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| 1 | Noncoding RNAs in cancer and cancer stem cells显示文摘In recent years, it has become increasingly apparent that noncoding RNAs(ncRNA) are of crucial importance for human cancer. The functional relevance of ncRNAs is particularly evident for microRNAs(miRNAs) and long noncoding RNAs(lncRNAs). miRNAs are endogenously expressed small RNA sequences that act as post-transcriptional regulators of gene expression and have been extensively studied for their roles in cancers, whereas lncRNAs are emerging as important players in the cancer paradigm in recent years. These noncoding genes are often aberrantly expressed in a variety of human cancers. However, the biological functions of most ncRNAs remain largely unknown. Recently, evidence has begun to accumulate describing how ncRNAs are dysregulated in cancer and cancer stem cells, a subset of cancer cells harboring self-renewal and differentiation capacities. These studies provide insight into the functional roles that ncRNAs play in tumor initiation, progression, and resistance to therapies, and they suggest ncRNAs as attractive therapeutic targets and potentially useful diagnostic tools. | Tianzhi Huang Angel Alvarez Bo Hu Shi-Yuan Cheng | 2013 | Chinese Journal of Cancer2013，32，11： | 8 |
| 2 | An elastin-like recombinamer-based bioactive hydrogel embedded with mesenchymal stromal cells as an injectable scaffold for osteochondral repair显示文摘The aim of this study was to evaluate injectable,in situ cross-linkable elastin-like recombinamers(ELRs)for osteochondral repair.Both the ELR-based hydrogel alone and the ELR-based hydrogel embedded with rabbit mesenchymal stromal cells(rMSCs)were tested for the regeneration of critical subchondral defects in 10 New Zealand rabbits.Thus,cylindrical osteochondral defects were filled with an aqueous solution of ELRs and the animals sacrificed at 4months for histological and gross evaluation of features of biomaterial performance,including integration,cellular infiltration,surrounding matrix quality and the new matrix in the defects.Although both approaches helped cartilage regeneration,the results suggest that the specific composition of the rMSC-containing hydrogel permitted adequate bone regeneration,whereas the ELR-based hydrogel alone led to an excellent regeneration of hyaline cartilage.In conclusion,the ELR cross-linker solution can be easily delivered and forms a stable well-integrated hydrogel that supports infiltration and de novo matrix synthesis. | Filippo Cipriani Blanca Arino Palao Israel Gonzalez de Torre Aurelio Vega Castrillo Hector Jose Aguado Hernandez Matilde Alonso Rodrigo Angel Jose Alvarez Barcia Ana Sanchez Veronica Garcıa Diaz Monica Lopez Pena Jose Carlos Rodriguez-Cabello | 2019 | Regenerative Biomaterials2019，6，6： | 3 |
| 3 | A phase II trial of docetaxel and bevacizumab in recurrent ovarian cancer within 12 months of prior platinum-based chemotherapy显示文摘 | Robert M. Wenham James Lapolla Hui-Yi Lin Sachin M. Apte Johnathan M. Lancaster Patricia L. Judson Jesus Gonzalez-Bosquet Amber Herschberger Laura J. Havrilesky Angeles Alvarez Secord | 2013 | Gynecologic Oncology2013，，1： | 2 |
| 4 | Assessment and simulation of the responsive demand potential in end-user facilities: Application to a university customer显示文摘 | Alvarez Carlos Gabaldon Antonio Molina Angel | 2004 | IEEE Transactions on Power Systems2004，19，2： | 2 |
| 5 | Radical hysterectomy and pelvic lymphadenectomy for stage IB2 cervical cancer显示文摘 | Laura J Havrilesky Charles A Leath Warner Huh Brian Calingaert Rex C Bentley John T Soper Angeles Alvarez Secord | 2004 | Gynecologic Oncology2004，，2： | 1 |
| 6 | Role of vascular endothelial growth factor in the response to vessel injury显示文摘 | Alvarez Arroyo MV Caramelo C Angeles Castilla M | | 0，，： | 1 |
| 7 | A multicenter, randomized, phase 2 clinical trial to evaluate the efficacy and safety of combination docetaxel and carboplatin and sequential therapy with docetaxel then carboplatin in patients with recurrent platinum‐sensitive ovarian cancer显示文摘 | Angeles Alvarez Secord Andrew Berchuck Robert V. Higgins Lawrence R. Nycum Matthew F. Kohler Larry E. Puls Robert W. Holloway George S. Lewandowski Fidel A. Valea Laura J. Havrilesky | 2011 | Cancer2011，，13： | 1 |
| 8 | Localized synthesis of the outer envelope from Thermus thermophi- lus显示文摘 | ACOSTA F ALVAREZ L ANGEL DE PEDRO M | 2012 | Extremophiles2012，16，： | 1 |
| 9 | Predicting pulmonary complications after pneumonectomy for lung cancer显示文摘 | Francisco Javier Algar Antonio Alvarez Angel Salvatierra | 2003 | European Journal of Cardio - thoracic Surgery2003，23，2： | 1 |
| 10 | Effect of temperature on carbon dioxide absorption in mono ethanolamine solutions显示文摘 | Rocio Maceiras Estrella alvarez Cancela M Angeles | 2008 | Chern Eng J2008，138，1： | 1 |
| 11 | The role of lymphadenectomy in the management of preoperative grade 1 endometrial carcinoma显示文摘 | Nikki L. Neubauer Laura J. Havrilesky Brian Calingaert Anuradha Bulusu Marcus Q. Bernardini Nicole D. Fleming Amy E. Bland Angeles Alvarez Secord | 2008 | Gynecologic Oncology2008，，3： | 1 |
| 12 | Resection of lymph node metastases influences survival in stage IIIC endometrial cancer显示文摘 | Laura J. Havrilesky Janiel M. Cragun Brian Calingaert Ingrid Synan Angeles Alvarez Secord John T. Soper Daniel L. Clarke-Pearson Andrew Berchuck | 2005 | Gynecologic Oncology2005，，3： | 1 |
| 13 | Oral bile acids reduce bacterial overgrowth, bacterial translocation, and endotoxemia in cirrhotic rats显示文摘 | Vicente Lorenzo-Zú?iga Ramón Bartol?? Ramón Planas Alan F. Hofmann Belén Vi?ado Lee R. Hagey José M a Hernández Josep Ma?é Marco A. Alvarez Vicente Ausina Miquel Angel Gassull | 2003 | Hepatology2003，，3： | 1 |
| 14 | Phenolic profiles, antioxidant activity and in vitro antivirat properties of apple pomace显示文摘 | Belen Suarez Angel L Alvarez Yolanda Dineiro Garcia | 2010 | Food chemistry2010，120，1： | 1 |
| 15 | Immunoglobulin G antibody response in children and adults with acute dengue 3 infection显示文摘 | Susana Vazquez Nadia Acosta Didye Ruiz Naifi Calzada Angel M. Alvarez Maria G. Guzman | 2009 | Journal of Virological Methods2009，，： | 1 |
| 16 | A pharmacological study of Cecropia obtusifolia Bertol aqueous extract显示文摘 | Concepción Pérez-Guerrero Mar??a Dolores Herrera Rafael Ortiz Mar??a Alvarez de Sotomayor Mar??a Angeles Fernández | 2001 | Journal of Ethnopharmacology2001，，3： | 1 |
| 17 | Trevo System: Single‐Center Experience with a Novel Mechanical Thrombectomy Device显示文摘 | Nuno Mendon?a Alan Flores Jorge Pagola Marta Rubiera David Rodríguez‐Luna M. Angels De Miquel Pere Cardona Helena Quesada Paloma Mora José Alvarez‐Sabín Carlos Molina Marc Ribó | 2011 | Journal of Neuroimaging2011，，1： | 1 |
| 18 | Phase II trial of cetuximab and carboplatin in relapsed platinum-sensitive ovarian cancer and evaluation of epidermal growth factor receptor expression: A Gynecologic Oncology Group study显示文摘 | Angeles Alvarez Secord John A. Blessing Deborah K. Armstrong William H. Rodgers Zoe Miner Mack N. Barnes George Lewandowski Robert S. Mannel | 2007 | Gynecologic Oncology2007，，： | 1 |
| 19 | Successful treatment with etanercept in a patient with hepatotoxicity closely related to infliximab显示文摘 | Angel M. García Aparicio José Rey Rey Azucena Hernández Sanz Juana Sampedro Alvarez | 2007 | Clinical Rheumatology2007，，5： | 1 |
| 20 | Temperature - sensitive chitosanpoly ( N - isopropylacrylamide) interpenetrated networks With enhanced loading capacity and controlled release properties 显示文摘 | Carmen Alvarez Lorenzo Angel Concheiro Alexander S | 2005 | Journal of Controlled Release2005，，102： | 1 |
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