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| 1 | 乳汁免疫和猪流行性腹泻病毒病疫苗:历史和现状(译文)显示文摘由于肠道病毒感染导致仔猪在发病率、死亡率和生产能力丧失方面的影响,每年给养猪者带来数百万美元的损失。2013—2014年间,猪流行性腹泻病毒(PEDV)病的暴发给美国养猪业带来了9亿~18亿美元的经济损失。被动乳汁免疫被认为是保护新生哺乳仔猪免受PED等肠道疾病危害的最有希望和有效的方法。通过乳汁免疫被动保护哺乳仔猪的效果依赖于病原特异性IgA浆细胞转运至乳腺的数量和乳汁中分泌型IgA的积累程度,这种免疫途径被定义为'肠-乳腺-sIgA轴'。由于胎盘的不可穿透性,新生仔猪处于无免疫球蛋白的状态,对很多的传染性病原体极易感。它们仅依靠来源于母源的初乳和乳汁抗体获得被动保护。先前开发的关于猪传染性胃肠炎病毒(TGEV)病的活疫苗和灭活疫苗,提供了对母源性免疫和仔猪被动保护机制的理解。在这篇文章中,综述了猪传染性胃肠炎病毒诱导乳汁免疫的研究进展,并指出对当前养猪业正努力控制的猪流行性腹泻病毒感染和相关疫苗的研究方向。同时研究和鉴别出影响乳汁免疫和'肠-乳腺-sIgA轴'的各种因素,有助于改善妊娠母猪预防猪流行性腹泻病毒感染以及改进其它肠道病原用疫苗方案,从而达到提升整个猪群的免疫力、猪群健康和企业生产力的目的。 | Langel Stephanie N Paim Francine Chimelo Lager Kelly M Vlasova Anastasia N Saif Linda J 吕茂杰 | 2017 | 养猪2017，，1： | 3 |
| 2 | Real-time reverse transcription-polymerase chain reaction assays for the detection and differentiation of North American swine influenza viruses显示文摘 | Rieht JA Lager KM Clouser DF | 2004 | J Vet Diagn Invest2004，16，5： | 1 |
| 3 | Effectof ma- temaltriglycerides and free fatty acids on placental LPL in cultured primary trophoblast cells and in a case of maternal LPL deficiency 显示文摘 | Magnusson Olsson AL Lager S Jacobsson B | 2007 | Am J Physiol Endocrinol Metab2007，293，1： | 1 |
| 4 | Clinical effects of porcine reproductive and respiratory syndrome virus on pigs during the early postnatal interval显示文摘 | Mengeling W L Lager K M Vorwald A C | 1998 | Am J Vet Res1998，59，1： | 1 |
| 5 | Evaluation of a recombinant human adenovirus25 vaccine administered via needle2free device and intramuscular injection for vaccination of pigs against swine influenza virus显示文摘 | Wesley RD Lager KM | 2005 | Am J Vet Res2005，66，11： | 1 |
| 6 | WGEMLab: simulation platform for the analysis of rectangular waveguide aperture radiation 显示文摘 | Lager I E Coman C I Hoop A T | 2003 | IEEE Transactions on Magnetics2003，39，3： | 1 |
| 7 | Protection of weaned pigs by vaccination with human adenovirus 5 recombinant viruses the hemagglutinin and the nucleoprotein of H3N2 swine influenza virus显示文摘 | Wesley D R Tang M Lager K M | 2004 | Vaccine2004，22，： | 1 |
| 8 | Identification and molecular cloning of a novel porcine parvovirus显示文摘 | Andrew K. Cheung Guang Wu David Wang Darrell O. Bayles Kelly M. Lager Amy L. Vincent | 2010 | Archives of Virology2010，，5： | 1 |
| 9 | Safety and efficacy of vaccination of pregnant gilts against porcine reproductive and respiratory syndrome 显示文摘 | Mengeling W L Lager K M Vorwald A C | 1999 | Vet Res1999，60，7： | 1 |
| 10 | Experimental airborne transmission of porcine reproductive and respiratory syndrome virus and Bordetella bronchiseptica显示文摘 | Brockmeier S L Lager K M | 2002 | Veterinary Microbiology2002，89，4： | 1 |
| 11 | Influence of surveillance renal allograft biopsy on diagnosis and prognosis of polyomavirus-associated nephropathy显示文摘 | BUEHRIG C K LAGER D J STEGALL M D | 2003 | Kidney Int2003，64，2： | 1 |
| 12 | The Role of Swine in the Generation of Novel Influenza Viruses 显示文摘 | Ma W Lager K M Vincent A L | 2009 | Zoonoses Public Health2009，20，： | 1 |
| 13 | Mutations in the NS1 protein of swine influenza virus impair anti-interferon activity and confer attenuation in pigs显示文摘 | Solorzano A Webby R J Lager K M | 2005 | J Virol2005，79，： | 1 |
| 14 | Contamination of bovinefetal serum with bovine viral diarrhea virus 显示文摘 | Zabal O Kobrak AL Lager IA | 2000 | Rev Argent Microbiol2000，32，1： | 1 |
| 15 | Subclinical rejection in tacrolimus treated renal transplant recipients显示文摘 | Cohen AJ Lager DJ | 2002 | Transplantation2002，73，12： | 1 |
| 16 | Comparative safety and efficacy of attenuated single-strain and multi-strain vaccines for porcine reproductive and respiratory syndrome显示文摘 | MENGELING W L LAGER K M VORWALD A C | 2003 | Vet Microbiol2003，93，1： | 1 |
| 17 | Identification and clinical assessment of suspected vaccine-related field strains of porcine reproductive and respiratory syndrome virus显示文摘 | Mengeling W L Vorwald A C Lager K M | 1999 | Am J Vet Res1999，60，： | 1 |
| 18 | Characterization of an influenza A virus isolated from pigs during an outbreak of respiratory disease in swine and people during a county fair in the United States显示文摘 | Vincent A L Swenson S L Lager K M | 2009 | Vet Microbiol2009，137，12： | 1 |
| 19 | Detection of two porcine circovirus type 2 genotypic groups in United States swine herds显示文摘 | Cheung A K Lager K M Kohutyuk O I | | 0，，05： | 1 |
| 20 | Development ofreal-time polymerase chain reaction assays for rapid detection and differentiation of wild-type pseudorabies and gene- deleted vaccine viruses显示文摘 | Ma W Lager K M Richt J A | 2008 | Journal of Veterinary Diagnostic Investigation2008，20，4： | 1 |
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