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| 1 | Antimicrobial and antispasmodic activity of leaf extract and fractions of Stachytarpheta cayennensis显示文摘Objective:To investigate the antimicrobial activity of the methanol leaf extract(ME),n-hexane fraction(HF),ethylacetate fraction(EF) and methanol fraction(MF),of Stachytarpheta cayennensis C.Rich(verbenaceae) as well as to ascertain the antispasmodic effects of the ME and the various fractions(HF,EF and MF) on acetylcholine(Ach) and histamine(H) induced contractions on isolated guinea pig ileum.Methods:The in vitro agar well diffusion method was used for the antimicrobial studies while the isolated tissue method was employed for the antispasmodic test. Organisms used were all clinical isolates of Bacillus subtilis,Staphylococcus aureus,Pseudomonas aeruginosa,Salmonella paratyphi,Candida albicans and Aspergillus niger.Results:The extract and fractions exhibited dose dependent inhibition against all the bacteria tested and also exhibited insignificant antifungal activity against Candida albicans and Aspergillus niger.The minimum inhibitory concentration(MIC) of the extract and fractions(mg/mL) on Bacillus subtilis, Staphylococcus aureus,Pseudomonas aeruginosa and Salmonella paratyphi respectively were ME 5.62,14.12,22.38,2.11;EF 1.25,6.30,9.40,9.40 and MF 3.98,8.81,39.80,21.13.The n-hexane fraction exhibited MIC of 1.07 mg/mL against only Bacillus subtilis.The extract and fractions exhibited significant(P< 0.05) dose dependent attenuation of contractions induced by acetylcholine and histamine on isolated guinea pig ileum.Concentrations of the extract and fractions(μg/mL) which evoked 50%inhibition of maximal response exhibited by Ach were ME 0.64,HF 0.16,EF 0.08 and MF 0.15,while that of histamine included ME 5.12,HF 0.16,EF 0.04 and MF 0.64.Preliminary phytochemical studies on the extract and fractions indicated the presence of carbohydrates,alkaloids,saponins,flavonoids,steroids and terpenoids.Conclusions: The extract and fractions of Stachytarpheta cayennensis possessed both antibacterial and antispasmodic effects confirming the claimed use in folkloric medicine for wound healing and gastrointestinal ulceration. | Okoye TC Akah PA Okoli CO Ezike AC Mbaoji FN | 2010 | Asian Pacific Journal of Tropical Medicine2010，3，3： | 3 |
| 2 | Evaluation of various solutions for small bowel graft preservation显示文摘EvaluationofvarioussolutionsforsmalbowelgraftpreservationLIYouSheng1,LIJieShou1,LINing1,JIANGZhiWei1,ZHAOYunZhao1,LINan?.. | Li YS Li JS Li N Jiang ZW Zhao YZ Li NY Liu FN | 1998 | World Journal of Gastroenterology1998，4，2： | 2 |
| 3 | Molecular mechanism of diabetic renal hypertrophy显示文摘 | Wolf G Ziyadeh FN | 1999 | Kidney Int1999，56，2： | 2 |
| 4 | Antiinflammatory activity of the methanolic extract of the seeds of Carica papaya in experimental animals显示文摘Objective:To scientifically verify the claims of our traditional healers on the anti-inflammatory activity of Carica papaya(C.papaya) and possibly deduce its activities.Methods:0.1 mL of fresh egg albumin was injected into the right hind-paw of adult white Wistar rats to induce inflammation an hour post intraperitoneal(IP) administration of 50-200 mg/kg doses of the extract to 3 groups of 5 rats per group.The 4th group of 5 rats was used as negative control and received 2 mL/kg(IP) of physiological saline,while the 5th group of 5 rats was used as positive-comparative control and received(IP) 150 mg/kg of aspirin.Increases in diameter of the paw were measured with the aid of Veneer Calipers before extract administration and at interval of 30 minutes post administration for further 2 hours.Percentage inhibition of oedema was calculated for each dose group and results were subjected to statistical analysis using student /-test and analysis of variance(ANOVA).Results:All doses of extract showed a dose and time dependent inhibition effects of oedema(P<0.05).Conclusions:This work is at present though limited to animals,the anti-inflammatory activity of the seeds of C.papaya is perhaps proven. | Amazu LU Azikiwe CCA Njoku CJ Osuala FN Nwosu PJC Ajugwo AO Enye JC | 2010 | Asian Pacific Journal of Tropical Medicine2010，3，11： | 2 |
| 5 | Pulmonary Cryptococcosis: CT Findings in Immunocompetent Patients 显示文摘 | Rebecca ML Thomas EH Hassan FN | 2005 | Radiology2005，236，1： | 1 |
| 6 | Thyroid function, morphology and autoimmunity in young patients with insulin-dependent diabetes mellitus 显示文摘 | Hansen D Bennedbaek FN Hansen LK | 1999 | Eur J Endocrinol1999，140，6： | 1 |
| 7 | Antimicrobial activity and biosynthesis of indole antibiotics produced by Xenorhabdus nematophilus显示文摘 | Chang FN | 1993 | Journal of General Microbiology1993，139，： | 1 |
| 8 | Mdecular mechanisms of diabetic renal hyperophy显示文摘 | Wolf G Ziyadeh FN | 1999 | Kidney Int1999，56，： | 1 |
| 9 | Treatment of recurrent thyroid cysts with ethanol: a randomined doudle bland controlled trial 显示文摘 | Bennedaek FN Hegedus L | 2003 | J Clin Endocrinol Metab2003，88，25： | 1 |
| 10 | Angiotensin Ⅱ stimulates expression of transforming growth factor beta receptor type Ⅱ in cultured mouse proximal tubular cells显示文摘 | Wolf G Ziyadeh FN Stah1 RA | 1999 | J Molmed1999，77，5： | 1 |
| 11 | Observation of Plasma Confinement in Picosecond Laser Plasma Interaction显示文摘 | Bell AR Beg FN Chang Z | 1993 | Phys Rev E1993，48，3： | 1 |
| 12 | Peritoneal carcinomatosis from digestive tract cancer: new management by cytoreductive surgery and intraperitoneal chemohyperthermia 显示文摘 | Glehen O Mohamed F Gilly FN | 2004 | Lancet Oncol2004，5，4： | 1 |
| 13 | Effect of percutaneous ethanol injection therapy versus suppressive doses of L-thyroxine on benign soditary solid cold thyroid nodules: randomized trail显示文摘 | Bennedback FN Nielsen LK Hegedues L | 1998 | J Clin Endocrinol1998，83，3： | 1 |
| 14 | Modern aspects of immunopathogenesis of autoimmune myocarditis 显示文摘 | Paleev FN Kotova AA Suchkov SV | 2002 | Russ J Immunol2002，7，4： | 1 |
| 15 | Role of microRNAs in cardiac preconditioning显示文摘 | Salloum FN Yin C Kukreja RC | 2010 | J Cardiovasc Pha~ol2010，56，6： | 1 |
| 16 | Pregnancy rates of recipient animals following application of a selective prostaglandin F2 c receptor antagonist during embryo recovery显示文摘 | Scenna FN Edwards JL Schuenemann GM | 2008 | Fertility Reproduction and Development2008，20，1： | 1 |
| 17 | The Notch ligand jag-ged I represents a novel growth factor of human hematopoietic stemcells显示文摘 | Karanu FN Murodoch B Gallacher La | 2007 | J Cell Biochem2007，101，3： | 1 |
| 18 | Insulin increases resistance to burn wound infection-associated sepsis 显示文摘 | Gauglitz GG Toliver-Kinsky TE Williams FN | 2010 | Crit Care Med2010，38，1： | 1 |
| 19 | Detrimental effects of prostaglandin F2α on embryo development in bovine are inhibited by a receptor antagonist显示文摘 | Scenna FN Edwards JL Schrick FN | | 0，，： | 1 |
| 20 | Involvement of transforming growth factor-beta and its receptors in the pathogenesis of diabetic nephrology显示文摘 | Ziyadeh FN Han DC | 1997 | Kidney Int Suppl1997，，60： | 1 |
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