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| 1 | PI3K signaling pathway targeting by using different molecular approaches to treat cancer显示文摘Recent evidence of research has been proposed that the phosphoinositide 3-kinase(PI3K) pathway is noticeable target for searching novel anticancer agents. The phosphoinositide 3-kinase(PI3K) is accountable for harmonizing a diverse range of cell functions, such as transcription, proliferation, cell survival, cell growth, degranulation, vesicular trafficking and cell migration, which are mostly involved in carcinogenesis. Particularly, PI3K-mediated signaling molecules and its effects on gene expression contribute to tumorigenesis. PI3Ks generally are grouped into three distinct classes: Ⅰ, Ⅱ and Ⅲ according to their structure and function. The class IA of PI3K includes an alpha, beta or delta p110 catalytic subunit(p110α, p110β, or p110γ), which are associated with the activation of RTKs. Mutations in PIK3CA, the gene encoding the p110α catalytic subunit of PI3K, have just been recognized as novel mechanisms of inducing oncogenic PI3K signaling. Therefore, the class IA PI3K is the only one of most evidently implicated in cancer. The PI3K pathway is mostly mutated in more cancer patients compared with normal person, making it an eyecatching molecular target for analyses based on inhibitor molecule. In this article, we highlighted the signaling effects and regulation pathway of PI3K involved in the development and survival of tumor cells. The consequence and intricacy of PI3K pathway made it an essential beneficial target for cancer treatment. | Mohammad Rashid Shahid Karim Babar Ali Shamshir Khan Makhmur Ahmad Asif Husain Ravinesh Mishra | 2017 | Journal of Chinese Pharmaceutical Sciences2017，26，9： | 7 |
| 2 | Pancreatic necrosis:Complications and changing trend of treatment显示文摘Incidence of acute pancreatitis seems to be increasing in the Western countries and has been associated with significantly increased morbidity. Nearly 80% of the patients with acute pancreatitis undergo resolution; some develop complications including pancreatic necrosis. Infection of pancreatic necrosis is the leading cause of death in these patients. A significant portion of these patients needs surgical interventions. Traditionally, the 'gold standard' procedure has been the open surgical necrosectomy, which is now being completed by the relatively lesser invasive interventions. Minimally invasive surgical(MIS) procedures include endoscopic drainage, percutaneous image-guided catheter drainage, and retroperitoneal drainage. This review article discusses the open and MIS interventions for pancreatic necrosis with each having its own respective benefits and disadvantages are covered. | Mamoon Ur Rashid Ishtiaq Hussain Sundas Jehanzeb Waqas Ullah Saeed Ali Akriti Gupta Jain Neelam Khetpal Sarfraz Ahmad | 2019 | World Journal of Gastrointestinal Surgery2019，11，4： | 7 |
| 3 | New coating formulation for the slow release of urea using a mixture of gypsum and dolomitic limestone显示文摘 | Farahnaz Eghbali Babadi Robiah Yunus Suraya Abdul Rashid Mohamad Amran Mohd Salleh Salmiaton Ali | 2015 | Particuology2015，13，6： | 6 |
| 4 | Histone deacetylase inhibitor pre-treatment enhances the efficacy of DNA-interacting chemotherapeutic drugs in gastric cancer显示文摘BACKGROUND The prognosis of gastric cancer continues to remain poor,and epigenetic drugs like histone deacetylase inhibitors(HDACi)have been envisaged as potential therapeutic agents.Nevertheless,clinical trials are facing issues with toxicity and efficacy against solid tumors,which may be partly due to the lack of patient stratification for effective treatments.To study the need of patient stratification before HDACi treatment,and the efficacy of pre-treatment of HDACi as a chemotherapeutic drug sensitizer.METHODS The expression activity of class 1 HDACs and histone acetylation was examined in human gastric cancer cells and tissues.The potential combinatorial regime of HDACi and chemotherapy drugs was defined on the basis of observed drug binding assays,chromatin remodeling and cell death.RESULTS In the present study,the data suggest that the differential increase in HDAC activity and the expression of class 1 HDACs are associated with hypoacetylation of histone proteins in tumors compared to normal adjacent mucosa tissue samples of gastric cancer.The data highlights for the first time that pretreatment of HDACi results in an increased amount of DNA-bound drugs associated with enhanced histone acetylation,chromatin relaxation and cell cycle arrest.Fraction-affected plots and combination index-based analysis show that pre-HDACi chemo drug combinatorial regimes,including valproic acid with cisplatin or oxaliplatin and trichostatin A with epirubicin,exhibit synergism with maximum cytotoxic potential due to higher cell death at low combined doses in gastric cancer cell lines.CONCLUSION Expression or activity of class 1 HDACs among gastric cancer patients present an effective approach for patient stratification.Furthermore,HDACi therapy in pretreatment regimes is more effective with chemotherapy drugs,and may aid in predicting individual patient prognosis. | Ramchandra Vigay Amnekar Shafqat Ali Khan Mudasir Rashid Bharat Khade Rahul Thorat Poonam Gera Shailesh V Shrikhande Duane T Smoot Hassan Ashktorab Sanjay Gupta | 2020 | World Journal of Gastroenterology2020，26，6： | 3 |
| 5 | Quantitative analysis of cefixime via complexation with palladium(Ⅱ) in pharmaceutical formulations by spectrophotometry显示文摘An optimized and validated spectrophotometric method has been developed for the determination of cefixime in pharmaceutical formulations. The method is based on the complexation reaction between cefixime and palladium ion in the presence of acidic buffer solution (pH 3) in ethanol-distilled water medium at room temperature. The complex absorbed maximally at 352 nm. Beer's law is obeyed in the working concentration range of 2.5-35 μg/mL with apparent molar absorptivity of 1.015×104L/mol cm and Sandell's sensitivity of 0.001 μg/cm2 /0.001 absorbance unit. The limits of detection and quantitation for the proposed method are 0.175 and 0.583 μg/mL, respectively. The effect of common excipients used as additives has been studied in the determination of cefixime. The proposed method has been successfully applied for the determination of cefixime in pharmaceutical formulations. The results obtained by the proposed method were statistically compared with the reference method using t and F values and found no significant difference between the two methods. | Syed Najmul Hejaz Azmi Bashir Iqbal Nada Said Hassan Al-Humaimi Iman Rashid Saif Al-Salmani Noora Ali Saad Al-Ghafri Nafisur Rahman | 2013 | Journal of Pharmaceutical Analysis2013，3，4： | 3 |
| 6 | Residual effects of tobacco biochar along with different fixing agents on stabilization of trace elements in multi-metal contaminated soils显示文摘The residual effect of tobacco biochar(TB≥500°C)mono and co-application with Cahydroxide(CH),Ca-bentonite(CB)and natural zeolite(NZ)on the bio-availability of trace elements TE(s)in alkaline soils has not been deeply studied yet.A pot study that had earlier been investigated TB mono and blended with CH,CB and NZ on the immobilization of Pb,Cu Cd,and Zn by Chinese cabbage.Maize crop in the rotation was selected as test plant to assess the residual impact of amendments on stabilization of Pb,Cu Cd,and Zn in mine polluted(M-P),smelter heavily and low polluted(S-HP and S-LP,respectively)soils.The obtained results showed that stabilization of Pb,Cd,Cu and Zn reached 63.84% with TB+CB,61.19% with TB+CH,83.31% with TB+CH and 35.27% with TB+CH for M-P soil,36.46% with TB+NZ,38.46% with TB+NZ,19.40% with TB+CH and 62.43% with TB+CH for S-LP soil,52.94%TB+NZ,57.65% with TB+NZ,52.94% with TB+NZ,and 28.44% with TB+CH for S-LP soil.Conversely,TB+CH and TB alone had mobilized Pb and Zn up to19.29% and 34.96% in M-P soil.The mobility of Zn reached 8.38% with TB+CB and 66.03% with TB for S-HP and S-LP soils.The uptake and accumulation of Pb,Cd,Cu and Zn in shoot and root were reduced in three polluted soils.Overall,the combination of TB along with CH,CB and NZ has been proven to be effective in Pb,Cd,Cu and Zn polluted mine/smelter soils restoration. | Altaf Hussain Lahori Monika Mierzwa-Hersztek Muhammad Rashid Shahmir Ali Kalhoro Mehrunisa Memon Zobia Naheed Muneer Ahmed Zengqiang Zhang | 2020 | Journal of Environmental Sciences2020，32，1： | 3 |
| 7 | Colon mucosal neoplasia referred for endoscopic mucosal resection:Recurrence of adenomas and prediction of submucosal invasion显示文摘BACKGROUND Endoscopic mucosal resection(EMR)is an effective and minimally invasive alternative to surgery for large polyps and laterally spreading lesions.Gross morphology and surface characteristics may help predict submucosal invasion of the lesion(SMIL)during endoscopic evaluation.This is one of the largest singlecenter studies reporting endoscopic mucosal resection for larger(≥20 mm)colorectal lesions in the United States.AIM To determine the recurrence rate of adenomas and endoscopic features that may predict submucosal invasion of colonic mucosal neoplasia.METHODS This is a retrospective cohort study of all the patients referred for endoscopic mucosal resection for lesions≥20 mm,spanning a period from January 2013 to February 2017.The main outcome measure was identifying features that may predict submucosal invasion of mucosal lesions and predict recurrence of adenomas on follow-up surveillance colonoscopy performed at 4-6 mo.RESULTS A total of 480 patients with 500 lesions were included in the study.The median age was 68(Inter quantile range:14)with 52%males.The most common lesion location was ascending colon(161;32%).Paris classification 0-IIa(Flat elevation of mucosa-316;63.2%);Kudo Pit Pattern IIIs(192;38%)and Granular surface morphology(260;52%)were most prevalent.Submucosal invasion was present in 23(4.6%)out of 500 lesions.The independent risk factors for SMIL were Kudo Pit Pattern IIIL+IV and V(Odds ratio:4.5;P value<0.004)and Paris classification 0-IIc(Odds ratio:18.2;P value<0.01).Out of 500,354 post-endoscopic mucosal resection scars were examined at surveillance colonoscopy.Recurrence was noted in 21.8%(77 cases).CONCLUSION There was overall low prevalence of SMIL in our study.Kudo pit pattern(IIIL+IV and V)and Paris classification 0-IIc were the only factors identified as an independent risk factor for submucosal invasion.The independent risk factor for recurrence was adenoma size(>40 mm).Almost all recurrences(98.8%)were treated endoscopically. | Mamoon Ur Rashid Neelam Khetpal Hammad Zafar Saeed Ali Evgeny Idrisov Yuan Du Assaf Stein Deepanshu Jain Muhammad Khalid Hasan | 2020 | World Journal of Gastrointestinal Endoscopy2020，12，7： | 3 |
| 8 | Forest Cover Change Assessment in Conflict-affected Areas of Northwest Pakistan: the Case of Swat and Shangla Districts显示文摘This study examines the spatial and temporal forest cover changes in Swat and Shangla districts to understand the deforestation pattern in context of the recent security conflict in these districts. We used multi-resolution satellite images to assess the long term deforestation from 2001 to 2009 and also to identify episodic forest cutting areas appeared during the conflict period of Oct. 2007 - Oct. 2008. There are only 58 ha of deforestation identified during the conflict period while 1268 ha of gross annual deforestation were assessed during last eight years. Most of the deforestation patches persist around the administrative boundaries at sub-district levels (tehsils) which can be attributed to ambiguity in unclear jurisdiction between the forest official. The results highlight that the forest cutting appeared in Swat and Shangla during the conflict period is not as significant when compared with the long term deforestation pattern in the area. On the one side the results of the study are supportive to the picture that emerges from international studies which report high rate of deforestation in the country and on the other side it negates any relation between the security situation and the increasing deforestation in the north western Pakistan. The study concludes that deforestation assessments require verification by independent sources of data, such as satellite imagery to improve our understanding of deforestation processes. | Faisal Mueen QAMER Sawaid ABBAS Rashid SALEEM Khurram SHEHZAD Hassan ALI Hammad GILANI | 2012 | Journal of Mountain Science2012，9，3： | 3 |
| 9 | 人类抗菌肽hepcidin在毕赤酵母中的分泌表达和纯化显示文摘报道了一种低分子量的人类抗菌肽hepcidin基因的克隆、表达以及纯化。试验证明在毕赤酵母中能成功分泌有活性的hepcidin,hepcidin在重组菌株中的表达量约为3 mg/L,Western blot显示2.2 kD的重组hepcidin条带,重组hepcidin通过凝胶过滤及反向高效液相色谱纯化,质谱验证,重组蛋白对金黄色葡萄球菌和枯草芽孢杆菌表现出抗菌活性。 | Farzana Rashid Ijaz Ali 袁其朋 孙新晓 李文进 李飞 | 2009 | 生物技术通报2009，25，9： | 3 |
| 10 | A facile and convenient method for synthesis of alkyl thiocyanates under homogeneous phase transfer catalyst conditions显示文摘一个简单、环境地友好的方法用 tetrabutylammonium 溴化物(TBAB ) 为烷基卤化物的有效变换被描述到烷基 thiocyanate 为阶段转移催化剂。反应在水里发生并且在高收益供应相应烷基 thiocyanate。当反应的副产品被观察,没有进一步的纯化,产品在纯形式被获得,不为 isothiocyanates 的形成证实。 | Ali Reza Kiasat Rashid Badri Soheil Sayyahi | 2008 | Chinese Chemical Letters2008，19，11： | 3 |
| 11 | Comparative investigation of the free radical scavenging potential and anticancer property of Diospyros blancoi(Ebenaceae)显示文摘Objective: To investigate the comparative effects of Diospyros blancoi(Ebenaceae)leaves(DBL), root bark(DBRB) and stem bark(DBSB) on free radicals and cancer.Methods: The polyphenol contents, antioxidant and free radical scavenging properties were determined using standard spectrophotometric methods. Cytotoxicity and anticancer activities were performed on brine shrimp nauplii and Ehrlich ascite carcinoma cells, respectively.Results: Among the extracts, DBSB showed the highest total antioxidant capacity and reducing capacity on ferrous ion. Based on 1,1-diphenyl-2-picrylhydrazyl and hydroxyl radical scavenging activities, DBSB showed(95.760 ± 0.343)% and(67.460 ± 2.641)%scavenging with IC50of(3.10 ± 0.17) and(50.00 ± 3.11) mg/m L, respectively. The IC50 values of standard butylated hydroxytoluene and catechin(CA) for 1,1-diphenyl-2-picrylhydrazyl and hydroxyl radicals were(8.50 ± 0.25) and(75.00 ± 0.14) mg/m L,respectively suggesting that DBSB had a significant(P < 0.05) radical scavenging activity than standards. In lipid peroxidation inhibition assay, the inhibitory activity of the extracts and the standard was in the following order: DBSB > DBRB > CA > DBL.Also, the phenolic [(139.91 ± 3.924) mg gallic acid equivalent/g] and flavonoid contents[(412.00 ± 16.70) mg catechin equivalent/g)] of DBSB were higher than that of other extracts. In addition, the DBSB showed the moderate cytotoxic and anticancer properties.Conclusions: Our results indicate that Diospyros blancoi stem bark had the significant highest antioxidant and free radical scavenging properties as well as moderate anticancer activity.Hence, we assume that the anticancer activity of this plant can be, at least in part, attributed to its content in phenolic compounds as well as its significant free radical scavenging properties. | Muhammad Ali Khan Mahbubur Rahman Nazmul Sardar Saiful Islam Arman Badrul Islam Jahangir Alam Khandakar Mamunur Rashid Golam Sadik AHM Khurshid Alam | 2016 | Asian Pacific Journal of Tropical Biomedicine2016，6，5： | 3 |
| 12 | 倾斜旋转盘对ZnO-SAE50纳米磁流体流动和传热的影响(英文)显示文摘考虑工业中外加磁场对倾斜旋转盘的影响,对氧化锌-SAE50纳米润滑剂的Darcy-Forchheimer混合对流进行了详细研究。研究中同时考虑了滑移流动、热辐射、黏性耗散、Joulian耗散和内部加热的影响,对当前研究进行了改进。考虑到纳米润滑剂热导率的增大,提出了一种新的微纳米对流模型,即Patel模型。该模型的特点是由于纳米粒子的布朗运动、基于动力学理论的微对流、液体分层和粒子聚集而引起的比表面积和纳米对流的变化。利用Runge-Kutta-Fehlberg方法,对适当变换的控制方程进行了数值求解。分析表明,外加磁场、介质的孔隙度、速度滑移和惯性系数减慢了ZnO-SAE50纳米润滑剂的径向和切向流动,从而导致速度和热边界层的改善。 | NAYAK M K MEHMOOD Rashid MAKINDE O D MAHIAN O CHAMKHA Ali J | 2019 | Journal of Central South University2019，26，5： | 3 |
| 13 | Development of bis-thiobarbiturates as successful urease inhibitors and their molecular modeling studies显示文摘Bis-thiobarbiturate derivatives 1–15 have been synthesized, characterized by1 HNMR and EI-MS and screened for urease inhibition. All compounds showed various degree of urease inhibitory activity with IC_(50) values ranging 7.45 0.12 74.24 0.81 mmol/L while the standard thiourea behaved normally(IC_(50) = 21.10 0.12). Compounds 1(IC_(50) = 7.45 0.12 μmol/L), 9(IC_(50) = 18.17 1.03 μmol/L) and 13(IC_(50) = 8.61 0.45 μmol/L) showed excellent urease inhibitory activity in the series. Molecular modeling studies were performed to understand the binding site with the bimetallic nickel center of the enzyme.Structure-activity relationship has also been established for these compounds. This study identified bisthiobarbiturate as a novel class of urease inhibitors. | Fazal Rahim Muhammad Ali Shifa Ullah Umer Rashid Hayat Ullah Muhammad Taha Muhammad Tariq Javed Wajid Rehman Aftab Ahmad Khan Obaid Ur Rahman Abid Muhammad Bilal | 2016 | Chinese Chemical Letters2016，27，5： | 2 |
| 14 | Recent Insights into Signaling Responses to Cope Drought Stress in Rice显示文摘Drought is one of the hot topics needing urgent attention in the current era of climate change.It massively disturbs the rice growth and productivity and is becoming a serious threat.The drought avoidance strategies in rice include stomatal closure,cellular adaptation and changes in root development.Moreover,the endogenous plant hormones(abscisic acid and jasmonic acid)and reactive oxygen species have paramount importance in drought tolerance in rice.The drought tolerance induces modification in biochemical,molecular and physiological properties of plants.At the molecular level,expression of several transcription-factors is modulated which further determine the activation of drought responsive gene families.Mitogen activated protein kinases and Ca signaling pathways initiate an array of signaling cascade for mediating the gene expression in rice.Approaches,conventional breeding methods combined with modern emerging techniques such as genetic engineering,to improve rice drought tolerance were discussed.This review provided recent insights into major regulatory factors against drought stress,signaling mechanisms and molecular engineering strategies(including conventional transgenic and recent genome editing approaches)to induce drought tolerance in rice. | Muhammad Mahran ASLAM Muhammad Abdul Rehman RASHID Mohammad Aquil SIDDIQUI Muhammad Tahir KHAN Fozia FARHAT Shafquat YASMEEN Imtiaz Ahmad KHAN Shameem RAJA Fatima RASOOL Mahboob Ali SIAL ZHAO Yan | 2022 | Rice science2022，29，2： | 2 |
| 15 | Evaluation of antioxidant activities of various solvent extracts of Carissa opaca fruits显示文摘 | Sumaira Sahreen Muhammad Rashid Khan Rahmat Ali Khan | 2010 | Food Chemistry2010，，4： | 1 |
| 16 | Real-Time Multiple Guava Leaf Disease Detection from a Single Leaf Using Hybrid Deep Learning Technique显示文摘The guava plant has achieved viable significance in subtropics and tropics owing to its flexibility to climatic environments,soil conditions and higher human consumption.It is cultivated in vast areas of Asian and Non-Asian countries,including Pakistan.The guava plant is vulnerable to diseases,specifically the leaves and fruit,which result in massive crop and profitability losses.The existing plant leaf disease detection techniques can detect only one disease from a leaf.However,a single leaf may contain symptoms of multiple diseases.This study has proposed a hybrid deep learning-based framework for the real-time detection of multiple diseases from a single guava leaf in several steps.Firstly,Guava Infected Patches Modified MobileNetV2 and U-Net(GIP-MU-NET)has been proposed to segment the infected guava patches.The proposed model consists of modified MobileNetv2 as an encoder,and the U-Net model’s up-sampling layers are used as a decoder part.Secondly,the Guava Leaf SegmentationModel(GLSM)is proposed to segment the healthy and infected leaves.In the final step,the Guava Multiple Leaf Diseases Detection(GMLDD)model based on the YOLOv5 model detects various diseases from a guava leaf.Two self-collected datasets(the Guava Patches Dataset and the Guava Leaf Diseases Dataset)are used for training and validation.The proposed method detected the various defects,including five distinct classes,i.e.,anthracnose,insect attack,nutrition deficiency,wilt,and healthy.On average,the GIP-MU-Net model achieved 92.41%accuracy,the GLSM gained 83.40%accuracy,whereas the proposed GMLDD technique achieved 73.3%precision,73.1%recall,71.0%mAP@0.5 and 50.3 mAP@0.5:0.95 scores for all the aforesaid classes. | Javed Rashid Imran Khan Ghulam Ali Shafiq ur Rehman Fahad Alturise Tamim Alkhalifah | 2023 | Computers, Materials & Continua2023，，1： | 1 |
| 17 | Wortmannin inhibits platelet aggregation produced by interaction of gamma-aminobutyric acid and the calcium tonophore,A23187显示文摘 | Saeed SA Connor JD Rasheed H Gilani AH Lodhi S Ali SS Rashid S Khan E Shah BH | 2001 | Res Commun Mol Pathol Pharmacol2001，109，12： | 1 |
| 18 | Replacement of resin-based com- posite restorations in permanent teeth 显示文摘 | Asghar S Ali A Rashid S | 2010 | J Coil Physicians Surg Pak2010，20，10： | 1 |
| 19 | The Pakistan Risk of Myocardial Infarction Study: a resource for the study of genetic, lifestyle and other determinants of myocardial infarction in South Asia显示文摘 | Danish Saleheen Moazzam Zaidi Asif Rasheed Usman Ahmad Abdul Hakeem Muhammed Murtaza Waleed Kayani Azhar Faruqui Assadullah Kundi Khan Shah Zaman Zia Yaqoob Liaquat Ali Cheema Abdus Samad Syed Zahed Rasheed Nadeem Hayat Mallick Muhammad Azhar Rashid Jooma | 2009 | European Journal of Epidemiology2009，，6： | 1 |
| 20 | A comparative study of single and double pulse of laser induced breakdown spectroscopy of silver显示文摘 | B Rashid R Ahmed R Ali | 2011 | Physics of Plasmas2011，18，07： | 1 |
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