|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Passive technologies for future large-scale photonic integrated circuits on silicon: polarization handling, light non-reciprocity and loss reduction显示文摘Silicon-based large-scale photonic integrated circuits are becoming important,due to the need for higher complexity and lower cost for optical transmitters,receivers and optical buffers.In this paper,passive technologies for large-scale photonic integrated circuits are described,including polarization handling,light non-reciprocity and loss reduction.The design rule for polarization beam splitters based on asymmetrical directional couplers is summarized and several novel designs for ultra-short polarization beam splitters are reviewed.A novel concept for realizing a polarization splitter–rotator is presented with a very simple fabrication process.Realization of silicon-based light non-reciprocity devices(e.g.,optical isolator),which is very important for transmitters to avoid sensitivity to reflections,is also demonstrated with the help of magneto-optical material by the bonding technology.Low-loss waveguides are another important technology for large-scale photonic integrated circuits.Ultra-low loss optical waveguides are achieved by designing a Si3N4 core with a very high aspect ratio.The loss is reduced further to,0.1 dB m21 with an improved fabrication process incorporating a high-quality thermal oxide upper cladding by means of wafer bonding.With the developed ultra-low loss Si3N4 optical waveguides,some devices are also demonstrated,including ultra-high-Q ring resonators,low-loss arrayed-waveguide grating(de)multiplexers,and high-extinction-ratio polarizers. | Daoxin Dai Jared Bauters John E Bowers | 2012 | Light(Science & Applications)2012，1，1： | 28 |
| 2 | Management of distal humeral coronal shear fractures显示文摘Coronal shear fractures of the distal humerus are rare,complex fractures that can be technically challenging to manage. They usually result from a low-energy fall and direct compression of the distal humerus by the radial head in a hyper-extended or semi-flexed elbow or from spontaneous reduction of a posterolateral subluxation or dislocation. Due to the small number of soft tissue attachments at this site, almost all of these fractures are displaced. The incidence of distal humeral coronal shear fractures is higher among women because of the higher rate of osteoporosis in women and the difference in carrying angle between men and women. Distal humeral coronal shear fractures may occur in isolation, may be part of a complex elbow injury, or may be associated with injuries proximal or distal to the elbow. An associated lateral collateral ligament injury is seen in up to 40% and an associated radial head fracture is seen in up to 30% of these fractures. Given the complex nature of distal humeral coronal shear fractures, there is preference for operative management. Operative fixation leads to stable anatomic reduction, restores articular congruity, and allows initiation of early range-of-motion movements in the majority of cases. Several surgical exposure and fixation techniques are available to reconstruct the articular surface fol owing distal humeral coronal shear fractures. The lateral extensile approach and fixation with countersunk headless compression screws placed in an anterior-to-posterior fashion are commonly used. We have found a two-incision approach(direct anterior and lateral) that results in less soft tissue dissection and better outcomes than the lateral extensile approach in our experience. Stiffness, pain, articular incongruity, arthritis, and ulnohumeral instability may result if reduction is non-anatomic or if fixation fails. | Shahram S Yari Nathan L Bowers Miguel A Craig Lee M Reichel | 2015 | World Journal of Clinical Cases2015，3，5： | 15 |
| 3 | Vascular endothelial growth factor for the treatment of femoral head osteonecrosis: An experimental study in canines显示文摘AIM To evaluate the treatment of osteonecrosis of the femoral head(ONFH) with the use of vascular endothelial growth factor(VEGF).METHODS In 30 mature beagles(6 groups of 5 beagles) ONFH was induced cryosurgically and one of the following solutions was administered locally in the femoral head(FH) in each group: Single injection of 500 μg VEGF(t-VEGFμ group); single injection of 500 ng VEGF(t-VEGFn group); continuous delivery of 500 μg VEGF through osmotic micropump(t-VEGFpump-μ group); continuous delivery of 500 ng VEGF through osmotic micropump(t-VEGFpump-n group); single injection of 0.9% sodium chloride(t-NS group), while one group that served as control group did not receive any local solution(No-t group). FHs were retrieved 12 wk postoperatively, underwent decalcification and hematoxylin/eosin and toluidine blue staining. In two canines per group, one half of FH was processed without decalcification and stained with modified Masson Trichrome. Histological sections were observed by light microscopy and measured with a semi-automatized bone histomorphometry system and Bone Volume/Total Volume(BV/TV), Marrow Volume/Total Volume(MaV/TV), and Trabecular Thickness(TbT h) were assessed. Standard and robust tests(Welch, Brown Forsythe) of analysis of variance along with multiple comparisons, were carried out among the categories.RESULTS The untreated(No-t) group had signs of osteonecrosis, whereas the VEGF groups revealed reversal of the osteonecrosis. Statistical analysis of the decalcified specimens revealed a significantly better BV/TV ratio and a higher Tb Th between the VEGF treatment groups(except the t-VEGFn group) and the No-t group or the control t-NS group. Single dose 500 μg VEGF group had significantly better BV/TV ratio and higher Tb Th when compared to the No-t group(50.45 ± 6.18 vs 29.50 ± 12.27, P = 0.002 and 151.44 ± 19.07 vs 107.77 ± 35.15, P = 0.161 respectively) and the control t-NS group(50.45 ± 6.18 vs 30.9 ± 6.67, P = 0.004 and 151.44 ± 19.07 vs 107.14 ± 35.71, P = 0.151 respectively). Similar differences were found for the prolonged VEGF delivery/pump groups of 500 μg and 500 ng. Analysis of the totality of specimens(decalcified/non-decalcified) enhanced the aforementioned differences and additionally revealed significant differences in the comparison of the TbT h.CONCLUSION In an experimental model of ONFH in canines it was found that local treatment with VEGF leads to bone tissue remodeling and new bone formation. | Zoe H Dailiana Nikolaos Stefanou Lubna Khaldi Georgios Dimakopoulos James R Bowers Cristian Fink James R Urbaniak | 2018 | World Journal of Orthopedics2018，9，9： | 13 |
| 4 | Chemoprotective effects of curcumin in esophageal epithelial cells exposed to bile acids显示文摘AIM:To investigate the ability of curcumin to counteract the impact of bile acids on gene expression of esophageal epithelial cells.METHODS:An esophageal epithelial cell line(HET1A)was treated with curcumin in the presence of deoxycholic acid.Cell proliferation and viability assays were used to establish an appropriate dose range for curcumin.The combined and individual effects of curcumin and bile acid on cyclooxygenase-2(COX-2)and superoxide dismutase(SOD-1 and SOD-2)gene expression were also assessed.RESULTS:Curcumin in a dose range of 10-100μmol/L displayed minimal inhibition of HET-1A cell viability.Deoxycholic acid at a concentration of 200μmol/L caused a 2.4-fold increase in COX-2 gene expression compared to vehicle control.The increased expression of COX-2 induced by deoxycholic acid was partially reversed by the addition of curcumin,and curcumin reduced COX-2 expression 3.3-to 1.3-fold.HET-1A cells exposed to bile acid yielded reduced expression of SOD-1 and SOD-2 genes with the exception that high dose deoxycholic acid at 200μmol/L led to a 3-fold increase in SOD-2 expression.The addition of curcumin treatment partially reversed the bile acid-induced reduction in SOD-1 expression at all concentrations of curcumin tested.CONCLUSION:Curcumin reverses bile acid suppression of gene expression of SOD-1.Curcumin is also able to inhibit bile acid induction of COX-2 gene expression. | Matthew R Bower Harini S Aiyer Robert CG Martin Yan Li | 2010 | World Journal of Gastroenterology2010，16，33： | 10 |
| 5 | Hepatocellular carcinoma,human immunodeficiency virus and viral hepatitis in the HAART era显示文摘The incidence of hepatocellular carcinoma(HCC)in patients with human immunodeficiency virus(HIV) is rising.HCC in HIV almost invariably occurs in the context of hepatitis C virus(HCV)or hepatitis B virus (HBV)co-infection and,on account of shared modes of transmission,this occurs in more than 33% and 10% of patients with HIV worldwide respectively.It has yet to be clearly established whether HIV directly accelerates HCC pathogenesis or whether the rising incidence is an epiphenomenon of the highly active antiretroviral therapy(HAART)era,wherein the increased longevity of patients with HIV allows long-term complications of viral hepatitis and cirrhosis to develop.Answering this question will have implications for HCC surveillance and the timing of HCV/HBV therapy,which in HIV co-infection presents unique challenges.Once HCC develops,there is growing evidence that HIV co-infection should not preclude conventional therapeutic strategies,including liver transplantation. | Douglas C Macdonald Mark Nelson Mark Bower Thomas Powles | 2008 | World Journal of Gastroenterology2008，14，11： | 9 |
| 6 | Graphene for energy harvesting/storage devices and printed electronics显示文摘Graphene-based materials are intriguing from the perspective of fundamental science and technology because they are non-toxic, chemically and thermally tolerant, and mechanically robust. Graphene exhibits superior electrical conductivity, high surface area and a broad electrochemical window that may be particularly advantageous for their applications in energy storage devices. In addition, graphene can be prepared in the form of a colloidal suspension with adjustable solubility and thus is suitable for printing applications and offers both transparency and good conductivity at the same time. In this review, applications of graphene in solar cells, batteries, supercapacitors and fuel cells are summarized with the latest developments. Furthermore, graphene as a conductive ink for printed electronics is also discussed. | Lorenzo Grande Vishnu Teja Chundi Di Wei Chris Bower Piers Andrew TapaniRyhanen | 2012 | Particuology2012，10，1： | 8 |
| 7 | Growth hormone releasing peptide 2 reverses anorexia associated with chemotherapy with 5-fluoruracil in colon cancer cell-bearing mice显示文摘The cancer-associated anorexia-cachexia syndrome is observed in 80% of patients with advanced-stage cancer, and is one of the major obstacles in chemo- therapy. Ghrelin is a orexigenic hormone that has been proposed to prevent anorexia. Aim of the study was to determine whether the addition of the ghrelin agonist growth hormone releasing peptide 2 (GHRP-2) to cytotoxic therapy with 5-fluoruracil (5-FU) prevents the anorexia associated with chemotherapy in cancer cachectic mice. Thirty-three BALB/c female tumourbearing mice were randomized to receive a solution containing: (a) placebo; (b) GHRP-2; (c) 5-FU; or (d) 5-FU + GHRP-2. Ten BALB/c no tumour-bearing mice received placebo solution. Food intake and survival were checked. Six hours after the drug injection the cumulative food intake was signifi cantly increased in mice treated with the combination of 5-FU + GHRP-2 versus the 5-FU alone (P = 0.0096). On day 3, the cumulative food intake of mice treated with GHRP-2,5-FU and 5-FU + GHRP-2 signifi cantly increased com- pared with naive and vehicle groups (P = 0.0007, P = 0.0038 and P = 0.0166, respectively). The median survival time was longer in 5-FU + GHRP-2 treated mice than in those with 5-FU, although it was not signifi cant (18 d versus 15.5 d, P = 0.7). For the fi rst time, we demonstrated that the addition of GHRP-2 to cytotoxic therapy with 5-FU improved appetite in tumour-bearing mice with anorexia/cachexia syndrome in early stage. These data suggest that GHRP-2 may improve the effi cacy of therapy and the quality of life of cancer patients thank to the amelioration of their nutritional state. | Simona Perboni Cyril Bowers Shinya Kojima Akihiro Asakawa Akio Inui | 2008 | World Journal of Gastroenterology2008，14，41： | 8 |
| 8 | National trends in resection of the distal pancreas显示文摘AIM:To investigate national trends in distal pancreatectomy(DP) through query of three national patient care databases.METHODS:From the Nationwide Inpatient Sample(NIS,2003-2009),the National Surgical Quality Improvement Project(NSQIP,2005-2010),and the Surveillance Epidemiology and End Results(SEER,2003-2009) databases using appropriate diagnostic and procedural codes we identified all patients with a diagnosis of a benign or malignant lesion of the body and/or tail of the pancreas that had undergone a partial or distal pancreatectomy.Utilization of laparoscopy was defined in NIS by the International Classification of Diseases,Ninth Revision correspondent procedure code;and in NSQIP by the exploratory laparoscopy or unlisted procedure current procedural terminology codes.In SEER,patients were identified by the International Classification of Diseases for Oncology,Third Edition diagnosis codes and the SEER Program Code Manual,third edition procedure codes.We analyzed the databases with respect to trends of inpatient outcome metrics,oncologic outcomes,and hospital volumes in patients with lesions of the neck and body of the pancreas that underwent operative resection.RESULTS:NIS,NSQIP and SEER identified 4242,2681 and 11 082 DP resections,respectively.Overall,laparoscopy was utilized in 15%(NIS) and 27%(NSQIP).No significant increase was seen over the course of the study.Resection was performed for malignancy in 59%(NIS) and 66%(NSQIP).Neither patient Body mass index nor comorbidities were associated with operative approach(P = 0.95 and P = 0.96,respectively).Mortality(3% vs 2%,P = 0.05) and reoperation(4% vs 4%,P = 1.0) was not different between laparoscopy and open groups.Overall complications(10% vs 15%,P < 0.001),hospital costs [44 741 dollars,interquartile range(IQR) 28 347-74 114 dollars vs 49 792 dollars,IQR 13 299-73 463,P = 0.02] and hospital length of stay(7 d,IQR 4-11 d vs 7 d,IQR 6-10,P < 0.001) were less when laparoscopy was utilized.One and two year survival after resection for malignancy were unchanged over the course of the study(ductal adenocarinoma 1-year 63.6% and 2-year 35.1%,P = 0.53;intraductal papillary mucinous neoplasm and nueroendocrine 1-year 90% and 2-year 84%,P = 0.25).The majority of resections were performed in teaching hospitals(77% NIS and 85% NSQIP),but minimally invasive surgery(MIS) was not more likely to be used in teaching hospitals(15% vs 14%,P = 0.26).Hospitals in the top decile for volume were more likely to be teaching hospitals than lower volume deciles(88% vs 43%,P < 0.001),but were no more likely to utilize MIS at resection.Complication rate in teaching and the top decile hospitals was not significantly decreased when compared to non-teaching(15% vs 14%,P = 0.72) and lower volume hospitals(14% vs 15%,P = 0.99).No difference was seen in the median number of lymph nodes and lymph node ratio in N1 disease when compared by year(P = 0.17 and P = 0.96,respectively).CONCLUSION:There appears to be an overall underutilization of laparoscopy for DP.Centralization does not appear to be occurring.Survival and lymph node harvest have not changed. | Armando Rosales-Velderrain Steven P Bowers Ross F Goldberg Tatyan M Clarke Mauricia A Buchanan John A Stauffer Horacio J Asbun | 2012 | World Journal of Gastroenterology2012，18，32： | 8 |
| 9 | 麦肯锡关于中国寿险业的最新研究报告(上)显示文摘中国的持续发展面临来自经济和社会的双重挑战。中国政府可以通过积极发展人寿保险行业来应对这些挑战。当前,中国政府的相关部门已经逐步认识到人寿保险的利益,并已经开始采取措施来促进中国人寿保险行业的发展。中国政府可考虑采取以下五个方面的措施来推动寿险业最大限度地发挥其作用和潜力:首先是加强教育,让百姓认识到人寿保险的作用和益处;其次是鼓励保险机构为广大农民及落后地区服务;第三是加强监管机构的力量;第四是为寿险行业创造更多的市场机会;最后是为保险机构和参保企业或个人提供优惠的税收政策。 | Peter Walker Tab Bowers Stephan Binder 胡忠兵 安琳 | 2006 | 四川经济研究2006，，1： | 5 |
| 10 | 麦肯锡关于中国寿险业的最新研究报告(下)显示文摘过去20年间,中国经济和社会都发生了一系列巨大变化。在中国经济高速发展以及工业化进程快速推进的同时,也给国家带来了很大的压力,具体表现在如何为基础设施建设筹措足够的资金,以及如何完善和发展中国的社会保障体系两方面。大力发展寿险业可以有效地解决上述问题。麦肯锡公司基于其在中国人寿保险行业的经验,以及在亚洲、欧洲和全球其他国家人寿保险行业的长期经验,撰写了一份关于中国寿险业发展的研究报告:《积极发展寿险行业促进中国经济持续增长及社会稳定和谐》。泣报告具有一定的理论及现实价值,本刊已在2006年第1期刊登了该报告的上半部分,本期继续刊登该报告的下半部分内容,以供广大读者参考。 | Peter Walker Tab Bowers Stephan Binder 胡忠兵 安琳 | 2006 | 保险研究2006，，2： | 4 |
| 11 | Cost analysis of open and laparoscopic pancreaticoduodenectomy: a single institution comparison显示文摘 | Marc G. Mesleh John A. Stauffer Steven P. Bowers Horacio J. Asbun | 2013 | Surgical Endoscopy2013，，12： | 3 |
| 12 | 围孕期补充叶酸和/或多种维生素预防神经管缺陷显示文摘1背景
神经管缺陷(NTDs)是在脑和脊索发育过程中形成的先天性畸形,包括无脑儿(颅骨、表面皮肤和脑组织全部或部分缺失)、脊柱裂(脊柱未闭合造成的脊索、脊膜分别或同时突出或暴露;有些病例合并脑积水)和脑膨出(脑膜疝,脑组织位于颅骨外,表面被正常或萎缩皮肤覆盖). | Lumnley J Watson L Watson M Bower C 陈晓军 丰有吉 | 2005 | 生殖与避孕2005，25，7： | 3 |
| 13 | Splenic Artery Aneurysms: Two Decades Experience at Mayo Clinic显示文摘 | Maher A. Abbas William M. Stone Richard J. Fowl Peter Gloviczki W. Andrew Oldenburg Peter C. Pairolero John W. Hallett Thomas C. Bower Jean M. Panneton Kenneth J. Cherry | 2002 | Annals of Vascular Surgery2002，，： | 2 |
| 14 | A Meta-analysis of Transient Elastography for the Detection of Hepatic Fibrosis显示文摘 | Justin Stebbing Lavanta Farouk George Panos Mike Anderson Long R. Jiao Sundhiya Mandalia Mark Bower Brian Gazzard Mark Nelson | 2010 | Journal of Clinical Gastroenterology2010，，3： | 2 |
| 15 | Systemic chemotherapy with or without cetuximab in patients with resectable colorectal liver metastasis: the New EPOC randomised controlled trial显示文摘 | John Primrose Stephen Falk Meg Finch-Jones Juan Valle Derek O’Reilly Ajith Siriwardena Joanne Hornbuckle Mark Peterson Myrddin Rees Tim Iveson Tamas Hickish Rachel Butler Louise Stanton Elizabeth Dixon Louisa Little Megan Bowers Sian Pugh O James Garden D | 2014 | Lancet Oncology2014，，6： | 2 |
| 16 | Inflammation and cancer-related fatigue: Mechanisms, contributing factors, and treatment implications显示文摘 | Julienne E. Bower Donald M. Lamkin | 2012 | Brain Behavior and Immunity2012，，： | 2 |
| 17 | 记忆,隐喻,箴言和神话:语言学习知文化意识显示文摘引言如果2000年是在世纪的最后一年,而不像通常认为的是下世纪的第一年,那么我就是在本世纪最后十年的第一个月内为一个专集撰写这篇文章的。该专集不仪为了庆贺“国际英语教师联合会”(IATEFL)诞生25周年,同时看到了92年的希望,这一年满含主观价值观念,也许还是以欧洲为中心的一年。当我们迈向下个世纪时。 | Roger Bowers 王世静 | 1994 | 外语教学理论与实践1994，，2： | 2 |
| 18 | Promotion of Hepatocellular Carcinoma by the Intestinal Microbiota and TLR4显示文摘 | Dianne H. Dapito Ali Mencin Geum-Youn Gwak Jean-Philippe Pradere Myoung-Kuk Jang Ingmar Mederacke Jorge M. Caviglia Hossein Khiabanian Adebowale Adeyemi Ramon Bataller Jay H. Lefkowitch Maureen Bower Richard Friedman R. Balfour Sartor Raul Rabadan Robert | 2012 | Cancer Cell2012，，4： | 2 |
| 19 | REFLECTION OF RADIANT ENERGY FROM SOILS显示文摘 | S. A. BOWERS R. J. HANKS | 1965 | Soil Science1965，，2： | 2 |
| 20 | Brn3b/Brn3c double knockout mice reveal an unsuspected role for Brn3c in retinal ganglion cell axon ougrowth显示文摘 | Wang SW Mu X Bowers WJ | 2002 | Development2002，129，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员