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| 1 | p63 is an essential pro- apoptotie protein during neural development 显示文摘 | Jacobs WB Govoni G Ho D | 2005 | Neuron2005，，48： | 1 |
| 2 | Downregulation of pro- tein disulfide isomerase in sepsis and its role in tumor necrosis factor-alpha release显示文摘 | Zhou M Jacob A Ho N | 2008 | Crit Care2008，，12： | 1 |
| 3 | p63 is an essential proapoptosis protein during development neural develop- ment显示文摘 | Jacobs WB Govoni G Ho D | 2005 | Neuron2005，48，： | 1 |
| 4 | Downregulation of protein disul- fide isomerase in sepsis and its role in tumor necrosis factor-alpha release显示文摘 | Zhou M Jacob A Ho N | 2008 | Crit Care2008，12，4： | 1 |
| 5 | p63 is an essential proapoptotic protein during neural development 显示文摘 | Jacobs W B Govoni G Ho D | 2005 | Neuron2005，48，8： | 1 |
| 6 | Determination of liquid-crystal polar anchoring energy by electrical measurements 显示文摘 | Anatoli Murauski Vladimir Chigrinov Alexander Muravsky Fion Sze-Yan Yeung Jacob Ho Hoi-Sing Kwok | 2005 | Phys Rev E2005，71，06： | 1 |
| 7 | Management of women who test positive for high-risk types of human papillomavirus: the HART study显示文摘 | J Cuzick A Szarewski H Cubie G Hulman H Kitchener D Luesley E McGoogan U Menon G Terry R Edwards C Brooks M Desai C Gie L Ho I Jacobs C Pickles P Sasieni | 2003 | The Lancet2003，，9399： | 1 |
| 8 | The role of gene variants in the pathogenesis of neurodegenerative disorders as revealed by next generation sequencing studies:a review显示文摘The clinical diagnosis of neurodegenerative disorders based on phenotype is difficult in heterogeneous conditions with overlapping symptoms.It does not take into account the disease etiology or the highly variable clinical course even amongst patients diagnosed with the same disorder.The advent of next generation sequencing(NGS)has allowed for a system-wide,unbiased approach to identify all gene variants in the genome simultaneously.With the plethora of new genes being identified,genetic rather than phenotype-based classification of Mendelian diseases such as spinocerebellar ataxia(SCA),hereditary spastic paraplegia(HSP)and Charcot-Marie-Tooth disease(CMT)has become widely accepted.It has also become clear that gene variants play a role in common and predominantly sporadic neurodegenerative diseases such as Parkinson’s disease(PD)and amyotrophic lateral sclerosis(ALS).The observation of pleiotropy has emerged,with mutations in the same gene giving rise to diverse phenotypes,which further increases the complexity of phenotype-genotype correlation.Possible mechanisms of pleiotropy include different downstream effects of different mutations in the same gene,presence of modifier genes,and oligogenic inheritance.Future directions include development of bioinformatics tools and establishment of more extensive public genotype/phenotype databases to better distinguish deleterious gene variants from benign polymorphisms,translation of genetic findings into pathogenic mechanisms through in-vitro and in-vivo studies,and ultimately finding disease-modifying therapies for neurodegenerative disorders. | Shirley Yin-Yu Pang Kay-Cheong Teo Jacob Shujui Hsu Richard Shek-Kwan Chang Miaoxin Li Pak-Chung Sham Shu-Leong Ho | 2017 | Translational Neurodegeneration2017，6，1： | 1 |
| 9 | p63 is an essential proapoptotic protein during neural development 显示文摘 | Jacobs WB Govoni G Ho D | 2005 | Neuron2005，48，5： | 1 |
| 10 | In vivo treatment of(NZB X NZW)F1 lupus-like nephritis with monoclonal antibody toγinterferon显示文摘 | Jacob CO van der Meide PH Mc Devitt HO | 1987 | J Exp Med1987，166，3： | 1 |
| 11 | Estimated prevalence and trends in smoking among adolescents in South Korea,2005-2021:a nationwide serial study显示文摘Background Although smoking is classified as a risk factor for severe COVID-19 outcomes,there is a scarcity of studies on prevalence of smoking during the COVID-19 pandemic.Thus,this study aims to analyze the trends of prevalence of smoking in adolescents over the COVID-19 pandemic period.Methods The present study used data from middle to high school adolescents between 2005 and 2021 who participated in the Korea Youth Risk Behavior Web-based Survey(KYRBS).We evaluated the smoking prevalence(ever or daily)by year groups and estimated the slope in smoking prevalence before and during the pandemic.Results A total of 1,137,823 adolescents participated in the study[mean age,15.04 years[95%confidence interval(CI)15.03-15.06];and male,52.4%(95%CI 51.7-53.1)].The prevalence of ever smokers was 27.7%(95%CI 27.3-28.1)between 2005 and 2008 but decreased to 9.8%(95%CI 9.3-10.3)in 2021.A consistent trend was found in daily smokers,as the estimates decreased from 5.4%(95%CI 5.2-5.6)between 2005 and 2008 to 2.3%(95%CI 2.1-2.5)in 2021.However,the downward slope in the overall prevalence of ever smokers and daily smokers became less pronounced in the COVID-19 pandemic period than in the pre-pandemic period.In the subgroup with substance use,the decreasing slope in daily smokers was significantly more pronounced during the pandemic than during the pre-pandemic period.Conclusions The proportion of ever smokers and daily smokers showed a less pronounced decreasing trend during the pandemic.The findings of our study provide an overall understanding of the pandemic's impact on smoking prevalence in adolescents. | Hyoin Shin Sangil Park Hyunju Yon Chae Yeon Ban Stephen Turner Seong Ho Cho Youn Ho Shin Jung U.Shin Ai Koyanagi Louis Jacob Lee Smith Chanyang Min Young Joo Lee So Young Kim Jinseok Lee Rosie Kwon Min Ji Koo Guillaume Fond Laurent Boyer Jong Woo Hahn Namwoo Kim Sang Youl Rhee Jae Il Shin Ho Geol Woo Hyeowon Park Hyeon Jin Kim Yoonsung Lee Man S.Kim Eléa Lefkir Vlasta Hadalin Jungwoo Choi Seung Won Lee Dong Keon Yon Sunyoung Kim | 2023 | World Journal of Pediatrics2023，19，4： | 1 |
| 12 | Oxidized LDL and the metabolic syndrome显示文摘 | Ho|voet P De-Keyer D Jacobs D R | 2005 | Future Lipidol2005，3，6： | 1 |
| 13 | Case of infantile onset spinocerebellar ataxia type 5显示文摘 | Jacob FD Ho ES Martinez-Ojeda M | 2013 | J Child Neurol2013，28，： | 1 |
| 14 | p63 is an essential proapop- totic protein during neural development 显示文摘 | Jacobs W B Govoni G Ho D | 2005 | Neuron2005，148，5： | 1 |
| 15 | Tumour necrosis factor-alpha in murine autoimmune 'lupus' nephritis显示文摘 | Jacob CO McDevitt HO | 1988 | Nature1988，331，6154： | 1 |
| 16 | P63 is an essential proapoptotic protein during neural development 显示文摘 | Jacobs WB Govoni G Ho D | 2005 | Neuron2005，48，5： | 1 |
| 17 | MHC class 11-associated variation in the production of tumor necrosis factor in mice and humans:relevance to the pathogenesis of sutoimmune diseases显示文摘 | Jacob CO Lewis GD McDevitt HO | 1991 | Immunol Res1991，10，2： | 1 |
| 18 | Tumor necrosis factor in murine autoimmune lupus nephritis显示文摘 | Jacob CO Mcdevitt HO | 1988 | Nature1988，331，6154： | 1 |
| 19 | Management of women who test positive for high-risk types of human papillomavirus: the HART study显示文摘 | J Cuzick A Szarewski H Cubie G Hulman H Kitchener D Luesley E McGoogan U Menon G Terry R Edwards C Brooks M Desai C Gie L Ho I Jacobs C Pickles P Sasieni | 2003 | The Lancet2003，，9399： | 1 |
| 20 | In vivo treatment of (NZBxNZW)F1 lupus-like nephritis with monoclonal antibody to gamma interferon显示文摘 | van der Meide PH McDevitt HO | 1987 | J Exp Med1987，166，： | 1 |
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