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| 1 | Programmable time-domain digital-coding metasurface for non-linear harmonic manipulation and new wireless communication systems显示文摘Optical non-linear phenomena are typically observed in natural materials interacting with light at high intensities, and they benefit a diverse range of applications from communication to sensing. However,controlling harmonic conversion with high efficiency and flexibility remains a major issue in modern optical and radio-frequency systems. Here, we introduce a dynamic time-domain digital-coding metasurface that enables efficient manipulation of spectral harmonic distribution. By dynamically modulating the local phase of the surface reflectivity, we achieve accurate control of different harmonics in a highly programmable and dynamic fashion, enabling unusual responses, such as velocity illusion. As a relevant application, we propose and realize a novel architecture for wireless communication systems based on the time-domain digital-coding metasurface, which largely simplifies the architecture of modern communication systems, at the same time yielding excellent performance for real-time signal transmission. The presented work, from new concept to new system, opens new pathways in the application of metamaterials to practical technology. | Jie Zhao Xi Yang Jun Yan Dai Qiang Cheng Xiang Li Ning Hua Qi Jun Chen Ke Guo Dong Bai Shuo Liu Shi Jin Andrea Alù Tie Jun Cui | 2019 | National Science Review2019，6，2： | 46 |
| 2 | Explicit diagnosis of the local ozone production rate and the ozone-NOx-VOC sensitivities显示文摘In the troposphere, ozone is a harmful gas compound to both human health and vegetation. Ozone is produced from the reaction of NO_x(@NO + NO_2) and VOCs(volatile organic compounds) with light. Due to the highly nonlinear relationships between ozone and its precursors, proper ozone mitigation relies on the knowledge of chemical mechanisms. In this study, an observation-based method is used to simulate ozone formation and elucidate its controlling factors for a rural site on the North China Plain. The instantaneous ozone production rate is calculated utilizing a box model using the dataset obtained from the Wangdu campaign. First, the model was operated in a time-dependent mode to calculate the ozone production rate at each time stamp. The calculated ozone formation rate showed a diurnal average maximum value of 17 ppbv/h(1-h diurnal averaged). The contribution of individual peroxy radicals to ozone production was analyzed. In addition, the functional dependence of calculated P(O_3) reveals that ozone production was in a NO_x-limited regime during the campaign. Furthermore, the missing peroxy radical source will further extend NO_x-limited conditions to earlier in the day, making NO_xlimitation dominate more of a day than the current chemical model predicts. Finally, a multiple scenarios mode,also known as EKMA(empirical kinetic modeling approach), was used to simulate the response of P(O_3) to the imaginary change in precursor concentrations. We found that ozone production was in the NO_x-limited region. However, the use of NO_2 measured by the molybdenum converter and/or the absence of a peroxy radical source in the current chemical model could over-emphasize the VOC-limited effect on ozone production. | Zhaofeng Tan Keding Lu Huabin Dong Min Hu Xin Li Yuhan Liu Sihua Lu Min Shao Rong Su Haichao Wang Yusheng Wu Andreas Wahner Yuanhang Zhang | 2018 | Science Bulletin2018，63，16： | 25 |
| 3 | Testing method and distribution characteristics of spatial pesticide spraying deposition quality balance for unmanned aerial vehicle显示文摘In order to explore the spatial pesticide spraying deposition distribution,the downwash flow field characteristics for unmanned aerial vehicle(UAV)pesticide application with accurate flight height and velocity and the relationship of these two aspects,a novel measurement method was proposed in this paper.A model‘3WQF80-10’single-rotor diesel UAV was tested using this method in wheat field and the effects of flight direction,flight parameters and crosswind on the distribution of spatial spraying deposition quality balance(SSDQB)and the downwash flow field distribution were researched.A cuboid aluminum sampling frame of spatial spraying deposition quality balance(SFSSDQB)with monofilament wires was made for collecting the droplets in four directions,and a set of multi-channel micro-meteorology measurement system(MMMS)was applied for measuring the downwash wind speed in three directions.Besides,BeiDou Navigation Satellite System(BNSS)was used for controlling and recording the working height,velocity and track of this model of single-rotor UAV.The results showed the distribution of the spatial spray deposition and the downwash flow field of UAV could be measured effectively at exact flight height and velocity via this method.When the average wind speed was 0.9 m/s,the average temperature was 31.5℃ and the average relative humidity was 34.1%,and the average distribution ratios of spraying deposition for model‘3WQF80-10’UAV on the upwind part,the top part,the downwind part and the bottom part were 4.4%,2.3%,50.4%and 43.7%,respectively.The flight directions of forward and backward had an impact on droplet deposition distribution and the working effect of flying backwards,with 60%of deposition ratio of the bottom part of the SFSSDQB,was better than flying forward.There was a linear negative correlation between the coefficient of variation(CV)of the bottom part and the flight height and the coefficient of determination was 0.9178,which means that the deposition distribution becomes more uniform with the increase of height.Additionally,there was a linear positive correlation between weighted mean deposition rate and crosswind speed and the coefficient of determination was 0.9684,which shows the deposition distribution gets more concentrated towards the downwind part with the rise of crosswind speed.Therefore,according to the results of tests of downwash airflow speed,it is shown that regardless of the flight direction and height and the crosswind,all these factors influence the droplet deposition distribution via weakening the intensity of the downwash airflow field in the direction perpendicular to the ground.The results can provide valuable information for the research of UAV pesticide application techniques and the establishment of the standard of spraying deposition and drift tests of UAV in crop field. | Changling Wang Xiongkui He Xiaonan Wang Zhichong Wang Shilin Wang Longlong Li Jane Bonds Andreas Herbst Zhiguo Wang | 2018 | International Journal of Agricultural and Biological Engineering2018，11，2： | 14 |
| 4 | Regulation of the water status in three co-occurring phreatophytes at the southern fringe of the Taklamakan Desert显示文摘Aims We investigated the regulation of the water status in three predominant perennial C3 phreatophytes(Alhagi sparsifolia,Populus euphratica,Tamarix ramosissima)at typical sites of their occurrence at the southern fringe of the hyperarid Taklamakan Desert(north-west China).Methods In the foreland of the river oasis of Qira(Cele),we determined meteorological variables,plant biomass production,plant water potentials(WL)and the water flux through the plants.We calculated the hydraulic conductance on the flow path from the soil to the leaves(kSL)and tested the effects of kSL,WL and the leaf-to-air difference in the partial pressure of water vapour(Dw)on stomatal regulation using regression analyses.Important Findings Despite high values of plant water potential at the point of turgor loss,all plants sustained WL at levels that were high enough to maintain transpiration throughout the growing season.In A.sparsifolia,stomatal resistance(rs;related to leaf area or leaf mass)was most closely correlated with kSL;whereas in P.euphratica,~70%of the variation in rs was explained by Dw.In T.ramosissima,leaf area-related rs was significantly correlated with WL and kSL.The regulation mechanisms are in accordance with the growth patterns and the occurrence of the species in relation to their distance to the ground water. | Frank M.Thomas Andrea Foetzki Dirk Gries Helge Bruelheide Xiangyi Li Fanjiang Zeng Ximing Zhang | 2008 | Journal of Plant Ecology2008，1，4： | 13 |
| 5 | The enhanced X-ray Timing and Polarimetry mission—eXTP显示文摘In this paper we present the enhanced X-ray Timing and Polarimetry mission—eXTP. eXTP is a space science mission designed to study fundamental physics under extreme conditions of density, gravity and magnetism. The mission aims at determining the equation of state of matter at supra-nuclear density, measuring effects of QED, and understanding the dynamics of matter in strong-field gravity. In addition to investigating fundamental physics, eXTP will be a very powerful observatory for astrophysics that will provide observations of unprecedented quality on a variety of galactic and extragalactic objects. In particular, its wide field monitoring capabilities will be highly instrumental to detect the electro-magnetic counterparts of gravitational wave sources.The paper provides a detailed description of:(1) the technological and technical aspects, and the expected performance of the instruments of the scientific payload;(2) the elements and functions of the mission, from the spacecraft to the ground segment. | ShuangNan Zhang Andrea Santangelo Marco Feroci YuPeng Xu FangJun Lu Yong Chen Hua Feng Shu Zhang Sφren Brandt Margarita Hernanz Luca Baldini Enrico Bozzo Riccardo Campana Alessandra De Rosa YongWei Dong Yuri Evangelista Vladimir Karas Norbert Meidinger Aline Meuris Kirpal Nandra Teng Pan Giovanni Pareschi Piotr Orleanski QiuShi Huang Stephane Schanne Giorgia Sironi Daniele Spiga Jiri Svoboda Gianpiero Tagliaferri Christoph Tenzer Andrea Vacchi Silvia Zane Dave Walton ZhanShan Wang Berend Winter Xin Wu Jean J.M.in't Zand Mahdi Ahangarianabhari Giovanni Ambrosi Filippo Ambrosino Marco Barbera Stefano Basso Jörg Bayer Ronaldo Bellazzini Pierluigi Bellutti Bruna Bertucci Giuseppe Bertuccio Giacomo Borghi XueLei Cao Franck Cadoux Francesco Ceraudo TianXiang Chen Yu Peng Chen Jerome Chevenez Marta Civitani Wei Cui WeiWei Cui Thomas Dauser Ettore Del Monte Sergio Di Cosimo Sebastian Diebold Victor Doroshenko Michal Dovciak YuanYuan Du Lorenzo Ducci QingMei Fan Yannick Favre Fabio Fuschino JoséLuis Ga'lvez Min Gao MingYu Ge Olivier Gevin Marco Grassi QuanYing Gu YuDong Gu DaWei Han Bin Hong Wei Hu Long Ji ShuMei Jia WeiChun Jiang Thomas Kennedy Ingo Kreykenbohm Irfan Kuvvetli Claudio Labanti Luca Latronico Gang Li MaoShun Li Xian Li Wei Li ZhengWei Li Olivier Limousin HongWei Liu XiaoJing Liu Bo Lu Tao Luo Daniele Macera Piero Malcovati Adrian Martindale Malgorzata Michalska Bin Meng Massimo Minuti Alfredo Morbidini Fabio Muleri Stephane Paltani Emanuele Perinati Antonino Picciotto Claudio Piemonte JinLu Qu Alexandre Rachevski Irina Rashevskaya Jerome Rodriguez Thomas Schanz ZhengXiang Shen LiZhi Sheng JiangBo Song LiMing Song Carmelo Sgro Liang Sun Ying Tan Phil Uttley Bo Wang DianLong Wang GuoFeng Wang Juan Wang LangPing Wang YuSa Wang Anna L.Watts XiangYang Wen Jörn Wilms ShaoLin Xiong JiaWei Yang Sheng Yang YanJi Yang Nian Yu WenDa Zhang Gianluigi Zampa Nicola Zampa Andrzej A.Zdziarski AiMei Zhang ChengMo Zhang Fan Zhang Long Zhang Tong Zhang Yi Zhang XiaoLi Zhang ZiLiang Zhang BaoSheng Zhao ShiJie Zheng Yu Peng Zhou Nicola Zorzi J.Frans Zwart | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，2： | 11 |
| 6 | A study of morphing aircraft on morphing rules along trajectory显示文摘Morphing aircraft can meet requirements of multi-mission during the whole flight due to changing the aerodynamic shape,so it is necessary to study itsmorphing rules along the trajectory.However,trajectory planning considering morphing variables requires a huge number of expensive CFD computations due to the morphing in view of aerodynamic performance.Under the given missions and trajectory,to alleviate computational cost and improve trajectory-planning efficiency formorphing aircraft,an offline optimizationmethod is proposed based onMulti-Fidelity Kriging(MFK)modeling.The angle of attack,Mach number,sweep angle and axial position of the morphing wing are defined as variables for generating training data for building the MFK models,in which many inviscid aerodynamic solutions are used as low-fidelity data,while the less high-fidelity data are obtained by solving viscous flow.Then the built MFK models of the lift,drag and pressure centre at the different angles of attack andMach numbers are used to predict the aerodynamic performance of the morphing aircraft,which keeps the optimal sweep angle and axial position of the wing during trajectory planning.Hence,themorphing rules can be correspondingly acquired along the trajectory,aswell as keep the aircraftwith the best aerodynamic performance during thewhole task.The trajectory planning of amorphing aircraft was performed with the optimal aerodynamic performance based on the MFK models,built by only using 240 low-fidelity data and 110 high-fidelity data.The results indicate that a complex trajectory can take advantage of morphing rules in keeping good aerodynamic performance,and the proposed method is more efficient than trajectory optimization by reducing 86%of the computing time. | Xiaoyu CHEN Chunna LI Chunlin GONG Liangxian GU Andrea Da RONCH | 2021 | Chinese Journal of Aeronautics2021，34，7： | 8 |
| 7 | Full-space Cloud of Random Points with a Scrambling Metasurface显示文摘With the rapid progress in computer science,including artificial intelligence,big data and cloud computing,full-space spot generation can be pivotal to many practical applications,such as facial recognition,motion detection,augmented reality,etc.These opportunities may be achieved by using diffractive optical elements(DOEs)or light detection and ranging(LIDAR).However,DOEs suffer from intrinsic limitations,such as demanding depth-controlled fabrication techniques,large thicknesses(more than the wavelength),Lambertian operation only in half space,etc.LIDAR nevertheless relies on complex and bulky scanning systems,which hinders the miniaturization of the spot generator.Here,inspired by a Lambertian scatterer,we report a Hermitian-conjugate metasurface scrambling the incident light to a cloud of random points in full space with compressed information density,functioning in both transmission and reflection spaces.Over 4044 random spots are experimentally observed in the entire space,covering angles at nearly 90°.Our scrambling metasurface is made of amorphous silicon with a uniform subwavelength height,a nearly continuous phase coverage,a lightweight,flexible design,and low-heat dissipation.Thus,it may be mass produced by and integrated into existing semiconductor foundry designs.Our work opens important directions for emerging 3D recognition sensors,such as motion sensing,facial recognition,and other applications. | Zile Li Qi Dai Muhammad Q.Mehmood Guangwei Hu Boris Luk’yanchuk Jin Tao Chenglong Hao Inki Kim Heonyeong Jeong Guoxing Zheng Shaohua Yu Andrea Alù Junsuk Rho Cheng-Wei Qiu | 2018 | Light(Science & Applications)2018，7，1： | 6 |
| 8 | Crystal structure of the ubiquitin-like domain of human TBK1显示文摘TANK-binding kinase 1(TBK1)is an important enzyme in the regulation of cellular antiviral effects.TBK1 regulates the activity of the interferon regulatory factors IRF3 and IRF7,thereby playing a key role in type I interferon(IFN)signaling pathways.The structure of TBK1 consists of an N-terminal kinase domain,a middle ubiquitin-like domain(ULD),and a C-terminal elongated helical domain.It has been reported that the ULD of TBK1 regulates kinase activity,playing an important role in signaling and mediating interactions with other molecules in the IFN pathway.In this study,we present the crystal structure of the ULD of human TBK1 and identify several con-served residues by multiple sequence alignment.We found that a hydrophobic patch in TBK1,containing residues Leu316,Ile353,and Val382,corresponding to the“Ile44 hydrophobic patch”observed in ubiquitin,was conserved in TBK1,IκB kinase epsilon(IKKε/IKKi),IκB kinase alpha(IKKα),and IκB kinase beta(IKKβ).In com-parison with the structure of the IKKβULD domain of Xenopus laevis,we speculate that the Ile44 hydrophobic patch of TBK1 is present in an intramolecular binding surface between ULD and the C-terminal elongated heli-ces.The varying surface charge distributions in the ULD domains of IKK and IKK-related kinases may be relevant to their specificity for specific partners. | Jian Li Jun Li Andrea Miyahira Jian Sun Yingfang Liu Genhong Cheng Huanhuan Liang | 2012 | Protein & Cell2012，3，5： | 5 |
| 9 | Towards a natural classification of Botryosphaeriales显示文摘The type specimens of Auerswaldia,Auerswaldiella,Barriopsis,Botryosphaeria,Leptoguignardia,Melanops,Neodeightonia,Phaeobotryon,Phaeobotryosphaeria,Phyllachorella,Pyrenostigme,Saccharata,Sivanesania,Spencermartinsia and Vestergrenia were examined and fresh specimens of Botryosphaeriales were collected from Thailand.This material is used to provide a systematic treatment of Botryosphaeriales based on morphology and phylogeny.Two new genera,Botryobambusa and Cophinforma are introduced and comparedwith existing genera.Four species newto science,Auerswaldia dothiorella,A.lignicola,Botryosphaeria fusispora and Phaeobotryosphaeria eucalypti,are also described and justified.We accept 29 genera in Botryosphaeriales,with Macrovalsaria being newly placed.In the phylogenetic tree,the 114 strains of Botyrosphaeriales included in the analysis cluster into two major clades with 80%,96%and 1.00(MP,ML and BY)support,with Clade A containing the family type of Botryosphaeriaceae,and Clade B containing Phyllosticta,Saccharata and Melanops species.This group may represent Phyllostictaceae.In Clade A the taxa analyzed cluster in eight sub-clades(Clades A1-8).Clade A1 comprises three distinct subclusters corresponding to the genera Diplodia(Diplodia Clade),Neodeightonia(Neodeightonia Clade)and Lasiodiplodia(Lasiodiplodia Clade).Clade A2 clusters into three groups representing Phaeobotryosphaeria(100%),Phaeobotryon(100%)and Barriopsis(94%).Clade A3 incorporates 17 strains that cluster into three well-supported genera(Dothiorella(86%),Spencermartinsia(100%)and Auerswaldia(63%);the position of Macrophomina is not stable.Clade A4 is a single lineage(100%)representing the new genus Botryobambusa.Clade A5 is a wellsupported subclade incorporating Neofussicoccum.Clade A6 represents the type species of Botryosphaeria,three other Botryosphaeria species and two other genera,Neoscytalidium and Cophinforma gen.nov.Clade A7 comprises two Pseudofusicoccum species and Clade A8 has two Aplosporella species.These sub-clades may eventually require separate families but this requires analysis of a much larger dataset.Our data advances the understanding of Botryosphaeriales,there is,however,still much research to be carried out with resolution of families and genera,linkage of sexual and asexual morphs and differentiation of cryptic species. | Jian-Kui Liu Rungtiwa Phookamsak Mingkhuan Doilom Saowanee Wikee Yan-Mei Li Hiran Ariyawansha Saranyaphat Boonmee Putarak Chomnunti Dong-Qin Dai Jayarama D.Bhat Andrea I.Romero Wen-Ying Zhuang Jutamart Monkai E.B.Gareth Jones Ekachai Chukeatirote Thida Win Ko Ko Yong-Chang Zhao Yong Wang Kevin D.Hyde | 2012 | Fungal Diversity2012，，6： | 4 |
| 10 | TiN Paper for Ultrafast-Charging Supercapacitors显示文摘Ultrafast-charging energy storage devices are attractive for powering personal electronics and electric vehicles.Most ultrafast-charging devices are made of carbonaceous materials such as chemically converted graphene and carbon nanotubes.Yet,their relatively low electrical conductivity may restrict their performance at ultrahigh charging rate.Here,we report the fabrication of a porous titanium nitride(TiN)paper as an alternative electrode material for ultrafast-charging devices.The TiN paper shows an excellent conductivity of 3.67×104 S m−1,which is considerably higher than most carbon-based electrodes.The paper-like structure also contains a combination of large pores between interconnected nanobelts and mesopores within the nanobelts.This unique electrode enables fast charging by simultaneously providing efficient ion diffusion and electron transport.The supercapacitors(SCs)made of TiN paper enable charging/discharging at an ultrahigh scan rate of 100 V s−1 in a wide voltage window of 1.5 V in Na2SO4 neutral electrolyte.It has an outstanding response time with a characteristic time constant of 4 ms.Significantly,the TiN paper-based SCs also show zero capacitance loss after 200,000 cycles,which is much better than the stability performance reported for other metal nitride SCs.Furthermore,the device shows great promise in scalability.The filtration method enables good control of the thickness and mass loading of TiN electrodes and devices. | Bin Yao Mingyang Li Jing Zhang Lei Zhang Yu Song Wang Xiao Andrea Cruz Yexiang Tong Yat Li | 2020 | Nano-Micro Letters2020，12，1： | 3 |
| 11 | Effect of NaCl on growth and ion relations in two salt-tolerant strains of Paxillus involutus显示文摘The effect of NaCl on growth,biomass and ion relations of two salt-tolerant isolates of Paxillus involutus,MAJ and NAU were investigated.The two Paxillus strains were exposed to the following concentrations of NaCl:0,100,200 and 500 mmol·L-1.Growth of MAJ and NAU was enhanced by 100 mmol·L-1 NaCl but severely inhibited at the concentration of 500 mmol·L-1.NAU exhibited a greater capacity to exclude Na+ and Clunder all salinity levels,whereas the salt-includer MAJ had a higher capacity in nutrient uptake under salt stress.The ratios Na+/K+,Na+/Ca2+ and Na+/Mg2+ in NaCl-treated MAJ and NAU did not increase at levels of 100 and 200 mmol·L-1 NaCl but markedly increased at 500 mmol·L-1.This suggests that the two strains,especially MAJ,enhanced nutrient uptake corresponding to the increased Na+ influx at moderate salinity.We conclude that both MAJ and NAU are able to tolerate 500 mmol·L-1 NaCl but there are species-specific differences in retaining ionic homeostasis in the two Paxillus strains.NAU is a salt-excluder,MAJ is a salt-includer but retains a high capacity in nutrient selectivity under saline conditions.Their definite mechanisms to enhance salt tolerance of mycorrhizal hosts need further study. | ZHANG Hua LI Jing CHEN Shao-liang LU Cun-fu WANG Rui-gang DAI Song-xiang ZHU Hui-juan ZHANG Yun-xia SHI Yong WANG Mei-juan LU Yan-jun LI Li-si Rosemarie LANGENFELD-HEYSER Fritz EBERHARD Andrea POLLE | 2008 | Forestry Studies in China2008，10，2： | 3 |
| 12 | Linking temporal records显示文摘许多数据集合包含跨越时间的一个长时期的时间的记录;每个记录与一枚时间邮票被联系并且在一特别时间描述一个真实世界的实体的一些方面(例如,在 DBLP 的作者信息) 。在如此的情况中,我们经常希望鉴别随着时间的过去并且那么描述一样的实体的记录能执行有趣的纵的数据分析。然而,存在记录连接技术忽略时间的信息并且突然相信时间的数据。这篇文章学习连接时间的记录。首先,我们使用时间腐烂在实体价值进化上捕获过去的时间的效果。而不是局部地比较每个记录,第二,我们求婚聚类考虑记录的时间顺序并且做全球决定的方法。试验性的结果证明我们的算法显著地在各种各样的时间的数据集合上超过传统的连接方法。 | Pei LI Xin Luna DONG Andrea MAURINO Divesh SRIVASTAVA | 2012 | Frontiers of Computer Science2012，6，3： | 3 |
| 13 | Surface Charging Phenomena on HVDC Spacers for Compressed SF_(6) Insulation and Charge Tailoring Strategies显示文摘Surface flashover of spacers is a key factor limiting the application of HVDC GIS/GIL,while the charge accumula-tion on the surface of the spacer could have a potential adverse effect on the surface flashover voltage.This paper discusses the laws regarding distribution patterns of surface charges and the related mechanisms.The field-dependent property is discussed in detail to comprehensively illustrate the charge transport mecha-nism and explain the research differences regarding different surface charge patterns obtained by previous researchers.In addition,the main surface charge control methods for epoxy resin are summarized and discussed.The potential research directions of charge control methods and key points in manufacturing of spacers used in HVDC GIS/GIL are also explored. | Chuanyang Li Yuan Xu Chuanjie Lin Geng Chen Youping Tu Yao Zhou Zhipeng Lei Tao Han Simone Vincenzo Suraci Jian Wang Weidong Liu M.Tariq Nazir Shun He Andrea Cavallini Giovanni Mazzanti Davide Fabiani Jinliang He | 2020 | CSEE Journal of Power and Energy Systems2020，6，1： | 3 |
| 14 | A modified airfoil-based piezoaeroelastic energy harvester with double plunge degrees of freedom显示文摘In this letter,a piezoaeroelastic energy harvester based on an airfoil with double plunge degrees of freedom is proposed to additionally take advantage of the vibrational energy of the airfoil pitch motion.An analytical model of the proposed energy harvesting system is built and compared with an equivalent model using the well-explored pitch-plunge configuration.The dynamic response and average power output of the harvester are numerically studied as the flow velocity exceeds the cut-in speed(flutter speed).It is found that the harvester with double-plunge configuration generates 4%–10% more power with varying flow velocities while reducing 6% of the cut-in speed than its counterpart. | Yining Wu Daochun Li Jinwu Xiang Andrea Da Ronch | 2016 | Theoretical & Applied Mechanics Letters2016，6，5： | 2 |
| 15 | Nature:研究鉴定出侵袭性胰腺癌细胞及其弱点显示文摘在一项新的研究中,来自美国德州大学MD安德森癌症中心的研究人员利用患者源性肿瘤异种移植(patient—derived tumorxenograft,PDx)和模式小鼠开展一系列临床前实验,鉴定出一种门卫蛋白(gatekee Perprotein)阻止胰腺癌细胞转化为一种极具侵袭性的细胞类型,并且也发现剔除这种门卫蛋白的疗法能够阻止这些癌细胞。这些发现有助为携带这种进展迅速的治疗抵抗性的胰腺癌细胞亚群的患者开发出潜在的疗法。 | Genovese, Giannicola Carugo, Alessandro Tepper, James Robinson, Frederick Scott Li, Liren Svelto, Maria Nezi, Luigi Corti, Denise Minelli, Rosalba Pettazzoni, Piergiorgio Gutschner, Tony Wu, Chia-Chin Seth, Sahil Akdemir, Kadir Caner Leo, Elisabetta Amin, Samirkumar Dal Molin, Marco Ying, Haoqiang Kwong, Lawrence N. Colla, Simona Takahashi, Koichi Ghosh, Papia Giuliani, Virginia Muller, Florian Dey, Prasenjit Jiang, Shan Garvey, Jill Liu, Chang-Gong Zhang, Jianhua Heffernan, Timothy P. Toniatti, Carlo Fleming, Jason B. Goggins, Michael G. Wood, Laura D. Sgambato, Alessandro Agaimy, Abbas Maitra, Anirban Roberts, Charles W. M. Wang, Huamin Viale, Andrea DePinho, Ronald A. Draetta, Giulio F. Chin, Lynda | 2017 | 现代生物医学进展2017，17，14： | 2 |
| 16 | p38α controls erythroblast enucleation and Rb signaling in stress erythropoiesis显示文摘成红血球细胞的 Enucleation 对哺乳动物在终端区别期间唯一。尽管 erythroid enucleation 广泛地被学习了,包括 retinoblastoma 蛋白质(Rb ) ,仅仅一些基因被识别了调整原子挤出。它由哪个仍然保持大部分未定义发信号的分子,外来的刺激例如 erythropoietin (Epo ) ,是 transduced 导致 enucleation。这里,我们显示出那 p38α,激活 mitogen 的蛋白质 kinase (MAPK ) ,为 erythroid enucleation 被要求。在包含高 Epo 层次并且模仿的一个前 vivo 区别系统强调红血球生成, p38α在 erythroid 区别期间被激活。p38α 的损失;完全堵住主要成红血球细胞的 enucleation。而且, p38α在胎儿、贫血的压力红血球生成期间在 vivo 以一种房间自治的方式调整成红血球细胞 enucleation。显著地, p38α 的损失;导致 p21 目标 Rb 的 p21,和减少的激活的 downregulation,哪个是成红血球细胞 enucleation 的重要管理者。这研究表明那 p38α在压力红血球生成期间是为成红血球细胞 enucleation 的一个关键发信号分子。 | Simon M Schultze Andreas Mairhofer Dan Li Jin Cen Hartmut Beug Erwin F Wagner Lijian Hui | 2012 | Cell Research2012，22，3： | 2 |
| 17 | FRAME: femtosecond videography for atomic and molecular dynamics显示文摘Many important scientific questions in physics,chemistry and biology require effective methodologies to spectroscopically probe ultrafast intra-and inter-atomic/molecular dynamics.However,current methods that extend into the femtosecond regime are capable of only point measurements or single-snapshot visualizations and thus lack the capability to perform ultrafast spectroscopic videography of dynamic single events.Here we present a laser-probe-based method that enables two-dimensional videography at ultrafast timescales(femtosecond and shorter)of single,non-repetitive events.The method is based on superimposing a structural code onto the illumination to encrypt a single event,which is then deciphered in a post-processing step.This coding strategy enables laser probing with arbitrary wavelengths/bandwidths to collect signals with indiscriminate spectral information,thus allowing for ultrafast videography with full spectroscopic capability.To demonstrate the high temporal resolution of our method,we present videography of light propagation with record high 200 femtosecond temporal resolution.The method is widely applicable for studying a multitude of dynamical processes in physics,chemistry and biology over a wide range of time scales.Because the minimum frame separation(temporal resolution)is dictated by only the laser pulse duration,attosecondlaser technology may further increase video rates by several orders of magnitude. | Andreas Ehn Joakim Bood Zheming Li Edouard Berrocal Marcus Aldén Elias Kristensson | 2017 | Light(Science & Applications)2017，6，1： | 2 |
| 18 | Long-term outcomes after fractional flow reserve-guided percutaneous coronary intervention in patients with severe coronary stenosis显示文摘Objective To explore the safety and efficacy of FFR-guided percutaneous coronary intervention (PCI) in vessels with severe diameter stenosis. Methods & Results Of 1090 patients undergoing fractional flow reserve (FFR) assessment from 2002 to 2009,we identified 167 patients in whom FFR was measured in at least one 70%–89% stenotic lesion. These patients were subdivided into an FFR-defer group (n = 49) if PCI was deferred (FFR > 0.80),and an FFR-perform group (n = 118) if PCI was performed (FFR ≤ 0.80). Comparatively,an additional 1176 patients undergoing PCI in at least one lesion with 70%–89% stenosis but without measurement of FFR served as a control (angiography- guided) group. Clinical outcomes were compared during a median follow-up of 49.0 months. The 5-year Kaplan-Meier estimated revascularization rates were 16% in the FFR-defer group and 33% in the FFR-perform group (P = 0.046). The incidence of major adverse cardiac events were comparable in these two groups (HR = 0.82,95% CI: 0.37–1.82,P = 0.63). The number of stents placed was significantly lower in the FFR-guided group (0.9 ± 0.8 vs. 1.4 ± 0.8,P < 0.001). Conclusions Functional revascularization for lesions with visually severe stenosis is clinically safe and associated with fewer stents use. This study suggests that extending the use of FFR to more severe coronary lesions may be reasonable. | Ying-Hua ZHANG Jing LI Andreas J. Flammer Yoshiki Matsuo Moo-Sik Lee Ryan J. Lennon Malcolm R. Bell David R. Holmes John F. Bresnahan Charanjit S. Rihal Lilach O. Lerman Amir Lerman | 2019 | Journal of Geriatric Cardiology2019，16，4： | 2 |
| 19 | Panda X-III: Searching for neutrinoless double beta decay with high pressure ^(136)Xe gas time projection chambers显示文摘Searching for the neutrinoless double beta decay(NLDBD)is now regarded as the topmost promising technique to explore the nature of neutrinos after the discovery of neutrino masses in oscillation experiments.Panda X-III(particle and astrophysical xenon experiment III)will search for the NLDBD of136Xe at the China Jin Ping Underground Laboratory(CJPL).In the first phase of the experiment,a high pressure gas Time Projection Chamber(TPC)will contain 200 kg,90%136Xe enriched gas operated at10 bar.Fine pitch micro-pattern gas detector(Microbulk Micromegas)will be used at both ends of the TPC for the charge readout with a cathode in the middle.Charge signals can be used to reconstruct the electron tracks of the NLDBD events and provide good energy and spatial resolution.The detector will be immersed in a large water tank to ensure~5 m of water shielding in all directions.The second phase,a ton-scale experiment,will consist of five TPCs in the same water tank,with improved energy resolution and better control over backgrounds. | Xun Chen Chang Bo Fu Javier Galan Karl Giboni Franco Giuliani Ling Hui Gu Ke Han Xiang Dong Ji Heng Lin Jiang Lai Liu Kai Xiang Ni Hiroki Kusano Xiang Xiang Ren Shao Bo Wang Yong Yang Dan Zhang Tao Zhang Li Zhao Xiang Ming Sun Shou Yang Hu Si Yu Jian Xing Long Li Xiao Mei Li Hao Liang Huan Qiao Zhang Ming Rui Zhao Jing Zhou Ya Jun Mao Hao Qiao Si Guang Wang Ying Yuan Meng Wang Amir N.Khan Neill Raper Jian Tang Wei Wang Jia Ning Dong Chang Qing Feng Cheng Li Jian Bei Liu Shu Bin Liu Xiao Lian Wang Dan Yang Zhu Juan F.Castel Susana Cebri'an Theopisti Dafni Javier G.Garza Igor G.Irastorza Francisco J.Iguaz Gloria Luz ′on Hector Mirallas Stephan Aune Eric Berthoumieux Yann Bedfer Denis Calvet Nicole d'Hose Alain Delbart Maria Diakaki Esther Ferrer-Ribas Andrea Ferrero Fabienne Kunne Damien Neyret Thomas Papaevangelou Franck Sabatie Maxence Vanderbroucke AnDi Tan Wick Haxton Yuan Mei Chinorat Kobdaj Yu-Peng Yan | 2017 | Science China(Physics,Mechanics & Astronomy)2017，60，6： | 2 |
| 20 | Persistently Activated Stat3 Maintains Constitutive NF-κB Activity in Tumors显示文摘 | Heehyoung Lee Andreas Herrmann Jie-Hui Deng Maciej Kujawski Guilian Niu Zhiwei Li Steve Forman Richard Jove Drew M. Pardoll Hua Yu | 2009 | Cancer Cell2009，，4： | 2 |
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