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| 1 | A matched-pair analysis of laparoscopic versus open pancreaticoduodenectomy: oncological outcomes using Leeds Pathology Protocol显示文摘BACKGROUND: Laparoscopic pancreaticoduodenectomy(LPD)is a safe procedure. Oncological safety of LPD is still a matter for debate. This study aimed to compare the oncological outcomes,in terms of adequacy of resection and recurrence rate following LPD and open pancreaticoduodenectomy(OPD).METHODS: Between November 2005 and April 2009, 12LPDs(9 ampullary and 3 distal common bile duct tumors)were performed. A cohort of 12 OPDs were matched for age,gender, body mass index(BMI) and American Society of Anesthesiologists(ASA) score and tumor site.RESULTS: Mean tumor size LPD vs OPD(19.8 vs 19.2 mm,P=0.870). R0 resection was achieved in 9 LPD vs 8 OPD(P=1.000). The mean number of metastatic lymph nodes and total number resected for LPD vs OPD were 1.1 vs 2.1(P=0.140)and 20.7 vs 18.5(P=0.534) respectively. Clavien complications grade I/II(5 vs 8), III/IV(2 vs 6) and pancreatic leak(2 vs 1)were statistically not significant(LPD vs OPD). The mean high dependency unit(HDU) stay was longer in OPD(3.7 vs 1.4 days,P<0.001). There were 2 recurrences each in LPD and OPD(logrank,P=0.983). Overall mortality for LPD vs OPD was 3 vs 6(log-rank, P=0.283) and recurrence-related mortality was 2 vs 1.There was one death within 30 days in the OPD group secondary to severe sepsis and none in the LPD group.CONCLUSIONS: Compared to open procedure, LPD achieved a similar rate of R0 resection, lymph node harvest and longterm recurrence for tumors less than 2 cm. Though technically challenging, LPD is safe and does not compromise oncological outcome. | Abdul R Hakeem Caroline S Verbeke Alison Cairns Amer Aldouri Andrew M Smith Krishna V Menon | 2014 | Hepatobiliary & Pancreatic Diseases International2014，13，4： | 24 |
| 2 | Inguinodynia following Lichtenstein tension-free hernia repair:A review显示文摘Chronic Groin Pain (Inguinodynia) following inguinal hernia repair is a significant,though under-reported problem. Mild pain lasting for a few days is common following mesh inguinal hernia repair. However,moderate to severe pain persisting more than 3 mo after inguinal herniorrhaphy should be considered as pathological. The major reasons for chronic groin pain have been identified as neuropathic cause due to inguinal nerve(s) damage or non-neuropathic cause due to mesh or other related factors. The symptom complex of chronic groin pain varies from a dull ache to sharp shooting pain along the distribution of inguinal nerves. Thorough history and meticulous clinical examination should be performed to identify the exact cause of chronic groin pain,as there is no single test to confirm the aetiology behind the pain or to point out the exact nerve involved. Various studies have been performed to look at the difference in chronic groin pain rates with the use of mesh vs non-mesh repair,use of heavyweight vs lightweight mesh and mesh fixation with sutures vs glue. Though there is no convincing evidence favouring one over the other,lightweight meshes are generally preferred because of their lesser foreign body reaction and better tolerance by the patients. Identification of all three nerves has been shown to be an important factor in reducing chronic groin pain,though there are no well conducted randomised studies to recommend the benefits of nerve excision vs preservation. Both nonsurgical and surgical options have been tried for chronic groin pain,with their consequent risks of analgesic sideeffects,recurrent pain,recurrent hernia and significant sensory loss. By far the best treatment for chronic groin pain is to avoid bestowing this on the patient by careful intra-operative handling of inguinal structures and better patient counselling pre-and post-herniorraphy. | Abdul Hakeem Venkatesh Shanmugam | 2011 | World Journal of Gastroenterology2011，17，14： | 13 |
| 3 | Meta‐analysis: recurrence and survival following the use of sirolimus in liver transplantation for hepatocellular carcinoma显示文摘 | K. V. Menon A. R. Hakeem N. D. Heaton | 2012 | Aliment Pharmacol Ther2012，，4： | 8 |
| 4 | Exogenous Selenium Mitigates Salt Stress in Soybean by Improving Growth,Physiology,Glutathione Homeostasis and Antioxidant Defense显示文摘The mechanism of selenium(Se)-induced salt tolerance was studied in moderately sensitive soybean(Glycine max L.)plants.To execute this view,soybean plants were imposed with salt stress(EC 6 dS m^(−1))applying NaCl.In other treatments,Se(0,25,50 and 75μM Na_(2)SeO_(4))was sprayed as co-application with that level of salt stress.Plant height,stem diameter,leaf area,SPAD value decreased noticeably under salt stress.Altered proline(Pro)level,together with decreased leaf relative water content(RWC)was observed in salt-affected plants.Salt stress resulted in brutal oxidative damage and increased the content of H_(2)O_(2),MDA level and electrolyte leakage.Exogenous Se spray alleviated oxidative damage through boosting up the antioxidant defense system by increasing the activity of antioxidant enzymes such as catalase(CAT),peroxidase(POD)and glutathione reductase(GR),as well as by improving non-enzymatic antioxidants like glutathione(GSH)and GSH/glutathione disulfide(GSSG).The upregulated antioxidant defense system,restored Pro and leaf RWC,higher SPAD value conferred better growth and development in Se-sprayed salt-affected soybean plants which altogether put forth for the progressive yield contributing parameters and finally,seed yield.Among different doses of Se,soybean plants sprayed with 50μM Na_(2)SeO_(4)showed better salt tolerance. | Hesham F.Alharby Mirza Hasanuzzaman Hassan S.Al-Zahrani Khalid Rehman Hakeem | 2021 | Phyton-International Journal of Experimental Botany2021，90，2： | 3 |
| 5 | 大田生产过程中施用电解水降解农残的作用显示文摘人与自然和谐相处,生态和经济可持续发展,是21世纪的主题。崇尚自然,维护环境,是现代绿色消费的潮流。随着电解水在农业领域的应用,电解水农业理念的提出,电解水肥系列产品的推出,在促进种子萌发与植物的光合作用,农作物的杀菌、驱虫,农副产品的防霉保鲜,以及提高农产品品质,对土壤酸、碱度的中和改良等作用明显,真正做到了“用自然的力量,创造健康的生活”,为中国绿色农业的发展开辟了新路径。 | 肖伟 Abdul Hakeem 张彩君 陈珂 | 2019 | 长江蔬菜2019，，16： | 3 |
| 6 | Current trends in the diagnosis and management of post-herniorraphy chronic groin pain显示文摘Inguinodynia(chronic groin pain) is one of the recognised complications of the commonly performed Lichtenstein mesh inguinal hernia repair.This has major impact on quality of life in a significant proportion of patients.The pain is classif ied as neuropathic and nonneuropathic related to nerve damage and to the mesh,respectively.Correct diagnosis of this problem is relatively difficult.A thorough history and clinical examination are essential,as is a good knowledge of the groin nerve distribution.In spite of the common nature of the problem,the literature evidence is limited.In this paper we discuss the diagnostic tools and treatment options,both non-surgical and surgical.In addition,we discuss the criteria for surgical intervention and its optimal timing. | Abdul Hakeem Venkatesh Shanmugam | 2011 | World Journal of Gastrointestinal Surgery2011，3，6： | 3 |
| 7 | Morpho-Physiological,Biochemical and Molecular Adaptation of Millets to Abiotic Stresses:A Review显示文摘Abiotic stresses such as drought,heat,cold,nutrient deficiency,excess salt and hazardous metals can hamper plantgrowth and development.Intensive agriculture of only a few major staple food crops that are sensitive and intolerant to environmental stresses has led to an agrarian crisis.On the other hand,nutritionally rich,gluten free and stress tolerant plants like millets are neglected and underutilized.Millets sustain about one-third of the world’s population and show exceptional tolerance to various abiotic and biotic stresses.Millets are C4 plants that are adapted to marginal and dry lands of arid and semi-arid regions,and survive low rainfall and poor soils.Abiotic stresses significantly affect plant growth which ultimately results in reduced crop yields.However,various adaptation mechanisms have evolved in millets to withstand different stresses.This review aims at exploring various of these morphophysiological,biochemical and molecular aspects of mechanisms in millets.Morphological adaptations include short life span,smallplant height and leaf area,dense root system,adjusted flowering time,increased root and decreased shoot lengths,high tillering,and leaf folding.A high accumulation of various osmoprotectants(proline,soluble sugars,proteins)improves hyperosmolarity and enhances the activity of antioxidant enzymes(e.g.,Ascorbate peroxidase,Superoxide dismutase,Catalase,Peroxidase)providing defense against oxidative damage.Physiologically,plants show low photosynthetic and stomatal conductance rates,and root respiration which help them to escape from water stress.Molecular adaptations include the upregulation of stress-related transcriptional factors,signalling genes,ion transporters,secondary metabolite pathways,receptor kinases,phytohormone biosynthesis and antioxidative enzymes.Lack of genetic resources hampers improvement of millets.However,several identified and characterized genes for stress tolerance can be exploited for further development of millet resilience.This will provide them with an extra characteristic plant resistance to withstand environmental pressures,besides their excellent nutritional value over the conventional staple crops like rice,wheat and maize. | Seerat Saleem Naveed Ul Mushtaq Wasifa Hafiz Shah Aadil Rasool Khalid Rehman Hakeem Reiaz Ul Rehman | 2021 | Phyton-International Journal of Experimental Botany2021，90，5： | 2 |
| 8 | 利用电解水农业技术体系生产还原性蔬菜樱桃番茄显示文摘人与自然和谐相处,生态和经济可持续发展,是21世纪的主题。崇尚自然,维护环境,是现代绿色消费的潮流。随着电解水在农业领域的应用,电解水农业理念的提出,电解水肥系列产品的推出,在促进种子萌发与植物的光合作用,农作物的杀菌、驱虫,农副产品的防霉保鲜,以及提高农产品品质,对土壤酸、碱度的中和改良等作用明显,真正做到了“用自然的力量,创造健康的生活”,为中国绿色农业的发展开辟了新路径。 | 肖伟 Abdul Hakeem 竹文坤 陈珂 张祥辉 张彩君 | 2020 | 长江蔬菜2020，，22： | 2 |
| 9 | 传统溶剂提取法和超临界流体萃取法对钟花蒲桃次生代谢产物的回收率的比较研究(英文)显示文摘目的:寻求一种最佳的钟花蒲桃次生代谢产物的萃取方法,以实现在工业上的应用。创新点:全面深入地比较传统溶剂提取法和超临界流体萃取法对钟花蒲桃的主要次生代谢产物的回收率。方法:在超临界流体萃取法中,应用Box-Behnken设计,以压力、温度和萃取粒径大小为自变量,以粗提取物、个别的和总的次生代谢产物的百分比产量为因变量。另外,还研究了调节剂乙醇对产量的影响。在传统溶剂提取中,结合十种不同的溶剂和三不同的技术(浸提、索氏和回流)产生二十种不同的提取产物。通过高效液相色谱法检测不同的提取方法对钟花蒲桃的主要次生代谢产物的回收率。结论:超临界流体萃取法优于传统溶剂提取法,省成本又省时。因此在工业使用上,超临界流体萃取法可替代传统溶剂提取法。 | Abdul Hakeem MEMON Mohammad Shahrul Ridzuan HAMIL Madeeha LAGHARI Fahim RITHWAN Salman ZHARI Mohammed Ali Ahmed SAEED Zhari ISMAIL Amin Malik Shah Abdul MAJID | 2016 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2016，17，9： | 2 |
| 10 | Physiological and Molecular Analysis of Applied Nitrogen in Rice Genotypes显示文摘Ten genotypes of rice (Oryza sativa L.) were grown for 30 d in complete nutrient solution with 1 mmol/L (N-insufficient),4 mmol/L (N-moderate) and 10 mmol/L (N-high) nitrogen levels,and nitrogen efficiency (NE) was analyzed.Growth performance,measured in terms of fresh weight,dry weight and lengths of root and shoot,was higher in N-efficient than in N-inefficient rice genotypes at low N level.Of these 10 genotypes,Suraksha was identified as the most N-efficient,while Vivek Dhan the most N-inefficient.To find out the physiological basis of this difference,the nitrate uptake rate of root and the activities of nitrate assimilatory enzymes in leaves of N-efficient and N-inefficient rice genotypes were studied.Uptake experiments revealed the presence of two separate nitrate transporter systems mediating high-and low-affinity nitrate uptake.Interestingly,the nitrate uptake by the roots of Suraksha is mediated by both high-and low-affinity nitrate transporter systems,while that of Vivek Dhan by only low-affinity nitrate transporter system.Study of the activities and expression levels of nitrate assimilatory enzymes in N-efficient and N-inefficient rice genotypes showed that nitrate reductase (NR) and glutamine synthetase (GS) play important roles in N assimilation under low-nitrogen conditions. | Khalid Rehman HAKEEM Ruby CHANDNA Altaf AHMAD1 Muhammad IQBAL | 2012 | Rice science2012，19，3： | 2 |
| 11 | Layered Software Patterns for Data Analysis in Big Data Environment显示文摘The proliferation of textual data in society currently is overwhelming, in particular, unstructured textual data is being constantly generated via call centre logs, emails, documents on the web, blogs, tweets, customer comments, customer reviews, etc.While the amount of textual data is increasing rapidly, users ability to summarise, understand, and make sense of such data for making better business/living decisions remains challenging. This paper studies how to analyse textual data, based on layered software patterns, for extracting insightful user intelligence from a large collection of documents and for using such information to improve user operations and performance. | Hossam Hakeem | 2017 | International Journal of Automation and computing2017，14，6： | 2 |
| 12 | Pancreatic pseudocyst or a cystic tumor of the pancreas?显示文摘Pancreatic pseudocysts are the most common cystic lesions of the pancreas and may complicate acute pancreatitis, chronic pancreatitis, or pancreatic trauma. While the majority of acute pseudocysts resolve spontaneously, few may require drainage. On the other hand, pancreatic cystic tumors, which usually require extirpation, may disguise as pseudocysts. Hence, the distinction between the two entities is crucial for a successful outcome. We conducted this study to highlight the fundamental differences between pancreatic pseudocysts and cystic tumors so that relevant management plans can be devised. We reviewed the data of patients with pancreatic cystic lesions that underwent intervention between June 2007 and December 2010 in our hospital. We identified 9 patients(5 males and 4 females) with a median age of 40 years(range, 30–70 years). Five patients had pseudocysts, 2 had cystic tumors, and 2 had diseases of undetermined pathology. Pancreatic pseudocysts were treated by pseudocystogastrostomy in 2 cases and percutaneous drainage in 3 cases. One case recurred after percutaneous drainage and required pseudocystogastrostomy. The true pancreatic cysts were serous cystadenoma, which was treated by distal pancreatectomy, and mucinous cystadenocarcinoma, which was initially treated by drainage, like a pseudocyst, and then by distal pancreatectomy when its true nature was revealed. We conclude that every effort should be exerted to distinguish between pancreatic pseudocysts and cystic tumors of the pancreas to avoid the serious misjudgement of draining rather than extirpating a pancreatic cystic tumor. Additionally, percutaneous drainage of a pancreatic pseudocyst is a useful adjunct that may substitute for surgical drainage. | Mohammad Ezzedien Rabie Ismail El Hakeem Mohammad Saad Al Skaini Ahmad El Hadad Salim Jamil Mian Tahir Shah Mahmoud Obaid | 2014 | Chinese Journal of Cancer2014，33，2： | 2 |
| 13 | Effect of alkaline metal ions on the photoluminescence properties of Eu^(3+)-doped Ca_3Al_2O_6 phosphors显示文摘Ca_3–xAl_2O_6:x Eu^(3+)(0.02≤x≤0.10) and Ca_(2.92)Al_2O_6:0.04Eu^(3+),0.04M^+(M^+=Li^+, Na^+, and K^+) phosphors were prepared by sol-gel method and their photoluminescence properties were investigated. The crystal structure of the annealed Ca_3–xAl_2O_6:x Eu^(3+) and Ca_(2.92)Al_2O_6:0.04Eu^(3+),0.04M^+ phosphors was analyzed with X-ray diffraction(XRD). The size and morphological characteristics of the annealed phosphors were investigated with a field emission scanning electron microscope(FE-SEM). The photoluminescence properties were evaluated with a spectrofluorometer. The phosphors were effectively excited by the light of 396 nm and showed intense red emission at 616 nm, which originated from the 5D_0→7F_2 transition of Eu^(3+). Among the prepared phosphors, the Ca_(2.96)Al_2O_6:0.04Eu^(3+) phosphor showed the strongest emission intensity and the highest color purity. The addition of alkaline metal ions(Li^+, Na^+, and K^+) to Ca_(2.96)Al_2O_6:0.04Eu^(3+) phosphor degraded the emission intensity and color purity. | Kyeongsoon Park Joon Woo Pi Deshmukh Abdul Hakeem | 2016 | Journal of Rare Earths2016，34，12： | 2 |
| 14 | 家庭装碱性电解水除农残特性和几种常见除农残方法效果比较显示文摘人与自然和谐相处,生态和经济可持续发展,是21世纪的主题。崇尚自然,维护环境,是现代绿色消费的潮流。随着电解水在农业领域的应用,电解水农业理念的提出,电解水肥系列产品的推出,在促进种子萌发与植物的光合作用,农作物的杀菌、驱虫,农副产品的防霉保鲜,以及提高农产品品质,对土壤酸、碱度的中和改良等作用明显,真正做到了“用自然的力量,创造健康的生活”,为中国绿色农业的发展开辟了新路径。 | 肖伟 Abdul Hakeem 刘李岚 张彩君 | 2020 | 长江蔬菜2020，，6： | 2 |
| 15 | Abnormal ankle brachial index and the presence of significant coronary artery disease 显示文摘 | Hakeem F Siddique S Saboor QA | 2010 | J Coil Physicians Surg Pak2010，20，2： | 1 |
| 16 | Meta-analysis:re- currence and survival following the use of sirolimus in liver transplantation for hepatocellular carcinoma显示文摘 | Menon KV Hakeem AR Heaton ND | 2013 | Ali- ment Pharmacol Ther2013，37，4： | 1 |
| 17 | Significance of anterior commissure involvement in early glottic squamous cell carcinoma treated with trans‐oral CO2 laser microsurgery显示文摘 | Arsheed H. Hakeem Jagadish Tubachi Sultan A. Pradhan | 2013 | The Laryngoscope2013，，8： | 1 |
| 18 | Changes in Growth,Photosynthetic Pigments,Cell Viability,Lipid Peroxidation and Antioxidant Defense System in Two Varieties of Chickpea(Cicer arietinum L.)Subjected to Salinity Stress显示文摘Salinity is one of the most severe abiotic stresses for crop production.The present study investigates the salinityinduced modulation in growth indicators,morphology and movement of stomata,photosynthetic pigments,activity of carbonic anhydrase as well as nitrate reductase,and antioxidant systems in two varieties of chickpea(Pusa-BG5023,and Pusa-BGD72).On 20^(th) day of sowing,plants were treated with varying levels of NaCl(0,50,100,150 and 200 mM)followed by sampling on 45 days of sowing.Recorded observations on both the varieties reveal that salt stress leads to a significant decline in growth,dry biomass,leaf area,photosynthetic pigments,protein content,stomatal behavior,cell viability,activity of nitrate reductase and carbonic anhydrase with the rise in the concentration of salt.However,quantitatively these changes were less in Pusa-BG5023 as compared to Pusa-BGD72.Furthermore,salinity-induced oxidative stress enhanced malondialdehyde content,superoxide radicals,foliar proline content,and the enzymatic activities of superoxide dismutase,catalase,and peroxidase.The variety Pusa-BGD72 was found more sensitive than Pusa-BG5023 to salt stress.Out of different graded concentrations(50,100,150 and 200 mM)of sodium chloride,50 mM was least toxic,and 200 mM was most damaging.The differential behavior of these two varieties measured in terms of stomatal behavior,cell viability,photosynthetic pigments,and antioxidant defense system can be used as prospective indicators for selection of chickpea plants for salt tolerance and sensitivity. | Zeenat Mushtaq Shahla Faizan Basit Gulzar Humira Mushtaq Sayyada Bushra Alisha Hussain Khalid Rehman Hakeem | 2022 | Phyton-International Journal of Experimental Botany2022，91，1： | 1 |
| 19 | Extranodal NK/T-cell lymphoma, nasal type显示文摘 | Hakeem DA Fedele S Carlos R | 2007 | Oral Oncology2007，43，1： | 1 |
| 20 | A comparison of the transcardial and the transfemoral approach in chronic total occlusion percutaneous coronary intervention显示文摘 | Rathore S Hakeem A Pauriah M | | 0，，07： | 1 |
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