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| 1 | Existing drugs as broad-spectrum and potent inhibitors for Zika virus by targeting NS2B-NS3 interaction显示文摘Zika 病毒(ZIKV ) 的最近的爆发为治疗学加亮迫切需要。朊酶建筑群 NS2B-NS3 在 flaviviral polyprotein 处理期间起必要作用,并且因此代表一个吸引人的药目标。这里,我们开发了裂口酶识别直接指向 flavivirus NS2B-NS3 相互作用的 orthosteric 禁止者的基于互补的高产量的屏蔽试金。由屏蔽一个总数 2 816 同意了并且 investigational 药,我们识别了三个有势力候选人, temoporfin, niclosamide,和 nitazoxanide,,有 nanomolar 力量的 flavivirus NS2B-NS3 相互作用禁止者。显著地,在老鼠的在人的胎盘、神经的祖先房间的大多数有势力化合物, temoporfin,不是仅仅禁止的 ZIKV 复制,而且阻止的导致 ZIKV 的 viremia 和死亡当模特儿。结构的停靠建议 temoporfin 潜在地绑保持批评 NS2B 残余的 NS3 衣袋,因此禁止以一种非竞争的方式处理的 flaviviral polyprotein。当这些药已经在 USA 或另外的国家在另外的指示任何一个为临床的使用被同意了,他们由 ZIKV 和另外的 flaviviruses 为感染的管理代表有希望、容易开发的治疗。 | Zhong Li Matthew Brecher Yong-Qiang Deng Jing Zhang Srilatha Sakamuru Binbin Liu Ruili Huang Cheri A Koetzner Christina A Allen Susan A Jones Haiying Chen Na-Na Zhang Min Tian Fengshan Gao Qishan Lin Nilesh Banavali Jia Zhou Nathan Boles Menghang Xia Laura D Kramer Cheng-Feng Qin Hongmin Li | 2017 | Cell Research2017，27，8： | 11 |
| 2 | Has the time come for metro- nomics in low-income and middle-income countries? 显示文摘 | Andr6 N Banavali S Snihur Y | 2013 | Lancet Oncol2013，14，6： | 1 |
| 3 | The CD34 hemapoietic progenitor cell associated antigen:biology and clinical applications显示文摘 | Silvestri F Banavali S Baccarani M | 1992 | Haematologica1992，77，： | 1 |
| 4 | Desmoplastic small round cell tumour: extra abdominal and abdominal presentations and the results of treatment显示文摘 | Biswas G Laskar S Banavali SD | 2005 | Indian J Cancer2005，42，2： | 1 |
| 5 | High level expressionof N-acetylgluosamine-6-O-sulfotransferase is characteristic of a sub-group of paediatric precursor-B acute lymphoblastic leukaemia显示文摘 | Timson G Banavali S Gutierrez MI | 2006 | Cancer Lett2006，242，2： | 1 |
| 6 | Danazol in treatment of angioimmunoblastic lymphadenopathy显示文摘 | Banavali SD Parikh PM Charka BS | 1989 | Cancer1989，64，： | 1 |
| 7 | Role of RT-PCR and FISH in diagnosis and monitoring of acute promyelocytic leukemia显示文摘 | S Polampalli A Choughule K Prabhash P Amare C Baisane S Kabre S Mahadik S Shinde R Nair S Banavali | 2011 | Indian Journal of Cancer2011，，1： | 1 |
| 8 | Hepatoblastoma: a single institutional experience of 18 cases显示文摘 | Parul J. Shukla Savio G. Barreto Sajid S. Qureshi Rohini Hawaldar Shailesh V. Shrikhande Mukta R. Ramadwar Shripad Banavali | 2008 | Pediatric Surgery International2008，，7： | 1 |
| 9 | Netrin-1:interaction with deleted in colorectal cancer (DCC) and alterations in brain tumors and neuroblastomas显示文摘 | Meyerhardt J A Caca K Eckstrand B C Hu G Lengauer C Banavali S | 1999 | Cell Growth Differ1999，10，： | 1 |
| 10 | Tertiary alkyl primary amines as stabilizers for middle distillate fuels显示文摘 | Banavali R C | 1997 | Fuel Chem1997，42，3： | 1 |
| 11 | Has the time come for metronomics in lowincome and middleincome countries?显示文摘 | André N Banavali S Snihur Y | 2013 | Lancet Oncol2013，14，6： | 1 |
| 12 | Flexibility and charge asymmetry in the activation loop of Src tyrosine kinases显示文摘 | Banavali NK Roux B | 2009 | Proteins2009，74，2： | 1 |
| 13 | Pictorial essay:acute neu- rological complications in children with acute lymphoblastic leukemia显示文摘 | Kembhavi SA Somvanshi S Banavali S | 2012 | Indian J Radiol Imaging2012，22，2： | 1 |
| 14 | Expression of hematopoietic progenitor cell associated antigen CD34 in chronic myeloid leukemia显示文摘 | Banavali S Silvestri F Hulette B | 1991 | Leuk Res1991，15，： | 1 |
| 15 | Desmoplastic small round cell tumor: extra abdominal and abdominal presentations and the results of treatment显示文摘 | Biswas G Laskar S Banavali SD | 2005 | Indian J Cancer2005，42，2： | 1 |
| 16 | Response assessment in metronomic chemotherapy: RECIST or PERCIST?显示文摘 | Archi Agrawal Nilendu Purandare Sneha Shah Ameya Puranik Shripad Banavali Venkatesh Rangarajan | 2014 | Indian Journal of Nuclear Medicine2014，，2： | 1 |
| 17 | The CD34 hemopoietic progenitor cell associated antigen:biology and clinical applications显示文摘 | Silvestri F Banavali S Baccarani M | | 0，，03： | 1 |
| 18 | Desmoplastic small round cell tumor: extra abdominal and abdominal presentations and the results of treatment 显示文摘 | Biswas G Laskar S Banavali SD | 2005 | Indian J Cancer2005，42，2： | 1 |
| 19 | Concurrent methylation of multiple genes in childhood ALL: Correlation with phenotype and molecular subgroup显示文摘 | Gutierrez MI Siraj AK Bhargava M Ozbek U Banavali S Chaudhary MA | 2003 | Leukemia2003，17，9： | 1 |
| 20 | Multiparame-ter assessmant of the cell cycle effects of bioactiv and cy-totxicagents显示文摘 | Harvvey D P Gopal V Banavali S D | 1992 | Joumal of Cancet Researsh1992，52，： | 1 |
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