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| 1 | Diffusion-weighted magnetic resonance imaging to predict response of hepatocellular carcinoma to chemoembolization显示文摘AIM: To investigate whether intra-procedural diffusion- weighted magnetic resonance imaging can predict response of hepatocellular carcinoma (HCC) during trans- catheter arterial chemoembolization (TACE). METHODS: Sixteen patients (15 male), aged 59 ±11 years (range: 42-81 years) underwent a total of 21 separate treatments for unresectable HCC in a hybrid magnetic resonance/interventional radiology suite. Ana- tomical imaging and diffusion-weighted imaging (b = 0, 500 s/mm2) were performed on a 1.5-T unit. Tumor enhancement and apparent diffusion coefficient (ADC, mm2/s) values were assessed immediately before and at 1 and 3 mo after TACE. We calculated the percent change (PC) in ADC values at all time points. We compared follow-up ADC values to baseline values using a paired t test (α = 0.05). RESULTS: The intra-procedural sensitivity, specificity, and positive and negative predictive values (%) for detecting a complete or partial 1-mo tumor response using ADC PC thresholds of ±5%, ±10%, and ±15% were 77, 67, 91, and 40; 54, 67, 88, and 25; and 46, 100, 100, and 30, respectively. There was no clear predictive value for the 3-mo follow-up. Compared to baseline, the immediate post-procedure and 1-mo mean ADC values both increased; the latter obtaining statistical significance (1.48 ± 0.29 mm2/s vs 1.65 ± 0.35 × 10-3 mm2/s, P < 0.014). CONCLUSION: Intra-procedural ADC changes of > 15% predicted 1-mo anatomical HCC response with the greatest accuracy, and can provide valuable feedback at the time of TACE. | Johnathan C Chung Neel K Naik Robert J Lewandowski Mary F Mulcahy Laura M Kulik Kent T Sato Robert K Ryu Riad Salem Andrew C Larson Reed A Omary | 2010 | World Journal of Gastroenterology2010，16，25： | 13 |
| 2 | A mobile incoherent Mie-Rayleigh Doppler wind lidar with a single frequency and tunable operation of an injection Nd︰YAG laser显示文摘A mobile incoherent Doppler lidar system has been experimentally demonstrated to be able to transmit reliable single frequency operation laser pulse, even after truck transit and in very high vibration environments. The linewidth of the injection-seeded pulse Nd:YAG laser can be measured by means of an I2 molecular filter. And, lidar validation experiments demonstrated the feasibility and capability of measuring wind field by the Mie-Rayleigh Doppler wind lidar. The un-certainty of measured wind speed is 0.985m/s in the altitude range from 2 to 4 km. | 刘智深 吴东 张凯临 刘金涛 Johnathan W.Hair Chiao-Yao She | 2003 | Science China(Technological Sciences)2003，46，3： | 10 |
| 3 | Metabolic Engineering of Plant-derived (E)-β-farnesene Synthase Genes for a Novel Type of Aphid-resistant Genetically Modified Crop Plants显示文摘Aphids are major agricultural pests that cause significant yield losses of crop plants each year.Excessive dependence on insec-ticides for long-term aphid control is undesirable because of the development of insecticide resistance,the potential negative effects on non-target organisms and environmental pollution.Transgenic crops engineered for resistance to aphids via a non-toxic mode of action could be an efficient alternative strategy.(E)-β-Farnesene (EβF) synthases catalyze the formation of EβF,which for many pest aphids is the main component of the alarm pheromone involved in the chemical communication within these species.EβF can also be synthesized by certain plants but is then normally contaminated with inhibitory compounds.Engineering of crop plants capable of synthesizing and emitting EβF could cause repulsion of aphids and also the attraction of natural enemies that use EβF as a foraging cue,thus minimizing aphid infestation.In this review,the effects of aphids on host plants,plants' defenses against aphid herbivory and the recruitment of natural enemies for aphid control in an agricultural setting are briefly introduced.Furthermore,the plant-derived EβF synthase genes cloned to date along with their potential roles in generating novel aphid resistance via genetically modified approaches are discussed. | Xiu-Dao Yu John Pickett You-Zhi Ma Toby Bruce Johnathan Napier Huw D.Jones Lan-Qin Xia | 2012 | Journal of Integrative Plant Biology2012，54，5： | 10 |
| 4 | Characteristics and advantages of adeno-associated virus vector-mediated gene therapy for neurodegenerative diseases显示文摘Common neurodegenerative diseases of the central nervous system are characterized by progressive damage to the function of neurons, even leading to the permanent loss of function. Gene therapy via gene replacement or gene correction provides the potential for transformative therapies to delay or possibly stop further progression of the neurodegenerative disease in affected patients. Adeno-associated virus has been the vector of choice in recent clinical trials of therapies for neurodegenerative diseases due to its safety and efficiency in mediating gene transfer to the central nervous system. This review aims to discuss and summarize the progress and clinical applications of adeno-associated virus in neurodegenerative disease in central nervous system. Results from some clinical trials and successful cases of central neurodegenerative diseases deserve further study and exploration. | Yuan Qu Yi Liu Ahmed Fayyaz Noor Johnathan Tran Rui Li | 2019 | Neural Regeneration Research2019，14，6： | 6 |
| 5 | Profile of the breast cancer susceptibility marker rs4245739 identifies a role for miRNAs显示文摘Objective:To determine the influence of the single nucleotide polymorphism(SNP)rs4245739 on the binding and expression of micro RNAs and subsequent MDM4 expression and the correlation of these factors with clinical determinants of ER-negative breast cancers.Methods:Find Tar and miRanda were used to detect the manner in which potential micro RNAs are affected by the SNP rs4245739-flanking sequence.RNA sequencing data for ER-negative breast cancer from The Cancer Genome Atlas(TCGA)were used to compare the expression of miR-184,miR-191,miR-193a,miR-378,and MDM4 in different rs4245739 genotypes.Results:Comparison of ER-negative cancer patients with and without the expression of miR-191 as well as profile micro RNAs(miR-184,miR-191,miR-193a and miR-378 altogether)can differentiate the expression of MDM4 among different rs4245739 genotypes.Although simple genotyping alone did not reveal significant clinical relationships,the combination of genotyping and micro RNA profiles was able to significantly differentiate individuals with larger tumor size and lower number of involved lymph nodes(P<0.05)in the risk group(A allele).Conclusions:We present two novel methods to analyze SNPs within 3′UTRs that use:(i)a single miRNA marker expression and(ii)an expression profile of miRNAs predicted to bind to the SNP region.We demonstrate that the application of these two methods,in particular the miRNA profile approach,permits detection of new molecular and clinical features related to the rs4245739 variant in ER-negative breast cancer. | Sumadi Lukman Anwar Wahyu Wulaningsih Johnathan Watkins | 2017 | Cancer Biology & Medicine2017，14，4： | 3 |
| 6 | A phase II trial of docetaxel and bevacizumab in recurrent ovarian cancer within 12 months of prior platinum-based chemotherapy显示文摘 | Robert M. Wenham James Lapolla Hui-Yi Lin Sachin M. Apte Johnathan M. Lancaster Patricia L. Judson Jesus Gonzalez-Bosquet Amber Herschberger Laura J. Havrilesky Angeles Alvarez Secord | 2013 | Gynecologic Oncology2013，，1： | 2 |
| 7 | Immunoglobulin G in non-alcoholic steatohepatitis predicts clinical outcome:A prospective multi-centre cohort study显示文摘BACKGROUND Autoimmune markers including plasma cells(PC),anti-smooth-muscle antibody(ASMA),anti-nuclear antibody(ANA),and raised immunoglobulin G(IgG)are commonly observed in non-alcoholic steatohepatitis(NASH),however their clinical significance is unknown.AIM To determine if autoimmune markers in NASH patients are independently associated with poorer clinical outcomes.METHODS Consecutive patients with biopsy proven NASH from Christchurch Hospital,New Zealand and Singapore General Hospital(SGH)were included between 2005 to 2016 in a prospective multi-centre cohort study.Patients with other causes of chronic liver disease were excluded.IgG>14 g/L or globulin fraction>50%,ANA≥1:40,SMA≥1:40 were considered positive.Multivariate analysis was performed to assess which markers were independently associated with mortality and hepatic decompensation.RESULTS Total 261 patients were included of which 201 were from SGH.The median age was 53 and 51.9%were male.Advanced fibrosis was present in 31.4%at diagnosis.PC,ASMA,ANA and raised IgG were observed in 13.1%,4.9%,27.8%and 30.1%of patients respectively.After multivariate analysis,elevated IgG[Hazard Ratio(HR)6.79,95%CI:2.93-17.15]and fibrosis stage(HR 1.37,95%CI:1.03-1.87)were found to be independently associated with increased risk of liver decompensation.Age(HR 1.06,95%CI:1.02-1.10)and elevated IgG(HR 3.79,95%CI:1.90-7.68)were independent factors associated with higher mortality risk.CONCLUSION Elevated IgG,rather than ANA,ASMA or plasma cells,is independently associated with increased risk of hepatic decompensation and mortality in NASH.It could hence be important for prognostication. | Marianne Anastasia De Roza Mehul Lamba George Boon-Bee Goh Johnathan Huey-Ming Lum Mark Chang-Chuen Cheah Jing Hieng Jeffrey Ngu | 2021 | World Journal of Gastroenterology2021，27，43： | 2 |
| 8 | Histone Demethylation Mediated by the Nuclear Amine Oxidase Homolog LSD1显示文摘 | Yujiang Shi Fei Lan Caitlin Matson Peter Mulligan Johnathan R. Whetstine Philip A. Cole Robert A. Casero Yang Shi | 2004 | Cell2004，，7： | 2 |
| 9 | The disinfectant residual dilemma显示文摘 | Johnathan A Clement | 1999 | Journal of American Water Works Association1999，91，1： | 1 |
| 10 | Phthalate ester-induced gubernacular lesions are associated with reduced ins 13 gene expression in the fetal rat testis显示文摘 | Vickie S W Christy L Johnathan F | 2004 | Toxicology Letters2004，46，： | 1 |
| 11 | Fluorescence Assay Based on Aptamer-Quantum Dot Binding to Bacillus thuringiensis Spores显示文摘 | Milada Ikanovic Walter E. Rudzinski John G. Bruno Amity Allman Maria P. Carrillo Sulatha Dwarakanath Suneetha Bhahdigadi Poornima Rao Johnathan L. Kiel Carrie J. Andrews | 2007 | Journal of Fluorescence2007，，2： | 1 |
| 12 | Holladay, Heather Brown,et al Metal Chlorides in lonic liquid Solvents Convert Sugars to 5-Hydroxymethylfurfural 显示文摘 | Haibo Zhao Johnathan E | 2007 | Science2007，316，5831： | 1 |
| 13 | Maintai- ning the male germline: regulation of spermatogonial stem cells 显示文摘 | KYLE C JOHNATHAN B DEREK M | 2010 | J Endocrinology2010，205，： | 1 |
| 14 | Simultaneous determination of tetracycline, oxytetracycline, and 4-epitetracycline in milk by high-performance liquid chromatography显示文摘 | Johnathan William Fritz Yuegang Zuo | 2007 | Food Chemistry2007，，3： | 1 |
| 15 | What attracts foreign multinational corporations? Evidence from branch plant location in the United States显示文摘 | Friedman Joseph Daniel A Gerlowski and Johnathan Silberman | 1992 | Journal of Regional Science1992，35，4： | 1 |
| 16 | Heat transfer enhancement in nano-fluids suspensions:possible mechanisms and explanations显示文摘 | JOHNATHAN J VADASZ S VADASZ G P | 2005 | International Journal of Heat and Mass Transfer2005，48，13： | 1 |
| 17 | Simultaneous determination of tetracycline, oxytetracycline, and 4-epitetracycline in milk by high-performance liquid chromatography显示文摘 | Johnathan William Fritz Yuegang Zuo | 2007 | Food Chemistry2007，，3： | 1 |
| 18 | Validation of a virtual reality-based robotic surgical skills curriculum显示文摘 | Michael Connolly Johnathan Seligman Andrew Kastenmeier Matthew Goldblatt Jon C. Gould | 2014 | Surgical Endoscopy2014，，5： | 1 |
| 19 | A Heterogeneous Population of Stem Cells Within Glioblastoma Tumors in the Setting of Disease Relapse显示文摘 | Johnathan A Engh | 2011 | Neurosurgery2011，，4： | 1 |
| 20 | Teams,repeated tasks,and implicit incentives显示文摘 | John Tellingham Johnathan Gloven | 1997 | Journal of Accounting and Economics1997，23，： | 1 |
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