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| 1 | Amelioration of experimental colitis by Astragalus membranaceus through anti-oxidation and inhibition of adhesion molecule synthesis显示文摘AIM: To investigate the protective effects of Astragalus membranaceus(Am) against hapten-induced colitis in male Sprague-Dawley rats as well as its underlying mechanism.METHODS: Experimental colitis was induced in rats by enema administration of 2,4-dinitrobenzene sulfonic acid (DNBS). Rats were either pretreated with Am extract (2 or 4 g/kg, p.o. once daily) starting from 10 d before DNBS enema, or received Am post-treatment (2 or 4 g/kg, p.o.twice daily) on the three consecutive days following DNBS administration. Colonic lesion area and histological damage were determined, while the activities of myeloperoxidase (MPO) and xanthine oxidase, as well as reduced glutathione (GSH) content were measured in the excised colonic tissues. Besides, protein expression of inducible nitrite oxide synthase (iNOS), intercellular adhesion molecule-1 (ICAM-1) and P-selectin was also detected by Western blot analysis.RESULTS: Our findings had shown that both macroscopic lesion area and histological colonic damage induced by DNBS were significantly reduced by both Am pre- and post-treatments. These were accompanied by attenuation of the elevated colonic MPO activity and downregulation of the iNOS, P-selectin, and ICAM-1 protein expression.Besides, deprivation of colonic GSH level under colitis condition was also preserved.CONCLUSION: These results demonstrate that Am possesses both preventive and therapeutic potential in experimental colitis. The anti-inflammatory actions involve anti-oxidation along with inhibition of adhesion molecule synthesis in the colonic tissues. | Joshua Ka-Shun Ko Flora Ying-Lee Lam Andrew Pok-Lap Cheung | 2005 | World Journal of Gastroenterology2005，11，37： | 17 |
| 2 | 澳大利亚临床共识指南:儿童卒中的诊断和急性期处理显示文摘卒中是导致儿童死亡的十大原因之一,幸存的致残患儿将面临几十年的残疾生活,给患儿及其家庭带来了巨大负担。由于安全性和有效性的证据有限,以及诊断的延误,目前卒中患儿无法接受再灌注治疗。儿童卒中诊断和急性期处理的澳大利亚临床共识指南,旨在最大限度地减少临床诊疗中的不确定性,并记录与成人卒中不同的危险因素、病因和假性卒中情况的最佳证据。临床问题的阐述来自于对2007年至2017年数据库的系统检索,但仅限于英语和儿科研究。该指南应用SIGN方法和国家健康与医学研究委员会系统对证据进行筛选和分类,通过推荐、评估、发展和评价系统(GRADE系统)对推荐进行强弱分级。该指南提供了60多项基于证据的推荐,以帮助参与院前和急症处理的临床医师快速识别儿童卒中,选择最合适的初步检查方案来确定诊断、明确病因,并选择最恰当的干预措施以挽救脑组织、预防复发。同时,指南也提供了颅内压和先天性心脏病管理方面的推荐。该指南的实施需要将院前和急诊系统重组,包括建立区域性卒中网络,建立儿科卒中疾病编码,快速MRI,以及对能够提供再灌注治疗的初级儿科卒中中心进行认证。该指南能够审核治疗的基准时间线,获得急性期的干预措施及预后判断。它还将促进澳大利亚儿童卒中登记的发展,并与国际登记处建立数据联系,以便准确收集卒中发病率、治疗和结果相关的数据。 | Medley TL Miteff C Andrews I Ware T Cheung M Monagle P Mandelstam S Wray A Pridmore C Troedson C Dale RC Fahey M Sinclair A Walsh P Stojanovski S Macka MT 徐佳丽(译) 吴川杰(译) 肖潇(译) 吕俊萱(译) 张博维(译) 吉训明(译) | 2019 | 中国脑血管病杂志2019，16，4： | 9 |
| 3 | Expression and reconstitution of the bioluminescent Ca2+reporter aequorin in human embryonic stem cells,and exploration of the presence of functional IP3 and ryanodine receptors during the early stages of their differentiation into cardiomyocytes显示文摘In order to develop a novel method of visualizing possible Ca^(2+) signaling during the early differentiation of h ESCs into cardiomyocytes and avoid some of the inherent problems associated with using fluorescent reporters, we expressed the bioluminescent Ca^(2+) reporter, apo-aequorin, in HES2 cells and then reconstituted active holo-aequorin by incubation with f-coelenterazine. The temporal nature of the Ca^(2+) signals generated by the holo-f-aequorin-expressing HES2 cells during the earliest stages of differentiation into cardiomyocytes was then investigated. Our data show that no endogenous Ca^(2+) transients(generated by release from intracellular stores) were detected in 1–12-day-old cardiospheres but transients were generated in cardiospheres following stimulation with KCl or Ca Cl_2, indicating that holo-f-aequorin was functional in these cells. Furthermore, following the addition of exogenous ATP, an inositol trisphosphate receptor(IP_3R) agonist, small Ca^(2+) transients were generated from day 1 onward. That ATP was inducing Ca^(2+) release from functional IP_3 Rs was demonstrated by treatment with 2-APB, a known IP_3 R antagonist. In contrast, following treatment with caffeine, a ryanodine receptor(Ry R) agonist, a minimal Ca^(2+) response was observed at day 8 of differentiation only. Thus, our data indicate that unlike Ry Rs, IP_3 Rs are present and continually functional at these early stages of cardiomyocyte differentiation. | Harvey Y.S.Chan Man Chun Cheung Yi Gao Andrew L.Miller Sarah E.Webb | 2016 | Science China(Life Sciences)2016，59，8： | 5 |
| 4 | A Subpopulation of CD26 + Cancer Stem Cells with Metastatic Capacity in Human Colorectal Cancer显示文摘 | Roberta Pang Wai Lun Law Andrew C.Y. Chu Jensen T. Poon Colin S.C. Lam Ariel K.M. Chow Lui Ng Leonard W.H. Cheung Xiao R. Lan Hui Y. Lan Victoria P.Y. Tan Thomas C. Yau Ronnie T. Poon Benjamin C.Y. Wong | 2010 | Cell Stem Cell2010，，6： | 4 |
| 5 | Randomized Controlled Trial of the Effects of Remote Ischemic Preconditioning on Children Undergoing Cardiac Surgery显示文摘 | Michael M.H. Cheung Rajesh K. Kharbanda Igor E. Konstantinov Mikiko Shimizu Helena Frndova Jia Li Helen M. Holtby Peter N. Cox Jeffrey F. Smallhorn Glen S. Van Arsdell Andrew N. Redington | 2006 | Journal of the American College of Cardiology2006，，11： | 2 |
| 6 | High-Resolution Peripheral Quantitative Computed Tomography for the Assessment of Bone Strength and Structure: A Review by the Canadian Bone Strength Working Group显示文摘 | Angela M. Cheung Jonathan D. Adachi David A. Hanley David L. Kendler K. Shawn Davison Robert Josse Jacques P. Brown Louis-Georges Ste-Marie Richard Kremer Marta C. Erlandson Larry Dian Andrew J. Burghardt Steven K. Boyd | 2013 | Current Osteoporosis Reports2013，，2： | 2 |
| 7 | Identification and molecular cloning of a novel porcine parvovirus显示文摘 | Andrew K. Cheung Guang Wu David Wang Darrell O. Bayles Kelly M. Lager Amy L. Vincent | 2010 | Archives of Virology2010，，5： | 1 |
| 8 | Skeletal Stability and Complications of Bilateral Sagittal Split Osteotomies and Mandibular Distraction Osteogenesis: An Evidence-Based Review显示文摘 | Andrew Ow Lim Kwong Cheung | 2009 | Journal of Oral and Maxillofacial Surgery2009，，11： | 1 |
| 9 | Tranexamic acid for intracerebral haemorrhage within 2 hours of onset: protocol of a phase Ⅱ randomised placebo-controlled double-blind multicentre trial显示文摘Rationale Haematoma growth is common early after intracerebral haemorrhage(ICH),and is a key determinant of outcome.Tranexamic acid,a widely available antifibrinolytic agent with an excellent safety profile,may reduce haematoma growth.Methods and design Stopping intracerebral haemorrhage with tranexamic acid for hyperacute onset presentation including mobile stroke units(STOP-MSU)is a phase Ⅱ double-blind,randomised,placebo-controlled,multicentre,international investigator-led clinical trial,conducted within the estimand statistical framework.Hypothesis In patients with spontaneous ICH,treatment with tranexamic acid within 2 hours of onset will reduce haematoma expansion compared with placebo.Sample size estimates A sample size of 180 patients(90 in each arm)would be required to detect an absolute difference in the primary outcome of 20%(placebo 39%vs treatment 19%)under a two-tailed significance level of 0.05.An adaptive sample size re-estimation based on the outcomes of 144 patients will allow a possible increase to a prespecified maximum of 326 patients.Intervention Participants will receive 1 g intravenous tranexamic acid over 10 min,followed by 1 g intravenous tranexamic acid over 8 hours;or matching placebo.Primary efficacy measure The primary efficacy measure is the proportion of patients with haematoma growth by 24±6 hours,defined as either≥33%relative increase or≥6 mL absolute increase in haematoma volume between baseline and follow-up CT scan.Discussion We describe the rationale and protocol of STOP-MSU,a phase Ⅱ trial of tranexamic acid in patients with ICH within 2 hours from onset,based in participating mobile stroke units and emergency departments. | Nawaf Yassi Henry Zhao Leonid Churilov Bruce C V Campbell Teddy Wu Henry Ma Andrew Cheung Timothy Kleinig Helen Brown Philip Choi Jiann-Shing Jeng Annemarei Ranta Hao-Kuang Wang Geoffrey C Cloud Rohan Grimley Darshan Shah Neil Spratt Der-Yang Cho Karim Mahawish Lauren Sanders John Worthington Ben Clissold Atte Meretoja Vignan Yogendrakumar Mai Duy Ton Duc Phuc Dang Nguyen Thai My Phuong Huy-Thang Nguyen Chung Y Hsu Gagan Sharma Peter J Mitchell Bernard Yan Mark W Parsons Christopher Levi Geoffrey A Donnan Stephen M Davis | 2022 | Stroke & Vascular Neurology2022，7，2： | 1 |
| 10 | Porcine cireovims: Transcription and DNA repli- cation 显示文摘 | Andrew K Cheung | 2012 | Vires Research2012，164，： | 1 |
| 11 | Porcine circovirus: Transcription and DNA replication显示文摘 | Andrew K. Cheung | 2011 | Virus Research (-)2011，，1： | 1 |
| 12 | Comparative analysis of the transcriptional patterns of pathogenic and nonpathogenic porcine circoviruses显示文摘 | Andrew K Cheung | 2003 | Virology2003，310，1： | 1 |
| 13 | Transcriptional analysis of porcine circovirus type 2显示文摘 | Andrew K Cheung | 2003 | Virology2003，305，1： | 1 |
| 14 | A novel doxorubicin-mitomycin C co-encapsulated nanoparticle formulation exhibits anti-cancer synergy in multidrug resistant human breast cancer cells显示文摘 | Adam J. Shuhendler Richard Y. Cheung Janet Manias Allegra Connor Andrew M. Rauth Xiao Yu Wu | 2010 | Breast Cancer Research and Treatment2010，，2： | 1 |
| 15 | Phospholipid transfer protein activity is associated with inflammatory markers in patients with cardiovascular disease显示文摘 | Marian C. Cheung B. Greg Brown Emily K. Marino Larsen Andrew D. Frutkin Kevin D. O’Brien John J. Albers | 2005 | BBA - Molecular Basis of Disease2005，，1： | 1 |
| 16 | Efficacy of Postoperative Patient-controlled and Continuous Infusion Epidural Analgesia versus Intravenous Patient-controlled Analgesia with Opioids: A Meta-analysis显示文摘 | Christopher L. Wu Seth R. Cohen Jeffrey M. Richman Andrew J. Rowlingson Genevieve E. Courpas Kristin Cheung Elaina E. Lin Spencer S. Liu | 2005 | Anesthesiology2005，，5： | 1 |
| 17 | An externally fixed femoral fracture model for mice显示文摘 | Cheung KM Kaluarachi K Andrew G | 2003 | J Orthop Res2003，21，4： | 1 |
| 18 | Trnascriptional Analysis of Porcine Circovirus Type 2显示文摘 | ANDREW K CHEUNG | 2003 | Virology2003，305，： | 1 |
| 19 | Transcriptional analysis of porcine circovirus type 2 显示文摘 | Andrew K Cheung | 2003 | Virology2003，5305，1： | 1 |
| 20 | Investigation of the Safety of Irreversible Electroporation in Humans显示文摘 | Kenneth R. Thomson Wa Cheung Samantha J. Ellis Dean Federman Helen Kavnoudias Deirdre Loader-Oliver Stuart Roberts Peter Evans Christine Ball Andrew Haydon | 2011 | Journal of Vascular and Interventional Radiology2011，，5： | 1 |
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