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| 1 | Histopathological comparison of topical therapy modalities for acute radiation proctitis in an experimental rat model显示文摘瞄准:与福尔马林相比评估为尖锐放射直肠炎的治疗可得到的流行热门治疗学的形式。方法:120 只老鼠的一个总数被使用。四个组(n = 30 ) 为每下列应用治疗形式与一个组一起被分析:控制, mesalazine,福尔马林, betamethasone,和 misoprostol。17.5 Gy 的单个部分被送到每只老鼠。在组老鼠被给 saline 的控制的老鼠,和在另外的三个组的老鼠在照耀以后开始第一天直到无痛苦的死亡的日子的一天收到了适当灌肠剂两次。在 d 上 5, 10,和 15,从每个组的十只老鼠是 euthanized,不知道处理赋值的一个病理学家用一个得分系统检验了直肠。结果:为表面上皮,腺(地窟) 和直肠的薄板 propria 基质的组织病理学说的分数在 d 上到达了他们的最大的水平 10。控制和福尔马林组有最高并且有的 mesalazine 最低,分别地在 d 上 10。在第 15 d 上, mesalazine, betamethasone,和 misoprostol 有 betamethasone 的最低分数。结论:Mesalazine, betamethasone,和 misoprostol 是最好的热门代理人因为放射直肠炎和福尔马林有煽动性的效果并且不应该被使用。 | Cagatay Korkut Oktar Asoglu Murat Aksoy Yersu Kapran Hatice Bilge Nese Kiremit-Korkut Mesut Parlak | 2006 | World Journal of Gastroenterology2006，12，30： | 18 |
| 2 | Ultrasound guided percutaneous cholecystostomy in high-risk patients for surgical intervention显示文摘AIM: To assess the efficacy and safety of ultrasound guided percutaneous cholecystostomy (PC) in the treatment of acute cholecystitis in a well-defined high risk patients under general anesthesia. METHODS: The data of 27 consecutive patients who underwent percutaneous transhepatic cholecystostomy for the management of acute cholecystitis from January 1999 to June 2003 was retrospectively evaluated. All of the patients had both clinical and sonographic signs of acute cholecystitis and had comorbid diseases. RESULTS: Ultrasound revealed gallbladder stones in 25 patients and acalculous cholecystitis in two patients. Cholecystostomy catheters were removed 14-32 d (mean 23 d) after the procedure in cases where complete regression of all symptoms was achieved. There were statistically significant reductions in leukocytosis, (13.7 × 103 ± 1.3 × 103 μg/L vs 13 × 103 ± 1 × 103 μg/L, P < 0.05 for 24 h after PC; 13.7 × 103 ± 1.3 × 103 μg/L vs 8.3 × 103 ± 1.2 × 103 μg/L, P < 0.0001 for 72 h after PC), C -reactive protein (51.2 ± 18.5 mg/L vs 27.3 ± 10.4 mg/L, P < 0.05 for 24 h after PC; 51.2 ± 18.5 mg/L vs 5.4 ± 1.5 mg/L, P < 0.0001 for 72 h after PC), and fever (38 ± 0.35℃ vs 37.3 ± 0.32℃, P < 0.05 for 24 h after PC; 38 ± 0.35℃ vs 36.9 ± 0.15℃, P < 0.0001 for 72 h after PC). Sphincterotomy and stone extraction was performed successfully with endoscopic retrograde cholangio-pancreatography (ERCP) in three patients. After cholecystostomy, 5 (18%) patients underwent delayed cholecystectomy without any complications. Three out of 22 patients were admitted with recurrent acute cholecystitis during the follow-up and recoveredwith medical treatment. Catheter dislodgement occurred in three patients spontaneously, and two of them were managed by reinsertion of the catheter. CONCLUSION: As an alternative to surgery, percutan- eous cholecystostomy seems to be a safe method in critically ill patients with acute cholecystitis and can be performed with low mortality and morbidity. Delayed cholecystectomy and ERCP, if needed, can be performed after the acute period has been resolved by percutaneous cholecystostomy. | Huseyin Bakkaloglu Hakan Yanar Recep Guloglu Korhan Taviloglu Fatih Tunca Murat Aksoy Cemalettin Ertekin Arzu Poyanli | 2006 | World Journal of Gastroenterology2006，12，44： | 15 |
| 3 | Targeted therapies in gastric cancer and future perspectives显示文摘Advanced gastric cancer(AGC) is associated with a high mortality rate and, despite multiple new chemotherapy options, the survival rates of patients with AGC remains poor. After the discovery of targeted therapies, research has focused on the new treatment options for AGC. In the last two decades, many targeted molecules were developed against AGC. Currently, two targeted therapy molecules have been approved for patients with AGC. In 2010, trastuzumab was the first molecule shown to improve survival in patients with HER2-positive AGC as part of a first-line combination regimen. In 2014, ramucirumab was the second targeted molecule to improve survival rates and was suggested as treatment for patients with AGC who had progressed after firstline platinum plus fluoropyrimidine with or without anthracycline chemotherapy. Ramucirumab was the first targeted therapy acting as a single agent in patients with advanced gastroesophageal cancers. Although these two molecules were introduced into clinical use, many other promising molecules have been tested in phase Ⅰ-Ⅱ trials. It is obvious that in the near future many different targeted therapies will be in use for treatment of AGC. In this review, the current status of targeted therapies in the treatment of AGC and gastroesophageal junction tumors, including HER(2-3) inhibitors, epidermal growth factor receptor inhibitors, tyrosine kinase inhibitors, antiangiogenic agents, c-MET inhibitors, mammalian target of rapamycin inhibitors, agents against other molecular pathways fibroblast growth factor, Claudins, insulin-like growth factor, heat shock proteins, and immunotherapy, will be discussed. | Ozan Yazici M Ali Nahit Sendur Nuriye Ozdemir Sercan Aksoy | 2016 | World Journal of Gastroenterology2016，22，2： | 11 |
| 4 | Nigella sativa relieves the deleterious effects of ischemia reperfusion injury on liver显示文摘AIM: To determine whether Nigella sativa prevents hepatic ischemia-reperfusion injury to the liver. METHODS: Thirty rats were divided into three groups as sham (Group 1), control (Group 2), and Nigella sati-va (NS) treatment group (Group 3). All rats underwent hepatic ischemia for 45 min followed by 60 min period of reperfusion. Rats were intraperitoneally infused with only 0.9% saline solution in group 2. Rats in group 3 received NS (0.2 mL/kg) intraperitoneally, before isch-emia and before reperfusion. Blood samples and liver tissues were harvested from the rats, and then the rats were sacrifi ced. Serum aspartate aminotransfera-se (AST), alanine aminotransferase (ALT), and lactate dehydrogenase (LDH) levels were determined. Total antioxidant capacity (TAC), catalase (CAT), total oxida-tive status (TOS), oxidative stress index (OSI) and my-eloperoxidase (MPO) in hepatic tissue were measured. Also liver tissue histopathology was evaluated by light microscopy. RESULTS: The levels of liver enzymes in group 3 weresignifi cantly lower than those in the group 2. TAC in liver tissue was significantly higher in group 3 than in group 2. TOS, OSI and MPO in hepatic tissue were signifi cantly lower in group 3 than the group 2. Histo-logical tissue damage was milder in the NS treatment group than that in the control group. CONCLUSION: Our results suggest that Nigella sa-tiva treatment protects the rat liver against to hepatic ischemia-reperfusion injury. | Fahrettin Yildiz Sacit Coban Alpaslan Terzi Mustafa Ates Nurten Aksoy Hale Cakir Ali Riza Ocak Muharrem Bitiren | 2008 | World Journal of Gastroenterology2008，14，33： | 8 |
| 5 | Comparison of intravitreal bevacizumab and triamcinolone acetonide theraphies for diffuse diabetic macular edema显示文摘AIM: To compare therapeutic effects of intravitreal triamcinolone acetonide(IVTA) versus intravitreal bevacizumab(IVB) injections for bilateral diffuse diabetic macular edema(DDME). METHODS: Forty eyes of 20 patients with bilateral DDME participated in this study. For each patient, 4 mg/0.1 m L IVTA was injected to one eye and 2.5 mg/0.1 m L IVB was injected to the other eye. The effects of injection for diabetic macular edema(DME) were evaluated using best-corrected visual acuity(BCVA), central macular thickness(CMT) by optical coherence tomography(OCT)and intraocular pressure(IOP) by applanation tonometer.Patients underwent eye examinations, including BCVA,CMT, and IOP at pre-injection, 1, 4, 8, 12 and 24 wk after injection. During the follow-up, second injections were performed to eyes which have CMT greater than 400 μm at 12 wk for salvage therapy.RESULTS: BCVA(logarithm of the minimum angle of resolution) at pre-injection, 1, 4, 8, 12 and 24 wk after injection was 0.71 ±0.19, 0.62 ±0.23, 0.63 ±0.12, 0.63 ±0.13,0.63±0.14 and 0.61±0.24 in the IVTA group and 0.68±0.25,0.61 ±0.22, 0.60 ±0.24, 0.62 ±0.25, 0.65 ±0.26 and 0.59 ±0.25 in the IVB group, respectively. CMT(μm) at pre-injection,1, 4, 8, 12 and 24 wk after injection was 544 ±125, 383±96,335 ±87, 323 ±87, 333 ±92, 335 ±61 in the IVTA group and514 ±100, 431 ±86, 428 ±107, 442 ±106, 478 ±112, 430 ±88 in the IVB group respectively. Reduction ratios of mean CMT were 29% at 1wk, 38% at 4wk, 40% at 8wk, 38% at12 wk, and 38% at 24 wk in the IVTA group. Second IVTA injections were performed to the 6 eyes(30%) at 12 wk.Reduction ratios of mean CMT were 16% at 1wk, 17% at4wk, 14% at 8wk, 7% at 12 wk, and 16% at 24 wk in the IVB group. Second IVB injections were performed to the15 eyes(75%) at 12 wk.CONCLUSION: This study showed earlier and more frequent macular edema recurrences in the eyes treated with bevacizumab compared with the ones treated with triamcinolone acetonide. Triamcinolone acetonide was found to provide more efficient and long-standing effect in terms of reducing CMT compared with the bevacizumab. | Sibel Aksoy Gursel Yilmaz Imren Akkoyun Ayse Canan Yazici | 2015 | International Journal of Ophthalmology(English edition)2015，8，3： | 6 |
| 6 | Incidence of toxoplasmosis in patients with cirrhosis显示文摘AIM:It is known that toxoplasmosis rarely leads to various liver pathologies,most common of which is granulomatose hepatitis in patients having normal immune systems. Patients who have cirrhosis of the liver are subject to a variety of cellular as well as humoral immunity disorders. Therefore, it may be considered that toxoplasmosis can cause more frequent and more severe diseases in patients with cirrhosis and is capable of changing the course of the disease.The aim of this study was to investigate the frequency of toxoplasmosis in patients with cirrhosis.METHODS:Serum samples were taken from 108 patients with cirrhosis under observation in the Hepatology Polyclinic of the Gastroenterology Clinic,and a control group made up of 50 healthy blood donors. IFAT and ELISA methods were used to investigate the IgG and IgM antibodies, which had developed from these sera.RESULTS:Toxoplasma IgG and IgM antibody positivity was found in 74 (68.5%) of the 108 cirrhotic patients and 24 (48%) of the 50 people in the control group. The difference between them was significant (P<0.05).CONCLUSION: In conclusion, it was found that the toxoplasma sero-prevalence in the cirrhotic patients in this study was higher. Cirrhotic patients are likely to form a toxoplasma risk group. More detailed studies are needed on this subject. | Sebnem Ustun Umit Aksoy Hande Dagci Galip Ersoz | 2004 | World Journal of Gastroenterology2004，10，3： | 6 |
| 7 | Hepatitis C virus reactivation in cancer patients in the era of targeted therapies显示文摘The purpose of this review is to summarize the evidence of hepatitis C reactivation in cancer patients in the era of targeted therapies.Targeted therapies are novel therapeutics frequently used in cancer patients.During treatment with targeted therapies,viral replication is one of the major problems that can occur.The PubMed database,ASCO,and ASCO Gastrointestinal Cancer Symposium abstracts were searched up until September 15,2013 using the following search keywords:'targeted therapies,rituximab,alemtuzumab,brentuximab,hepatitis,hepatitis C reactivation,tyrosine kinase inhibitors,imatinib,mammalian target of rapamycin(mTOR)inhibitors,everolimus,anti-HER therapies,trastuzumab,pertuzumab,lapatinib,antiepidermal growth factor receptor therapies,cetuximab,panitumumab,and ipilimumab'.Papers considered relevant for the aim of this review were selected by the authors.The data about rituximab-induced hepatic flare in hepatitis C virus(HCV)positive patients is controver-sial.However,there is the possibility of life-threatening hepatic flare that can develop after HCV ribonucleic acid(HCV-RNA)viral load increases.Routine followup of liver function tests should be advised.Especially in high-risk patients,such as those with baseline chronic active hepatitis and cirrhosis,and where there are plans to administer rituximab concomitantly with corticosteroids,it is advised to have close follow-up of HCV viral load.The data is insufficient to make accurate statements about the association of alemtuzumab therapy and HCV reactivation.However,alemtuzumab may cause deep immunosuppression.Due to this,it is better to follow up with liver function tests and HCV RNA levels during alemtuzumab therapy.Brentuximab has effects on antibody dependent cellular toxicity and may decrease humoral immunity.Thus,we believe that during brentuximab treatment of HCV infected patients,clinicians may encounter hepatitis C reactivation.There have been no reported cases of hepatitis C reactivation with imatinib therapy.However,there are many reports of hepatitis B reactivation with imatinib treatment.Based on the evidence of hepatitis B reactivation with imatinib and the effects of imatinib on immune system functions,we suggest that imatinib therapy might be a risk factor for HCV reactivation.Anti-human epidermal growth factor receptor 2 therapies are not associated with hepatic flare in HCV infected patients.Post-transplant studies reported that mTOR was safely administered to patients with active hepatitis C without causing hepatic flare.Cetuximab and panitumumab have not been associated with HCV reactivation.Two cases of HCV infected melanoma were safely treated with ipilimumab without any HCV reactivation or hepatic flare.Targeted therapies are a new and emerging area of oncology treatment modalities.While treating HCV infected cancer patients,clinicians should be mindful of the immunosuppressive properties of targeted therapies.Further randomized trials are needed to establish algorithms for this issue. | Ozan Yazici Mehmet Ali Nahit ?endur Sercan Aksoy | 2014 | World Journal of Gastroenterology2014，20，22： | 5 |
| 8 | Role of diabetes in heart rhythm disorders显示文摘The incidence of diabetes mellitus(DM) is increasing rapidly. DM is the leading cause of cardiovascular diseases, which can lead to varied cardiovascular complications by aggravated atherosclerosis in large arteries and coronary atherosclerosis, thereby grows the risk for macro and microangiopathy such as myocardial infarction, stroke, limb loss and retinopathy. Moreover diabetes is one of the strongest and independent risk factor for cardiovascular morbidity and mortality, which associated frequently rhythm disorders such as atrial fibrillation(AF) and ventricular arrhythmias(VA). The present article provides a concise overview of the association between DM and rhythm disorders such as AF and VA with underlying pathophysiological mechanisms. | Buelent Koektuerk Murat Aksoy Marc Horlitz Ilkay Bozdag-Turan Ramazan Goekmen Turan | 2016 | World Journal of Diabetes2016，7，3： | 3 |
| 9 | Determination of aflatoxin levels in some dairy and food products which consumed in Ankara, Turkey显示文摘 | Hasan Aycicek Abdurrahman Aksoy Sahan Saygi | 2004 | Food Control2004，，3： | 3 |
| 10 | Prevalence of amebiasis in inflammatory bowel disease in Turkey显示文摘AIM: To explore the prevalence of amebiasis in inflammatory bowel disease (IBD) in Turkey.METHODS: In this study, amoeba prevalence in 160 cases of IBD, 130 of ulcerative colitis and 30 of Crohn′s disease were investigated in fresh faeces by means of wet mount+Lugol′s iodine staining, modified formol ethyl acetate and trichrome staining methods and to compare the diagnostic accuracy of wet mount+Lugol′s iodine staining,modified formol ethyl acetate and trichrome staining methods in the diagnosis of Entamoeba histolytica (E. histolytica)/Entamoeba dispar (E. dispar).RESULTS: E. histolytica/E. dispar cysts and trophozoites were found in 14 (8.75 %) of a total of 160 cases, 13 (10.0 %)of the 130 patients with ulcerative colitis and 1 (3.3 %) of the 30 patients with Crohn′s disease. As for the 105 patients in the control group who had not any gastrointestinal complaints, 2 (1.90 %) patients were found to have E.histolytica/E. dispar cysts in their faeces. Parasite prevalence in the patient group was determined to be significantly higher than that in the control group (Fischer′s Exact Test, P<0.05).When the three methods of determining parasites were compared with one another, the most effective one was found to be trichrome staining method (Kruskal-Wallis Test, P<0.01).CONCLUSION: Consequently, amoeba infections in IBD cases have a greater prevalence compared to the normal population. The trichrome staining method is more effective for the detection of E. histolytica/E. dispar than the wet mount+Lugol′s iodine staining, modified formol ethyl acetate methods. | Sebnem Ustun Hande Dagci Umit Aksoy Yuksel Guruz Galip Ersoz | 2003 | World Journal of Gastroenterology2003，9，8： | 3 |
| 11 | Evaluation of an erosion-sediment transport model for a hillslope using laboratory flume data显示文摘Climate change can escalate rainfall intensity and cause further increase in sediment transport in arid lands which in turn can adversely affect water quality. Hence, there is a strong need to predict the fate of sediments in order to provide measures for sound erosion control and water quality management. The presence of microtopography on hillslopes influences processes of runoff generation and erosion, which should be taken into account to achieve more accurate modelling results. This study presents a physically based mathematical model for erosion and sediment transport coupled to one-dimensional overland flow equations that simulate rainfall-runoff generation on the rill and interrill areas of a bare hillslope. Modelling effort at such a fine resolution considering the flow connection between interrill areas and rills is rarely verified. The developed model was applied on a set of data gathered from an experimental setup where a 650 cm×136 cm erosion flume was pre-formed with a longitudinal rill and interrill having a plane geometry and was equipped with a rainfall simulator that reproduces natural rainfall characteristics. The flume can be given both longitudinal and lateral slope directions. For calibration and validation, the model was applied on the experimental results obtained from the setup of the flume having 5% lateral and 10% longitudinal slope directions under rainfall intensities of 105 and 45 mm/h, respectively. Calibration showed that the model was able to produce good results based on the R2(0.84) and NSE(0.80) values. The model performance was further tested through validation which also produced good statistics(R2=0.83, NSE=0.72). Results in terms of the sedigraphs, cumulative mass curves and performance statistics suggest that the model can be a useful and an important step towards verifying and improving mathematical models of erosion and sediment transport. | Anya Catherine CARGUELLES MinJae JUNG Kristine Joy BMALLARI GiJung PAK Hafzullah AKSOY Levent M KAVVAS Ebru ERIS JaeYoung YOON YoungJoon LEE SeonHwa HONG | 2014 | Journal of Arid Land2014，6，6： | 3 |
| 12 | Diagnostic value of CRP and Lp(a) in coronary heart disease显示文摘 | ERBAGCI A B TARAKCIOGLU M AKSOY M | 2002 | Acta Cardiol2002，57，3： | 2 |
| 13 | A geriatric patient with diffuse idiopathic skeletal hyperostosis显示文摘The most frequent health problems seen in senility are chronic and degenerative diseases. A 75-year-old male patient with the complaints of weight loss and difficulty in swallowing was admitted to our hospital from a nursing home. Upper system fiber-optic gastrointestinal endoscopy was performed and a mass at the junction of the hypopharynx and esophagus just below recessus piriformis obstructing almost the whole of the lumen and blocking the distal passage was detected. Computed tomography revealed marked narrowing secondary to osseous hypertrophy in the air column of the hypopharynx and proximal esophagus. Diffuse idiopathic skeletal hyperostosis or Forestier’s disease is an idiopathic disease characterized by the ossification of the anterior longitudinal ligament of vertebra and some of the extraspinal ligaments. In the present case we aim to discuss an elderly patient who suffered from dysphagia and weight loss and the diagnostic stages. | Berrin Karadag Huseyin Cat Selma Aksoy Banu Ozulu Ali Osman Ozturk Sukru Oguz Yuksel Altuntas | 2010 | World Journal of Gastroenterology2010，16，13： | 2 |
| 14 | YALIKAVAK精品酒店,博德鲁姆-穆拉,土耳其显示文摘这座40间客房的精品酒店位于博德鲁姆的Yalikavak,美丽的爱琴海沿岸。设计通过在不同层高上交错布置遮蔽、半遮蔽和露天开放区域,营造出呼应场所地形、主导风向和景观的连续空间。 | Suna Birsen-Otay Sevim Aslan Ipek Yurekli Deniz Aslan Arda Inceoglu Kemal Ozmen Ilker Aksoy Ceren Hancioglu Esin Gumus Gunseli Dolluk 项琳斐 | 2010 | 世界建筑2010，，7： | 2 |
| 15 | Numerical modeling of non-deformable support in swelling and squeezing rock显示文摘 | C.O. Aksoy K. Ogul I. Topal S.C. Ozer V. Ozacar E. Posluk | 2012 | International Journal of Rock Mechanics and Mining Sciences2012，，： | 2 |
| 16 | 提高客户满意度是否会增加企业盈利显示文摘 | Timothy L.Keiningham Tiffany Perkins-Munn Lerzan Aksoy Demitry Estrin 李海岚 | 2006 | 市场研究2006，，6： | 2 |
| 17 | Corrosion behavior of tempered dual-phase steel embedded in concrete显示文摘Dual-phase(DP) steels with different martensite contents were obtained by appropriate heat treatment of an SAE1010 structural carbon steel,which was cheap and widely used in the construction industry. The corrosion behavior of DP steels in con-crete was investigated under various tempering conditions. Intercritical annealing heat treatment was applied to the reinforcing steel to obtain DP steels with different contents of martensite. These DP steels were tempered at 200,300,and 400°C for 45 min and then cooled to room temperature. Corrosion experiments were conducted in two stages. In the first stage,the corrosion potential of DP steels embedded in concrete was measured every day for a period of 30 d based on the ASTM C 876 standard. In the second stage,the anodic and cathodic polarization values of these steels were obtained and subsequently the corrosion currents were determined with the aid of cathodic polarization curves. It was observed that the amount of second phase had a definite effect on the corrosion behavior of the DP steel embedded in concrete. As a result of this study,it is found that the corrosion rate of the DP steel increases with an increase in the amount of martensite. | Oguzhan Kelestemur Mustafa Aksoy Servet Ylldlz | 2009 | International Journal of Minerals,Metallurgy and Materials2009，16，1： | 2 |
| 18 | The effect of manganese on the microstructure and mechanical properties of leaded-tin bronze显示文摘 | Hurhan T Aksoy M Kuzucu V | 2001 | Journal of Materials Processing Technology2001，114，： | 1 |
| 19 | QUAD: Quadrant-based relative location estimates for representative topologies in wireless sensor networks显示文摘 | WONG M AKSOY D | 2009 | Computer Networks2009，53，12： | 1 |
| 20 | Detection of escherichia coli O157:H7 in ground beef using immunomagnetic separation and multiplex PCR 显示文摘 | Belgin Sarimehmetoglu Mihriban Hatun Aksoy Naim Deniz Ayaz | 2009 | Food Control2009，20，4： | 1 |
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