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| 1 | Pancreatic fistula after pancreatectomy:Evolving definitions,preventive strategies and modern management显示文摘Pancreatic resection is the treatment of choice for pancreatic malignancy and certain benign pancreatic disorders. However, pancreatic resection is technically a demanding procedure and whereas mortality after a pancreaticoduodenectomy is currently < 3%-5% in experienced high-volume centers, post-operative morbidity is considerable, about 30%-50%. At present, the single most significant cause of morbidity and mortality after pancreatectomy is the development of pancreatic leakage and fistula (PF). The occurrence of a PF increases the length of hospital stay and the cost of treatment, requires additional investigations and procedures, and can result in life-threatening complications. There is no universally accepted definition of PF that would allow standardized reporting and proper comparison of outcomes between different centers. However, early recognition of a PF and prompt institution of appropriate treatment is critical to the prevention of potentially devastating consequences. The present article, reviews the evolution of post resection pancreatic fistula as a concept, and discusses evolving definitions, the current preventive strategies and the management of this problem. | Shailesh V Shrikhande Melroy A D'Souza | 2008 | World Journal of Gastroenterology2008，14，38： | 26 |
| 2 | Histone deacetylase inhibitor pre-treatment enhances the efficacy of DNA-interacting chemotherapeutic drugs in gastric cancer显示文摘BACKGROUND The prognosis of gastric cancer continues to remain poor,and epigenetic drugs like histone deacetylase inhibitors(HDACi)have been envisaged as potential therapeutic agents.Nevertheless,clinical trials are facing issues with toxicity and efficacy against solid tumors,which may be partly due to the lack of patient stratification for effective treatments.To study the need of patient stratification before HDACi treatment,and the efficacy of pre-treatment of HDACi as a chemotherapeutic drug sensitizer.METHODS The expression activity of class 1 HDACs and histone acetylation was examined in human gastric cancer cells and tissues.The potential combinatorial regime of HDACi and chemotherapy drugs was defined on the basis of observed drug binding assays,chromatin remodeling and cell death.RESULTS In the present study,the data suggest that the differential increase in HDAC activity and the expression of class 1 HDACs are associated with hypoacetylation of histone proteins in tumors compared to normal adjacent mucosa tissue samples of gastric cancer.The data highlights for the first time that pretreatment of HDACi results in an increased amount of DNA-bound drugs associated with enhanced histone acetylation,chromatin relaxation and cell cycle arrest.Fraction-affected plots and combination index-based analysis show that pre-HDACi chemo drug combinatorial regimes,including valproic acid with cisplatin or oxaliplatin and trichostatin A with epirubicin,exhibit synergism with maximum cytotoxic potential due to higher cell death at low combined doses in gastric cancer cell lines.CONCLUSION Expression or activity of class 1 HDACs among gastric cancer patients present an effective approach for patient stratification.Furthermore,HDACi therapy in pretreatment regimes is more effective with chemotherapy drugs,and may aid in predicting individual patient prognosis. | Ramchandra Vigay Amnekar Shafqat Ali Khan Mudasir Rashid Bharat Khade Rahul Thorat Poonam Gera Shailesh V Shrikhande Duane T Smoot Hassan Ashktorab Sanjay Gupta | 2020 | World Journal of Gastroenterology2020，26，6： | 3 |
| 3 | Is laparoscopic colorectal cancer surgery equal to open surgery? An evidence based perspective显示文摘Laparoscopic colorectal surgery(LCS) is an evolving subject.Recent studies show that LCS can not only offer safe surgery but evidence is growing that this new technique can be superior to classical open procedures.Fewer perioperative complications and faster postoperative recovery are regularly mentioned when studies of LCS are presented.Even though the learning curve of LCS is frequently debated when limitations of laparoscopic surgeries are reviewed,studies show that in experienced hands LCS can be a safe procedure for colorectal cancer treatment.The learning curve however,is associated with high conversion rates and economical aspects such as higher costs and prolonged hospital stay.Nevertheless,laparoscopic colorectal cancer surgery(LCCR) offers several advantages such as less co-morbidity and less postoperative pain in comparison with open procedures.Furthermore,the good exposure of the pelvic cavity by laparoscopy and the magnification of anatomical structures seem to facilitate pelvic dissection laparoscopically.Moreover,recent studies describe no difference in safety and oncological radicalness in LCCR compared to the open total mesorectal excision(TME).The oncological adequacy of LCCR still remains unproven today,because long-term results do not yet exist.To date,only a few studies have described the results of laparoscopic TME combined with preoperative adjuvant treatment for colorectal cancer.The aim of this review is to examine the various areas of development and controversy of LCCR in comparison to the conventional open approach. | Beat M Künzli Helmut Friess Shailesh V Shrikhande | 2010 | World Journal of Gastrointestinal Surgery2010，2，4： | 3 |
| 4 | Extended pancreatic resections and lymphadenectomy:An appraisal of the current evidence显示文摘Surgery remains the mainstay of treatment for pancreatic ductal adenocarcinoma and complete removal of the cancer confers a definite survival advantage,especially in early disease.However,the majority of patients do not present with early disease,thus precluding the chance of a cure by standard pancreatoduodenectomy(PD),distal pancreatectomy or total pancreatectomy.For this reason,pancreatic surgeons have attempted to push the limits of resection over the last three decades.The aim of these resections has been to determine whether obtaining a complete resection by extending the limits of conventional resection in patients with advanced disease will yield the results seen with PD alone in early disease.This article revisits the data from such studies in an attempt to determine if the available literature supports the performance of extended resections for pancreatic cancer in terms of improvement of survival. | Shailesh V Shrikhande Savio G Barreto | 2010 | World Journal of Gastrointestinal Surgery2010，2，2： | 2 |
| 5 | Cell-type specificity of β-actin expression and its clinicopathological correlation in gastric adenocarcinoma显示文摘AIM:To investigate cell type specific distribution ofβ-actin expression in gastric adenocarcinoma and its correlation with clinicopathological parameters.METHODS:β-actin is a housekeeping gene,frequently used as loading control,but,differentially expresses in cancer.In gastric cancer,an overall increased expression ofβ-actin has been reported using tissue disruptive techniques.At present,no histological data is available to indicate its cell type-specific expression and distribution pattern.In the present study,we analyzedβ-actin expression and distribution in paired normal and tumor tissue samples of gastric adenocarcinoma patients using immunohistochemistry(IHC),a tissue non-disruptive technique as well as tissue disruptive techniques like reverse transcriptase-polymerase chain reaction(RT-PCR)and western blotting.Correlation ofβ-actin level with clinicopathological parameters was done using univariate analysis.RESULTS:The results of this study showed significant overexpression,at both mRNA and protein level in tumor tissues as confirmed by RT-PCR(1.47±0.13 vs2.36±0.16;P<0.001)and western blotting(1.92±0.26 vs 2.88±0.32;P<0.01).IHC revealed thatβ-actin expression is majorly distributed between epithelial and inflammatory cells of the tissues.Inflammatory cells showed a significantly higher expression compared to epithelial cells in normal(2.46±0.13 vs 5.92±0.23,P<0.001),as well as,in tumor tissues(2.79±0.24 vs6.71±0.14,P<0.001).Further,comparison of immunostaining between normal and tumor tissues revealed that both epithelial and inflammatory cells overexpressβ-actin in tumor tissues,however,significant difference was observed only in inflammatory cells(5.92±0.23vs 6.71±0.14,P<0.01).Moreover,combined expression in epithelial and inflammatory cells also showed significant increase(4.19±0.15 vs 4.75±0.14,P<0.05)in tumor tissues.In addition,univariate analysis showed a positive correlation ofβ-actin level of inflammatory cells with tumor grade(P<0.05)while epithelial cells exhibited negative correlation(P>0.05).CONCLUSION:In gastric cancer,β-actin showed an overall higher expression predominantly contributed by inflammatory or tumor infiltrating immune cells of the tissue microenvironment and correlates with tumor grade. | Shafqat A Khan Monica Tyagi Ajit K Sharma Savio G Barreto Bhawna Sirohi Mukta Ramadwar Shailesh V Shrikhande Sanjay Gupta | 2014 | World Journal of Gastroenterology2014，20，34： | 2 |
| 6 | Pancreatic Resection for M1 Pancreatic Ductal Adenocarcinoma显示文摘 | Shailesh V. Shrikhande MD J?rg Kleeff MD Carolin Reiser MD Jürgen Weitz MD Ulf Hinz MSc Irene Esposito MD Jan Schmidt MD Helmut Friess MD Markus W. Büchler MD | 2007 | Annals of Surgical Oncology2007，，1： | 2 |
| 7 | Evolution of pancreatoduodenectomy in a tertiary cancer center in India: Improved results from service reconfiguration显示文摘 | Shailesh V. Shrikhande Savio George Barreto B.A. Somashekar Kunal Suradkar Guruprasad S. Shetty Sanjay Talole Bhawna Sirohi Mahesh Goel Parul J. Shukla | 2013 | Pancreatology2013，，1： | 2 |
| 8 | Surgery for gallbladder cancer:The need to generate greater evidence显示文摘The outcomes for gallbladder cancer remain largely dismal to this day.Overall,the low incidence of gallbladder cancer around the world coupled with an even lower number of patients amenable to surgery at the time of presentation,has precluded the generation of evidence-based guidelines for the management of this cancer.However,while the incidence of the cancer may be decreasing in some parts of the world,in other countries such as India,Japan and Chile,gallbladder cancer continues to affect a sizeable population of patients.As such,there is a growing need to define what constitutes an adequate surgery for each stage of this cancer,based on sound evidence.This editorial provides a broad overview of the existing problems in the management of gallbladder cancer and appeals for multi-institutional studies aimed at answering some of the pertinent questions on the surgical management of gallbladder cancer. | Shailesh V Shrikhande Savio G Barreto | 2009 | World Journal of Gastrointestinal Surgery2009，1，1： | 2 |
| 9 | Pancreatic fistula after pancreaticoduodenectomy: the impact of a standardized technique of pancreaticojejunostomy显示文摘 | Shailesh V. Shrikhande George Barreto Parul J. Shukla | 2008 | Langenbeck’s Archives of Surgery2008，，1： | 2 |
| 10 | Role of the hepatocyte growth factor receptor,c-Met,in oncogenesis and potential for therapeutic inhibition显示文摘 | Gautam Maulik a Amol Shrikhande a Takashi Kijima a | 2002 | Cytokin & Growth FactorReviews2002，13，： | 1 |
| 11 | Management of hepatobiliary cystadenocarcinoma显示文摘 | Shrikhande S Kleeff J Adyanthaya K | | 0，，01： | 1 |
| 12 | Role of the hepatocyte growth factor receptor, c-Met,in oncogenesis and potential for ther- apeutic inhibition 显示文摘 | Maulik G Shrikhande A Kijima T | 2002 | Cytokine Growth Factor Rev2002，13，1： | 1 |
| 13 | Role of the hepatocyte growth receptor, c- Met,in oncogenesis and potential for therapeutic inhibition 显示文摘 | Maulik G Shrikhande A Kijima T | 2002 | Cytokine Growth factor Rev2002，13，1： | 1 |
| 14 | Role of the hepatocyte growth factor receptor,c-Met,in oncogenesis and potential for therapeutic inhibition显示文摘 | Maulik G Shrikhande A Kijima T | 2002 | Cytokine Growth Factor Rev2002，13，1： | 1 |
| 15 | Role of the protein tyrosine kinase Syk in regulating cell-cell adhesion and motility in breast cancer cells显示文摘 | Zhang X Shrikhande U Alicie BM Zhou Q Geahlen RL | 2009 | Mol Cancer Res2009，7，5： | 1 |
| 16 | Role of the hepatocyte growth factor receptor c-Met in oncogenesis and potential for therapeutic inhibition显示文摘 | Maulik G Shrikhande A Kijima T | 2002 | Cytokine Growth Factor Rev2002，13，1： | 1 |
| 17 | Superior mesenteric artery first combined with uncinate process approach versus uncinate process first approach in pancreatoduodenectomy: a comparative study evaluating perioperative outcomes 显示文摘 | Shrikhande SV Barreto SG Bodhankar YD | 2011 | Langenbecks Arch Surg2011，396，8： | 1 |
| 18 | Pancreatic anastomoses after pancreaticoduodenectomy: do we need further studies?显示文摘 | Shrikhande SV Qureshi SS Rajneesh N | 2005 | World J Surg2005，29，12： | 1 |
| 19 | Management of earlyhemorrhage from pancreatic anastomoses after pancreatico-duodenectomy显示文摘 | Wente M N Shrikhande S V KteelT J | 2006 | Dig Surg2006，23，： | 1 |
| 20 | On hereditary and cohereditary modules显示文摘 | | 1973 | Canad J Math1973，25，： | 1 |
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