior to colonoscopy显示文摘 | Flavio Valiante Stefano Pontone Cesare Hassan Angelo Bellumat Manuela De Bona Angelo Zullo Vincenzo de Francesco Michele De Boni | 2011 | Digestive and Liver Disease2011，，3： | 2 |
| 7 | Inhibition of adherence of Candida albicans and Candida dubliniensis to a resin composite restorative dental material by salivary secretory IgA and monoclonal antibodies显示文摘 | Maza JL Ponton J | 2004 | Oral Dis2004，10，2： | 1 |
| 8 | An improvement in processing of hydroxyapatite ceramics 显示文摘 | MURRAY M G S WANG J PONTON C B | 1995 | J Mater Sei1995，30，12： | 1 |
| 9 | Gender differences in cochlear response time:an explanation for gender amplitude differences in the unmasked auditory brain-stem response显示文摘 | Don M Ponton C W Eggermont J J | 1993 | J Acoust Soc Am1993，94，4： | 1 |
| 10 | Complication of ureterorenoseopy显示文摘 | Alapont AJM Broseta RE Pontones MJL | 2003 | Actas Urol Esp2003，27，9： | 1 |
| 11 | Early or delayed laparoscopic choleeystectomy in acute cholecystitis?显示文摘 | Gonzalez-Rogriguez FJ Paredes-Cotore JP Ponton C | 2009 | Hepato gastroenterology2009，56，89： | 1 |
| 12 | Development and healing of matrix microcracks in fibre reinforced glass matrix composites:assessment by internal friction显示文摘 | Boccaccini A R Ponton C B Chawla K K | 1998 | Materials Science and Engineering A1998，241，1： | 1 |
| 13 | A study in short alumina fiber-reinforced mullite composites显示文摘 | WANG J PIRAMOON M R PONTON C B | 1991 | Trans J Br Ceram Soc1991，90，4： | 1 |
| 14 | Clinical, tomographic, and histological assessment of periosteal guided bone regeneration with cortical perforations in advanced human critical size defects显示文摘 | Verdugo F D' Addona A Ponton J | 2012 | Clin Implant Dent RelatRes2012，14，11： | 1 |
| 15 | Microstructural characterization of hydroxyapatite coating on titanium显示文摘 | Ponton C B Marquis P M | 1992 | J Mater Sci Mater Med1992，3，2： | 1 |
| 16 | Compli- cation of uretero-renoscopy显示文摘 | Alapont AJM Broseta RE Pontones MJL | 2003 | Actas Uro Esp2003，27，9： | 1 |
| 17 | Synergistic efficacy of enalapril and losartan on exercise performance and oxygen consumption at peak exercise in congestive heart failure 显示文摘 | Guazzi M Palermo P Pontone G | 1999 | Am J Cardiol1999，84，9： | 1 |
| 18 | The Failure of Protective Oxides on Plasma-Sprayed NiCrAlY Overlay Coatings显示文摘 | P. Niranatlumpong C. B. Ponton H. E. Evans | 2000 | Oxidation of Metals (-)2000，，3： | 1 |
| 19 | Rate of return to military active duty after single level lumbar interbody fu- sion: a 5 - year retrospective review 显示文摘 | Tumialan LM Ponton RP Riccio AL | 2012 | Neurosurgery2012，71，2： | 1 |
| 20 | Maturational delays in cortical evoked potentials in cochlear implant users显示文摘 | EGGERMONT J J PONTON C W DON M | 1997 | Acta Otolaryngol1997，117，： | 1 |
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