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| 1 | Catheter ablation of atrial fibrillation in elderly population显示文摘Background Although elderly patients have been included in published series of catheter ablation for atrial fibrillation (AF), clinicalbenefit and safety remain still less defined in this population. A retrospective analysis of the results of catheter ablation for AF in a large volumecenter focused on comparison of elderly patients with the rest of the patient cohort was conducted in this study. Methods Consecutive patientswho underwent catheter ablation for AF between January 2001 and December 2016 were analysed. A total population of 3197 patients wasdichotomized by the age of 70 years (394 elderly vs. 2803 younger subjects). Patients were followed in terms of arrhythmia status and sur-vival for a median period of 18 vs. 21 and 35 vs. 57 months, respectively. Results Elderly patients were more frequently females (49% vs.29%, P 〈 0.0001), had a history of hypertension (79% vs. 57%, P 〈 0.0001), diabetes (16% vs. 11%, P 〈 0.01), stroke (9% vs. 6%, P 〈 0.01),coronary/peripheral artery disease (14% vs. 8%, P 〈 0.0001), and CHAzDS2-VASc score (3.1 ± 1.3 vs. 1.5 ± 1.2 s, P 〈 0.0001). Major com-plications were more frequent in elderly (5.3% vs. 3.2%, P = 0.03); however, this difference was driven by vascular complications (3.6% vs.1.9%, P = 0.04). There were comparable rates of cerebrovascular (0.3 vs. 0.3%) or nonvascular complications (1.8 vs. 1.2%). Good arrhyth-mia control was inferior in elderly patients as compared with the rest of the cohort, both without and with antiarrhythmic drugs: 44.2% vs.58.2% (P 〈 0.0001) and 78.2 vs. 83.2% (P 〈 0.01), respectively. Poor arrhythmia control was associated with relative risk of all-cause mor-tality of 2.7 (95% CI: 1.1-6.4) in elderly patients and 1.4 (95% CI: 0.9-2.0) in younger subjects. Conclusions Catheter ablation for AF inelderly patients is safe although somewhat less effective. Good arrhythmia control is associated with better survival, especially in elderly patients. | Josef Kautzner Petr Peichl Marek Sramko Robert Cihak Bashar Aldhoon Dan Wichterle | 2017 | Journal of Geriatric Cardiology2017，14，9： | 9 |
| 2 | Resveratrol engages selective apoptotic signals in gastric adenocarcinoma cells显示文摘AIM: To investigate the intracellular apoptotic signals engaged by resveratrol in three gastric adenocarcinoma cancer cell lines, two of which (AGS and SNU-1) express p53 and one (KATO-Ⅲ) with deleted p53. METHODS: Nuclear fragmentation was used to quanti- tate apoptotic cells; caspase activity was determined by photometric detection of cleaved substrates; formation of oxidized cytochrome C was used to measure cytochrome C activity, and Western blot analysis was used to determine protein expression. RESULTS: Gastric cancer cells, irrespective of their p53 status, responded to resveratrol with fragmentation of DNA and cleavage of nuclear lamins A and B and PARP. Resveratrol, however, has no effect on mitochondria-associated apoptotic proteins Bcl-2, Bcl- xl, Bax, Bid or Smac/Diablo, and did not promote sub- cellular redistribution of cytochrome C, indicating that resveratrol-induced apoptosis of gastric carcinoma cells does not require breakdown of mitochondrial membrane integrity. Resveratrol up-regulated p53 protein in SNU-1 and AGS cells but there was a difference in response of intracellular apoptotic signals between these cell lines. SNU-1 cells responded to resveratrol treatment with down-regulation of survivin, whereas in AGS and KATO- Ⅲ cells resveratrol stimulated caspase 3 and cytochrome C oxidase activities. CONCLUSION: These findings indicate that even within a specific cancer the intracellular apoptotic signals engaged by resveratrol are cell type dependent and suggest that such differences may be related to differentiation or lack of differentiation of these cells. | William L Riles Jason Erickson Sanjay Nayyar Mary Jo Atten Bashar M Attar Oksana Holian | 2006 | World Journal of Gastroenterology2006，12，35： | 8 |
| 3 | Predicting standard penetration test N-value from cone penetration test data using artificial neural networks显示文摘Standard Penetration Test(SPT) and Cone Penetration Test(CPT) are the most frequently used field tests to estimate soil parameters for geotechnical analysis and design.Numerous soil parameters are related to the SPT N-value.In contrast,CPT is becoming more popular for site investigation and geotechnical design.Correlation of CPT data with SPT N-value is very beneficial since most of the field parameters are related to SPT N-values.A back-propagation artificial neural network(ANN) model was developed to predict the N6o-value from CPT data.Data used in this study consisted of 109 CPT-SPT pairs for sand,sandy silt,and silty sand soils.The ANN model input variables are:CPT tip resistance(q_c),effective vertical stress(σ'_v),and CPT sleeve friction(f_s).A different set of SPT-CPT data was used to check the reliability of the developed ANN model.It was shown that ANN model either under-predicted the N_(60)-value by 7-16%or over-predicted it by 7-20%.It is concluded that back-propagation neural networks is a good tool to predict N_(60)-value from CPT data with acceptable accuracy. | Bashar Tarawneh | 2017 | Geoscience Frontiers2017，8，1： | 7 |
| 4 | 市场乏力,如何突出重围——抗生素之市场销售及研发分析显示文摘抗生素市场正日趋成熟,过去5年的年平均增长率仅为4%。在现有市场机制以及制药工业以追求利益最大化的前提下,如何通过新药开发来突出重围成为各企业战略部署的重要考量。 | Bashar Hamad 石永进 | 2010 | 中国处方药2010，9，10： | 5 |
| 5 | Procalcitonin,and cytokines document a dynamic inflammatory state in non-infected cirrhotic patients with ascites显示文摘AIM:To quantitate the simultaneous serum and ascitic fluid levels of procalcitonin and inflammatory markers in cirrhotics with and without ascites.METHODS:A total of 88 consecutive severe cirrhotic patients seen in a large city hospital liver clinic were studied and divided into two groups,those with and without ascites.Group 1 consisted of 41 cirrhotic patients with massive ascites,as demonstrated by necessity for therapeutic large-volume paracentesis.Group 2consisted of 47 cirrhotic patients without any clinically documented ascites to include either a recent abdominal computed tomography scan or ultrasound study.Serum and ascitic fluid levels of an array of inflammatory markers,including procalcitonin,were measured and compared to each other and a normal plasma panel(NPP).RESULTS:The values for inflammatory markers assayed in the serum of Groups 1 and 2,and ascitic fluid of the Group 1.The plasma levels of the inflammatory cytokines interleukin(IL)-2,IL-4,IL-6,IL-8,interferon gamma(IFNγ)and epidermal growth factor(EGF)were all significantly greater in the serum of Group 1as compared to that of the serum obtained from the Group 2 subjects(all P<0.05).There were significantly greater serum levels of IL-6,IL-8,IL-10,monocyte chemoattractant protein-1,tumor necrosis factor-α,vascular endothelial growth factor and EGF when comparing Group 2 to the NPP.There was no significant difference for IL-1A,IL-1B,IL-2,IL-4 and IFNγlevels between these two groups.Serum procalcitonin levels were increased in cirrhotics with ascites compared to cirrhotics without ascites,but serum levels were similar to ascites levels within the ascites group.Furthermore,many of these cytokines,but not procalcitonin,demonstrate an ascites-to-serum gradient.Serum procalcitonin does not demonstrate any significant difference segregated by liver etiology in the ascites group;but ascitic fluid procalcitonin is elevated significantly in car-diac cirrhosis/miscellaneous subgroup compared to the hepatitis C virus and alcoholic cirrhosis subgroups.CONCLUSION:Procalcitonin in the ascitic fluid,but not in the serum,differentiates between cirrhotic subgroup reflecting the dynamic interplay of ascites,bacterial translocation and the peri-peritoneal cytokine. | Bashar M Attar Christopher M Moore Magdalena George Nicolae Ion-Nedelcu Rafael Turbay Annamma Zachariah Guiliano Ramadori Jawed Fareed David H Van Thiel | 2014 | World Journal of Gastroenterology2014，20，9： | 4 |
| 6 | Endoscopic treatment of anastomotic biliary strictures after living donor liver transplantation: outcomes after maximal stent therapy显示文摘 | Ting-Hui Hsieh Kristin L. Mekeel Michael D. Crowell Cuong C. Nguyen Ananya Das Bashar A. Aqel Elizabeth J. Carey Thomas J. Byrne Hugo E. Vargas David D. Douglas David C. Mulligan M. Edwyn Harrison | 2013 | Gastrointestinal Endoscopy2013，，1： | 3 |
| 7 | 耕作机具能耗模拟研究进展(英文)显示文摘耕作机具的能耗模拟研究始于20世纪60年代。近年来,性能强大的计算机应用和先进建模技术与软件的发展,提高了研究人员建模分析和预测不同耕作条件下(如耕作机具所引起的土壤运动、土体破坏分布、作物残茬处理和肥料施用等)机具性能和能耗状况的能力。研究人员使用解析分析、数值模拟和经验法等方法,建立了耕作机具能耗的多种数学模型。该文对耕作机具能耗数学模型进行了系统的概述,总结了已有的研究成果,重点论述了数学模型的分类和特点,模型参数的测定、验证和模型的适用范围,可为耕作机理深入研究和耕作机具优化改进提供参考。 | Mehrez Bashar 杨洲 李君 王亮 | 2014 | 农业工程学报2014，30，9： | 3 |
| 8 | Disease dependent qualitative and quantitative differences in the inflammatory response to ascites occurring in cirrhotics显示文摘AIM:To assess differing patterns and levels of ascitic fluid cyctokine and growth factors exist between those with a high risk and low risk of spontaneous bacterial peritonitis(SBP). METHODS: A total of 57 consecutive patients with ascites requiring a large volume paracentesis were studied. Their age, gender, specific underlying disease conditions were recorded after a review of their clinical records. Each underwent a routine assessment prior to their paracentesis consisting of a complete blood count, complete metabolic profile and prothrombin time/international normalized ratio(INR) determination. The ascitic fluid was cultured and a complete cellcount and albumin determination was obtained on the fluid. In addition, blood and ascitic fluid was assessed for the levels of interleukin interleukin(IL)-1A, IL-1B, IL-2, IL-4, IL-8, IL-10, monocyte chemotactic protein(MCP)-1, tumor necrosis factor(TNF)-α, interferon(IFN)-γ, vascular endothelial growth factor(VEGF) and epidermal growth factor(EGF) utilizing the Randox Biochip platforms(Boston, MA). A serum-ascites gradient, for each cytokine and growth factor was calculated. The results are reported as mean ± SEM between disease groups with statistical analysis consisting of the student t-test(two tailed) with a P value of 0.05 defining significance. RESULTS: No clinically important demographic or biochemical differences between the 4 groups studied were evident. In contrast, marked difference in the cytokine and growth factors levels and pattern were evident between the 4 disease groups. Individuals with alcoholic cirrhosis had the highest levels of IL-1A, IL-1B, IL-4, IFNγ. Those with malignant disease had the highest levels of IL-2. Those with hepatitis C virus(HCV) associated cirrhosis had the highest value for IL-6, IL-8, IL-10, MCP-1 and VEGF. Those with cardiac disease had the highest level of TNF-α and EGF. The calculated serum- ascites gradients for the cardiac and malignant disease groups had a greater frequency of negative values signifying greater levels of IL-8, IL-10 and MCP-1 in ascites than did those with alcohol or HCV disease. CONCLUSION: These data document important differences in the cytokine and growth factor levels in plasma, ascitic fluid and the calculated plasma- ascites fluid gradients in cirrhotics requiring a large volume paracentesis. These differences may be important in determining the risk for bacterial peritonitis. | Bashar M Attar Magdalena George Nicolae Ion-Nedelcu Guilliano Ramadori David H Van Thiel | 2014 | World Journal of Hepatology2014，6，2： | 3 |
| 9 | Gastrointestinal Kaposi's sarcoma: Case report and review of the literature显示文摘Kaposi's sarcoma(KS) of the gastrointestinal tract is not an uncommon disease among individuals with acquired immunodeficiency syndrome(AIDS). The majority is asymptomatic, and for this reason, gastrointestinal KS(GI-KS) remains undiagnosed. With continued tumor growth, considerable variation in clinical presentation occurs including abdominal pain, nausea, vomiting, iron deficiency anemia(either chronic or frank gastrointestinal bleeding), and rarely mechanical obstruction alone or combined with bowel perforation. Endoscopy with biopsy allows for histological and immunohistochemical testing to confirm the diagnosis of GI-KS among those with clinical symptoms. In previous studies, dual treatment with highly active antiretroviral therapy and systemic chemotherapy have been associated with improved morbidity and mortality in individuals with visceral KS. Therefore, investigators have suggested performing screening endoscopies in select patients for early detection and treatment to improve outcome. In this review, we describe a 44 years old man with AIDS and cutaneous KS who presented for evaluation of postprandial abdominal pain, vomiting, and weight loss. On upper endoscopy, an extensive, infiltrative,circumferential, reddish mass involving the entire body and antrum of the stomach was seen. Histologic examination later revealed spindle cell proliferation, and confirmatory immunohistochemical testing revealed human herpes virus 8 latent nuclear antigen expression consistent with a diagnosis of gastric KS. Following this, we present a comprehensive review of literature on KS with emphasis on gastrointestinal tract involvement and management. | Ann Joo Lee Lacie Brenner Bashar Mourad Carmela Monteiro Kenneth J Vega Juan Carlos Munoz | 2015 | World Journal of Gastrointestinal Pharmacology and Therapeutics2015，6，3： | 2 |
| 10 | Multicenter experience using simeprevir and sofosbuvir with or without ribavirin to treat hepatitis C genotype 1 after liver transplant显示文摘 | Surakit Pungpapong Bashar Aqel Michael Leise K. Tuesday Werner Jennifer L. Murphy Tanisha M. Henry Kristen Ryland Amy E. Chervenak Kymberly D. Watt Hugo E. Vargas Andrew P. Keaveny | 2015 | Hepatology2015，，6： | 2 |
| 11 | Finite element analysis and structural design of pretensioned inverted T-beams with web openings显示文摘This paper presents the results of a research project aimed at providing standard circular web openings to the popular precast pretensioned inverted T-beam.Opening size and placement and required materials strengths were investigated.In this paper the nonlinear analysis and design of simply supported pretensioned inverted T-beam with circular web openings are presented.Two design parameters are varied:opening location and number of openings.The results from nonlinear finite element analysis were substantiated by test results from five pretensioned inverted T-beams with web opening and one solid beam.Good agreement is shown between the theoretical and the experimental results.The test results obtained from this investigation show that the performance of the specimens with web openings is almost identical to that of the specimen without web openings.A simple design method for pretensioned inverted T-beam with circular web openings is proposed. | Hock Tian CHENG Bashar S.MOHAMMED Kamal Nasharuddin MUSTAPHA | 2009 | Frontiers of Structural and Civil Engineering2009，3，2： | 2 |
| 12 | Anti-hyperglycemic activity of the leaves of Tetracera scandens Linn. Merr. (Dilleniaceae) in alloxan induced diabetic rats显示文摘 | Abdulrashid Umar Qamar U. Ahmed Bala Y. Muhammad Bashar Bello S. Dogarai Siti Zaiton Bt. Mat Soad | 2010 | Journal of Ethnopharmacology2010，，1： | 2 |
| 13 | QuantiFERON TB gold testing for tuberculosis screening in an inflammatory bowel disease cohort in the United States显示文摘 | Bashar J.Qumseya Ashwin N.Ananthakrishnan SueSkaros MichaelBonner MazenIssa YelenaZadvornova AmarNaik LilaniPerera David G.Binion | 2010 | Inflamm Bowel Dis2010，，1： | 2 |
| 14 | Anti-hyperglycemic activity of the leaves of Tetracera scandens Linn. Merr. (Dilleniaceae) in alloxan induced diabetic rats显示文摘 | Abdulrashid Umar Qamar U. Ahmed Bala Y. Muhammad Bashar Bello S. Dogarai Siti Zaiton Bt. Mat Soad | 2010 | Journal of Ethnopharmacology2010，，1： | 2 |
| 15 | Mesenteric Venous Thrombosis显示文摘 | Bashar Hmoud Ashwani K. Singal Patrick S. Kamath | 2014 | Journal of Clinical and Experimental Hepatology2014，，： | 2 |
| 16 | A Randomized, Double-Blinded, Placebo-Controlled Multicenter Trial of Etanercept in the Treatment of Alcoholic Hepatitis显示文摘 | Nicholas C. Boetticher Craig J. Peine Paul Kwo Gary A. Abrams Tushar Patel Bashar Aqel Lisa Boardman Gregory J. Gores William S. Harmsen Craig J. McClain Patrick S. Kamath Vijay H. Shah | 2008 | Gastroenterology2008，，6： | 2 |
| 17 | Computatioa of stiffness and stiffness hounds for parallel link manipulators 显示文摘 | Bashar S Khasawneh E L Placid M F | 1999 | International Journal of Tools & Manufacture1999，39，2： | 1 |
| 18 | Should bowel preparation, antifoaming agents, or prokinetics be used before video capsule endoscopy? A systematic review and meta-analysis显示文摘 | Vikram S. Kotwal Bashar M. Attar Saurabh Gupta Rajender Agarwal | 2014 | European Journal of Gastroenterology & Hepatology2014，，2： | 1 |
| 19 | Increased incidence of multi-drugresistant tuberculosis in diabetic patients on the Bellevue Chest Service 1987 to 1997显示文摘 | Bashar M Alcabes P Rom WN | 2001 | Chest2001，120，5： | 1 |
| 20 | 对急性憩室出血患者进行早期结肠镜诊治可提高医疗资源利用率显示文摘背景:在发达国家,憩室出血是严重的急性下消化道出血最常见的原因。早期结肠镜(≤24小时)的作用仍然存在争议,目前尚无早期肠镜应用于急性憩室出血的数据。本研究旨在通过美国全国住院患者样本库,评估结肠镜诊治的时机对急性憩室出血患者预后的影响。方法:采用第9版国际疾病分类(ICD 9),对全国住院患者样本库中2012-2014年间的病例进行选择并提取资料。纳入出院诊断(包括主要诊断或第二诊断)为憩室病合并出血和憩室炎合并出血的病例,排除年龄不满18周岁以及住院期间未行结肠镜检查的病例。首要结局指标为住院时间和住院总费用。结果:共计88,600例患者纳入研究,其中45,020例(50.8%)在入院24小时内接受了结肠镜检查(早期肠镜组),而另外43,580例(49.2%)则是在入院24小时后行结肠镜检查(晚期肠镜组)。早期肠镜组较晚期肠镜组患者住院时间显著缩短(3.7天vs 5.6天,P<0.001),住院总花费显著降低($9317 vs$11,767,P<0.001)。两组患者病死率的差异无统计学意义(0.7%vs 0.8%)。对潜在致混淆因素进行校正后,两组间住院时间和住院总费用的差异仍然具有统计学意义。结论:对于急性憩室出血,早期结肠镜诊治可显著缩短住院时间,降低住院费用,而且并不会增加病死率。选择适宜的急性憩室出血病例进行早期结肠镜诊治,具有节省医疗资源的潜在意义。进一步研究需明确哪些憩室出血患者能从早期结肠镜诊治中获益。 | Hamzeh Saraireh Obada Tayyem Mohamed Tausif Siddiqui Bashar Hmoud Mohammad Bilal | 2019 | Gastroenterology Report2019，7，2： | 1 |
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