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    题名 作者 年代 出处 被引量
1欧洲新生儿呼吸窘迫综合征防治共识指南:2016版显示文摘新生儿呼吸窘迫综合征(RDS)是早产儿的重要疾病,尽管治疗手段不断成熟,低龄早产儿存活率逐渐增高,但支气管肺发育不良(BPD)发病率也随之升高,其中部分原因是减少了出生后激素的使用.2006年以来,来自欧洲许多国家的新生儿专家每3年一次回顾最新文献,就RDS或有RDS风险早产儿的防治达成共识,立志于改善欧洲新生儿的预后.欧洲RDS防治指南2007年开始发布,2010年和2013年进行了更新,期间获得了欧洲围产医学学会的大力支持.RDS是由于肺表面活性物质(PS)缺乏导致生后早期出现呼吸窘迫,典型临床表现随着防治手段的改进发生了巨大变化.DavidG.Sweet Virgilio Carnielli Gorm Greisen Mikko Hallman Eren Ozek Richard Plavka Ola Didrik Saugstad Umberto Simeoni Christian P. Speer Maximo Vento Gerard H. A. Visser Henry L. Halliday 2017中华儿科杂志2017,55,3:90
2Role of triamcinolone in radiation enteritis management显示文摘AIM:To investigate the role of triamcinolone in the management of acute and chronic enteritis caused by pelvic radiotherapy.METHODS:Twenty-eight patients with rectum adenocarcinoma or endometrium adenocarcinoma were studied.We compared the results of 14 patients treated with injected triamcinolone acetonide(TA)with those of 14 patients who were not treated with TA.For the TA group,40 mg of TA was injected intramuscularly on the 1st,11th and 21st d of radiotherapy;the control group received no injections.All of the study participants had a median age of 65 years,had undergone postoperative radiotherapy and were evaluated weekly using Radiation Therapy Oncology Group and the European Organization for Research and Treatment of Cancer Acute Morbidity Score Criteria,and complete blood counts for every 10 d.RESULTS:Triamcinolone was found to effectively prevent and treat radiation-induced acute gastrointestinal(enteritis)and genitourinary(cystitis)side effects(P=0.022 and P=0.023).For the lower GI side effect follow up,11 patients in the control group had Grade 2toxicity and 3 patients had Grade 1 toxicity.In the TA group,5 patients had Grade 2 toxicity and 9 patients had Grade 1 toxicity.For the genitourinary system side effect follow up,4 patients had Grade 2 toxicity and 6patients had Grade 1 toxicity.Additionally,2 patients had Grade 2 toxicity and 2 patients had Grade 1 toxicity.The neutrophil counts did not differ between the TA group and the control group.There was no meaningful difference between age groups and primary cancers.At the 12th mo of follow up,there were no differences between groups for chronic side effects.CONCLUSION:Triamcinolone is a moderately potent steroid,that is inexpensive and has a good safety profile.It would be beneficial for reducing medical expenses related to treatment of radiation induced enteritis.Eren Cetin Aysen Sevgi Ozturk Haluk Orhun Sukran Ulger 2014World Journal of Gastroenterology2014,20,15:12
3Comparison of subconjunctivally injected bevacizumab, ranibizumab, and pegaptanib for inhibition of corneal neovascularization in a rat model显示文摘AIM: To compare the efficacies of subconjunctival bevacizumab, ranibizumab, and pegaptanib sodium injections for the inhibition of corneal neovascularization in an experimental rat model. METHODS: Sixteen corneas of 16 rats were chemically cauterized and randomized into four groups: bevacizumab group that treated with 0.05mL/1.25mg bevacizumab, ranibizumab group that treated with 0.05mL/0.5mg ranibizumab, pegaptanib group that treated with 0.05mL/0.15mg pegaptanib sodium, and control group that treated with 0.05mL saline solution. Digital photographs of the corneas were taken and analyzed using an image analysis software program. All corneas were excised and examined histologically on the 15 th day. RESULTS: Each treatment group had significantly less neovascularized corneal areas and fewer blood vessels than the control group (all P <0.05). In addition, bevacizumab group had significantly less neovascu-larized corneal areas and fewer blood vessels than ranibizumab and pegaptanib groups (both P <0.05). However, there was no significant difference between the ranibizumab and pegaptanib groups regarding percentage of neovascularized corneal areas and number of blood vessels (both P >0.05). CONCLUSION: Subconjunctival bevacizumab, ranibiz-umab, and pegaptanib sodium were effective with no corneal epitheliopathy for inhibiting corneal neovascularization after corneal burn in rats .Bevacizumab was more effective than ranibizumab and pegaptanib sodium.Ebru Eren Akar Veysi ner Cem Küükerdnmez Yonca Aydin Akova 2013International Journal of Ophthalmology(English edition)2013,6,2:9
41型糖尿病视网膜病变患者血清唾液酸浓度的增加(英文)显示文摘目的:探讨血清唾液酸和糖尿病性视网膜病变几个阶段之间潜在的关联。方法:1型糖尿病视网膜不同程度病变组40例。对照组30例,对其血清唾液酸水平进行研究。结果:结果显示,研究组与对照组相比有较高的血清唾液酸浓度(95.95±9.5 vs 45.05±19.91mmoL/L,P=0.0001)。我们也观察到糖尿病性视网膜病变的水平逐步上升,其浓度升高(P<0.05),但相关性较弱。血清唾液酸浓度与血糖浓度呈正相关(r=0.67,P=0.0001)。结论:血清唾液酸浓度的增加与视网膜病变阶段有关。这对确定1型糖尿病患者视网膜病变的程度有帮助。但是,仍然需要更详细的研究,以得到更精确的结论。Muhsin Eraslan 0zlem Yenice Haluk Kazokoglu Dilek Goga Yavuz Eren Cerman Hande Celiker 2013国际眼科杂志2013,13,10:5
5Adrenomedullin in cirrhotic and non-cirrhotic portal hypertension显示文摘AIM:Adrenomedullin (ADM) is a potent vasodilator peptide.ADM and nitric oxide (NO) are produced in vascular endothelial cells. Increased ADM level has been linked to hyperdynamic circulation and arterial vasodilatation in cirrhotic portal hypertension (CPH). The role of ADM in non-cirrhotic portal hypertension (NCPH) is unknown, plasma ADM levels were studied in patients with NCPH, compensated and decompensated cirrhosis in order to determine its contribution to portal hypertension (PH) in these groups.METHODS: There were 4 groups of subjects. Group 1consisted of 27 patients (F/M: 12/15) with NCPH due to portal and/or splenic vein thrombosis (mean age: 41±12years), group 2 consisted of 14 patients (F/M: 6/8) with compensated (Child-Pugh A) cirrhosis (mean age: 46±4),group 3 consisted of 16 patients (F/M: 6/10) with decompensated (Child-Pugh C) cirrhosis (mean age: 47±12).Fourteen healthy subjects (F/M: 6/8) (mean age: 44±8) were used as controls in Group 4. ADM level was measured by ELISA. NO was determined as nitrite/nitrate level by chemoluminescence.RESULTS: Adl level in Group 11 (236±61.4 pg/mL) was significantly higher than that in group 2 (108.4±28.3 pg/mL)and group 4 (84.1±31.5 pg/mL) (both P<0.0001) but was lower than that in Group3 (324±93.7 pg/mL) (P=0.002). NO level in group 1 (27±1.4 μmol/L) was significantly higher than that in group 2 (19.8±2.8 μmol/L) and group 4 (16.9±1.6μmol/L) but was lower than that in Group 3 (39±3.6 μmol/L)(for all three P<0.0001). A strong correlation was observed between ADM and NO levels (r=0.827, P<0.0001).CONCLUSION: Adrenomedullin and NO levels were high in both non-cirrhotic and cirrhotic portal hypertension and were closely correlated, Adrenomedullin and NO levels increased proportionally with the severity of cirrhosis, and were significantly higher than those in patients with NCPH.Portal hypertension plays an important role in the increase of ADM and NO. Parenchymal damage in cirrhosis may contribute to the increase in these parameters.V Tahan E Avsar C Karaca E Uslu F Eren S Aydin H Uzun HO Hamzaoglu F Besisik C Kalayci A Okten N Tozun 2003World Journal of Gastroenterology2003,9,10:5
6Laparoscopic liver resection for malignancy:A review of the literature显示文摘AIM: To review the published literature about laparoscopic liver resection for malignancy.METHODS: A PubMed search was performed for original published studies until June 2013 and original series containing at least 30 patients were reviewed.RESULTS: All forms of hepatic resections have been described ranging from simple wedge resections to extended right or left hepatectomies. The usual approach is pure laparoscopic, but hand-assisted, as well as robotic approaches have been described. Most studies showed comparable results to open resection in terms of operative blood loss, postoperative morbidity and mortality.Many of them showed decreased postoperative pain,shorter hospital stays, and even lower costs. Oncological results including resection margin status and long-term survival were not inferior to open resection. CONCLUSION: In the hands of experienced surgeons,laparoscopic liver resection for malignant lesions is safe and offers some short-term advantages over open resection. Oncologically, similar survival rates have been observed in patients treated with the laparoscopic approach when compared to their open resection counterparts.Eyas Alkhalili Eren Berber 2014World Journal of Gastroenterology2014,20,37:5
7Transcriptome-wide reprogramming of N^6-methyladenosine modification by the mouse microbiome显示文摘Dear Editor, Microbiome affects many aspects of human health and disease and elicits a wide range of host responses including remarkable epigenetic changes such as DNA methylation,histone modification and non-coding RNA expression.A still poorly explored area of microbiome-host interaction is the response of host RNA modification.N^6-methyladenosine (m^6A)is the most abundant mRNA modification in mammalian cells,occurring at -3 modified adenosine residues per transcript.Xiaoyun Wang Yan Li Wenjun Chen Hailing Shi A.Murat Eren Aleksey Morozov Chuan He Guan-Zheng Luo Tao Pan 2019Cell Research2019,29,2:4
8Ceftriaxone-induced toxic hepatitis显示文摘Toxic hepatitis or drug-induced liver injury encompasses a spectrum of clinical disease ranging from mild biochemical abnormalities to acute liver failure.The advantages of a long half-life,wide spectrum,high tissue penetration rate,and a good safety profile,make ceftriaxone,a third-generation cephalosporin,a frequent choice in the treatment of childhood infections.Previous studies have reported a few cases of high aspartate aminotransferase and alanine aminotransferase levels,along with three cases of hepatitis caused by ceftriaxone.Here,we report a case of drug-induced toxic hepatitis in a patient who was treated with ceftriaxone for acute tonsillitis.Erdal Peker Eren Cagan Murat Dogan 2009World Journal of Gastroenterology2009,15,21:4
9Incorporating travel time reliability in predicting the likelihood of severe crashes on arterial highways using non-parametric random-effect regression显示文摘Travel time reliability(TTR) modeling has gain attention among researchers’ due to its ability to represent road user satisfaction as well as providing a predictability of a trip travel time.Despite this significant effort,its impact on the severity of a crash is not well explored.This study analyzes the effect of TTR and other variables on the probability of the crash severity occurring on arterial roads.To address the unobserved heterogeneity problem,two random-effect regressions were applied;the Dirichlet random-effect(DRE)and the traditional random-effect(TRE) logistic regression.The difference between the two models is that the random-effect in the DRE is non-parametrically specified while in the TRE model is parametrically specified.The Markov Chain Monte Carlo simulations were adopted to infer the parameters’ posterior distributions of the two developed models.Using four-year police-reported crash data and travel speeds from Northeast Florida,the analysis of goodness-of-fit found the DRE model to best fit the data.Hence,it was used in studying the influence of TTR and other variables on crash severity.The DRE model findings suggest that TTR is statistically significant,at 95 percent credible intervals,influencing the severity level of a crash.A unit increases in TTR reduces the likelihood of a severe crash occurrence by 25 percent.Moreover,among the significant variables,alcohol/drug impairment was found to have the highest impact in influencing the occurrence of severe crashes.Other significant factors included traffic volume,weekends,speed,work-zone,land use,visibility,seatbelt usage,segment length,undivided/divided highway,and age.Emmanuel Kidando Ren Moses Eren Erman Ozguven Thobias Sando 2019Journal of Traffic and Transportation Engineering(English Edition)2019,6,5:4
10Late clinical characteristics of infants with retinopathy of prematurity and treated with cryotherapy显示文摘AIM: To describe the clinical characteristics and late results of patients with retinopathy of prematurity(ROP)treated with '6h cryotherapy'.·METHODS: Out of 1252 infants screened for ROP, 52 patients were treated with temporal 6h cryotherapy from1997 to 2005 were recalled to our clinic. Among these 23 patients were available and 46 eyes of 23 infants were included to evaluate for visual acuity, refractive error,ocular alignment, nystagmus, retinal examination(abnormal branching of retinal vessels, retinal thinning,latis degenerations, tortuosity of vessels, straightening of temporal vessels, narrowing of the angle of vessel in the juxtapapillary entrance, pigment changes, macular heterotopia), optic atrophy and optic disc cupping, axial length at birth and axial length at 1y.·RESULTS: The median age at examination was 7(5-18)y.In 32.6% of patients, the visual acuity was ≤20/200 and the mean best corrected visual acuity was 20/35 as measured with a Snellen chart. Mean spherical refractive error was-1.76±2.69 D. The degree of myopia at the last examination was found to be correlated with the elongation of the eye in the first year of life. Exotropia was present in 17.4%(n =8) of infants and esotropia in13%(n =6). The most common retinal abnormality was abnormal branching of retinal vessels(82.6%) followed by retinal thinning(52.2%).·CONCLUSION: The late clinical outcomes of infants with ROP treated in our clinic with cryotherapy seems to comparable with results of laser treatment.Eren Cerman Deniz Ozarslan Ozcan Hande Celiker Muhsin Eraslan Ozlem Sahin Haluk Kazokoglu 2016International Journal of Ophthalmology(English edition)2016,9,4:4
11Lung parenchymal changes in patients with ankylosing spondylitis显示文摘AIM: To assess lung parenchymal changes in ankylosing spondylitis (AS) using high resolution computed tomography (HRCT). METHODS: We included 78 AS patients whose average age was 33.87 (18-56) years with a ratio of 53 males to 25 females who were followed up for 3.88 (1-22) years on average. neumonia and tuberculosis were excluded. In a detailed examination of lung HRCT findings, we investigated the presence of parenchymal micronodules,parenchymal bands, subpleural bands, interlobular and intralobular septal thickening, irregularity of interfaces,ground glass opacity, consolidation, mosaic pattern,bronchial wall thickening, bronchial dilatation, tracheal dilatation, pleural thickening, emphysema, thoracic cage asymmetry, honeycomb appearance, structural distortion, apical fibrosis and other additional findings.RESULTS: In detailed HRCT evaluations, lung parenchymal changes were found in 46 (59%) of all patients. We found parenchymal bands in 21 (27%) cases, interlobular septal thickening in 9 (12%), emphysema in 9 (12%), apical fibrosis in 8 (10%), ground-glass opacities in 7 (9%), parenchymal micronodules in 5 (6%), irregularity in interfaces in 3 (4%), bronchial dilatation in 3 (4%), mosaic pattern in 2 (3%), pleural thickening in 2 (3%), consolidation in 1 (1%), bronchial wall thick ening in 1 (1%) and a subpleural band in 1 (1%) case. Furthermore, we detected subsegmental atelectasis in 2 patients and a cavitary lesion in 1 patient. CONCLUSION: Our study had the highest number of AS cases of all previous studies in evaluating lung paren chymal changes. The rate of lung parenchymal changes was slightly lower than that reported in recent literature.Zehra Isik Hasiloglu Nuri Havan Aylin Rezvani Mustafa Akif Sariyildiz Halil Eren Erdemli Ilhan Karacan 2012World Journal of Radiology2012,4,5:3
12European Consensus Guidelines on the Management of Neonatal Respiratory Distress Syndrome in Preterm Infants - 2013 Update显示文摘Sweet David G Carnielli Virgilio Greisen Gorm Hallman Mikko Ozek Eren Plavka Richard Saugstad Ola D Simeoni Umberto Speer Christian P Vento Maximo Halliday Henry L 2013Neonatology2013,,4:3
13Framework for Measuring the Resilience of Utility Poles of an Electric Power Distribution Network显示文摘The utility poles of an electric power distribution system are frequently damaged by wind-related disasters.This study notes that the wooden poles are particularly vulnerable to such disasters and the failures of the poles can cause a network-level failure leading to short-or longterm power outages. To mitigate the problem, this study proposes a framework for measuring the resilience of the wooden utility poles based on the angular deflection of a pole due to the wind force. Given the existing inclination angle of a pole, the angular deflection is measured by finite element analysis using ANSYS~? Workbench^1 to determine the resilience area under various wind speeds. For this, the conditions of load and support for a pole, which are called boundary conditions in ANSYS~?, are generated. The proposed framework also includes an approach to cost–benefit analysis that compares different strategies for corrective action. The results of the case study in which the framework was applied show that the proposed framework can be effectively utilized by electric power distribution companies to increase the resilience of their systems.MdMorshedul Alam Berna Eren Tokgoz Seokyon Hwang 2019International Journal of Disaster Risk Science2019,10,2:3
14Assessment of traffic performance measures and safety based on driver age and experience:A microsimulation based analysis for an unsignalized T-intersection显示文摘Traffic safety and performance measures such as crash risk and queue lengths or travel times are influenced by several important factors including those related to environment,human,and roadway design,especially at intersections.Previous research has studied different aspects related to these factors,yet these characteristics are not fully investigated with a focus on age and experience of drivers.In this paper,we investigate this issue by using a two-phase approach via a case study application on a critical T-intersection in the City of Tallahassee,Florida.The first phase includes a scenario-based microsimulation analysis through the use of a microscopic simulation software,namely VISSIM,to illustrate the variations in traffic performance measures with respect to driver compositions of different age groups in the traffic stream.A variety of scenarios is created where the driving characteristics are provided as inputs to these scenarios in terms of decision making and risk taking.This is also supported by a sensitivity analysis conducted based on the driver composition in the traffic.The second phase includes the analysis of microsimulation outputs via a tool developed by Federal Highway Administration tool,namely the Surrogate Safety Assessment Model(SSAM),in order to determine the traffic conflicts that occur in each scenario.These conflicts are also compared with real-life crash data for validation purposes.Results show that(a) the differences in risk perception that affect driving behavior might be significant in influencing traffic safety and performance measures,and(b) the proposed approach is considerably successful in simulating the actual crash conflict points.Mehmet Baran Ulak Eren Erman Ozguven Ren Moses Thobias Sando Walter Boot Yassir AbdelRazig John Olusegun Sobanjo 2019Journal of Traffic and Transportation Engineering(English Edition)2019,6,5:2
15Comment on: Statin use and risk of diabetes mellitus显示文摘In manuscript named 'Statin use and risk of diabetes mellitus' by Chogtu et al, authors defined that pravastatin 40 mg/dL reduced the risk of diabetes by 30% in West of Scotland Coronary Prevention study. In fact, pravastatin 40 mg/d L reduced coronary heart disease risk approximately 30% in mentioned study.Mehmet Ali Eren Tevfik Sabuncu Hüseyin Karaaslan 2016World Journal of Diabetes2016,7,8:2
16Lactic acid bacteria as pro-technological,bioprotective and health-promoting cultures in the dairy food industry显示文摘Lactic acid bacteria (LAB) constitute pivotal microorganisms for the food industry due to their considerable technological and functional potential.Fermented dairy products,that is ancient traditions worldwide,still have been accepted and consumed today for their nutritional and organoleptic attributes.In accordance with the current trends in the market and greater awareness of consumer well-being,a detailed assessment of the health effects of dairy product consumption has been undertaken with particular reference to the production of bioactive metabolites including i.e.,γ-aminobutyric acid,conjugated linoleic acid,bioactive peptides,exopolysaccharides as well as vitamins during LAB fermentation.The long histories of yogurt,kefir,and traditional fermented milk drink as sources of some certain probiotic bacteria as well as the opportunity to bio-fortify the matrix with bioactive microbial compounds in situ make fermented dairy products an attractive model in the efforts to develop sustainable functional food systems.Therefore,this review provides the main biochemical characteristics and biotechnological application of LAB as pro-technological,bioprotective,and health-promoting in the food chain.Duygu Ağagündüz Teslime Özge Şahin Şerife Ayten Birsen Yılmaz Bartu Eren Güneşliol Pasquale Russo Giuseppe Spano Fatih Özogul 2022Food Bioscience2022,47,3:2
17Acetabular components with or without screws in total hip arthroplasty显示文摘AIM To compare the operation time, blood loss, and early outcomes of acetabular components with and without the screw.METHODS Thirty patients who underwent cementless acetabular component with or without screw and whose follow-up exceeded one year period in total hip arthroplasty were evaluated. A posterior approach was used in all surgical procedures by one experienced surgeon. Demographic data, operation time, intra-and postoperative blood loss volume, follow-up clinical score, cup migration, and osteolysis were recorded. The Kolmogorov-Smirnov test was performed for testing the normality of study data. Mann-Whitney U test was used to analyze the intergroup differences. A P-value of ≤ 0.05 was considered statistically significant.RESULTS Acetabular components were used in 16(53.3%) patients with screw and 14(46.7%) without screw. After one year of follow-up, an osteolytic lesion of 3 mm was found in only one patient in the screw group. No cup migrationwas encountered. Intra-group mean Harris hip score significantly increased, but there was no significant intergroup difference. While the mean operation time of the screw group was 121.8 min(range; 95-140), it was 102.7 min(range; 80-120) in the no-screw group, and this difference was statistically significant(P = 0.002). The mean intraoperative/postoperative, and total blood loss were 556.6 mL(range: 350-800)/423.3 mL(range: 250-600), and 983.3 mL(range: 600-1350), respectively in the screw group; and 527 mL(range: 400-700)/456 mL(range: 230-600), and 983 mL(range: 630-1250), respectively in the no-screw group. The blood loss difference between the two groups was not significant. In the screw group, the operation time was 19.1 min longer than the no-screw group, and this difference was statistically significant.CONCLUSION Acetabular components with or without screw have similar results, but the use of screw increases the operation time significantly, while not changing the blood loss volume.Murad Pepe Onur Kocadal Tamer Erener Kubilay Ceritoglu Ertugrul Aksahin Cem Nuri Aktekin 2017World Journal of Orthopedics2017,8,9:2
18新型经脉络膜上腔引流房水植入装置Suprajet的疗效观察(英文)显示文摘目的:评估一种由睫状体前和脉络膜上腔引流房水的新型植入装置Suprajet的有效性和安全性。方法:该项研究使用5只兔子。每只兔子的一眼植入Suprajet。引流器通过位于上方的透明角膜切口,经由前房置入脉络膜上腔。引流器近端位于睫状体根部,远端位于脉络膜上腔。兔子饲养、观察4wk。使用Tonopen AVIA测量术前和术后的眼压。最后一次随访观察时,兔子被牺牲处死,眼球摘除,进行大体上和组织学的观察评估。结果:术前眼压为18.6±6.1mmH g。术后1wk眼压为8.4±1.1mmH g。术后2wk 1只兔子死亡。因此,仅有4只兔子进行了后续观察。术后2wk眼压为11.0±2.8mmH g,术后3wk为9.50±3.1mmH g,术后4wk为11.3±3.3mmH g。与术前平均眼压相比,仅第1周的平均眼压显著降低(P=0.042),术后2wk、3wk和术后4wk的平均眼压无明显变化(P=0.66,P=0.66,P=0.102)。术中并发症包括3眼少量出血。术后2d出血已经完全吸收。对摘除眼球的大体观察发现,1眼中引流器的远端位于玻璃体内,而不是位于脉络膜上腔;其它3眼引流器的远端位于脉络膜上腔。所有眼中,近端都位于前房角。对摘除眼的组织学检查发现:不规则的胶原蛋白束和纤维沉积,包括引流器周围大量的成纤维细胞和组织细胞。结论:这一项初始动物研究显示,青光眼中Suprajet植入是一项有前景的术式。需要进行更进一步的研究以评估其有效性和安全性。Uzeyir Gunenc Gul Arikan Ferim Gunenc Banu Lebe Sitki Eren Elvan Ocmen Arif Taylan Ozturk 2017国际眼科杂志2017,17,10:2
19The superior vena eava syndrome caused by malignant disease,imaging with multi-detector row CT显示文摘Eren S Karaman A Okur A 2006Eur J Radiol2006,59,1:1
20Enzymatic pre-preatment of cotton, part 1 : desizing and glucose generation in desiz- ing liquor显示文摘ANIS P DAVULCU A EREN H A 2008Fibers & Textiles in Eastern Europe2008,16,4:1
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