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| 1 | Mesenchymal stem cells: Molecular characteristics and clinical applications显示文摘Mesenchymal stem cells (MSCs) are non-hematopoietic stem cells with the capacity to differentiate into tissues of both mesenchymal and non-mesenchymal origin. MSCs can differentiate into osteoblastic, chondrogenic, and adipogenic lineages, although recent studies have demonstrated that MSCs are also able to differentiate into other lineages, including neuronal and cardiomyogenic lineages. Since their original isolation from the bone marrow, MSCs have been successfully harvested from many other tissues. Their ease of isolation and ex vivo expansion combined with their immunoprivileged nature has made these cells popular candidates for stem cell therapies. These cells have the potential to alter disease pathophysiology through many modalities including cytokine secretion, capacity to differentiate along various lineages, immune modulation and direct cell-cell interaction with diseased tissue. Here we first review basic features of MSC biology including MSC characteristics in culture, homing mechanisms, differentiation capabilities and immune modulation. We then highlight some in vivo and clinical evidence supporting the therapeutic roles of MSCs and their uses in orthopedic, autoimmune, and ischemic disorders. | Farbod Rastegar Deana Shenaq Eric R Wagner Stephanie H Kim Russell R Reid Hue H Luu Rex C Haydon | 2010 | World Journal of Stem Cells2010，2，4： | 35 |
| 2 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 3 | Transcriptomic landscape regulated by the 14 types of bone morphogenetic proteins(BMPs)in lineage commitment and differentiation of mesenchymal stem cells(MSCs)显示文摘Mesenchymal stem cells(MSCs)are ubiquitously-existing multipotent progenitors that can self-renew and differentiate into multiple lineages including osteocytes,chondrocytes,adipocytes,tenocytes and myocytes.MSCs represent one of the most commonly-used adult progenitors and serve as excellent progenitor cell models for investigating lineagespecific differentiation regulated by various cellular signaling pathways,such as bone morphogenetic proteins(BMPs).As members of TGFb superfamily,BMPs play diverse and important roles in development and adult tissues.At least 14 BMPs have been identified in mammals.Different BMPs exert distinct but overlapping biological functions.Through a comprehensive analysis of 14 BMPs in MSCs,we demonstrated that BMP9 is one of the most potent BMPs in inducing osteogenic differentiation of MSCs.Nonetheless,a global mechanistic view of BMP signaling in regulating the proliferation and differentiation of MSCs remains to be fully elucidated.Here,we conducted a comprehensive transcriptomic profiling in the MSCs stimulated by 14 types of BMPs.Hierarchical clustering analysis classifies 14 BMPs into three subclusters:an osteo/chondrogenic/adipogenic cluster,a tenogenic cluster,and BMP3 cluster.We also demonstrate that six BMPs(e.g.,BMP2,BMP3,BMP4,BMP7,BMP8,and BMP9)can induce ISmads effectively,while BMP2,BMP3,BMP4,BMP7,and BMP11 up-regulate Smad-independent MAP kinase pathway.Furthermore,we show that many BMPs can upregulate the expression of the signal mediators of Wnt,Notch and PI3K/AKT/mTOR pathways.While the reported transcriptomic changes need to be further validated,our expression profiling represents the first-of-its-kind to interrogate a comprehensive transcriptomic landscape regulated by the 14 types of BMPs in MSCs. | Linghuan Zhang Qing Luo Yi Shu Zongyue Zeng Bo Huang Yixiao Feng Bo Zhang Xi Wang Yan Lei Zhenyu Ye Ling Zhao Daigui Cao Lijuan Yang Xian Chen Bin Liu William Wagstaff Russell R*Reid Hue H*Luu Rex C*Haydon Michael J*Lee Jennifer Moriatis Wolf Zhou Fu Tong-Chuan He Quan Kang | 2019 | Genes & Diseases2019，6，3： | 11 |
| 4 | Dietary cation-anion balance and cation source effets on production and acid-base status heated stressed Cows显示文摘 | West J W Haydon K D Mullinix B G | 1992 | J Dairy Sci1992，75，： | 1 |
| 5 | Body size and composition and risk of rectal cancer (Australia) 显示文摘 | Maclnnis RJ English DR Haydon AM | 2006 | Cancer Causes Control2006，17，10： | 1 |
| 6 | Water quality in mountain ash forests - separating the impacts of roads from those of logging operations显示文摘 | Grayson R B Haydon S R Jayasuriya M D A | 1993 | Journal of Hydrology1993，150，2： | 1 |
| 7 | Nuclear receptor agonists as potential differentiation therapy agents for human osteosarcoma显示文摘 | Haydon RC Zhou L Feng T | 2002 | Clin Cancer Res2002，8，5： | 1 |
| 8 | Glia: listening and talking to the synapse 显示文摘 | | 2001 | Neuroscience2001，2，： | 1 |
| 9 | Emerging pathways in colorectal-cancer development显示文摘 | Haydon AM Jass JR | 2002 | Lancet Onco12002，3，： | 1 |
| 10 | The effect of various diet nutrient densities and electrolyte balances on sow and litter performance during two seasons of the year 显示文摘 | Dove C R Haydon K D | 1994 | Journal of Animal Science1994，72，： | 1 |
| 11 | Critical interplay be- tween parasite differentiation, host immunity, and antigenic variation in trypanosome infections显示文摘 | GJINI E HAYDON D T BARRY J D | 2010 | Am Nat2010，176，4： | 1 |
| 12 | Increased expression of S100A6 is associated with decreased metastasis and inhibition of cell migration and anchorage independent growth in human osteosarcoma显示文摘 | Luu H H Zhou Haydon R C | 2005 | Cancer Letters2005，229，1： | 1 |
| 13 | Effect of dietary elec- trolyte balance on performance and blood parameters of grow- ing finishing swine fed in high ambient temperatures 显示文摘 | Haydon K D West J W McCarter M N | 1990 | J Ani- mal Science1990，68，： | 1 |
| 14 | The effect of various diet nutrient den- sities and electrolyte balances on sow and litter performance dur- ing two seasons of the year显示文摘 | Dove C R Haydon K D | 1994 | Anim Sci1994，72，： | 1 |
| 15 | Increased expression of S100A6 is associated with decreased metastasis and inhibition of cell migration and anchorage independent growth in human osteosarcoma 显示文摘 | Luu HH Zhou Lan Haydon RC | 2005 | Cancer Lett2005，229，1： | 1 |
| 16 | Molecular evolution of swine vesicular disease virus 显示文摘 | Zhang G Haydon D T Knowels N J | 1999 | J Gen Virol1999，80，： | 1 |
| 17 | Tyrosine kinase inhibitor STI-571/gleevec down-regulates the β-catenin signaling activity显示文摘 | Zhou L An N Haydon RC | 2003 | Cancer Letters2003，193，2： | 1 |
| 18 | Potential use of SOX9 gene therapy for inter-vertebral degenerative disc disease显示文摘 | Paul R Haydon RC Cheng H | 2003 | Spine2003，28，8： | 1 |
| 19 | GLIA: listening and talking to the synapse 显示文摘 | Haydon P G | 2001 | Nat Rev Neurosci2001，2，3： | 1 |
| 20 | Effect of dietary electrolyte balance on nutrient digestibility determined at the end of the small intestine and over the total digestive tract in growing pigs 显示文摘 | Haydon K D | 1990 | J Animal Sci- ence1990，68，： | 1 |
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