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| 1 | Overview of the phytomedicine approaches against Helicobacter pylori显示文摘Helicobacter pylori(H.pylori)successfully colonizes thehuman stomach of the majority of the human popula-tion.This infection always causes chronic gastritis,butmay evolve to serious outcomes,such as peptic ulcer,gastric carcinoma or mucosa-associated lymphoid tis-sue lymphoma.H.pylori first line therapy recommend-ed by the Maastricht-4 Consensus Report comprises theuse of two antibiotics and a proton-pomp inhibitor,butin some regions failure associated with this treatmentis already undesirable high.Indeed,treatment failure isone of the major problems associated with H.pylori in-fection and is mainly associated with bacterial antibioticresistance.In order to counteract this situation,someeffort has been allocated during the last years in theinvestigation of therapeutic alternatives beyond antibi-otics.These include vaccines,probiotics,photodynamic inactivation and phage therapy,which are briefly revis-ited in this review.A particular focus on phytomedicine,also described as herbal therapy and botanical therapy,which consists in the use of plant extracts for medicinal purposes,is specifically addressed,namely considering its history,category of performed studies,tested com-pounds,active principle and mode of action.The herbs already experienced are highly diverse and usually selected from products with a long history of employ-ment against diseases associated with H.pylori infec-tion from each country own folk medicine.The studies demonstrated that many phytomedicine products have an anti-H.pylori activity and gastroprotective action.Al-though the mechanism of action is far from being com-pletely understood,current knowledge correlates the beneficial action of herbs with inhibition of essential H.pylori enzymes,modulation of the host immune system and with attenuation of inflammation. | Filipa F Vale Monica Oleastro | 2014 | World Journal of Gastroenterology2014，20，19： | 13 |
| 2 | Helicobacter pylori infection- recent developments in diagnosis显示文摘Considering the recommended indications for Helicobacter pylori(H.pylori)eradication therapy and the broad spectrum of available diagnostic methods,a reliable diagnosis is mandatory both before and after eradication therapy.Only highly accurate tests should be used in clinical practice,and the sensitivity and specificity of an adequate test should exceed 90%.The choice of tests should take into account clinical circumstances,the likelihood ratio of positive and negative tests,the cost-effectiveness of the testing strategy and the availability of the tests.This review concerns some of the most recent developments in diagnostic methods of H.pylori infection,namely the contribution of novel endoscopic evaluation methodologies for the diagnosis of H.pylori infection,such as magnifying endoscopy techniques and chromoendoscopy.In addition,the diagnostic contribution of histology and the urea breath test was explored recently in specific clinical settings and patient groups.Recent studies recommend enhancing the number of biopsy fragments for the rapid urease test.Bacterial culture from the gastric biopsy is the gold standard technique,and is recommended for antibiotic susceptibility test.Serology is used for initial screening and the stool antigen test is particularly used when the urea breath test is not available,while molecular methods have gained attention mostly for detecting antibiotic resistance. | Ana Isabel Lopes Filipa F Vale Mónica Oleastro | 2014 | World Journal of Gastroenterology2014，20，28： | 12 |
| 3 | Characterization of monocarboxylate transporter activity in hepatocellular carcinoma显示文摘AIM: To assess the immunoexpression of hypoxiarelated markers in samples from cirrhosis and primary and metastatic hepatocellular carcinoma(HCC).METHODS: From a total of 5836 autopsies performed at the Pathology Department- University of Sao Paulo School of Medicine Hospital- from 2003 to 2009, 188 presented primary liver tumors. Immunohistochemical reactivity for monocarboxylate transporters(MCTs)-1, 2 and 4, CD147 and glucose transporter-1(GLUT1)was assessed in necropsies from 80 cases of HCC. Data were stored and analyzed using the IBM SPSS statistical software(version 19, IBM Company, Armonk, NY). All comparisons were examined for statistical significance using Pearson's χ2 test and Fisher's exact test(when n < 5). The threshold for significant P values was established as P < 0.05.RESULTS: Plasma membrane expression of MCT4 and overall expression of GLUT1 showed progressively higher expression from non-neoplastic to primary HCC and to metastases. In contrast, overall expression of MCT2 was progressively decreased from non-neoplastic to primary HCC and to metastases. MCT1(overall and plasma membrane expression), MCT2 and CD147 plasma membrane expression were associated with absence of cirrhosis, while plasma membrane expression of CD147 was also associated with absence of HBV infection. MCT2 overall expression was associated with lower liver weight, absence of metastasis and absence of abdominal dissemination. Additionally, MCT4 plasma membrane positivity was strongly associated with Ki-67 expression. CONCLUSION: MCT4 and GLUT1 appear to play a role in HCC progression, while MCT2 is lost during progression and associated with better prognosis. | Venncio AF Alves Céline Pinheiro Filipa Morais-Santos Aloisio Felipe-Silva Adhemar Longatto-Filho Fátima Baltazar | 2014 | World Journal of Gastroenterology2014，20，33： | 11 |
| 4 | 安徽铜陵地区幔源镁铁质团块研究及其地质意义显示文摘幔源岩石包体研究,是认识上地幔岩石圈物质组成、幔源岩浆演化及壳幔动力学过程的重要手段。铜陵地区小铜官山石英二长闪长岩中发育有微粒闪长质包体,并且这些微粒闪长质包体中不均匀地分布着镁铁质团块,三者的形成过程可视为铜陵地区岩浆演化的缩影,为了解本区深部岩浆作用过程提供了有力的证据。在前人研究的基础上,笔者借助电子探针、扫描电镜、电镜能谱和二次飞行时间离子探针(Tof-SIMS)对产于铜陵地区微粒闪长质包体中的镁铁质团块进行了详细的研究,首次获得了一套精确的矿物化学资料和元素分布图,总结了镁铁质团块的特征,并讨论了本区的深部岩浆作用过程。矿物学研究表明,镁铁质团块中的角闪石和辉石均已发生了不同程度的透闪石化和阳起石化蚀变,蚀变过程中,从镁钙闪石到镁角闪石,再到透闪石,随着Si的增加,角闪石呈现出Mg的富集和Ti、Al贫化的特点。团块中的富Cr磁铁矿、Ti磁铁矿和少量的铝直闪石指示了其具有深源性。Tof-SIMS元素分布图显示,透闪石主要由Al、Si、Ca、Sc、V、Cr、Mn、Cu和Sr元素组成,透辉石主要由Si、Mg、Ca、Cu和Rb组成。在铜陵地区,上地幔部分熔融形成一套玄武岩浆,受岩浆底侵作用影响,玄武岩浆上侵,进入下地壳深位岩浆房,与下地壳硅镁层发生同化混染作用,形成一套轻度演化的中基性(辉长质)玄武岩浆,镁铁质团块就是这类中基性玄武岩浆直接结晶形成的。后受构造作用影响,这类中基性玄武岩浆上侵到中地壳岩浆房(12-16 km),与中地壳的变质岩系发生同化混染和结晶分异作用形成一套中性闪长质岩浆,微粒闪长质包体就是这套闪长质岩浆发生结晶分异作用而形成的。镁铁质团块和微粒闪长质包体清楚地解释了铜陵地区深部岩浆作用过程,并有力地证明了铜陵地区中地壳的闪长质岩浆来源于下地壳的壳幔混源岩浆。 | 李大鹏 杜杨松 于学峰 秦新龙 Steve SCOTT 王树星 Filipa MARQUES | 2014 | 地球学报2014，35，5： | 4 |
| 5 | Magnetic resonance imaging ancillary features used in Liver Imaging Reporting and Data System:An illustrative review显示文摘Hepatocellular carcinoma (HCC) usually develops in the setting of chronic liver disease. In the adequate clinical context, both multiphasic contrast-enhanced CT and magnetic resonance imaging are non-invasive modalities that allow accurate diagnosis and staging of HCC, although the latter demonstrates greater sensitivity and specificity. Imaging criteria for HCC diagnosis rely on hemodynamic features such as hyperenhancement in the arterial phase and washout in the portal or equilibrium phase. However, imaging performance drops considerably for small (< 20 mm) nodules because their tendency to exhibit atypical enhancement patterns. In order to improve accuracy in the diagnosis and staging of HCC, particularly in cases of atypical nodules, ancillary features, i.e., imaging characteristics that modify the likelihood of HCC, have been described and incorporated into clinical reports, especially in Liver Imaging Reporting and Data System. In this paper, ancillary imaging features will be reviewed and illustrated. | David Campos-Correia Joao Cruz António P Matos Filipa Figueiredo Miguel Ramalho | 2018 | World Journal of Radiology2018，10，2： | 3 |
| 6 | Obstructive Sleep Apnea Hypopnea Syndrome and Pulmonary Embolism: Warfarin Versus Positive Airway Pressure as Determinant显示文摘To the Editor:Xie et al.analyzed warfarin doses in pulmonary embolism (PE) and its adverse effects in patients with obstructive sleep apnea hypopnea syndrome (OSAHS).The key findings were that OSAHS patients required a significantly higher dose of warfarin than their non-OSAHS counterparts (4.73 mg vs.3.61 mg,P < 0.001) and that PE recurrence was higher in OSAHS than in non-OSAHS groups after withdrawal of warfarin (21.43% vs.6.78%,P =0.047).They conclude that OSAHS patients may present with hypercoagulation and relatively high risk of recurrence of PE after cessation of 6-month warfarin treatment.We have read this with great interest.[1] | Filipa Ramalho Fernandes Dulce Apolinario Antonio M Esquinas | 2016 | Chinese Medical Journal2016，，2： | 3 |
| 7 | Soil and Rhizosphere Associated Fungi in Gray Mangroves(Avicennia marina) from the Red Sea—A Metagenomic Approach显示文摘Covering a quarter of the world's tropical coastlines and being one of the most threatened ecosystems, mangroves are among the major sources of terrestrial organic matter to oceans and harbor a wide microbial diversity. In order to protect, restore, and better understand these ecosystems, researchers have extensively studied their microbiology, yet few surveys have focused on their fungal communities. Our lack of knowledge is even more pronounced for specific fungal populations, such as the ones associated with the rhizosphere. Likewise, the Red Sea gray mangroves(Avicennia marina) remain poorly characterized, and understanding of their fungal communities still relies on cultivation-dependent methods. In this study, we analyzed metagenomic datasets from gray mangrove rhizosphere and bulk soil samples collected in the Red Sea coast, to obtain a snapshot of their fungal communities. Our data indicated that Ascomycota was the dominant phylum(76%–85%), while Basidiomycota was less abundant(14%–24%), yet present in higher numbers than usually reported for such environments. Fungal communities were more stable within the rhizosphere than within the bulk soil, both at class and genus level. This finding is consistent with the intrinsic patchiness in soil sediments and with the selection of specific microbial communities by plant roots. Our study indicates the presence of several species on this mycobiome that were not previously reported as mangrove-associated. In particular, we detected representatives of several commercially-used fungi, e.g., producers of secreted cellulases and anaerobic producers of cellulosomes. These results represent additional insights into the fungal community of the gray mangroves of the Red Sea, and show that they are significantly richer than previously reported. | Marta Filipa Simoes Andr Antunes Cristiane A.Ottoni Mohammad Shoaib Amini Intikhab Alam Hanin Alzubaidy Noor-Azlin Mokhtar John A.C.Archer Vladimir B.Bajic | 2015 | Genomics, Proteomics & Bioinformatics2015，13，5： | 2 |
| 8 | Vaginoplasty显示文摘 | Filipas D | 2001 | Current Opine Urology2001，11，3： | 1 |
| 9 | Nephron sparing surgery for central renal tumors:experience with 33cases显示文摘 | Black P Filipas D Fichtner J | 2000 | J Urol2000，163，3： | 1 |
| 10 | Nephron-sparing surgery of renal cell carcinoma with a normal opposite kidney: long-term outcome in 180 patients显示文摘 | Dragana Filipas Jan Fichtner Claudia Spix Peter Black Wolfgang Carus Rudolf Hohenfellner Joachim W Thüroff | 2000 | Urology2000，，3： | 1 |
| 11 | Neuromuscular training improves performance on the star excursion balance test in young female athletes显示文摘 | FILIPA A BYRNES R PATERNO M V | 2010 | J Orthop Sports Phys Ther2010，40，9： | 1 |
| 12 | Chemical composition and nutritional value of the most widely appreciated cultivated mushrooms: An inter-species comparative study显示文摘 | Filipa S. Reis Lillian Barros Anabela Martins Isabel C.F.R. Ferreira | 2011 | Food and Chemical Toxicology2011，，2： | 1 |
| 13 | Primary pulmonary lymphomas:a clinicopathologic analysis of 36 cases显示文摘 | Hoste RJ Filipa DA Lieberman PH | 1984 | Carcer1984，54，11： | 1 |
| 14 | Diabetic Nephropathy Amelioration by a Low-Dose Sitagliptin in an Animal Model of Type 2 Diabetes (Zucker Diabetic Fatty Rat)显示文摘 | Cristina Mega Edite Teixeira de Lemos Helena Vala Rosa Fernandes Jorge Oliveira Filipa Mascarenhas-Melo Frederico Teixeira Flávio Reis Yoshio Shimizu | 2011 | Experimental Diabetes Research2011，，： | 1 |
| 15 | The neurosphere assay:an effective in vitro technique to study neural stem cells显示文摘Neural stem cells(NSCs)are known to be present in the adult mammalian brain where they constitutively differentiate into the neuronal,astroglial,and oligodendroglial lineages,in defined processes termed neurogenesis,ast rogl iogenesis and oligodendrogenesis,respectively(reviewed in Braun and Jessberger,2014).During brain development,NSCs are present throughout the brain,becoming progressively restricted to defined brain regions.In the adult brain,NSCs are mainly present in areas classically known as neurogenic niches,i.e.the subventricular zone(SVZ),along the lateral walls of the lateral ventricles,and the subgranular zone,located in the dentate gyrus(DG)of the hippocampus. | Rita Soares Filipa F.Ribeiro Diogo M.Lourenço Rui S.Rodrigues João B.Moreira Ana M.Sebastião Vanessa A.Morais Sara Xapelli | 2021 | Neural Regeneration Research2021，16，11： | 1 |
| 16 | High pressure processing, thermal processing and freezing of 'camarosa' strawberry for the inactivation of polyphenoloxidase and control of browning显示文摘 | Alifdalino Sulaiman Silva Filipa V M | 2013 | Food Control2013，33，2： | 1 |
| 17 | Melo Cristino, S nia Mendo, and Aida Duarte molecular characterization of a new Class 3 integron in klebsiella pneumoniae显示文摘 | Mrio C Filipa B Filipa G | 2003 | American Society for Microbiology2003，47，9： | 1 |
| 18 | Nephron sparing surgery for central renal tumors:experience with 33 cases显示文摘 | Black P Filipas D Fichtner J | 2000 | J Urol2000，163，： | 1 |
| 19 | Neuromuscular training improves performance on the star excursion balance test in young female athletes显示文摘 | Filipa A Byrnes R Paterno MY | 2010 | J Orthop Sports Phys Ther2010，40，9： | 1 |
| 20 | Microbial conversion of glycerol to 1,3-propanediol: Physiological comparison of a natural producer, Clostridium butyricum VPI 3266, and an engineered strain,Clostridium acetobuty- licum DG1 (pSPD5) 显示文摘 | MARIA G P ISABELLE M S FILIPA M | 2006 | Applied and Environmental Microbiology2006，72，1： | 1 |
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