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| 1 | Different effects of ghrelin, des-acyl ghrelin and obestatin on gastroduodenal motility in conscious rats显示文摘Three peptides, ghrelin, des-acyl ghrelin and obestatin are derived from a common prohormone, preproghrelin by posttranslational processing, originating from endocrine cells in the stomach. To examine the effects of these peptides, we applied the manometric measurement of gastrointestinal motility in freely moving conscious rat models. Ghrelin exerts stimulatory effects on the motility of antrum and duodenum in both fed and fasted state of animals. Des-acyl ghrelin exerts inhibitory effects on the motility of antrum, but not on the motility of duodenum in the fasted state of animals. Obestatin exerts inhibitory effects on the motility of antrum and duodenum in the fed state, but not in the fasted state of animals. NPY Y2 or Y4 receptors in the brain may mediate the action of ghrelin, CRF type 2 receptors in the brain mediate the action of des-acy ghrelin, whereas CRF type 1 and type 2 receptors in the brain mediate the action of obestatin. Vagal afferent pathways might be involved in the action of ghrelin, but not involved in the action of des-acyl ghrelin, whereas vagal afferent pathways might be partially involved in the action of obestatin. | Mineko Fujimiya Akihiro Asakawa Koji Ataka Ikuo Kato Akio Inui | 2008 | World Journal of Gastroenterology2008，14，41： | 12 |
| 2 | Growth hormone releasing peptide 2 reverses anorexia associated with chemotherapy with 5-fluoruracil in colon cancer cell-bearing mice显示文摘The cancer-associated anorexia-cachexia syndrome is observed in 80% of patients with advanced-stage cancer, and is one of the major obstacles in chemo- therapy. Ghrelin is a orexigenic hormone that has been proposed to prevent anorexia. Aim of the study was to determine whether the addition of the ghrelin agonist growth hormone releasing peptide 2 (GHRP-2) to cytotoxic therapy with 5-fluoruracil (5-FU) prevents the anorexia associated with chemotherapy in cancer cachectic mice. Thirty-three BALB/c female tumourbearing mice were randomized to receive a solution containing: (a) placebo; (b) GHRP-2; (c) 5-FU; or (d) 5-FU + GHRP-2. Ten BALB/c no tumour-bearing mice received placebo solution. Food intake and survival were checked. Six hours after the drug injection the cumulative food intake was signifi cantly increased in mice treated with the combination of 5-FU + GHRP-2 versus the 5-FU alone (P = 0.0096). On day 3, the cumulative food intake of mice treated with GHRP-2,5-FU and 5-FU + GHRP-2 signifi cantly increased com- pared with naive and vehicle groups (P = 0.0007, P = 0.0038 and P = 0.0166, respectively). The median survival time was longer in 5-FU + GHRP-2 treated mice than in those with 5-FU, although it was not signifi cant (18 d versus 15.5 d, P = 0.7). For the fi rst time, we demonstrated that the addition of GHRP-2 to cytotoxic therapy with 5-FU improved appetite in tumour-bearing mice with anorexia/cachexia syndrome in early stage. These data suggest that GHRP-2 may improve the effi cacy of therapy and the quality of life of cancer patients thank to the amelioration of their nutritional state. | Simona Perboni Cyril Bowers Shinya Kojima Akihiro Asakawa Akio Inui | 2008 | World Journal of Gastroenterology2008，14，41： | 8 |
| 3 | Weight loss induced by whole grain-rich diet is through a gut microbiota-independent mechanism显示文摘The prevalence of overweight and obesity has increased worldwide.Obesity is a well-known risk factor of type 2 diabetes mellitus and cardiovascular disease and raises public health concerns.Many dietary guidelines encourage the replacement of refined grains with whole grains(WGs)to enhance body weight management.Current evidence regarding interrelationships among WGs,body weight,and gut microbiota is limited and inconclusive.In this editorial,we comment on the article by Roager et al published in the recent issue of the Gut 2019;68(1):83-93.In the study,obese patients(25 | Wen-Chi Wu Akio Inui Chih-Yen Chen | 2020 | World Journal of Diabetes2020，11，2： | 5 |
| 4 | Stimulation of leptin secretion by insulin显示文摘 | Minglun Tsai Akihiro Asakawa Haruka Amitani Akio Inui | 2012 | Indian Journal of Endocrinology and Metabolism2012，，9： | 2 |
| 5 | Sero- tonin stimulates endotoxin translocation via 5-HT3 receptors in the rat ileum 显示文摘 | Tadanori Yamada Akio Inui Naoki Hayashi | 2003 | Am J Physiol Gastrointest Liver Physiol2003，284，5： | 1 |
| 6 | Plasma ghrelin isoforms and gastric ghrelin O -acyltransferase expression are influenced by Helicobacter pylori status显示文摘 | Takashi Ando Shigeto Mizuno Tsukasa Ishida Yasuyuki Kondo Ikuya Miki Masaru Yoshida Takeshi Azuma Takeshi Ishikawa Tomohisa Takagi Nobuaki Yagi Satoshi Kokura Yuji Naito Toshikazu Yoshikawa Akihiro Asakawa Akio Inui | 2012 | Nutrition2012，，10： | 1 |
| 7 | Peptidergic regulation of gastrointestinal motility in rodents显示文摘 | Mineko Fujimiya Akio Inui | 2000 | Peptides2000，，： | 1 |
| 8 | Ghrelin is an appetite-stimulatory signal from stomach with structural resemblance to motilin显示文摘 | Akihiro Asakawa Akio Inui Oshihiro Kaga Hideki Yuzuriha Toshiaki Nagata Naohiko Ueno Susumu Makino Mineko Fujimiya Akira Niijima Masayuki A. Fujino Masato Kasuga | 2001 | Gastroenterology2001，，2： | 1 |
| 9 | Cancer Anorexia-Cachexia Syndrome:Current issues in research and management显示文摘 | Akio Inui | 2002 | Cancer Journal for Clinicians2002，52，： | 1 |
| 10 | Feeding and body-weight regulation by hypothalamic neuropeptides-mediation of the actions of leptin显示文摘 | Akio Inui | 1999 | Trends Neurosci1999，22，： | 1 |
| 11 | Control of food intake and muscle wasting in cachexia显示文摘 | Marie Amitani Akihiro Asakawa Haruka Amitani Akio Inui | 2013 | International Journal of Biochemistry and Cell Bi2013，，： | 1 |
| 12 | Centrally administered nesfatin-1 inhibits feeding behaviour and gastroduodenal motility in mice显示文摘 | Kaori Atsuchi Akihiro Asakawa Miharu Ushikai Koji Ataka Minglun Tsai Kenichiro Koyama Yuki Sato Ikuo Kato Mineko Fujimiya Akio Inui | 2010 | NeuroReport2010，，15： | 1 |
| 13 | Plasma nesfatin-1 concentrations in restricting-type anorexia nervosa显示文摘 | Kazuma Ogiso Akihiro Asakawa Haruka Amitani Toshihiro Nakahara Miharu Ushikai Izumi Haruta Ken-Ichiro Koyama Marie Amitani Toshiro Harada Daisuke Yasuhara Akio Inui | 2010 | Peptides2010，，1： | 1 |
| 14 | The effect of mosapride citrate on constipation in patients with diabetes显示文摘 | Naohiko Ueno Akio Inui Yoshiko Satoh | 2009 | Diabetes Research and Clinical Practice2009，，1： | 1 |
| 15 | What's new about ghrelin in 2008?显示文摘9th NPY Meeting was held for the f irst time in Japan in March 2008, which was organized by Akio Inui, Profes-sor and Chairman, Department of Psychosomatic In-ternal Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan. We have invited him to write TOPIC HIGHLIGHT for WJG focused on ghrelin along the gut-brain axis.This TOPIC HIGHLIGHT is the 'ghrelin version' of the proceedings of 9th NPY Meeting and presents ex-amples of the critical interplay in ghrelin-NPY pathway in response to environmental, | Akio Inui | 2008 | World Journal of Gastroenterology2008，14，41： | 0 |
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