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| 1 | Treatment of functional dyspepsia with sertraline:A double-blind randomized placebo-controlled pilot study显示文摘AIM:To evaluate sertraline,a selective serotonin reuptake inhibitor in the treatment of patients with functional dyspepsia.METHODS:Consecutive tertiary hospital patients with a clinical diagnosis of functional dyspepsia(FD) according to the Rome Ⅱ criteria with a Hong Kong dyspepsia index(HKDI) of greater than 16 were recruited.Patients commenced enrolment prior to the inception of the Rome Ⅲ criteria for functional dyspepsia.All patients were ethnic Chinese,had a normal upper endoscopy and were Helicobacter pylori negative prior to enrolment.Study patients were randomized to receive sertraline 50 mg or placebo daily for 8 wk.HKDI symptom scores,quality of life,hospital anxiety and depression(HAD) scale and global symptom relief were evaluated before,during and after treatment.Adverse effects were monitored during and after treatment.RESULTS:A total of 193 patients were randomized in the intention to treat(ITT),and 150 patients were included in the per protocol(PP) analysis.In both the ITT and PP,there was no difference in the primary outcome of global dyspepsia symptoms between the sertraline and placebo groups at week 8.In the ITT analysis,98 and 95 patients were randomized to the sertraline and placebo groups respectively.A total of 43 patients withdrew from the study(22.3%) by week 8,with 23 of the 24 drop-outs in the sertraline group occurring prior to week 4(95.8%).In contrast,in the placebo arm,11 of 19 patients dropped out by week 4(57.9%).Utilizing the last response carried forward to account for the drop-outs,there were no differences between the sertraline and placebo groups at baseline in terms of the HKDI,HKDI 26.08 ± 6.19 vs 26.70 ± 5.89,P = 0.433;and at week 8,HKDI 22.41 ± 6.36 vs 23.25 ± 7.30,P = 0.352 respectively.In the PP analysis,74 and 76 patients were randomized to the sertraline and placebo groups respectively.At baseline,there were no statistically significant differences between the sertraline and placebo groups,HKDI 25.83 ± 6.313 vs 27.19 ± 5.929 respectively,P = 0.233;however by week 8,patients in the sertraline group demonstrated a statistically significant difference in their Hong Kong Dyspepsia Index compared to placebo,HKDI 20.53 ± 6.917 vs 23.34 ± 7.199,P = 0.02,respectively).There was also no statistically significant difference in overall quality of life measures or the HAD scale related to treatment in either the ITT or PP analysis at week 8.CONCLUSION:This pilot study,the first to examine sertraline,a selective serotonin reuptake inhibitor,for the management of FD,did not find that it was superior to placebo. | Victoria PY Tan Tin K Cheung Wai M Wong Roberta Pang Benjamin CY Wong | 2012 | World Journal of Gastroenterology2012，18，42： | 14 |
| 2 | 澳大利亚临床共识指南:儿童卒中的诊断和急性期处理显示文摘卒中是导致儿童死亡的十大原因之一,幸存的致残患儿将面临几十年的残疾生活,给患儿及其家庭带来了巨大负担。由于安全性和有效性的证据有限,以及诊断的延误,目前卒中患儿无法接受再灌注治疗。儿童卒中诊断和急性期处理的澳大利亚临床共识指南,旨在最大限度地减少临床诊疗中的不确定性,并记录与成人卒中不同的危险因素、病因和假性卒中情况的最佳证据。临床问题的阐述来自于对2007年至2017年数据库的系统检索,但仅限于英语和儿科研究。该指南应用SIGN方法和国家健康与医学研究委员会系统对证据进行筛选和分类,通过推荐、评估、发展和评价系统(GRADE系统)对推荐进行强弱分级。该指南提供了60多项基于证据的推荐,以帮助参与院前和急症处理的临床医师快速识别儿童卒中,选择最合适的初步检查方案来确定诊断、明确病因,并选择最恰当的干预措施以挽救脑组织、预防复发。同时,指南也提供了颅内压和先天性心脏病管理方面的推荐。该指南的实施需要将院前和急诊系统重组,包括建立区域性卒中网络,建立儿科卒中疾病编码,快速MRI,以及对能够提供再灌注治疗的初级儿科卒中中心进行认证。该指南能够审核治疗的基准时间线,获得急性期的干预措施及预后判断。它还将促进澳大利亚儿童卒中登记的发展,并与国际登记处建立数据联系,以便准确收集卒中发病率、治疗和结果相关的数据。 | Medley TL Miteff C Andrews I Ware T Cheung M Monagle P Mandelstam S Wray A Pridmore C Troedson C Dale RC Fahey M Sinclair A Walsh P Stojanovski S Macka MT 徐佳丽(译) 吴川杰(译) 肖潇(译) 吕俊萱(译) 张博维(译) 吉训明(译) | 2019 | 中国脑血管病杂志2019，16，4： | 9 |
| 3 | 儿童期肥胖、成年期肥胖和心血管风险因子显示文摘过去30年,儿童超重或肥胖的发生率明显增加[1]。儿童期肥胖是死亡率增加的预测因子,这主要是由于儿童期肥胖可导致心血管疾病发生率增加。相关的预测研究提示"肥胖流行症"可能改变目前心血管疾病死亡率下降的趋势,使现今儿童的寿命缩短。 | Juonala M Magnussen CG Berenson GS Venn A Burns TL Sabin MA Srinivasan SR Daniels SR Davis PH Chen W Sun C Cheung M Viikari JS Dwyer T Raitakari OT 叶鹏 | 2012 | 中华高血压杂志2012，20，1： | 6 |
| 4 | The impact of electronic word-of-mouth显示文摘 | Cheung Christy M K Lee Matthew K O Rabjohn Neil | 2008 | Internet Research2008，，3： | 3 |
| 5 | Ammonia stripping as a pretreatment for landfill leachate显示文摘 | Cheung K C Chu L M Wong M H | 1997 | Water Air and Soil Pollution1997，94，： | 2 |
| 6 | Ozone and related gaseous pollutants in the boundary layer of eastern China:Overview of the recent measurements at a rural site显示文摘 | Wang T Cheung V T F Anson M | 2001 | Geophysical Research Letters2001，28，12： | 2 |
| 7 | Two-photon excitation of the lowest 4f 2→4f 5d near-ultraviolet transitions in Pr3+ : Y3Al5O12 显示文摘 | Gayen S K Xie B Q Cheung Y M | 1992 | Phys Rev B1992，45，1： | 2 |
| 8 | Making and reading microarrays 显示文摘 | Cheung V G Morley M Aguilar F | 1999 | Nature Genetic1999，21，： | 2 |
| 9 | Microcellular polymeric materials from microemulsions:Control of microstructure and morphology显示文摘 | W R P Raj M Sasthav H M Cheung | 1993 | Journal of Applied Polymer Science1993，47，3： | 2 |
| 10 | 简单计算危险评价工具用于妇女骨质疏松症筛检效果Mata分析显示文摘目的评价骨质疏松症简单计算危险评价工具(SCORE)筛检骨质疏松症的效果。方法采用循证医学荟萃分析方法,检索Medline,EMBASE及PubMed数据库1966~2006年英文相关文献,同时手工检索参考文献中的相关文献。按照事先制定的入选与剔除标准筛选文献。荟萃分析采用随机效应模型(DerSimonian and Laird)。结果纳入的研究敏感度在83.6%~98.0%,特异度在12.5%~53.9%。在截断值为6、T值≤-2.0时,随机效应模型拟合效果好,合并接受者操作特征曲线下面积(SAUC)为0.802,说明筛检低骨密度效果好。结论SCORE具有一定筛检效果,但特异度不高。对SCORE的效果验证研究与Meta分析有待于深入进行。 | 吴秀云 刘典恩 Angela M Cheung | 2008 | 中国全科医学2008，11，2： | 2 |
| 11 | Is there an anatomical endophenotype for neurodevelopmental disorders? A review of dual disorder anatomical likelihood estimation (ALE) meta-analyses of grey matter volumes显示文摘The term 'neurodevelopmental disorder' broadly encompasses conditions thought to arise early in development and includes schizophrenia, bipolar disorder and autism among others. These conditions share a number of genetic and environmental risk factors postulated to lead to common difficulties in socio-emotional processing, communication and cognitive function. The alternative position is that, while the same traits are affected across these conditions, the nature or direction in which they are modified may be distinct. MRI studies provide a rapidly expanding and rich database which we propose can be used to contribute to this debate. Anatomical likelihood estimation (ALE) is a method of meta-analysis applied to voxel-based MRI studies. We have adapted this method to explore the extent to which schizophrenia and bipolar disorder and schizophrenia and autism share a common brain structural phenotype. We will review this work here and discuss whether there is sufficient other evidence to justify a common framework for further research into the inter-relatedness of such conditions. | MCALONAN Grainne M YU Kevin K CHAN Raymond C K CHUA Siew E CHEUNG Charlton | 2011 | Chinese Science Bulletin2011，56，32： | 2 |
| 12 | RAC/ROP GTPases:hubs for signal integration and diversification in plants显示文摘 | Nibau C Wu H M Cheung A Y | 2006 | Trends Plant Sci2006，11，： | 1 |
| 13 | Pollutants in Hong Kong soils: Potycyclic aromatic hydrocarbons显示文摘 | CHUNG M K HU R CHEUNG K C | 2007 | Chemosphere2007，67，3： | 1 |
| 14 | Indigenous Chinese personality constructs: Is the five factor model complete? 显示文摘 | CHEUNG F M LEUNG K ZI-IANG J X | 2001 | J Cross Cultural Psychol2001，32，40： | 1 |
| 15 | Visualization of ischaemic penumbra using a computed tomography pefusion method 显示文摘 | Cheung R T Cheng P W Lui W M | 2003 | Cerebrovasc Dis2003，15，： | 1 |
| 16 | Soil parameters for deformation analysis of sand masses显示文摘 | Cheung H Yan L | 1987 | Canadian Geotechnical Journal1987，24，： | 1 |
| 17 | Relationshipsbetween tissue concentrations of polycyclic aromatic hydro-carbons and antioxidative responses of marine musselsPerna viridis显示文摘 | Cheung C C C Zheng G J Li A M Y | 2001 | Aquatic Toxicology2001，52，34： | 1 |
| 18 | A prospective randomized controlled trial on ureteral stenting after ureteroscopic holmium laser lithotripsy显示文摘 | CHEUNG M C LEE F LEUNG Y L | 2003 | J Urol2003，169，4： | 1 |
| 19 | Recombinant human tumor necrosis factor alpha promotes adherence of Staphylococcus aureus to cultured human endothelial cells 显示文摘 | Cheung A L Koomey J M Lee S | 1991 | Infect Immun1991，59，： | 1 |
| 20 | Genome-wide analysis of gene expression associated with MYCN in human neuroblastoma显示文摘 | Alaminos M Mora J Cheung NK Smith A Qin J Chen L Gerald WL | 2003 | Cancer Res2003，63，8： | 1 |
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