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| 1 | 急性ST段抬高型心肌梗死行急诊经皮冠状动脉介入治疗的二联和三联抗血小板治疗比较显示文摘在药物洗脱支架(DES)时代,对于急诊经皮冠状动脉介入治疗(PCI)的急性ST段抬高型心肌梗死(STEMI)患者,三联抗血小板治疗优于还是相同于二联抗血小板治疗?结论仍不明确。 | Chen KY Rha SW Li YJ 刘兵 | 2009 | 中国心血管杂志2009，14，5： | 23 |
| 2 | 内镜下经皮胃造瘘术的并发症及防治进展显示文摘自从1980年第一次报告经内镜下经皮胃造瘘术(percuta-neous endoscopic gastrostomy,PEG)以来[1],现已日益较广泛地应用于临床。方法有Pull(Ponsky)、Push(Sachs-Vine)、Intro-ducer(Russell)及Versa(t-fastener)等。目前最常用的是Pull(Ponsky)即提拉式,被认为是比较安全和有效的方法。PEG是一种有创操作,在操作中及操作后都会有并发症出现,而且使用的镇静药物本身就可能加重患者的病情,有1%~2%的患者的死亡与操作相关[2]。关于并发症的报道显示, | 姜跃龙 Xinsheng Liu Daniel KY Chan | 2013 | 临床消化病杂志2013，25，1： | 22 |
| 3 | 沸石咪唑酯骨架结构材料ZIF-8催化Friedel-Crafts酰基化反应(英文)显示文摘A zeolite imidazolate framework,ZIF-8,was synthesized and characterized by dynamic laser light scattering,X-ray powder diffraction,scanning electron microscopy,transmission electron microscopy,thermogravimetric analysis,Fourier transform infrared,atomic absorption spectrophotometry,and nitrogen adsorption measurements.The ZIF-8 was highly crystalline and porous with a surface area of over 1600 m2 /g.Friedel-Crafts acylation of anisole and benzoyl chloride proceeded well in the presence of ZIF-8(2-6 mol%) without the need for an inert atmosphere.The reaction afforded a selectivity of 93%-95% to the p-isomer.The solid catalyst can be separated from the reaction mixture by simple centrifugation and reused without significant degradation in catalytic activity.There was no leaching of active acid species into the reaction solution. | Lien T. L. NGUYEN Ky K. A. LE Nam T. S. PHAN | 2012 | 催化学报2012，33，4： | 15 |
| 4 | 住院期间反复跌倒的老年患者认知损伤特点的临床回顾性研究显示文摘目的:探索导致老年患者住院期间反复跌倒的相关因素,焦点在其认知损伤的特点,目的是探索可借鉴的管理经验。方法:回顾性地研究了在澳大利亚新南威尔士州Bankstown-Lidcombe医院老年科住院治疗期间发生跌倒的患者,其中住院期间跌倒1次以上的70例、1次的269例,并随机抽取没发生过跌倒的70例为对照组。同时,分析了部分患者的简易智能检查量表(MMSE)总分和各亚项目分数。结果:住院老年患者反复跌倒的独立危险因素是痴呆、脑卒中、房颤和住院时间>5周,保护性因素有英语背景。反复跌倒的患者的MMSE分值明显低于单次跌倒和未发生跌倒的患者(分别为17.3±6.7,20.2±6.2,24.0±5.1,P<0.01),反复跌倒患者在'瞬间记忆'、'注意力和计算力'和'视空间结构'方面分值明显低于单次跌倒患者。结论:认知功能障碍是住院老年患者反复跌倒的主要原因,尤其是在瞬间记忆、延时记忆和视空间结构方面。老年人住院期间跌倒应规范管理,预防为主,尤其是认知功能损伤的患者。 | 王玉波 陈雪丽 Qing Shen Daniel KY Chan Huong Van Nguyen | 2010 | 中国康复医学杂志2010，25，8： | 12 |
| 5 | 半边旗提取物5F对非小细胞肺癌NCI-H460细胞生长的抑制作用显示文摘目的研究半边旗提取物5F对非小细胞肺癌NCI-H460细胞生长的抑制作用。方法MTT法检测5F对NCI-H460细胞的生长抑制作用;用PI-Hoechst荧光双染法和TUNEL法检测细胞凋亡;流式细胞仪检测5F对DNA含量的影响。结果5F抑制NCI-H460细胞的生长,其效果与5F的浓度和作用时间相关,24、48、72h的IC50分别为:21.40、4.52、1.02μg/ml;荧光双染色法显示经5F作用后细胞出现变形,染色质浓缩,产生凋亡小体;细胞被阻滞在G2/M期。结论5F在体外能有效地抑制NCI-H460细胞的生长,其作用可能是通过诱导其凋亡产生的。 | 刘义 吴科锋 李立 George G CHEN Michael KY HSIN Malcolm J UNDERWOOD 梁念慈 | 2009 | 肿瘤防治研究2009，36，1： | 9 |
| 6 | SF6断路器开断过程的数值模拟显示文摘本文通过在N-S方程组中加入源项以考虑电弧效应的方法建立了一个电弧模型,数值方法采用Taylor-galerkin有限元法。使用该模型计压气压SF6断路器的开发过程进行了数值模拟。计算模型考虑了移动的边界条件。给出了在不同开距下电弧温度分布、压力分布以及电弧电压等的数值计算结果,数值模拟结果与试验结果吻合。 | 牟京卫 Park.,KY | 2000 | 高压电器2000，36，4： | 9 |
| 7 | Friction characteristics of mechanically exfoliated and CVD-grown single-layer MoS_2显示文摘In this work, the friction characteristics of single-layer MoS_2 prepared with chemical vapor deposition(CVD) at three different temperatures were quantitatively investigated and compared to those of single-layer MoS_2 prepared using mechanical exfoliation. The surface and crystalline qualities of the MoS_2 specimens were characterized using an optical microscope, atomic force microscope(AFM), and Raman spectroscopy. The surfaces of the MoS2 specimens were generally flat and smooth. However, the Raman data showed that the crystalline qualities of CVD-grown single-layer MoS2 at 800 °C and 850 °C were relatively similar to those of mechanically exfoliated MoS2 whereas the crystalline quality of the CVD-grown single-layer MoS_2 at 900 °C was lower. The CVD-grown single-layer MoS_2 exhibited higher friction than mechanically exfoliated single-layer MoS_2, which might be related to the crystalline imperfections in the CVD-grown MoS_2. In addition, the friction of CVD-grown single-layer MoS_2 increased as the CVD growth temperature increased. In terms of tribological properties, 800 °C was the optimal temperature for the CVD process used in this work. Furthermore, it was observed that the friction at the grain boundary was significantly larger than that at the grain, potentially due to defects at the grain boundary. This result indicates that the temperature used during CVD should be optimized considering the grain size to achieve low friction characteristics. The outcomes of this work will be useful for understanding the intrinsic friction characteristics of single-layer MoS2 and elucidating the feasibility of single-layer MoS_2 as protective or lubricant layers for micro- and nano-devices. | Dinh Le Cao KY Bien-Cuong TRAN KHAC Chinh Tam LE Yong Soo KIM Koo-Hyun CHUNG | 2018 | Friction2018，6，4： | 9 |
| 8 | 血液及体液溅落物在大型教学医院中的分布调查显示文摘血液和体液的溅落(BBFSs)是潜在的感染源。但它在医院中的分布却从未有人描述过。我们在香港玛丽皇后医院就此进行了一次流行状况调查。在调查的第一阶段,我们调查了当班护士以肯定BBFSs已被医院中的勤杂人员加以清除,在第二阶段,我们对227位勤杂人员进行了提问,以确定在他们上班时发生BBFSs的次数、类型和原因。据报告,在手术室及急诊室出现了130例溅落,其中大部分是血液(分别为82%及60%)。在病房中出现的518例溅落中,38%为尿液,26%为血液,13%为痰液,9%为呕吐物,8%为粪便,4%为脓液或引流液,4%为透析液,溅落平均发生频度为40次/100张床/日。血液出现频度最高处为ICU(25次/100张床),尿液出现频度最高处为大学部内科和骨科,(27次/100张床),痰液出现频度最高处为内科(14次/100张床),粪便出现频度最高处为骨科(7次/100张床),呕吐物出现频度最高处为儿科(8次/100张床),据报告,80%的溅落是病人引起的。 | Scto WH Ching TY Yucn KY Chu YB 艾成绪 | 1991 | 中华医院感染学杂志1991，1，1： | 5 |
| 9 | 垂向环流作用下湖泊沉积物磷迁移行为显示文摘以巢湖十五里河入湖河口原位底泥为研究对象,通过室内模型实验,模拟了垂向环流的动水条件下,溶解态无机磷(DIP)在泥水界面的释放-吸附过程,探讨了不同强度环流对河口底泥DIP迁移的影响行为.结果表明:垂向环流扰动会引起上覆水中溶解氧(DO)和悬浮颗粒物(SPM)含量明显上升,且其平衡浓度与扰动强度均呈正相关,但悬浮物中值粒径(D_(50))则随扰动强度的增大而降低;垂向环流作用下沉积物DIP的释放量随时间呈“Λ”型分布,显著区别于其他动水扰动情形,释放峰值与环流强度成显著正相关(P=0.047<0.05),但平衡值则与之呈显著负相关(P=0.034<0.05);环流扰动的增强促进了DIP在沉积物上的吸附,并构建了耦合天然水动力效应的沉积物DIP Freundlich等温吸附经验公式:lgQe=2.7074e^(1.3487τ)+0.9463e^(-1.4830τ)lgCe. | 刘园园 褚克坚 陆滢 华祖林 KY Sereyvatanak 顾莉 刘晓东 徐龙龙 | 2021 | 中国环境科学2021，41，6： | 5 |
| 10 | Copper transportion of WD protein in hepatocytes from Wilson disease patients in vitro显示文摘AIM: To study the effect of copper transporting P-type ATPase in copper metabolism of hepatocyte and pathogenesis of Wilson disease (WD).METHODS: WD copper transporting properties in some organelles of the cultured hepatocytes were studied from WD patients and normal controls. These cultured hepatocytes were incubated in the media of copper 15mg.L-1 only, copper 15 mg. L-1 with vincristine (agonist of P-type ArPase) 0.5mg. L-1, or copper 15 mg. L-1 withvanadate (antagonist of P-type ATPase) 18.39 mg. L-1separately. Microsome (endoplasmic reticulum and Golgi apparatus), lysosome, mitochondria, and cytosol were isolated by differential centrifugation. Copper contents in these organelles were measured with atomic absorption spectrophotometer, and the influence in copper transportion of these organelles by vanadate and vincristine were comparatively analyzed between WD patients and controls.WD copper transporting P-type ATPase was detected by SDS-PAGE in conjunction with Western blot in liver samples of WD patients and controls.RESULTS: The specific WD proteins (Mr155 000 lanes) were expressed in human hepatocytes, including the control and WD patients. After incubation with medium containing copper for 2 h or 24 h, the microsome copper concentration in WD patients was obviously lower than that of controls,and the addtion of vanadate or vincristine would change the copper transporting of microsomes obviously. When incubated with vincristine, levels of copper in microsome were significantly increased, while incubated with vanadate,the copper concentrations in microsome were obviously decreased. The results indicated that there were Wdproteins, the copper transportion P-type ATPase in the microsome of hepatocytes. WD patients possessed abnormal copper transporting function of WD protein in the microsome, and the agonist might correct the defect of copper transportion by promoting the activity of copper transportion P-type ATPase.CONCLUSION: Copper transportion P-type ATPase plays an important role in hepatocytic copper metabolism.Dysfunction of hepatocytic WD protein copper transportion might be one of the most important factors for WD. | Guo-Qing Hou~1 Xiu-Ling Liang~2 Rong Chen~2 Li-Wen Tang~3 Ying Wang~2 Ping-Yi Xu~2 Ying-Ru Zhang~2 Cui-Hua Ou~2 1 Department of Neurology.Guangzhou First Municipal People’s Hospital,Guangzhou Medical College,Guangzhou 510180,Guangdong Province.China2 Department of Neurology.First Affiliated Hospital.Sun Yat-Sen University of Medical Sciences.Guangzhou 510080.Guangdong Province.China3 Department of Pharmacology,University of Kentucky.Lexington,KY 40506.USA | 2001 | World Journal of Gastroenterology2001，7，6： | 4 |
| 11 | Syntax of first-order lattice valued logic system FM显示文摘PAVELKA in ref. [1] established a propositional logic system whose truth values domain is an enriched residuated lattice and obtained some beautiful results. In order to study more general lattice valued logic systems, we proposed the concept of lattice implication algebra, discussed the corresponding lattice valued propositional logic system, and established a | Xu, Y Qin, KY Song, ZM | 1997 | Chinese Science Bulletin1997，42，16： | 4 |
| 12 | The association between frailty and vascular dementia显示文摘 | Daniel KY Chan Vivek Srinivasan Ciaran Upton Xueli Chen Roman Romero-Ortuno | 2015 | 中华老年医学杂志2015，34，12： | 4 |
| 13 | Distribution of Prestin on Outer Hair Cell Basolateral Surface显示文摘Prestin has been identified as a motor protein responsible for outer hair cell (OHC) electromotility and is expressed on the OHC surface. Previous studies revealed that OHC electromotility and its associated nonlinear capacitance were mainly located at the OHC lateral wall and absent at the apical cuticular plate and the basal nucleus region. Immunofluorescent staining for prestin also failed to demonstrate prestin expression at the OHC basal ends in whole-mount preparation of the organ of Corti. However, there lacks a definitive demonstration of the pattern of prestin distribution. The OHC lateral wall has a trilaminate organization and is composed of the plasma membrane, cortical lattice, and subsurface cisternae. In this study, the location of prestin proteins in dissociated OHCs was examined using immunofluorescent staining and confocal microscopy. We found that prestin was uniformly expressed on the basolateral surface, including the basal pole. No staining was seen on the cuticular plate and stereocilia. When co-stained with a membrane marker di-8-ANEPPS, prestin-labeling was found to be in the outer layer of the OHC lateral wall. After separating the plasma membrane from the underlying subsurface cisternae using a hypotonic extracellular solution, prestin-labeling was found to be in the plasma membrane, not the subsurface cisternae. The data show that prestin is expressed in the plasma membrane on the entire OHC basolateral surface. | YU Ning1,2, ZHAI Suo-qiang1, YANG Shi-ming1, HAN Dong-yi1, ZHAO Hong-bo2, 1 Department of Otolaryngology & Institute of Otolaryngology, CPLA General Hospital, BJ, 100853 2 Department of Surgery-Otolaryngology, University of Kentucky Medical Center, Lexington, KY 40536-0293 | 2008 | Journal of Otology2008，3，2： | 3 |
| 14 | Genetic polymorphism in pathogenesis of irritable bowel syndrome显示文摘Irritable bowel syndrome(IBS)is a complex symptombased disorder without established biomarkers or putative pathophysiology.IBS is a common functional gastrointestinal disorder which is defined as recurrent abdominal pain or discomfort that has at least two of the following symptoms for 3 d per month in the past 3mo according to ROMEⅢ:relief by defecation,onset associated with a change in stool frequency or onset with change in appearance or form of stool.Recent discoveries revealed genetic polymorphisms in specific cytokines and neuropeptides may possibly influence the frequencies and severity of symptoms,as well as the therapeutic responses in treating IBS patients.This review gives new insights on how genetic determinations influence in clinical manifestations,treatment responses and potential biomarkers of IBS. | Cynthia KY Cheung Justin CY Wu | 2014 | World Journal of Gastroenterology2014，20，47： | 3 |
| 15 | A generalization of Tychonoff’s fixed point theorem显示文摘 | Ky Fan | 1961 | Mathematische Annalen1961，，3： | 3 |
| 16 | Minimum spouting velocity of flat-base spouted fluid bed显示文摘 | Esmail R. Monazam Ronald W. Breault Justin Weber Ky Layfield | 2018 | Particuology2018，16，1： | 3 |
| 17 | 经皮内镜下胃造瘘在治疗中风后患者中的应用进展显示文摘中风后很多患者都会出现吞咽困难,并且在短时间内无法恢复.经皮内镜下胃造瘘术(percutaneous endoscopic gastrostomy,PEG)可以为中风后吞咽功能障碍的患者提供长期的营养支持,与静脉营养以及传统的鼻胃管治疗相比有很多的优势,因此传统的观念认为PEG可以减少并发症,提高患者的生活质量,但是近年来的关于并发症和死亡率的研究有相反的结果.因此如何选择合适的患者,合适的时机,预测可能出现的各种并发症以及生存时间才能使患者从中获益.本文全面地分析了近年来的研究并对比了早期的研究,阐述了PEG在中风患者中的应用应该个体化综合分析的理念,为临床上PEG应用前提供参考依据. | 姜跃龙 Daniel KY Chan | 2012 | 世界华人消化杂志2012，20，23： | 3 |
| 18 | 应变率效应对短纤维增强热塑性树脂PPS力学性能的影响显示文摘本文通过大量的实验,研究了应变率效应对短纤维增强热塑性树脂PPS(聚苯硫醚)力学性能的影响,应变率变化范围从10-4/s~102/s。并对断口形貌及破坏形式进行了观察。研究结果表明:应变率较高时对材料的强度和模量有明显影响,而且应变率不同断口形貌也存在一定的差别。断口形貌呈脆性破坏。 | 田兰桥 Robert KY Li | 1996 | 复合材料学报1996，13，4： | 3 |
| 19 | Some properties of convex sets related to fixed point theorems显示文摘 | Ky Fan | 1984 | Mathematische Annalen1984，，4： | 3 |
| 20 | An introduction to load management显示文摘 | K. Kostková ?. Omelina P. Ky?ina P. Jamrich | 2013 | Electric Power Systems Research2013，，： | 2 |
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