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| 1 | Procalcitonin,and cytokines document a dynamic inflammatory state in non-infected cirrhotic patients with ascites显示文摘AIM:To quantitate the simultaneous serum and ascitic fluid levels of procalcitonin and inflammatory markers in cirrhotics with and without ascites.METHODS:A total of 88 consecutive severe cirrhotic patients seen in a large city hospital liver clinic were studied and divided into two groups,those with and without ascites.Group 1 consisted of 41 cirrhotic patients with massive ascites,as demonstrated by necessity for therapeutic large-volume paracentesis.Group 2consisted of 47 cirrhotic patients without any clinically documented ascites to include either a recent abdominal computed tomography scan or ultrasound study.Serum and ascitic fluid levels of an array of inflammatory markers,including procalcitonin,were measured and compared to each other and a normal plasma panel(NPP).RESULTS:The values for inflammatory markers assayed in the serum of Groups 1 and 2,and ascitic fluid of the Group 1.The plasma levels of the inflammatory cytokines interleukin(IL)-2,IL-4,IL-6,IL-8,interferon gamma(IFNγ)and epidermal growth factor(EGF)were all significantly greater in the serum of Group 1as compared to that of the serum obtained from the Group 2 subjects(all P<0.05).There were significantly greater serum levels of IL-6,IL-8,IL-10,monocyte chemoattractant protein-1,tumor necrosis factor-α,vascular endothelial growth factor and EGF when comparing Group 2 to the NPP.There was no significant difference for IL-1A,IL-1B,IL-2,IL-4 and IFNγlevels between these two groups.Serum procalcitonin levels were increased in cirrhotics with ascites compared to cirrhotics without ascites,but serum levels were similar to ascites levels within the ascites group.Furthermore,many of these cytokines,but not procalcitonin,demonstrate an ascites-to-serum gradient.Serum procalcitonin does not demonstrate any significant difference segregated by liver etiology in the ascites group;but ascitic fluid procalcitonin is elevated significantly in car-diac cirrhosis/miscellaneous subgroup compared to the hepatitis C virus and alcoholic cirrhosis subgroups.CONCLUSION:Procalcitonin in the ascitic fluid,but not in the serum,differentiates between cirrhotic subgroup reflecting the dynamic interplay of ascites,bacterial translocation and the peri-peritoneal cytokine. | Bashar M Attar Christopher M Moore Magdalena George Nicolae Ion-Nedelcu Rafael Turbay Annamma Zachariah Guiliano Ramadori Jawed Fareed David H Van Thiel | 2014 | World Journal of Gastroenterology2014，20，9： | 4 |
| 2 | Endogenous Release of Tissue Factor Pathway Inhibitor by Topical Application of an Ointment Containing Mucopolysaccharide Polysulfate to Nonhuman Primates显示文摘 | Debra A. Hoppensteadt Jawed Fareed Phillip Raake Wolfram Raake | 2001 | Thrombosis Research2001，，2： | 2 |
| 3 | Determination Of specific activity Of recombinant himdin using a thrombin titration method显示文摘 | Lalithalyer and Jawed Fareed | 1995 | Thrombosis Research1995，，78： | 1 |
| 4 | Preclinical studies on a low molecular weight heparin显示文摘 | Jawed Fareed Walter Jeske Volker Eschenfelder Orner Iqbal Debra Hoppensteadt Ahmad Ahsan | 1996 | Thrombosis Research1996，，2： | 1 |
| 5 | A Modified Stasis Thrombosis Model to Study the Antithrombotic Actions of Heparin and Its Fractions显示文摘 | Jawed Fareed Jeanine Walenga Arvind Kumar Alice Rock | 1985 | Semin Thromb Hemost1985，，02： | 1 |
| 6 | Determination of specific activity of recombinant hirudin using a thrombin titration method显示文摘 | Lalitha lyer and Jawed Fareed | 1995 | Thrombosis Research1995，，78： | 1 |
| 7 | Pharmacological Profiling of Recombinant Tissue Factor Pathway Inhibitor显示文摘 | Walter Jeske Debra Hoppensteadt Demetra Callas Michael Koza Jawed Fareed | 1996 | Semin Thromb Hemost1996，，02： | 1 |
| 8 | 肝素酶Ⅰ对合成的肝素五糖的酶解作用及对其抗Xa因子活性的影响(英文)显示文摘研究肝素酶 (来源于 Flavobacterum heparinase,EC4 .2 .2 .7)对人工合成的且含有与抗凝血酶 特定结合位点的肝素五糖 (SHP)的酶解作用 ,并对酶解作用的动力学进行研究。利用强阴离子高效液相色谱 (SAX- HPL C)对酶解混合物进行分离 ,利用质谱 (ESIMS)和核磁共振波谱 (1H- NMR)技术对得到的二糖和三糖的结构进行确证。研究结果表明 ,这种被作为肝素反向试剂的肝素酶 可水解人工所合成的肝素五糖 ,从而使之丧失抗 Xa因子活性。 | 于广利 管华诗 Robert J.Linhardt Jawed Fareed | 2001 | 青岛海洋大学学报(自然科学版)2001，31，4： | 1 |
| 9 | Presence of asymmetric dimethylarginine gradients across high-grade lesions in patients with coronary artery disease显示文摘 | Dominique Joyal Ferdinand Leya M. Obada Al-Chekakie Dinesh Arab Robert S. Dieter Ali Morshedi-Meibodi Bruce Lewis Lowell Steen Jawed Fareed Debra Hoppenstead Joseph G. Akar | 2007 | Coronary Artery Disease2007，，6： | 1 |
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