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| 1 | Double negative T cells,a potential biomarker for systemic lupus erythematosus显示文摘Systemic lupus erythematosus(SLE)is an autoimmune disease that is a challenge to diagnose and treat.There is an urgent need for biomarkers to help define organ involvement,and more effective therapies.A unique population of T cells,the CD3^(+)CD4^(−)CD8^(−)(DNeg)cells,is significantly increased in lupus patients.Twentyseven cases(53%)of pediatric SLE patients had elevated DNeg cells in their peripheral blood,which correlated with kidney function(R^(2)=0.54).Significant infiltration of DNeg cells was observed in both adult and pediatric lupus kidneys by immunofluorescence.For the first time,this study provides direct evidence that DNeg cells facilitate kidney injury in preclinical 8-week-old MRL/lpr lupus mice.In lupus mice,the increase in DNeg cells tracked with worsening disease and correlated with kidney function(R^(2)=0.85).Our results show that DNeg cells per se can cause kidney dysfunction,increase in number with increase in disease pathology,and could serve as a potential biomarker. | Jessy J.Alexander Alexander Jacob Anthony Chang Richard J.Quigg James N.Jarvis | 2020 | Precision Clinical Medicine2020，3，1： | 4 |
| 2 | Preventive treatment of alveolar pulmonary edema of cardiogenic origin显示文摘Objective To evaluate the efficacy of preventive treatment (PT) on alveolar pulmonary edema (APE) of cardiogenic origin using a monitor based on principles of internal thoracic impedance (ITI) measurements.Methods We conducted blinded clinical trials on patients with ST-elevation myocardial infarction (STEMI) and monitored whether the condition would progress to APE. ITI was measured noninvasively by the Edema Guard Monitor (EGM, model RS-207) every 30 min. The measurement threshold for the diagnosis of APE was fixed at > 12% decrease in ITI from baseline as described in our methodology. The patients were divided into one group that received standard treatment after the appearance of clinical signs of APE without considering the prediction of APE by EGM devise (Group 1), and another group of asymptomatic patients in whom development of APE was predicted by using only EGM measurements (Group 2). The latter participants’PT consisted of furosemide, intravenous nitroglycerine and supplemental oxygen. Results One-hundred and fifty patients with acute STEMI were enrolled into this study. Group 1 included 100 patients (53% males, age 64.1 ±12.6 years). Treatment was started after the clinical appearance of overt signs of APE. Group 2 included 50 patients (54% males, age 65.2 ±11.9 years) who received PT based on EGMmeasurements. Group 2 had significantly fewer cases of APE (n = 4, 8%) than Group 1 (n = 100, 100%) (P > 0.001). While APE was lethal in six (6%) Group 1 patients, PT resulted in prompt resolution of APE in all four (8%) Group 2 patients. Conclusion ITI is a usefulmodality for early diagnosis and PT of pulmonary edema of cardiogenic origin. | Gideon Charach Michael Shochat Alexander Rabinovich Oded Ayzenberg Jacob George Lior Charach Pavel Rabinovich | 2012 | Journal of Geriatric Cardiology2012，9，4： | 3 |
| 3 | 在长期的心失败的氧化反的低密度的脂蛋白抗体显示文摘 Oxidative stress may play a significant role in the pathogenesis of heart failure(HF).Antibodies to oxidized low-density lipoprotein(oxLDL Abs) reflect an immune response to LDL over a prolonged period and may represent long-term oxidative stress in HF.The oxLDL plasma level is a useful predictor of mortality in HF patients,and measurement of the oxLDL Abs level may allow better management of those patients.Antibodies to oxLDL also significantly correlate with the New York Heart Association score.Hypercholesterolemia,smoking,hypertension,and obesity are risk factors for atherosclerotic coronary heart disease(CHD) leading to HF,but these factors account for only onehalf of all cases,and understanding of the pathologic process underlying HF remains incomplete.Nutrients with antioxidant properties can reduce the susceptibility of LDL to oxidation.Antioxidant therapy may be an adjunct to lipid-lowering,angiotensin converting enzyme inhibition and metformin(in diabetes) therapy for the greatest impact on CHD and HF.Observational data suggest a protective effect of antioxidant supple-mentation on the incidence of HD.This review summarizes the data on oxLDL Abs as a predictor of morbidity and mortality in HF patients. | Gideon Charach Alexander Rabinovich Ori Argov Moshe Weintraub Lior Charach Oded Ayzenberg Jacob George | 2012 | World Journal of Cardiology2012，4，11： | 2 |
| 4 | TNF is a key mediator of septic encephalopathy acting through its receptor, TNF re-ceptor~l 显示文摘 | Alexander JJ Jacob A Cunningham P | 2008 | Neurochem lnt2008，52，3： | 1 |
| 5 | TNF is a key mediator of septic encephalopathy acting through its receptor, TNF receptor-1显示文摘 | Jessy J. Alexander Alexander Jacob Patrick Cunningham Lauren Hensley Richard J. Quigg | 2007 | Neurochemistry International2007，，： | 1 |
| 6 | TNF is a key me- diator of septic encephalopathy acting through its receptor, TNF receptor-1 显示文摘 | Alexander J J Jacob A Cunningham P | 2008 | Neurochem Int2008，52，3： | 1 |
| 7 | TNF is a key mediator of septic encephalopathy acting through its receptor,TNF receptor-1 显示文摘 | Alexander JJ Jacob A Cunningham P | 2008 | Neurochem Int2008，52，3： | 1 |
| 8 | Sulfate formation in sea-salt aerosols:Constraints from oxygen isotopes显示文摘 | Alexander B Park R J Jacob D J | 2005 | Journal of Geophysical Research2005，110，10： | 1 |
| 9 | TNF is a key mediator of septic encephalopathy acting through its receptor, TNF receptor-1 显示文摘 | Alexander J J Jacob A Cunningham P | 2008 | Neurochem Int2008，52，3： | 1 |
| 10 | Do Magnetic Resonance Imaging and Ultrasound Add Anything to the Preoperative Workup of Parotid Gland Tumors?显示文摘 | Jacob Alexander de Ru Maarten S. van Leeuwen Peter Paul G. van Benthem Birgitta K. Velthuis Daisy M.D.S. Sie-Go Gerrit Jan Hordijk | 2007 | Journal of Oral and Maxillofacial Surgery2007，，5： | 1 |
| 11 | Strenuous exercise : analogous to the a- cute-phase response? 显示文摘 | Weight LM Alexander D Jacobs P | 1991 | Clin Sci (Lond)1991，81，5： | 1 |
| 12 | Neural stem cells improve intracranial nanoparticle retention and tumor-selective distribution显示文摘 | Rachael Mooney Yiming Weng Revathiswari Tirughana-Sambandan Valerie Valenzuela Soraya Aramburo Elizabeth Garcia Zhongqi Li Margarita Gutova Alexander J Annala Jacob M Berlin Karen S Aboody | 2014 | Future Oncology2014，，3： | 1 |
| 13 | Object-based fusion of multitemporal multiangle envisat asar and hj-1b multispectral data for urban land-cover mapping显示文摘 | Ban Yifang Alexander Jacob | | 0，，04： | 1 |
| 14 | Patent Foramen Ovale Closure versus Medical Therapy for Stroke Prevention: Meta Analysis of Randomized Trials and Review of Heterogeneity in Meta Analyses显示文摘 | Jacob A. Udell Alexander R. Opotowsky Paul Khairy Candice K. Silversides David J. Gladstone Patrick T. O’Gara Michael J. Landzberg | 2014 | Canadian Journal of Cardiology2014，，： | 1 |
| 15 | Acute Neurocardiogenic Injury After Subarachnoid Hemorrhage显示文摘 | Nader M. Banki Alexander Kopelnik Michael W. Dae Jacob Miss Poyee Tung Michael T. Lawton Barbara J. Drew Elyse Foster Wade Smith William W. Parmley Jonathan G. Zaroff | 2005 | Circulation2005，，21： | 1 |
| 16 | Vital Signs: Carbapenem-Resistant Enterobacteriaceae显示文摘 | Jacob Jesse T Klein Eili Laxminarayan Ramanan Beldavs Zintars Lynfield Ruth Kallen Alexander J Ricks Philip Edwards Jonathan Srinivasan Arjun Fridkin Scott Rasheed J Kamile Lonsway David Bulens Sandie Herrera Rosa McDonald L Clifford Patel | 2013 | MMWR Morbidity and Mortality Weekly Report2013，，9： | 1 |
| 17 | Hiatal hernia repair with mesh: a survey of SAGES members显示文摘 | Constantine T. Frantzides Mark A. Carlson Sofronis Loizides Anastasia Papafili Mihn Luu Jacob Roberts Tallal Zeni Alexander Frantzides | 2010 | Surgical Endoscopy2010，，5： | 1 |
| 18 | TNF is a key mediator of septic encephalopathy acting through its receptor,TNF receptor-1 显示文摘 | Alexander JJ Jacob A Cunningham P | 2008 | Neurochem Int2008，52，3： | 1 |
| 19 | Determination of nicotine metabolite trans- 3'-hydroxycotinine in urine of smokers using gas chromatography with nitrogen- selective detection selected ion monitoring显示文摘 | Jacob P Alexander T Yu L | 1992 | J Chromato1992，583，： | 1 |
| 20 | Determination of liquid-crystal polar anchoring energy by electrical measurements 显示文摘 | Anatoli Murauski Vladimir Chigrinov Alexander Muravsky Fion Sze-Yan Yeung Jacob Ho Hoi-Sing Kwok | 2005 | Phys Rev E2005，71，06： | 1 |
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