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| 1 | 血管紧张素转换酶抑制剂和血管紧张素受体拮抗剂的使用与2019冠状病毒疾病检测阳性之间的关系显示文摘血管紧张素转换酶抑制剂(angiotensin-converting enzyme inhibitor,ACEI)和血管紧张素受体拮抗剂(angiotensin receptor blocker,ARB)在2019新型冠状病毒疾病(coronavirus disease 2019,COVID-19)全球大流行背景下的作用备受争议。此类药物是治疗一些慢性病的必须药物,有建议停止使用这些药物. | Mehta N KalraA Nowacki AS Anjewierden S Han Z Bhat p Rubio AEC Jacob M Procop GW Harrington S Milinovich A Svensson LG Jehi L Young JB Chung MK 周卫(译) 叶鹏(校) | 2020 | 中华高血压杂志2020，28，5： | 9 |
| 2 | Metabolic and hepatic effects of liraglutide,obeticholic acid and elafibranor in diet-induced obese mouse models of biopsy-confirmed nonalcoholic steatohepatitis显示文摘AIM To evaluate the pharmacodynamics of compounds in clinical development for nonalcoholic steatohepatitis(NASH) in obese mouse models of biopsy-confirmedNASH.METHODS Male wild-type C57 BL/6 J mice(DIO-NASH) and Lep^(ob/ob)(ob/ob-NASH) mice were fed a diet high in trans-fat(40%), fructose(20%) and cholesterol(2%) for 30 and 21 wk, respectively. Prior to treatment, all mice underwent liver biopsy for confirmation and stratification of liver steatosis and fibrosis, using the nonalcoholic fatty liver disease activity score(NAS) and fibrosis staging system. The mice were kept on the diet and received vehicle, liraglutide(0.2 mg/kg, SC, BID), obeticholic acid(OCA, 30 mg/kg PO, QD), or elafibranor(30 mg/kg PO, QD) for eight weeks. Within-subject comparisons were performed on changes in steatosis, inflammation, ballooning degeneration, and fibrosis scores. In addition, compound effects were evaluated by quantitative liver histology, including percent fractional area of liver fat, galectin-3, and collagen 1 a1.RESULTS Liraglutide and elafibranor, but not OCA, reduced body weight in both models. Liraglutide improved steatosis scores in DIO-NASH mice only. Elafibranor and OCA reduced histopathological scores of hepatic steatosis and inflammation in both models, but only elafibranor reduced fibrosis severity. Liraglutide and OCA reduced total liver fat, collagen 1 a1, and galectin-3 content, driven by significant reductions in liver weight. The individual drug effects on NASH histological endpoints were supported by global gene expression(RNA sequencing) and liver lipid biochemistry.CONCLUSION DIO-NASH and ob/ob-NASH mouse models show distinct treatment effects of liraglutide, OCA, and elafibranor, being in general agreement with corresponding findings in clinical trials for NASH. The present data therefore further supports the clinical translatability and utility of DIO-NASH and ob/ob-NASH mouse models of NASH for probing the therapeutic efficacy of compounds in preclinical drug development for NASH. | Kirstine S Tolbol Maria NB Kristiansen Henrik H Hansen Sanne S Veidal Kristoffer TG Rigbolt Matthew P Gillum Jacob Jelsing Niels Vrang Michael Feigh | 2018 | World Journal of Gastroenterology2018，24，2： | 5 |
| 3 | New oral pharmacotherapeutic agents for venous thromboprophylaxis after total hip arthroplasty显示文摘Patients undergoing total hip arthroplasty(THA)are at high risk for developing venous thromboembolism and,therefore,require short term prophylaxis with antithrombotic agents.Recently,target specific oral anticoagulants(TSOA)including the direct thrombin inhibitor,dabigatran,and the factorⅩa inhibitors rivaroxaban,apixaban,and edoxaban have been approved for THA thrombopropylaxis in various countries.The TSOAs provide a rapid acting,oral alternative to parenteral agents including low-molecular weight heparins(LMWH)and fondaparinux;and compared to warfarin,they do not require routine laboratory monitoring and possess much fewer drug-drug interactions.Based on phaseⅢclinical studies,TSOAs have established themselvesas an effective and safe option for thromboprophylaxis after THA compared to LMWH,particularly enoxaparin,but require additional evaluation in specific populations such as the renally impaired or elderly.The ability to monitor and reverse these TSOAs in the case of bleeding complications or suspected sub-or supra-therapeutic anticoagulation is of importance,but remains investigational.This review will focus on the drug-specific characteristics,efficacy,safety,and economic impact of the TSOAs for thromboprophylaxis following THA,as well as the aspects of therapeutic monitoring and anticoagulation reversal in the event of bleeding complications or a need for urgent reversal. | Garrett B Aikens Jacob R Osmundson Michael P Rivey | 2014 | World Journal of Orthopedics2014，5，3： | 3 |
| 4 | Distribution and effects of polymorphic RANTES gene alleles in HIV/HCV coinfection - A prospective cross-sectional study显示文摘AIM: Chemokines and their receptors are crucial for immune responses in HCV and HIV infection. RANTES gene polymorphisms lead to altered gene expression and influence the natural course of HIV infection. Therefore,these mutations may also affect the course of HIV/HCV coinfection.METHODS: We determined allele frequencies of RANTES-403 (G→A), RANTES-28 (C→G) and RANTESIN1.1 (T→C) polymorphisms using real-time PCR and hybridization probes in patients with HIV (n = 85), HCV (n= 112), HIV/HCV coinfection (n = 121), and 109 healthy controls. Furthermore, HIV and HCV loads as well as CD4+ and CD8+ cell counts were compared between different RANTES genotypes.RESULTS: Frequencies of RANTES-403 A, RANTES-28 G and RANTES-IN1.1 C alleles were higher in HIV infected patients than in healthy controls (-403: 28.2% vs 15.1%,P = 0.002; -28: 5.4% vs 2.8%, not significant; IN1.1:19.0% vs 11.0%, P = 0.038). In HIV/HCV coinfected patients, these RANTES alleles were less frequent than in patients with HIV infection alone (15.4% P = 0.002;1.7%; P = 0.048; 12.0%; not significant). Frequencies of these alleles were not significantly different between HIV/HCV positive patients, HCV positive patients and healthy controls.CONCLUSION: All three RANTES polymorphisms showed increased frequencies of the variant allele exclusively in patients with HIV monoinfection. The finding that the frequencies of these alleles remained unaltered in HIV/HCV coinfected patients suggests that HCV coinfection interferes with selection processes associated with these alleles in HIV infection. | Golo Ahlenstiel Agathe Iwan Jacob Nattermann Karin Bueren Jürgen K Rockstroh Hans H Brackmann Bernd Kupfer Olfert Landt Amnon Peled Tilman Sauerbruch Ulrich Spengler Rainer P Woitas | 2005 | World Journal of Gastroenterology2005，11，48： | 3 |
| 5 | Interaction of insulin receptor substrate 3 with insulin receptor, insulin receptor-related receptor, insulinlike growth factor-1 receptor, and downstream signaling proteins显示文摘 | Xu P Jacobs A R Taylor S I | 1999 | J Biol Chem1999，274，15： | 1 |
| 6 | Dietary iron deficiency and sports anaemia显示文摘 | Weight LM Jacobs P Noakes TD | 1992 | Br J Nutr1992，68，1： | 1 |
| 7 | Extracorporeal photochemotherapy for treatment of clonal T cell proliferations 显示文摘 | Plumas J Drillat P Jacob MC | 2003 | Bull Cancer2003，90，89： | 1 |
| 8 | Sediment-related growth limitation of Elodea nuttallii as indicated by a fertilization experiment显示文摘 | BEST E P WOLTMAN H JACOBS F H | 1996 | Fresh Water Biology1996，36，： | 1 |
| 9 | Use of a robust dehydrogenase from an archael hyperthermophile in asymmetric catalysisdynamic reductive kinetic resolution entry into (S)-profens 显示文摘 | Jacob AF Maezato BS Blum P | 2010 | J Am Chem Soc2010，132，17： | 1 |
| 10 | Venture capital:structure and incentives显示文摘 | Yoram L Jacob P | 1995 | International Review of Economics and Fiannce1995，4，4： | 1 |
| 11 | Evidence for the nature of true Lewis sites in faujasite - type zeolites显示文摘 | JACOBS P A H K BEYER | 1979 | J Phys Chem1979，83，9： | 1 |
| 12 | Meta-analysis of 143 Reported Cases of Aortic Intramural Hematoma显示文摘 | Maraj R Rerkpattanapipat P Jacobs LE | 2000 | Am J Cardiol2000，86，6： | 1 |
| 13 | Autologous stem cell transplantation for systemic lupus erythematosus显示文摘 | David J Jacob P Alberto M | 2004 | Lupus2004，13，3： | 1 |
| 14 | Protection of experimentally infected pigs by suil- ysin, the thiol-activated haemolysin of Streptococcus suis 显示文摘 | JACOBS A A VAN DEN BERG A J LOEFFEN P L | 1996 | Vet Rec1996，139，10： | 1 |
| 15 | Efficient hydrolytic hydrogenation of cellulose in the presence of Ru-loaded zeolites and trace amounts of mineral acid显示文摘 | GEBOERS J VAN DE VYVER S CARPENTIER K JACOBS P SELS B | 2011 | Catal Commun2011，47，19： | 1 |
| 16 | Water-gas shift:in situ spectroscopic studies of noble metal promoted ceria catalysts for CO removal in fuel cell reformers and mechanistic implications显示文摘 | Jacobs G Patterson P M Williams L | 2004 | Appl Phys A2004，262，2： | 1 |
| 17 | Measured context-sensitive half-times of remifentanil and alfentanil 显示文摘 | KAPILA A GLASS P S JACOBS J R | 1995 | Anesthesiology1995，83，5： | 1 |
| 18 | Landscape prospects of the next millennium显示文摘 | JACOBS P MANN R | 2000 | Landscape and Urban Planning2000，，47： | 1 |
| 19 | Mast cell try ptase controls paracellular pemreability of the intestine : role of protease activated receptor 2and-arrestins 显示文摘 | JACOB C YANG P C DARMOUL D | 2005 | J Biol Chem2005，280，31： | 1 |
| 20 | Apidaecins:antibacterial peptides from honeybees显示文摘 | Ampe C Jacobs F | 1989 | Eur MolBiol Organiz J1989，8，8： | 1 |
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